Main Campus; CHOP Newborn Care at the Hospital of the University of Pennsylvania
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
Main Campus; CHOP Newborn Care at the Hospital of the University of Pennsylvania
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
Scott A. Lorch, MD, MSCE, is a professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania and the Director for the Center for Clinical Epidemiology and Biostatistics. He also serves as Associate Chief of the Division of Neonatology.
Dr. Lorch received his Master of Science degree in Clinical Epidemiology (MSCE) from the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania and has been a faculty investigator at the Center for Outcomes Research centrally involved with projects concerning health economics and quality of care research in both adult and pediatric settings.
Dr. Lorch is the director of the Center for Perinatal and Pediatric Health Disparities Research and is the principal investigator on four federally funded projects. Currently he is the principal investigator of a study entitled Parental Trust and Racial Disparities in the Care of Discharged Premature Infants, funded by the National Institute of Child Health and Human Development (Grant Number 1R01HD57168); a study entitled Aggregated Complication Measure for Neonatal Quality of Care funded by the Maternal and Child Health Bureau (Grant Number R40MC05474), a three-year study funded by the Agency for Healthcare Research and Quality entitled Perinatal Regionalization and Quality of Care (Grant Number 1R01HS015696-01A2); and a four-year study funded by the Agency for Healthcare Research and Quality entitled Impact of Obstetric Unit Closures on Pregnancy Outcomes (R018661).
Dr. Lorch is also an investigator in the Pediatric Quality Metric Consortium site at The Children's Hospital of Philadelphia. He was worked with Pennsylvania and New York pediatric discharge data to examine the effects of hospital occupancy on the efficiency of pediatric hospital care, and the difference between urban and rural hospitals in terms of treatment of children. These outcomes studies were conducted at the Center for Outcomes Research, working with the COR research staff.
His work has investigated various measures of infant quality of care and analyses of systems for delivering neonatal care, specifically using an instrumental variables approach and other methods to reduce systematic biases in these types of studies.
MD - Northwestern University School of Medicine, Chicago, IL
Vanderbilt University School of Medicine, Nashville, TN
Pediatrics - Vanderbilt University School of Medicine, Nashville, TN
Neonatal-Perinatal Medicine - The Children's Hospital of Philadelphia, Philadelphia, PA
Associate Chief, Division of Neonatology
Director, Clinical and Epidemiological Research
Kristine Sandberg Knisely Professor of Pediatrics
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Measurement of the quality of neonatal intensive care and pediatric care using hospital and state-level data
Economics of new technologies in neonatology
Bamat N, Gibbs K, Eichenwald E, Lorch S, Jensen E. Loop Diuretics in Severe Bronchopulmonary Dysplasia: Cumulative Use and Associations with Mortality and Age at Discharge. (J Pediatr 2020;1-7). doi.org/10.1016/j.jpeds.2020.10.073.
Changes in Preterm Birth Phenotypes and Stillbirth at 2 Philadelphia Hospitals During the SARS-CoV-2 Pandemic, March-June 2020. Handley SC, Mullin AM, Elovitz MA, Gerson KD, Montoya-Williams D, Lorch SA, Burris HH. JAMA. 2020 Dec 7. doi: 10.1001/jama.2020.20991. Online ahead of print. PMID: 33284323 No abstract available.
Racial and Ethnic Disparities in the Delayed Diagnosis of Appendicitis Among Children. Goyal MK, Chamberlain JM, Webb M, Grundmeier RW, Johnson TJ, Lorch SA, Zorc JJ, Alessandrini E, Bajaj L, Cook L, Alpern ER; Pediatric Emergency Care Applied Research Network (PECARN). Acad Emerg Med. 2020 Sep 29. doi: 10.1111/acem.14142. Online ahead of print. PMID: 32991770.
Chuo J, Macy ML, Lorch SA. Strategies for Evaluating Telehealth. Pediatrics. 2020 Aug 18:e20201781. doi: 10.1542/peds.2020-1781. Online ahead of print. PMID: 32817398 Review. No abstract available.
D'Agostino JA, Passarella M, Martin AE, Lorch SA. Medication Utilization at School Age for Children Born Preterm. J Pediatr. 2020 Jan 3. pii: S0022-3476(19)31552-5. doi: 10.1016/j.jpeds.2019.11.015. [Epub ahead of print] PMID: 31910993
Travers CP, Carlo WA, McDonald SA, Das A, Ambalavanan N, Bell EF, Sánchez PJ, Stoll BJ, Wyckoff MH, Laptook AR, Van Meurs KP, Goldberg RN, D'Angio CT, Shankaran S, DeMauro SB, Walsh MC, Peralta-Carcelen M, Collins MV, Ball MB, Hale EC, Newman NS, Profit J, Gould JB, Lorch SA, Bann CM, Bidegain M, Higgins RD; Racial/Ethnic Disparities Among Extremely Preterm Infants in the United States From 2002 to 2016. Generic Database and Follow-up Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. JAMA Netw Open. 2020 Jun 1;3(6):e206757. doi: 10.1001/jamanetworkopen.2020.6757. PMID: 32520359 [PubMed - in process] Free PMC Article
Mukhopadhyay S, Puopolo KM, Hansen NI, Lorch SA, DeMauro SB, Greenberg RG, Cotten CM, Sánchez PJ, Bell EF, Eichenwald EC, Stoll BJ; Impact of Early-Onset Sepsis and Antibiotic Use on Death or Survival with Neurodevelopmental Impairment at 2 Years of Age among Extremely Preterm Infants. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 2020 Jun;221:39-46.e5. doi: 10.1016/j.jpeds.2020.02.038. PMID: 32446491 [PubMed - in process]
Travers CP, Carlo WA, McDonald SA, Das A, Ambalavanan N, Bell EF, Sánchez PJ, Stoll BJ, Wyckoff MH, Laptook AR, Van Meurs KP, Goldberg RN, D'Angio CT, Shankaran S, DeMauro SB, Walsh MC, Peralta-Carcelen M, Collins MV, Ball MB, Hale EC, Newman NS, Profit J, Gould JB, Lorch SA, Bann CM, Bidegain M, Higgins RD; Racial/Ethnic Disparities Among Extremely Preterm Infants in the United States From 2002 to 2016. Generic Database and Follow-up Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. JAMA Netw Open. 2020 Jun 1;3(6):e206757. doi: 10.1001/jamanetworkopen.2020.6757. PMID: 32520359 [PubMed - in process]
Lorch SA. Interhospital Transfers for Quality Assessment of Healthcare Systems. J Hosp Med. 2019 Aug;14(8):514-515. doi: 10.12788/jhm.3243. No abstract available.
Boghossian NS, Geraci M, Lorch SA, Phibbs CS, Edwards EM, Horbar JD. Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation. Pediatrics. 2019 Aug 12. pii: e20191106. doi: 10.1542/peds.2019-1106. [Epub ahead of print]
Burris HH, Wright CJ, Kirpalani H, Collins JW Jr, Lorch SA, Elovitz MA, Hwang SS. The promise and pitfalls of precision medicine to resolve black-white racial disparities in preterm birth. Pediatr Res. 2019 Aug 5. doi: 10.1038/s41390-019-0528-z. [Epub ahead of print] Review.
Handley SC, Srinivas SK, Lorch SA. Regionalization of Care and the Maternal-Infant Dyad Disconnect. JAMA. 2019 Jul 8. doi: 10.1001/jama.2019.6403. [Epub ahead of print] No abstract available.
Bamat NA, Kirpalani H, Feudtner C, Jensen EA, Laughon MM, Zhang H, Monk HM, Passarella M, Lorch SA. Medication use in infants with severe bronchopulmonary dysplasia admitted to United States children's hospitals. J Perinatol. 2019 Jun 21. doi: 10.1038/s41372-019-0415-9. [Epub ahead of print]
DeMauro SB, Jensen E, Bann C, Bell E, Hibbs AM, Hintz S, Lorch S: Home Oxygen and 2-Year Outcomes of Preterm Infants with Bronchopulmonary Dysplasia. Pediatrics e-pub ahead of print, April 2019.
Horbar JD, Edwards EM, Greenberg LT, Profit J, Draper D, Helkey D, Lorch SA, Lee HC, Phibbs CS, Rogowski J, Gould JB, Firebaugh G. Racial Segregation and Inequality in the Neonatal Intensive Care Unit for Very Low-Birth-Weight and Very Preterm Infants. JAMA Pediatr. 2019 Mar 25. doi: 10.1001/jamapediatrics.2019.0241. [Epub ahead of print]
Burris HH, Lorch SA, Kirpalani H, Pursley DM, Elovitz MA, Clougherty JE. Racial disparities in preterm birth in the US; a biosensor of physical and social environmental exposures. Arch Dis Child. 2019 Mar 8. pii: archdischild-2018-316486. doi: 10.1136/archdischild-2018-316486. [Epub ahead of print]
Bozzuto L, Passarella M, Lorch S, Srinivas S. Effects of Delivery Volume and High-Risk Condition Volume on Maternal Morbidity Among High-Risk Obstetric Patients. Obstet Gynecol. 2019 Feb;133(2):261-268.
Handley S, Passarella M, Lorch S, Lee H: Survey of Preterm Neuro-Centric Care Practices in California Neonatal Intensive Care Units. J Perinatol 39(2): 256-262, Feb 2019.
Lee K, Lorch SA, Small DS. Sensitivity analyses for average treatment effects when outcome is censored by death in instrumental variable models. Stat Med. 2019 Feb 20. doi: 10.1002/sim.8117. [Epub ahead of print]
Enlow E, Gray MM, Wallace-Keeshen S, D'Agostino JA, Abbasi S, Lorch SA. Health literacy of parents of very preterm infants at NICU admission and discharge: a prospective cohort study. J Perinatol. 2019 Feb 15. doi: 10.1038/s41372-019-0340-y. [Epub ahead of print]
MR Boland, A Kashyap, J Xiong, JH Holmes, S Lorch: Development and Validation of the PEPPER Framework (Prenatal Exposure PubMed ParsER) with Applications to Food Additives. J Am Med Inform Assoc. 2018 Nov 1;25(11):1432-1443. doi: 10.1093/jamia/ocy119.
GBD 2017 Mortality Collaborators. Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018 Nov 10;392(10159):1684-1735. doi: 10.1016/S0140-6736(18)31891-9. Epub 2018 Nov 8.
Phibbs CS, Schmitt SK, Cooper M, Gould JB, Lee HC, Profit J, Lorch SA: Birth Hospitalization Costs and Days of Care for Mothers and Neonates in California, 2009-2011. J Pediatr. 2019 Jan;204:118-125.e14. doi: 10.1016/j.jpeds.2018.08.041. Epub 2018 Oct 5.
Handley SC, Passarella M, Lee HC, Lorch SA. Incidence Trends and Risk Factor Variation in Severe Intraventricular Hemorrhage across a Population Based Cohort. J Pediatr. 2018 May 10. pii: S0022-3476(18)30510-9. doi: 10.1016/j.jpeds.2018.04.020. [Epub ahead of print]
Phibbs CS, Lorch SA. Choice of Hospital as a Source of Racial/Ethnic Disparities in Neonatal Mortality and Morbidity Rates. JAMA Pediatr. 2018 Jan 2. doi: 10.1001/jamapediatrics.2017.4917. [Epub ahead of print] No abstract available. PMID: 29297051
Goyal MK, Johnson TJ, Chamberlain JM, Casper TC, Simmons T, Alessandrini EA, Bajaj L, Grundmeier RW, Gerber JS, Lorch SA, Alpern ER. Pediatric Care Applied Research Network (PECARN). Racial and Ethnic Differences in Antibiotic Use for Viral Illness in Emergency Departments. Pediatrics. 2017 Sep 5. pii: e20170203. doi: 10.1542/peds.2017-0203. [Epub ahead of print]
Lorch SA. Health Equity and Quality of Care Assessment: A Continuing Challenge. Pediatrics. 2017 Sep;140(3). pii: e20172213. doi: 10.1542/peds.2017-2213.
Lorch SA. Perinatal legislative policies and health outcomes. Semin Perinatol. 2017 Aug 28. pii: S0146-0005(17)30078-2. doi: 10.1053/j.semperi.2017.07.006. [Epub ahead of print]
Lorch SA. Understanding pregnancy outcomes using epidemiology and health services research. Semin Perinatol. 2017 Aug 28. pii: S0146-0005(17)30080-0. doi: 10.1053/j.semperi.2017.07.008. [Epub ahead of print]
Jensen EA, Lorch SA. Association between off-peak hour birth and neonatal morbidity and mortality among very low birth weight infants. J Pediatr. 2017;186:41-48
Bamat NA, Tharakan SJ, Connelly JT, Hedrick HL, Lorch SA, Rintoul NE, Williams SB, Dysart D’Agostino JA KC. Venoarterial extracorporeal life support for neonatal respiratory failure: indications and impact on mortality. ASAIO J. 2016 Dec 13. Doi:10.1097/MAT.0000000000000495 [Epub ahead of print]
Martin AE, D'Agostino JA, Passarella M, Lorch SA. Racial differences in parental satisfaction with neonatal intensive care unit nursing care. J Perinatol. 2016 Nov;36(11):1001-1007. doi: 10.1038/jp.2016.142.
Peltz A, Wu CL, White ML, Wilson KM, Lorch SA, Thurm C, Hall M, Berry JG. Characteristics of Rural Children Admitted to Pediatric Hospitals. sp;Pediatrics. 2016 May;137(5). pii: e20153156. doi: 10.1542/peds.2015-3156. Epub 2016 Apr 11. PMID: 27244794.
Zubizarreta JR, Lorch SA, Marshall G, D'Apremont I, Tapia JL. Effect of prophylactic CPAP in very low birth weight infants in South America. J Perinatol. 2016 Apr 7. doi: 10.1038/jp.2016.56. [Epub ahead of print] PMID: 27054844.
Kozhimannil KB, Hung P, Casey MM, Lorch SA. Factors associated with high-risk rural women giving birth in non-NICU hospital settings. J Perinatol. 2016 Feb 18. doi: 10.1038/jp.2016.8.
Jensen EA, Lorch SA. Effects of a Birth Hospital's Neonatal Intensive Care Unit Level and Annual Volume of Very Low-Birth-Weight Infant Deliveries on Morbidity and Mortality. JAMA Pediatr. 2015 Aug 3;169(8):e151906. doi: 10.1001/jamapediatrics.2015.1906. Epub 2015 Aug 3. PMID: 26237466
Tucker Edmonds B, Mckenzie F, Macheras M, Srinivas SK, Lorch SA. Morbidity and mortality associated with mode of delivery for breech periviable deliveries. Am J Obstet Gynecol. 2015 Mar 3. pii: S0002-9378(15)00196-9. doi: 10.1016/j.ajog.2015.03.002. [Epub ahead of print] PMID: 25747545 [PubMed - as supplied by publisher]
Lorch SA. The Clinical and Policy Implications of New Measures of Premature Infant Growth. Pediatrics. 2015 Feb 16. pii: peds.2014-3774. [Epub ahead of print]
Lorch SA. Ensuring Access to the Appropriate Healthcare Professionals: Regionalization and Centralization of Care in a New Era of Healthcare Financing and Delivery. JAMA Pediatr. 2014 Nov 10. doi: 10.1001/jamapediatrics.2014.2468. [Epub ahead of print]
Rabner M, Meurling J, Ahlberg C, Lorch SA: The impact of growth curves changes in assessing premature infant growth. J Perinatol 34: 49-53, Jan 2014.
Liu Y, Traskin M, Lorch SA, George E, Small D: Ensemble of trees approaches to risk adjustment for evaluating a hospital's performance. Special Issues: Health Analytics of Healthcare Manag Sci Page: [Epub ahead of print] Apr 2014.
Tucker Edmonds B, Ahlberg C, McPherson K, Srinivas S, Lorch SA: Predictors and adverse pregnancy outcomes associated with antepartum discharge against medical advice. Matern Child Health J 18(3): 640-647, Apr 2014.
DeMauro SB, Abbasi S, Lorch SA: Enteral feeding strategies in low birth weight infants: A retrospective analysis. J Perinatol in press.
Enlow E, Herbert S, Jovel I, Lorch SA, Anderson C, Chamberlain L: Neonatal Intensive Care Unit to home: The transition from parent and pediatrician perspectives, a Prospective Cohort Study. J Perinatol in press.
Kozhimannil K, Macheras M, Lorch SA: Trends in childbirth before 39 weeks' gestation without medical indication. Med Care in press.
Patrick S, Kaplan H, Passarella M, Davis M, Lorch SA: Variation in treatment of neonatal abstinence syndrome in US children's hospitals, 2004-2011. J Perinatol in press.
Yang F, Lorch SA, Small DS: Estimation of causal effects using instrumental variables with nonignorable missing covariates: Application to effect of type of delivery NICU on premature infants. Ann Appl Stat in press.
Goyal N, Zubizarreta JR, Small DS, Lorch SA: Length of stay and readmissions among late preterm infants: an instrumental variable approach. Hospital Pediatrics 38(1): 7-15, Jan 2013.
Lorch SA, Srinivas SK, Ahlberg C, Small DS: The impact of obstetric unit closures on maternal and infant pregnancy outcomes. Health Serv Res 48(2 Pt 1): 455-75, Apr 2013.
Ray KN and Lorch SA: Hospitalization of early preterm, late preterm, and term infants during the first year of life by gestational age. Hospital Pediatrics 3(3): 194-203, Jul 2013.
Srinivas SK, Fager C, Lorch SA: Variations in postdelivery infection and thrombosis by hospital teaching status. Am J Obstet Gynecol 209(6): e1-7, Dec 2013.
Zubizarreta JR, Small DS, Goyal N, Lorch SA, and Rosenbaum PR: Stronger instruments via integer programming in an observational study of late preterm birth outcomes. Ann Appl Stat 7(1): 25-50, 2013.
Lorch SA: Quality measurements in pediatrics: What do they assess? JAMA Pediatr 167(1): 89-90, January 2013.
Lorch SA: Neonatology enters the 21st century for healthcare oversight: The public reporting of healthcare outcomes. J Perinatol 32(4): 245-246, April 2012.
Lorch SA, Mollen T: Part II. Fetal Development. Chapter 8. Non-immune hydrops. Avery's Diseases of the Newborn, 9th Edition. Gleason CA, Devaskar S (eds.). Philadelphia: Elsevier, Page: 67-74, 2011.
Lorch SA: BIOETHICS: The most fragile of newborns. Science 316(5823): 374-375, April 2007.
Lorch SA, Mollen TJ, Ballard RA: Part II. Fetal Development. Chapter 8. Non-immune hydrops. In: Avery's Diseases of the Newborn, 8th ed. Taeusch HW, Ballard RA, Gleason CA. (eds.). Philadelphia: Elsevier, Page: 63-71, 2005.
Souza JM, Chen Q, Blanchard-Fillion B, Lorch SA, Hertkorn C, Lightfoot R, Weisse M, Friel T, Paxinou E, Themistocleous M, Chov S, Ischiropoulos H: Reactive nitrogen species and proteins: biological significance and clinical relevance. Adv Exp Med Biol 500: 169-174, 2001.
2012-present, Member, Neonatology Innovation Committee, CHOP Strategy Planning Committee
2009-present, Reviewer: Pilot Projects Program, Center for Pediatric Clinical Effectiveness
2007-present, Career Advisor: Department of Pediatrics
2007-present, Member: Clinical Research Committee, Division of Neonatology
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