Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
Michael A. Manfredi, MD, is a gastroenterologist with the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia with special expertise in esophageal and airway treatment. He is the co-director of the Esophageal and Airway Treatment (EAT) Program and holds the Distinguished Endowed Chair in the Department of Pediatrics.
Dr. Manfredi specializes in the treatment of children with esophageal atresia, esophageal strictures/stenosis of all etiologies, tracheomalacia and other types of complex airway narrowing or compression. He is working closely with other CHOP specialists, including general surgery, cardiology, neurosurgery, nephrology, urology, colorectal surgery, orthopedics, and more, to further advance the comprehensive, collaborative care offered to patients with these complex conditions through the EAT Program.
Dr. Manfredi also has special interest in the advancement of pediatric endoscopy through innovation and teaching, working with GI and surgical experts to treat children with innovative minimally invasive endoscopy techniques and devices.
MD - SUNY Downstate Medical Center, Brooklyn, NY
New York Presbyterian Weill Cornell Medical Center, New York, NY
Pediatrics - New York Presbyterian Weill Cornell Medical Center, New York, NY
Clinical Fellow, Combined Program - Children's Hospital Boston and Massachusetts General Hospital, Harvard Medical School, Boston, MA
Pediatrics – American Board of Pediatrics
Gastroenterologist
Co-Director, Esophageal and Airway Treatment (EAT) Program
Distinguished Endowed Chair in the Department of Pediatrics
Svetanoff WJ, Zendejas B, Hernandez K, Davbidson K, Ngo P, Manfredi MA, Hamilton TE, Jennings R, Smithers CJ: Contemporary outcomes of the Foker process and evolution of treatment algorithms for long-gap Esophageal Atresia. Journal of pediatric surgery Feb 2021.
Jo Svetanoff W, Zendejas B, Ngo P, Manfredi MA, Hamilton TE, Jennings RW, Smithers CJ: The left-sided repair: An alternative approach for difficult esoophageal atresia repair. Journal of pediatric surgery 56(5): 938-943, May 2021.
Kamran A, Zendejas B, Meisner J, Choi SS, Munoz-San Julian C, Ngo P, Manfredi MA, Yasuda J, Smithers CJ, Hamilton TE, Jennings RW: Effect of Posterior ?Tracheopexy on Risk of Recurrence in Children after Recurrent Tracheo-Esophageal Fistula Repair. Journal of the American College of Surgeons 232(5): 690-698, May 2021.
Thompson K, Zendejas B, Svetanoff WJ, Labow B, Taghinia A, Ganor O, Manfredi MA, Ngo P, Smithers CJ, Hamilton TE, Jennings RW: Evolution, lessons learned, and contemporary outcomes of esophageal replacement with jejunum for children. Surgery 170(1): 114-125, Jul 2021.
Yasuda JL, Staffa SJ, Nurko S, Kane M, Wall S, Mougey EB, Franciosi JP, Manfredi MA, Rosen R.: Pharmacogenomics fail to explain proton pump inhibitor refractory esophagitis in pediatric esophageal atresia. Neurogastroenterol Motil Aug 2021.
Shieh HF, Jennings RW, Manfredi MA, Ngo PD, Zendejas B, Hamilton TE.: Cautionary tales in the use of magnets for the treatment of long gap esophageal atresia. J Pediatr Surg Page: 778-8, Nov 2021.
Baghdadi O, Clark SJ, Yasuda J, Staffa SJ, Ngo P, Hamilton TE, Zendejas B, Jennings RW, Manfredi MA: Initial Esophageal Anastomosis Diameter Predicts Treatment Outcomes in Esophageal Atresia Patients with a High Risk for Stricture Development. Frontiers in Pediatrics 2021 Notes: Accepted for publication.
Baghdadi O, Yasuda J, Staffa SJ, Ngo P, Hamilton TE, Zendejas B, Jennings RW, Manfredi MA: Predictors and Outcomes of Fully Covered Stent Treatment for Anastomotic Esophageal Strictures in Esophageal Atresia. Journal of pediatric gastroenterology and nutrition 2021 Notes: Accepted for publication.
Yasuda JL, Svetanoff WJ, Staffa SJ, Zendejas B, Hamilton TE, Jennings RW, Ngo PD, Jason Smithers C, Manfredi MA.: Prophylactic negative vacuum therapy of high-risk esophageal anastomoses in pediatric patients. J Pediatr Surg 2021.
Ngo PD, Kamran A, Clark SJ, Jennings RW, Hamilton TE, Smithers CJ, Zendejas B, Yasuda JL, Zurakowski D, Manfredi MA.: Intralesional Steroid Injection Therapy for Esophageal Anastomotic Stricture Following Esophageal Atresia Repair. J Pediatr Gastroenterol Nutr 70(4): 462-467, Apr 2020 Notes: doi: 10.1097/MPG.0000000000002562.
Muensterer OJ, Sterlin A, Oetzmann von Sochaczewski C, Lindner A, Heimann A, Balus A, Dickmann J, Nuber M, Patel VH, Manfredi MA, Jennings RW, Smithers CJ, Fauza DO, Harrison MR.: An experimental study on magnetic esophageal compression anastomosis in piglets. J Pediatr Surg 55(3): 425-32, May 2020.
Yasuda JL, Staffa SJ, Ngo PD, Clark SJ, Jennings RW, Manfredi MA.: Comparison of Detection Methods for Tracheoesophageal Fistulae With a Novel Method: Capnography With CO2 Insufflation. J Pediatr Gastroenterol Nutr 70(5): e88-e93, May 2020.
Yasuda JL, Staffa SJ, Clark SJ, Ngo PD, Zendejas B, Hamilton TE, Jennings RW, Manfredi MA.: Endoscopic incisional therapy and other novel strategies for effective treatment of congenital esophageal stenosis. J Pediatr Surg 55(11): 2342-2347, Nov 2020 Notes: doi: 10.1016/j.jpedsurg.2020.01.013.
Wong J, Lai D, Schneider J, Mejaddam A, Manfredi MA, Lerner D: Novel placement of an esophageal wound vacuum for a persistent anastomitic leak. Endoscopy Dec 2020.
Yasuda JL, Taslitsky GN, Staffa SJ, Clark SJ, Ngo PD, Hamilton TE, Zendejas B, Jennings RW, Manfredi MA.: Utility of repeated therapeutic endoscopies for pediatric esophageal anastomotic strictures. Dis Esophagus 33: doaa031, Dec 2020.
de Moura DTH, de Moura BFBH, Manfredi MA, Hathorn KE, Bazarbashi AN, Ribeiro IB, de Moura EGH, Thompson CC.: Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects. World J Gastrointest Endosc 11: 329-344, May 2019 Notes: doi: 10.4253/wjge.v11.i5.329.
Yasuda JL, Clark SJ, Staffa SJ, Blansky B, Ngo PD, Hamilton TE, Smithers CJ, Jennings R, Manfredi MA.: Esophagitis in Pediatric Esophageal Atresia: Acid May Not Always Be the Issue. J Pediatr Gastroenterol Nutr 69(2), aug 2019 Notes: doi: 10.1097/MPG.0000000000002336.
Shieh HF, Smithers CJ, Hamilton TE, Zurakowski D, Visner GA, Manfredi MA, Jennings RW, Baird CW.: Descending Aortopexy and Posterior Tracheopexy for Severe Tracheomalacia and Left Mainstem Bronchomalacia. Semin Thorac Cardiovasc Surg 31(3): 479-485, 2019 Notes: doi: 10.1053/j.semtcvs.2018.02.031.
Shieh HF, Smithers CJ, Hamilton TE, Zurakowski D, Visner GA, Manfredi MA, Baird CW, Jennings RW.: Posterior Tracheopexy for Severe Tracheomalacia Associated with Esophageal Atresia (EA): Primary Treatment at the Time of Initial EA Repair versus Secondary Treatment. Front Surg 4: 80, Jan 2018.
Antunes AA, Jesus LOP, Manfredi MA, de Souza AA, Machado MFM, E Silva PM, Icimoto MY, Juliano MA, Juliano L, Judice WAS.: Thermodynamic analysis of Kex2 activity: The acylation and deacylation steps are potassium- and substrate-dependent. Biophys Chem 235: 29-39, Apr 2018 Notes: doi: 10.1016/j.bpc.2017.11.007.
Kamran A, Smithers CJ, Manfredi MA, Hamilton TE, Ngo PD, Zurakowski D, Jennings RW.: Slide Esophagoplasty vs End-to-End Anastomosis for Recalcitrant Esophageal Stricture after Esophageal Atresia Repair. J Am Coll Surg 226(6): 1045-1050, Jun 2018 Notes: doi: 10.1016/j.jamcollsurg.2017.11.020.
Manfredi MA, Clark SJ, Medford S, Staffa SJ, Ngo PD, Hamilton TE, Smithers CJ, Jennings RW.: Endoscopic Electrocautery Incisional Therapy as a Treatment for Refractory Benign Pediatric Esophageal Strictures. J Pediatr Gastroenterol Nutr 67(4): 464-468, Oct 2018 Notes: doi: 10.1097/MPG.0000000000002008.
Manfredi MA, Clark SJ, Staffa SJ, Ngo PD, Smithers CJ, Hamilton TE, Jennings RW.: Endoscopic Esophageal Vacuum Therapy: A Novel Therapy for Esophageal Perforations in Pediatric Patients. J Pediatr Gastroenterol Nutr 67(6): 706-12, Dec 2018 Notes: doi: 10.1097/MPG.0000000000002073.
Hwang JH, Aslanian HR, Thosani N, Goodman A, Manfredi MA, Navaneethan U, Pannala R, Parsi MA, Smith ZL, Sullivan SA, Bannerjee S, Maple JT: Devices for use with EUS. VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy 12(3): 35-45, Feb 2017.
Maple JT, Pannala R, Abu Dayyeh BK, Aslanian HR, Enestvedt Bk, Goodman A, Komanduri S, Manfredi MA, Navaneethan U, Parsi MA, Smith ZL, Thosani N, Sillivan SA, Banerjee S: Interventional EUS (with videos). Gastrointestial Endoscopy 85(3): 465-81, Mar 2017.
Smithers CJ, Hamilton TE, Manfredi MA, Rhein L, Ngo P, Gallagher D, Foker JE, Jennings RW.: Categorization and repair of recurrent and acquired tracheoesophageal fistulae occurring after esophageal atresia repair. J Pediatr Surg 52(3): 424-430, Mar 2017.
Shieh HF, Smithers CJ, Hamilton TE, Zurakowski D, Rhein LM, Manfredi MA, Baird CW, Jennings RW.: Posterior tracheopexy for severe tracheomalacia. J Pediatr Surg 52(6): 951-55, Jun 2017 Notes: doi: 10.1016/j.jpedsurg.2017.03.018.
Navaneethan U, Thosani N, Goodman A, Manfredi MA, Pannala R, Parsi MA, Smith ZL, Sullivan SA, Banerjee S, Maple JT: Radiofrequncy ablation devices. VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy 2(10): 252-259, Sept 2017.
Thosani N, Goodman A, Manfredi MA, Navaneethan U, Parsi MA, Smith ZL, Sullivan SA, Banerjee S, Maple JT: Endoscopic anti-reflux devices (with videos). Gastrointestinal endoscopy 86(6): 931-48, Dec 2017.
ASGE Technology Committee, Manfredi MA, Chauhan SS, Enestvedt BK, Fujii-Lau LL, Konda V, Hwang JH, Lo SK, Maple JT, Murad FM, Pannala R, Woods KL, Banerjee S.: Endoscopic electronic medical record systems. Gastrointest Endosc 83(1): 29-36, Jan 2016.
Manfredi MA.: Endoscopic Management of Anastomotic Esophageal Strictures Secondary to Esophageal Atresia. Gastrointest Endosc Clin N Am 26(1): 201-19, Jan 2016.
Bairdain S, Foker JE, Smithers CJ, Hamilton TE, Labow BI, Baird CW, Taghinia AH, Feeins N, Manfredi MA, Jennings RW: Jejunal Interposition after Failed Esophageal Atresia Repair. Journal of the American College of Surgeons 222(6): 1001-8, Jun 2016.
Enestvedt BK, Kathari S, Pannala R, Yang J, Fuji-Lau LL, Hwant JH, Konda V, Manfredi MA, Maple JT, Murad FM, Woods KL, Banerjee S: Devices and techniques for ERCP in the surgically altered GI tract. Gastrointestinal endoscopy 83(6): 1061-75, Jun 2016.
Pannala R, Abu Dayyeh BK, Aslanian HR, Enestvedt BK, Komanduri S, Manfredi MA, Maple JT, Navaneethan U, Parsi MA, Smith ZL, Sullivan SA, Thosani N, Banerjee S: Per-oral endoscopic myotomy (with video). Gastrointestinal endoscopy 83(6): 1051-60, Jun 2016.
Komanduri S, Thosani N, Abu Dayyeh BK, Aslanian HR, Enestvedt BK, Manfredi MA, Maple JT, Navaneethan U, Pannala R, Parsi MA, Smith ZL, Sullivan SA, Banerjee S: Cholangiopancreatoscopy. Gastrointestinal endoscopy 84(2): 209-21, Aug 2016.
Manfredi MA, Antunes AA, Jesus LO, Juliano MA, Juliano L, Judice WA.: Specificity characterization of the α-mating factor hormone by Kex2 protease. Biochimie(131), 149-158, Dec 2016 Notes: doi: 10.1016/j.biochi.2016.10.003.
Parsi MA, Sullivan SA, Goodman A, Manfredi MA, Navaneethan U, Pannala R, Smith ZL, Thosani N, Banerjee S, Maple JT: Automated endoscope reprocessors. Gastrointestial endoscopy 84(6): 885-92, 2016.
Maple JT, Abau DFayyeh BK, Chauhan SS, Hwanaag JH, Komanduri S, Manfredi MA, Konda V, Murad FM, Siddiqui UD, Banerjee S: Endoscopic submucosal dissection. Gastrointestial endoscopy 81(6): 1311-25, Jan 2015.
Bairdain S, Hamilton TE, Smithers CJ, Manfredi MA, Nga P, Gallagher D, Zurakowski D, Foker JE, Jennings RW: Foker process for the correction of long gap esophageal atresia: Primary treatment versus secondary treatment after prior esophageal surgery. Journal of pediatric surgery 50(6): 933-7, Jun 2015.
ASGE Technology Committee, Manfredi MA, Abu Dayyeh BK, Bhat YM, Chauhan SS, Gottlieb KT, Hwang JH, Komanduri S, Konda V, Lo SK, Maple JT, Murad FM, Siddiqui UD, Wallace MB, Banerjee S.: Electronic chromoendoscopy. Gastrointest Endosc 81(2): 249-61, 2015.
Manfredi MA, Jennings RW, Anjum MW, Hamilton TE, Smithers CJ, Lightdale JR.: Externally removable stents in the treatment of benign recalcitrant strictures and esophageal perforations in pediatric patients with esophageal atresia. Gastrointest Endosc 80(2): 246-52, Aug 2014 Notes: doi: 10.1016/j.gie.2014.01.033.
Komanduri S, Abu Dayye BK, Bhat YM, Chauhan SS, Gottlieb KT, Hwnt JH, Konda V, Lo SK, Manfredi MA, Maple JT, Murad FM, Siddiqui UD, Wallace MB, Banerjee S: Technologies for monitoring the quality of endoscope reprocessing. Gastrointestinal endoscopy 80(3): 369-73, Sept 2014.
Judice WA, Manfredi MA, Souza GP, Sansevero TM, Almeida PC, Shida CS, Gesteira TF, Juliano L, Westrop GD, Sanderson SJ, Coombs GH, Tersariol IL.: Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8. PLoS One 8: e80153, Nov 2013.
Manfredi MA: Hereditary hamartomatous polyposis syndromes: understanding the disease risks as children reach adulthood. Gastroenterol Hepatol 6(3): 185-96, 2010 Notes: https://www.ncbi.nim.nih.gov/pubmed/20567567.
Manfredi MA, Fox VL, Zurakowski D, Kutok JL, Glickman JN, Moses MA.: Matrix metalloproteinases in the urine and tissue of patients with juvenile polyps: potential biomarkers for the presence of polyps. J Pediatr Gastroenterol Nutr 48(4): 405-111, Apr 2009 Notes: doi: 10.1097/mpg.0b013e318180e65b.
Di Fonzo A, Fabrizio E, Thomas A, Fincati E, Marconi R, Tinazzi M, Breedveld GJ, Simons EJ, Chien HF, Ferreira JJ, Horstink MW, Abbruzzese G, Borroni B, Cossu G, Dalla Libera A, Fabbrini G, Guidi M, De Mari M, Lopiano L, Martignoni E, Marini P, Onofrj M, Padovani A, Stocchi F, Toni V, Sampaio C, Barbosa ER, Meco G; Italian Parkinson Genetics Network, Oostra BA, Bonifati V.: GIGYF2 mutations are not a frequent cause of familial Parkinson's disease. Parkinsonism Relat Disord 15(9): 703-5, Nov 2009 Notes: doi: 10.1016/j.parkreldis.2009.05.001.
Manfredi MA, Zurakowski D, Rufo PA, Walker TR, Fox VL, Moses MA.: Increased incidence of urinary matrix metalloproteinases as predictors of disease in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis 14(8): 1091-6, Aug 2008 Notes: doi: 10.1002/ibd.20419.
Fishman DS, Manfredi MA, LaBelle JL, Levine JE, Shamberger RC, Rufo PA.: Pancreatitis as the initial manifestation of stage IV neuroblastoma. J Pediatr Gastroenterol Nutr 44(1): 146-8, Jan 2007.
Manfredi MA, Gottrand F, Call'Oglio L, Thomson M, Gershman G, Quiros A, Lamireau T: Endoscopic management of esophageal strictures. Practical Pediatric Gastrointestinal Endoscopy, 3rd edition. Oxford: Wiley Blackwell, Page: 223-234, 2021.
Yasuda JL, Manfredi MA: Caustic Ingestion and Foreign Bodies. Pediatric Gastrointestinal and Liver Disease. Elsevier, Page: 206-221, 2020.
Manfredi MA: Upper Gastrointestinal Bleedidng. The 5-Minute Pediatric Consult Page: 912-13, 2018.
Manfredi MA: Lower Gastroentestinal Bleeding. The 5-Minute Pediatric Consult Page: 508-9, 2018.
Manfredi MA: Lower Gastrointestial Bleeding. The 5-Minute Pediatric Consult Page: 544-545, 2015.
Manfredi MA: Upper Gastrointestinal Bleeding. The 5-Minute Pediatric Consult Page: 962-963, 2015.
Treves ST, Manfredi MA: Gastrointestinal Bleeding. Pediatric Nuclear Medicine and Molecular Imaging Page: 265-282, 2014.
Manfredi MA, Lightdale JR: Training in Pediatric Endoscopy. Training in Pediatric Endoscopy. Oxford Wiley-Blackwell Health Sciences, Page: 143-156, 2011.
Manfredi MA, Lightdale JR: Endoscopy. Pediatric Practice: Gastroenterology. McGraw-Hill, Page: 126-141, 2010.
Manfredi MA, Israel EJ: Gastritis and Peptic Ulcer Disease. Current Pediataric Therapy. Gellis and Kagan (eds.). Elsevier, Page: 535-540, 2006.
"Endoscopic Session and Case Presentations - Esophageal strictures and fistula," panelist, PETDW International Workshop Therapeutic Digestive Endoscopy in Children, Rome, Italy. Jan 2021.
"Conservative treatment of esophageal perforation," PETDW International Workshop Therapeutic Digestive Endoscopy in Children, Rome, Italy. Jan 2021.
"Non-Surgical Therapies for Esophageal Perforation," World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Vienna Austria. Jan 2021.
"Advances in Esophagitis: Endoscopic and Surgical," North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting, Chicago, IL. Nov 2019.
"Comparison of Current Detection Modalities for Recurrent Tracheoesophageal Fistula with a Novel Method: Rising End-Tidal Carbon Dioxide During Esophagoscopy with Carbon Dioxide Insufflation," North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting, Chicago, IL. Nov 2019.
"Endoscopic Clipping and Submucosal Injection/Hands on Teaching Station, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting, Chicago, IL. Nov 2019.
"Rules are meant to be broken: Examining the 'rules of 3' for Esophageal balloon dilations in pediatric stricture patients," Digestive Disease Week, San Diego, CA. May 2019.
"Endoscopic Incisional Theray Offers a Novel and Less Invasive Treatment Strategy for Congenital Esophageal Stenosis," Digestive Disease Week, San Diego, CA. May 2019.
"Esophageal Dilation and Stenting/Hands on Teaching Station," International Conference on Esophageal Atresia, Rome, Italy. Jan 2019.
"An Insider's Guide to the Difficult Esophagus," Hands on Innovation and Methods in Endoscopy, American Society for Gastrointestinal Endoscopy, Downers Grove, IL. Jan 2019.
"Esophageal Incisional Therapy, Stenting and dilation/Hands on Teaching Station," American Society for Gastrointestinal Endoscopy, Downers Grove, IL. Jan 2019.
"Management of Esophageal Strictures and Leaks," Schneider Children's Medical Center Grand Rounds, Petah Tikva, Israel. Jan 2019.
"Rules are meant to be broken: Examining the 'rule of 3' for esophageal balloon dilations in pediatric stricture patients," International Conference on Esophageal Atresia, Rome, Italy. Jan 2019.
"Endoscopic Incisional Therapy Offers a Novel and Less Invasive Treatment Strategy for Congenital Esophageal Stenosis," International Conference on Esophageal Atresia, Rome, Italy. Jan 2019.
"Esophageal anastomosis diameter at initial endoscopy after surgery predicts treatment outcomes in patients with esophageal atresia," International Conference on Esophageal Atresia, Rome, Italy. Jan 2019.
"Prophylactic Endoscopic Esophageal Vacuum (EVAC) Therapy of High Risk Esophageal Anastomoses in Pediatric Surgical Patients," International Conference on Esophageal Atresia, Rome, Italy. Jan 2019.
"Esophageal Stents in the Management of Esophageal Strictures," International Conference on Esophageal Atresia, Rome, Italy. Jan 2019.
2018, Endoscopy Research Prize for Abstract, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
2018, Endoscopic Esophageal Research Prize, Digestive Disease Week
2017, Endoscopy Research Prize for Abstract, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
2014, Endoscopy Research Prize for Abstract, Digestive Disease Week
2006, Research Poster of Distinction, North American Pediatric Society for Pediatric Gastroenterology, Hepatology and Nutrition
2003, Excellence in Teaching Award, New York-Presbyterian/Weill Cornell
1996, Summa Cum Laude, SUNY Stoney Brook
1995-present, Phi Beta Kappa, SUNY Stony Brook
1994-present, Golden Key National Honor Society, SUNY Stony Brook
1993-1996, Sigma Beta Honor Society, SUNY Stony Brook
1992-1996, Dean's List, SUNY Stony Brook
2016-present, Frontiers Pediatric, ad hoc reviewer
2016-present, BMC Surgery, ad hoc reviewer
2016-present, The Journal of Pediatrics, ad hoc reviewer
2016-present, World Journal of Gastroenterology, ad hoc reviewer
2016-present, Journal of Pediatric Surgery, ad hoc reviewer
2016-present, Gastrointestinal Endoscopy, ad hoc reviewer
2016-present, Up-to-Date, ad hoc reviewer
2016-present, Journal of Pediatric Gastroenterology and Nutrition, ad hoc reviewer
2003-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
- 2021-present, Vice Chair, Endoscopy Committee
- 2016-present, Endoscopy Committee
2009-present, American Society for Gastrointestinal Endoscopy