Main Hospital; CHOP Newborn Care at the Hospital of the University of Pennsylvania
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
Main Hospital; CHOP Newborn Care at the Hospital of the University of Pennsylvania
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
Scott A. Lorch, MD, MSCE, is a professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania. He also serves as Associate Chief and Director of Clinical and Epidemiological research of the Division of Neonatology.
Dr. Lorch received an MD from Northwestern University and a Master of Science degree in Clinical Epidemiology (MSCE) from the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania. His overarching research goal to understand the root causes for variations in health outcomes and health care utilization experienced by high-risk children, particularly those born prematurely.
He has extensive expertise in three key components: (1) quality of care assessment; (2) racial/ethnic and socioeconomic disparities of care; and (3) the role of health care organization on the outcomes of ill children. These topic areas have served as the primary areas for mentorship of 3 pre-doctorial trainees and 28 post-doctoral fellows, with over 50 publications performed by these trainees. He also has extensive experience with population-based data and the development and analysis of large patient cohorts along with expertise in the statistical methodologies such as causal inference techniques and mediation analysis.
Dr. Lorch has been an investigator on 11 federally funded projects, with current projects focusing on Access to high-quality hospital and racial/ethnic disparities in perinatal outcomes; obstetric and neonatal intensive care volume-outcome relationships; risk assessment and targeted interventions for postpartum mothers; and the role of COVID on perinatal health care use and outcomes.
MD - Northwestern University School of Medicine, Chicago, IL
Vanderbilt University School of Medicine, Nashville, TN
Pediatrics - Vanderbilt University School of Medicine, Nashville, TN
Neonatal-Perinatal Medicine - The Children's Hospital of Philadelphia, Philadelphia, PA
Associate Chief, Division of Neonatology
Director, Clinical and Epidemiological Research
Kristine Sandberg Knisely Professor of Pediatrics
Harriet and Ronald Lassin Endowed Chair in Pediatric Neonatology
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Measurement of the quality of neonatal intensive care and pediatric care using hospital and state-level data
Economics of new technologies in neonatology
Bamat NA, Nelin TD, Eichenwald EC, Kirpalani H, Laughon MM, Jackson WM, Jensen EA, Gibbs KA, Lorch SA. Loop Diuretics in Severe Bronchopulmonary Dysplasia: Cumulative Use and Associations with Mortality and Age at Discharge. J Pediatr. 2021 Apr;231:43-49.e3. doi: 10.1016/j.jpeds.2020.10.073. Epub 2020 Nov 3.PMID: 33152371
Lorch SA, Rogowski J, Profit J, Phibbs CS. Access to risk-appropriate hospital care and disparities in neonatal outcomes in racial/ethnic groups and rural-urban populations. Semin Perinatol. 2021 Mar 21:151409. doi: 10.1016/j.semperi.2021.151409. Online ahead of print. PMID: 33931237
Montoya-Williams D, Passarella M, Grobman WA, Lorch SA. Racial/ethnic differences in maternal resilience and associations with low birthweight. J Perinatol. 2021 Feb;41(2):196-203. doi: 10.1038/s41372-020-00837-2. Epub 2020 Oct 7.PMID: 33028937
Mukhopadhyay S, Puopolo KM, Hansen NI, Lorch SA, DeMauro SB, Greenberg RG, Cotten CM, Sanchez PJ, Bell EF, Eichenwald EC, Stoll BJ; NICHD Neonatal Research Network. Neurodevelopmental outcomes following neonatal late-onset sepsis and blood culture-negative conditions. Arch Dis Child Fetal Neonatal Ed. 2021 Jan 21:fetalneonatal-2020-320664. doi: 10.1136/archdischild-2020-320664. Online ahead of print. PMID: 33478957.
Burris HH, Passarella M, Handley SC, Srinivas SK, Lorch SA. Black-White disparities in maternal in-hospital mortality according to teaching and Black-serving hospital status. Am J Obstet Gynecol. 2021 Jan 13:S0002-9378(21)00027-2. doi: 10.1016/j.ajog.2021.01.004. Online ahead of print. PMID: 33453183
Handley SC, Mullin AM, Elovitz MA, Gerson KD, Montoya-Williams D, Lorch SA, Burris HH. Changes in Preterm Birth Phenotypes and Stillbirth at 2 Philadelphia Hospitals During the SARS-CoV-2 Pandemic, March-June 2020. JAMA. 2021 Jan 5;325(1):87-89. doi: 10.1001/jama.2020.20991.PMID: 33284323
Patrick SW, Lorch SA. It Is Time to ACT NOW to Improve Quality for Opioid-Exposed Infants. Pediatrics. 2021 Jan;147(1):e2020028340. doi: 10.1542/peds.2020-028340. Epub 2020 Dec 21.PMID: 33386340 No abstract available.
Montoya-Williams D, Salloum RG, Lorch SA. New Strategies to Tackle the Combined Biological and Social Context of Preterm Birth. Am J Perinatol. 2021 Jan;38(2):202-204. doi: 10.1055/s-0039-1695774. Epub 2019 Sep 3.PMID: 31480082
Montoya-Williams D, Passarella M, Lorch SA. Retrospective development of a novel resilience indicator using existing cohort data: The adolescent to adult health resilience instrument. PLoS One. 2020 Dec 10;15(12):e0243564. doi: 10.1371/journal.pone.0243564. eCollection 2020.PMID: 33301500 Free PMC article.
Small DS, Firth DW, Keele LJ, Huber M, Passarella M, Lorch SA, Burris HH. Surface mining and low birth weight in central appalachia. Environ Res. 2020 Oct 22:110340. doi: 10.1016/j.envres.2020.110340. Online ahead of print.PMID: 33098818
Montoya-Williams D, Passarella M, Lorch SA. The impact of paid family leave in the United States on birth outcomes and mortality in the first year of life. Health Serv Res. 2020 Oct;55 Suppl 2(Suppl 2):807-814. doi: 10.1111/1475-6773.13288. Epub 2020 Apr 5.PMID: 32249413 Free PMC article.
Goyal MK, Chamberlain JM, Webb M, Grundmeier RW, Johnson TJ, Lorch SA, Zorc JJ, Alessandrini E, Bajaj L, Cook L, Alpern ER; Pediatric Emergency Care Applied Research Network (PECARN). Racial and Ethnic Disparities in the Delayed Diagnosis of Appendicitis Among Children. Acad Emerg Med. 2020 Sep 29. doi: 10.1111/acem.14142. Online ahead of print. PMID: 32991770.
Nance ML, DeSimone JD, Lorch SA, Passarella M, Cronin KM, Kreinces J, Myers SR. Locations of Mass Shootings Relative to Schools and Places Frequented by Children. JAMA Pediatr. 2020 Sep 8;174(11):1109-10. doi: 10.1001/jamapediatrics.2020.3371. Online ahead of print.PMID: 32897315
Chuo J, Macy ML, Lorch SA. Strategies for Evaluating Telehealth. Pediatrics. 2020 Aug 18:e20201781. doi: 10.1542/peds.2020-1781. Online ahead of print. PMID: 32817398 Review. No abstract available.
Travers CP, Carlo WA, McDonald SA, Das A, Ambalavanan N, Bell EF, Sánchez PJ, Stoll BJ, Wyckoff MH, Laptook AR, Van Meurs KP, Goldberg RN, D'Angio CT, Shankaran S, DeMauro SB, Walsh MC, Peralta-Carcelen M, Collins MV, Ball MB, Hale EC, Newman NS, Profit J, Gould JB, Lorch SA, Bann CM, Bidegain M, Higgins RD; Racial/Ethnic Disparities Among Extremely Preterm Infants in the United States From 2002 to 2016. Generic Database and Follow-up Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. JAMA Netw Open. 2020 Jun 1;3(6):e206757. doi: 10.1001/jamanetworkopen.2020.6757. PMID: 32520359 [PubMed - in process] Free PMC Article
Travers CP, Carlo WA, McDonald SA, Das A, Ambalavanan N, Bell EF, Sánchez PJ, Stoll BJ, Wyckoff MH, Laptook AR, Van Meurs KP, Goldberg RN, D'Angio CT, Shankaran S, DeMauro SB, Walsh MC, Peralta-Carcelen M, Collins MV, Ball MB, Hale EC, Newman NS, Profit J, Gould JB, Lorch SA, Bann CM, Bidegain M, Higgins RD; Racial/Ethnic Disparities Among Extremely Preterm Infants in the United States From 2002 to 2016. Generic Database and Follow-up Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. JAMA Netw Open. 2020 Jun 1;3(6):e206757. doi: 10.1001/jamanetworkopen.2020.6757. PMID: 32520359 [PubMed - in process]
Mukhopadhyay S, Puopolo KM, Hansen NI, Lorch SA, DeMauro SB, Greenberg RG, Cotten CM, Sánchez PJ, Bell EF, Eichenwald EC, Stoll BJ; Impact of Early-Onset Sepsis and Antibiotic Use on Death or Survival with Neurodevelopmental Impairment at 2 Years of Age among Extremely Preterm Infants. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 2020 Jun;221:39-46.e5. doi: 10.1016/j.jpeds.2020.02.038. PMID: 32446491 [PubMed - in process]
Gregory EF, Passarella M, Levine LD, Fiks AG, Lorch SA. Preventive Health Care Utilization Among Mother-infant Dyads With Medicaid Insurance in the Year Following Birth. Med Care. 2020 Jun;58(6):519-525. doi: 10.1097/MLR.0000000000001310.PMID: 32149923
Myers SR, DeSimone JD, Lorch SA, Passarella M, Cronin KM, Nance ML. US Hospital Type and Proximity to Mass Shooting Events. JAMA Surg. 2020 May 1;155(5):446-447. doi: 10.1001/jamasurg.2020.0095.PMID: 32186689 Free PMC article.
D'Agostino JA, Passarella M, Martin AE, Lorch SA. Medication Utilization at School Age for Children Born Preterm. J Pediatr. 2020 Jan 3. pii: S0022-3476(19)31552-5. doi: 10.1016/j.jpeds.2019.11.015. [Epub ahead of print] PMID: 31910993
Patrick SW, Lorch SA. It Is Time to ACT NOW to Improve Quality for Opioid-Exposed Infants. Pediatrics. 2021 Jan;147(1):e2020028340. doi: 10.1542/peds.2020-028340. Epub 2020 Dec 21. PMID: 33386340 No abstract available.
Bamat N, Gibbs K, Eichenwald E, Lorch S, Jensen E. Loop Diuretics in Severe Bronchopulmonary Dysplasia: Cumulative Use and Associations with Mortality and Age at Discharge. (J Pediatr 2020;1-7). doi.org/10.1016/j.jpeds.2020.10.073.
Lorch SA. Interhospital Transfers for Quality Assessment of Healthcare Systems. J Hosp Med. 2019 Aug;14(8):514-515. doi: 10.12788/jhm.3243. No abstract available.
Boghossian NS, Geraci M, Lorch SA, Phibbs CS, Edwards EM, Horbar JD. Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation. Pediatrics. 2019 Aug 12. pii: e20191106. doi: 10.1542/peds.2019-1106. [Epub ahead of print]
Burris HH, Wright CJ, Kirpalani H, Collins JW Jr, Lorch SA, Elovitz MA, Hwang SS. The promise and pitfalls of precision medicine to resolve black-white racial disparities in preterm birth. Pediatr Res. 2019 Aug 5. doi: 10.1038/s41390-019-0528-z. [Epub ahead of print] Review.
Handley SC, Srinivas SK, Lorch SA. Regionalization of Care and the Maternal-Infant Dyad Disconnect. JAMA. 2019 Jul 8. doi: 10.1001/jama.2019.6403. [Epub ahead of print] No abstract available.
Bamat NA, Kirpalani H, Feudtner C, Jensen EA, Laughon MM, Zhang H, Monk HM, Passarella M, Lorch SA. Medication use in infants with severe bronchopulmonary dysplasia admitted to United States children's hospitals. J Perinatol. 2019 Jun 21. doi: 10.1038/s41372-019-0415-9. [Epub ahead of print]
DeMauro SB, Jensen E, Bann C, Bell E, Hibbs AM, Hintz S, Lorch S: Home Oxygen and 2-Year Outcomes of Preterm Infants with Bronchopulmonary Dysplasia. Pediatrics e-pub ahead of print, April 2019.
Horbar JD, Edwards EM, Greenberg LT, Profit J, Draper D, Helkey D, Lorch SA, Lee HC, Phibbs CS, Rogowski J, Gould JB, Firebaugh G. Racial Segregation and Inequality in the Neonatal Intensive Care Unit for Very Low-Birth-Weight and Very Preterm Infants. JAMA Pediatr. 2019 Mar 25. doi: 10.1001/jamapediatrics.2019.0241. [Epub ahead of print]
Burris HH, Lorch SA, Kirpalani H, Pursley DM, Elovitz MA, Clougherty JE. Racial disparities in preterm birth in the US; a biosensor of physical and social environmental exposures. Arch Dis Child. 2019 Mar 8. pii: archdischild-2018-316486. doi: 10.1136/archdischild-2018-316486. [Epub ahead of print]
Bozzuto L, Passarella M, Lorch S, Srinivas S. Effects of Delivery Volume and High-Risk Condition Volume on Maternal Morbidity Among High-Risk Obstetric Patients. Obstet Gynecol. 2019 Feb;133(2):261-268.
Handley S, Passarella M, Lorch S, Lee H: Survey of Preterm Neuro-Centric Care Practices in California Neonatal Intensive Care Units. J Perinatol 39(2): 256-262, Feb 2019.
Lee K, Lorch SA, Small DS. Sensitivity analyses for average treatment effects when outcome is censored by death in instrumental variable models. Stat Med. 2019 Feb 20. doi: 10.1002/sim.8117. [Epub ahead of print]
Enlow E, Gray MM, Wallace-Keeshen S, D'Agostino JA, Abbasi S, Lorch SA. Health literacy of parents of very preterm infants at NICU admission and discharge: a prospective cohort study. J Perinatol. 2019 Feb 15. doi: 10.1038/s41372-019-0340-y. [Epub ahead of print]
MR Boland, A Kashyap, J Xiong, JH Holmes, S Lorch: Development and Validation of the PEPPER Framework (Prenatal Exposure PubMed ParsER) with Applications to Food Additives. J Am Med Inform Assoc. 2018 Nov 1;25(11):1432-1443. doi: 10.1093/jamia/ocy119.
GBD 2017 Mortality Collaborators. Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018 Nov 10;392(10159):1684-1735. doi: 10.1016/S0140-6736(18)31891-9. Epub 2018 Nov 8.
Phibbs CS, Schmitt SK, Cooper M, Gould JB, Lee HC, Profit J, Lorch SA: Birth Hospitalization Costs and Days of Care for Mothers and Neonates in California, 2009-2011. J Pediatr. 2019 Jan;204:118-125.e14. doi: 10.1016/j.jpeds.2018.08.041. Epub 2018 Oct 5.
Handley SC, Passarella M, Lee HC, Lorch SA. Incidence Trends and Risk Factor Variation in Severe Intraventricular Hemorrhage across a Population Based Cohort. J Pediatr. 2018 May 10. pii: S0022-3476(18)30510-9. doi: 10.1016/j.jpeds.2018.04.020. [Epub ahead of print]
Phibbs CS, Lorch SA. Choice of Hospital as a Source of Racial/Ethnic Disparities in Neonatal Mortality and Morbidity Rates. JAMA Pediatr. 2018 Jan 2. doi: 10.1001/jamapediatrics.2017.4917. [Epub ahead of print] No abstract available. PMID: 29297051
Goyal MK, Johnson TJ, Chamberlain JM, Casper TC, Simmons T, Alessandrini EA, Bajaj L, Grundmeier RW, Gerber JS, Lorch SA, Alpern ER. Pediatric Care Applied Research Network (PECARN). Racial and Ethnic Differences in Antibiotic Use for Viral Illness in Emergency Departments. Pediatrics. 2017 Sep 5. pii: e20170203. doi: 10.1542/peds.2017-0203. [Epub ahead of print]
Lorch SA. Health Equity and Quality of Care Assessment: A Continuing Challenge. Pediatrics. 2017 Sep;140(3). pii: e20172213. doi: 10.1542/peds.2017-2213.
Lorch SA. Perinatal legislative policies and health outcomes. Semin Perinatol. 2017 Aug 28. pii: S0146-0005(17)30078-2. doi: 10.1053/j.semperi.2017.07.006. [Epub ahead of print]
Lorch SA. Understanding pregnancy outcomes using epidemiology and health services research. Semin Perinatol. 2017 Aug 28. pii: S0146-0005(17)30080-0. doi: 10.1053/j.semperi.2017.07.008. [Epub ahead of print]
Jensen EA, Lorch SA. Association between off-peak hour birth and neonatal morbidity and mortality among very low birth weight infants. J Pediatr. 2017;186:41-48
Bamat NA, Tharakan SJ, Connelly JT, Hedrick HL, Lorch SA, Rintoul NE, Williams SB, Dysart D’Agostino JA KC. Venoarterial extracorporeal life support for neonatal respiratory failure: indications and impact on mortality. ASAIO J. 2016 Dec 13. Doi:10.1097/MAT.0000000000000495 [Epub ahead of print]
Martin AE, D'Agostino JA, Passarella M, Lorch SA. Racial differences in parental satisfaction with neonatal intensive care unit nursing care. J Perinatol. 2016 Nov;36(11):1001-1007. doi: 10.1038/jp.2016.142.
Peltz A, Wu CL, White ML, Wilson KM, Lorch SA, Thurm C, Hall M, Berry JG. Characteristics of Rural Children Admitted to Pediatric Hospitals. sp;Pediatrics. 2016 May;137(5). pii: e20153156. doi: 10.1542/peds.2015-3156. Epub 2016 Apr 11. PMID: 27244794.
Zubizarreta JR, Lorch SA, Marshall G, D'Apremont I, Tapia JL. Effect of prophylactic CPAP in very low birth weight infants in South America. J Perinatol. 2016 Apr 7. doi: 10.1038/jp.2016.56. [Epub ahead of print] PMID: 27054844.
Kozhimannil KB, Hung P, Casey MM, Lorch SA. Factors associated with high-risk rural women giving birth in non-NICU hospital settings. J Perinatol. 2016 Feb 18. doi: 10.1038/jp.2016.8.
Jensen EA, Lorch SA. Effects of a Birth Hospital's Neonatal Intensive Care Unit Level and Annual Volume of Very Low-Birth-Weight Infant Deliveries on Morbidity and Mortality. JAMA Pediatr. 2015 Aug 3;169(8):e151906. doi: 10.1001/jamapediatrics.2015.1906. Epub 2015 Aug 3. PMID: 26237466
Tucker Edmonds B, Mckenzie F, Macheras M, Srinivas SK, Lorch SA. Morbidity and mortality associated with mode of delivery for breech periviable deliveries. Am J Obstet Gynecol. 2015 Mar 3. pii: S0002-9378(15)00196-9. doi: 10.1016/j.ajog.2015.03.002. [Epub ahead of print] PMID: 25747545 [PubMed - as supplied by publisher]
Lorch SA. The Clinical and Policy Implications of New Measures of Premature Infant Growth. Pediatrics. 2015 Feb 16. pii: peds.2014-3774. [Epub ahead of print]
Lorch SA. Ensuring Access to the Appropriate Healthcare Professionals: Regionalization and Centralization of Care in a New Era of Healthcare Financing and Delivery. JAMA Pediatr. 2014 Nov 10. doi: 10.1001/jamapediatrics.2014.2468. [Epub ahead of print]
Rabner M, Meurling J, Ahlberg C, Lorch SA: The impact of growth curves changes in assessing premature infant growth. J Perinatol 34: 49-53, Jan 2014.
Liu Y, Traskin M, Lorch SA, George E, Small D: Ensemble of trees approaches to risk adjustment for evaluating a hospital's performance. Special Issues: Health Analytics of Healthcare Manag Sci Page: [Epub ahead of print] Apr 2014.
Tucker Edmonds B, Ahlberg C, McPherson K, Srinivas S, Lorch SA: Predictors and adverse pregnancy outcomes associated with antepartum discharge against medical advice. Matern Child Health J 18(3): 640-647, Apr 2014.
DeMauro SB, Abbasi S, Lorch SA: Enteral feeding strategies in low birth weight infants: A retrospective analysis. J Perinatol in press.
Enlow E, Herbert S, Jovel I, Lorch SA, Anderson C, Chamberlain L: Neonatal Intensive Care Unit to home: The transition from parent and pediatrician perspectives, a Prospective Cohort Study. J Perinatol in press.
Kozhimannil K, Macheras M, Lorch SA: Trends in childbirth before 39 weeks' gestation without medical indication. Med Care in press.
Patrick S, Kaplan H, Passarella M, Davis M, Lorch SA: Variation in treatment of neonatal abstinence syndrome in US children's hospitals, 2004-2011. J Perinatol in press.
Yang F, Lorch SA, Small DS: Estimation of causal effects using instrumental variables with nonignorable missing covariates: Application to effect of type of delivery NICU on premature infants. Ann Appl Stat in press.
Goyal N, Zubizarreta JR, Small DS, Lorch SA: Length of stay and readmissions among late preterm infants: an instrumental variable approach. Hospital Pediatrics 38(1): 7-15, Jan 2013.
Lorch SA, Srinivas SK, Ahlberg C, Small DS: The impact of obstetric unit closures on maternal and infant pregnancy outcomes. Health Serv Res 48(2 Pt 1): 455-75, Apr 2013.
Ray KN and Lorch SA: Hospitalization of early preterm, late preterm, and term infants during the first year of life by gestational age. Hospital Pediatrics 3(3): 194-203, Jul 2013.
Srinivas SK, Fager C, Lorch SA: Variations in postdelivery infection and thrombosis by hospital teaching status. Am J Obstet Gynecol 209(6): e1-7, Dec 2013.
Zubizarreta JR, Small DS, Goyal N, Lorch SA, and Rosenbaum PR: Stronger instruments via integer programming in an observational study of late preterm birth outcomes. Ann Appl Stat 7(1): 25-50, 2013.
Lorch SA: Quality measurements in pediatrics: What do they assess? JAMA Pediatr 167(1): 89-90, January 2013.
Lorch SA: Neonatology enters the 21st century for healthcare oversight: The public reporting of healthcare outcomes. J Perinatol 32(4): 245-246, April 2012.
Lorch SA, Mollen T: Part II. Fetal Development. Chapter 8. Non-immune hydrops. Avery's Diseases of the Newborn, 9th Edition. Gleason CA, Devaskar S (eds.). Philadelphia: Elsevier, Page: 67-74, 2011.
Lorch SA: BIOETHICS: The most fragile of newborns. Science 316(5823): 374-375, April 2007.
Lorch SA, Mollen TJ, Ballard RA: Part II. Fetal Development. Chapter 8. Non-immune hydrops. In: Avery's Diseases of the Newborn, 8th ed. Taeusch HW, Ballard RA, Gleason CA. (eds.). Philadelphia: Elsevier, Page: 63-71, 2005.
Souza JM, Chen Q, Blanchard-Fillion B, Lorch SA, Hertkorn C, Lightfoot R, Weisse M, Friel T, Paxinou E, Themistocleous M, Chov S, Ischiropoulos H: Reactive nitrogen species and proteins: biological significance and clinical relevance. Adv Exp Med Biol 500: 169-174, 2001.
2012-present, Member, Neonatology Innovation Committee, CHOP Strategy Planning Committee
2009-present, Reviewer: Pilot Projects Program, Center for Pediatric Clinical Effectiveness
2007-present, Career Advisor: Department of Pediatrics
2007-present, Member: Clinical Research Committee, Division of Neonatology
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