Sissel Lund-Katz, PhD

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Sissel Lund-Katz, PhD, is a member of the Stokes' Research Institute with the Division of Gastroenterology, Hepatology and Nutrition at The Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Fellowship

Post-doctoral Fellow, Department of Physiology and Biochemistry - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Undergraduate Degree

BS in Chemical Technology - Oslo Institute of Technology, Oslo, Norway
BS in Chemical Engineering - Gothenburg Technical Institute, Gothenburg, Sweden

Graduate Degree

PhD in Organic and Biophysical Chemistry - Bryn Mawr College, Bryn Mawr, PA

Titles and Academic Titles

Senior Member, Stokes' Research Institute

Research Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Publications

Papers

2013

Adachi E, Nakajima H, Mizuguchi C, Dhanasekaran P, Kawashima H, Nagao K, AkajiK, Lund-Katz S, Phillips MC, Saito H: Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation. J Biol Chem 288(4): 2848-56, January 2013.

Kothapalli D, Castagnino P, Rader DJ, Phillips MC, Lund-Katz S, Assoian RK: Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222. Atherosclerosis 227(1): 65-71, March 2013.

Nguyen D, Nickel M, Mizuguchi C, Saito H, Lund-Katz S, Phillips MC: Interactions of apolipoprotein A-I with high-density lipoprotein particles Biochemistry 19(52): 1963-72, March 2013.

Li H, Dhanasekaran P, Alexander ET, Rader DJ, Phillips MC, Lund-Katz S. Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. : Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. Arterioscler Thromb Vasc Biol 33(4): 687-93, April 2013.

Chetty PS, Nguyen D, Nickel M, Lund-Katz S, Mayne L, Englander SW, Phillips MC : Comparison of apoA-I helical structure and stability in discoidal and spherical HDL particles by HX and mass spectrometry. J Lipid Res 54(6): 1589-97, June 2013.

Lund-Katz S, Lyssenko NN, Nickel M, Nguyen D, Sevugan Chetty P, Weibel G, Phillips MC: Mechanisms responsible for the compositional heterogeneity of nascent high density lipoprotein. J Biol Chem [Epub ahead of print] , July 2013.

2012

Lyssenko NN, Hata M, Dhanasekaran P, Nickel M, Nguyen D, Chetty PS, Saito H, Lund-Katz S, Phillips MC: Influence of C-terminal Alpha-helix Hydrophobicity and Aromatic Amino Acid Content on Apolipoprotein A-I Functionality. Biochim Biophys Acta 1821(3): 456-63, March 2012.

Mizuguchi C, Hata M, Dhanasekaran P, Nickel M, Phillips MC, Lund-Katz S, Saito H: Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4. Biochemistry 51(28): 5580-8, July 2012.

Sevugan Chetty P, Mayne L, Kan ZY, Lund-Katz S, Englander SW, Phillips MC : Apolipoprotein A-I helical structure and stability in discoidal high-density lipoprotein (HDL) particles by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A 109(29): 11687-92, July 2012.

Strong A, Ding Q, Edmondson AC, Millar JS, Sachs KV, Li X, Kumaravel A, Wang MY, Ai D, Guo L, Alexander ET, Nguyen D, Lund-Katz S, Phillips MC, Morales CR, Tall AR, Kathiresan S, Fisher EA, Musunuru K, Rader DJ : Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest 122(8): 2807-16, August 2012.

Kothapalli D, Liu SL, Bae YH, Monslow J, Xu T, Hawthorne EA, Byfield FJ, Castagnino P, Rao S, Rader DJ, Puré E, Phillips MC, Lund-Katz S, Janmey PA, Assoian RK: Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell Rep 2(5): 1259-71, November 2012.

Chetty PS, Ohshiro M, Saito H, Dhanasekaran P, Lund-Katz S, Mayne L, Englander W, Phillips MC. : Effects of the Iowa and Milano mutations on apolipoprotein A-I structure and dynamics determined by hydrogen exchange and mass spectrometry Biochemistry 51(44): 8993-9001, November 2012.

Books

Chapters

2004

Saito H, Lund-Katz S, Phillips MC.: Contributions of Domain Structure and Lipid Interaction to the Functionality of Exchangeable Human Apolipoproteins. Prog Lipid Res 43(4): 350-380, 2004.

2003

S. Lund-Katz, L. Liu, S.T. Thuahnai, M.C. Phillips: "High Density Lipoprotein Structure" Frontiers in Bioscience 8: D1044-54, 2003.

1998

M.C. Phillips, K. Gillotte, S. Lund-Katz, W. Johnson, G. Rothblat: "High-density Lipoproteins and Cellular Cholesterol Efflux" Atherosclerosis XI-Proceedings of the XIth International Symposium on Atherosclerosis. B. Jacotot, D. Mathè, and J.-C. Fruchart (eds.). Elsevier Science, Singapore, Page: 861-865, 1998.

M. C. Phillips, K.L. Gillotte, M.P. Haynes, W.J. Johnson, S. Lund-Katz, G.H. Rothblat: "Mechanisms of High Density Lipoprotein-Mediated Efflux of Cholesterol from Cell Plasma Membranes" Atherosclerosis 137: S13-S17, 1998.

1995

G.H. Rothblat, P. Yancey, W.S. Davidson, V. Atger, S. Lund-Katz, W.J. Johnson, M. de la Llera-Moya, M. C. Phillips: "Cholesterol Efflux from Cells in Culture: Studies with Lipid-free Acceptors, Reconstituted Particles and Whole Serum" Cardiovascular Disease 2. Cellular and Molecular Mechanisms, Prevention and Treatment. L.L. Gallo (eds.). Plenum Press, New York, Page: 89-96, 1995.

1992

K.H. Weisgraber, S., Lund-Katz, M.C. Phillips: Apolipoprotein E: Structure-function Correlations. High Density Lipoproteins and Atherosclerosis III. N.E. Miller and A.R. Tall (eds.). Elsevier Science Publishers, Amsterdam, Page: 175-181, 1992.

Awards and Honors

1995, Commencement Ceremony, Benediction (elected), Class of 1995, School of Medicine, The Medical College of Pennsylvania, now Drexel University College of Medicine, Philadelphia, PA

1992, Lindback Award for "Distinguished Teaching" The Medical College of Pennsylvania

1983, Alumnae/i Association of The Medical College of Pennsylvania Mary DeWitt Pettit Fellowship

1981-1983, Special Investigatorship, American Heart Association "Interaction of Lipoprotein Cholesterol with Cell Membranes"

1979-1981, Postdoctoral Fellow, National Research Service Award, National Heart, Lung and Blood Institute

1974-1979, Atlantic Richfield Company Scholarship

1973-1974, Bryn Mawr Alumnae Regional Scholarship, Bryn Mawr College, Bryn Mawr, PA

1966-1967, Norwegian Government Select Scholarship

Editorial and Academic Positions

Academic and institutional committees

2001-present, Radiation Safety Committee, The Children's Hospital of Philadelphia

Leadership and Memberships

Memberships in professional organizations

American Association for the Advancement of Science
American Heart Association
American Society of Biochemistry and Molecular Biology
The Council on Arteriosclerosis, Thrombosis and Vascular Biology