Susan E. McClory, MD, PhD

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Susan E. McClory, MD, PhD, is an attending physician with the Cancer Center at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Ohio State University, Columbus, OH


Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA


Pediatric Hematology/Oncology - Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatrics – American Board of Pediatrics

Graduate Degree

PhD in Integrated Biomedical Sciences - Ohio State University, Columbus, OH

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS.: The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR(+) CD8(+) effector state, and its deletion improves checkpoint blockade. Cell Rep 42: 112905, Jul 2023.


Rome, K. S.,  Stein, S. J.,  Kurachi, M.,  Petrovic, J.,  Schwartz, G. W.,  Mack, E. A.,  Uljon, S.,  Wu, W. W.,  DeHart, A. G.,  McClory, S. E.,  Xu, L.,  Gimotty, P. A.,  Blacklow, S. C.,  Faryabi, R. B.,  Wherry, E. J.,  Jordan, M. S.,  Pear, W. S.: Trib1 regulates T cell differentiation during chronic infection by restraining the effector program. J Exp Med 217(5): e20190888, May 2020.


Victor, A. R.,  Nalin, A. P.,  Dong, W.,  McClory, S.,  Wei, M.,  Mao, C.,  Kladney, R. D.,  Youssef, Y.,  Chan, W. K.,  Briercheck, E. L.,  Hughes, T.,  Scoville, S. D.,  Pitarresi, J. R.,  Chen, C.,  Manz, S.,  Wu, L. C.,  Zhang, J.,  Ostrowski, M. C.,  Freud, A. G.,  Leone, G. W.,  Caligiuri, M. A.,  Yu, J.: IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-kappaB. J Immunol 199(7): 2333-2342, Oct 2017.


Scoville, S. D.,  Mundy-Bosse, B. L.,  Zhang, M. H.,  Chen, L.,  Zhang, X.,  Keller, K. A.,  Hughes, T.,  Chen, L.,  Cheng, S.,  Bergin, S. M.,  Mao, H. C.,  McClory, S.,  Yu, J.,  Carson, W. E., 3rd,  Caligiuri, M. A.,  Freud, A. G.: A Progenitor Cell Expressing Transcription Factor RORgammat Generates All Human Innate Lymphoid Cell Subsets. Immunity 44(5): 1140-50, May 2016.


Martin del Campo, S. E.,  Levine, K. M.,  Mundy-Bosse, B. L.,  Grignol, V. P.,  Fairchild, E. T.,  Campbell, A. R.,  Trikha, P.,  Mace, T. A.,  Paul, B. K.,  Jaime-Ramirez, A. C.,  Markowitz, J.,  Kondadasula, S. V.,  Guenterberg, K. D.,  McClory, S.,  Karpa, V. I.,  Pan, X.,  Olencki, T. E.,  Monk, J. P.,  Mortazavi, A.,  Tridandapani, S.,  Lesinski, G. B.,  Byrd, J. C.,  Caligiuri, M. A.,  Shah, M. H.,  Carson, W. E., 3rd: The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells. J Immunol 195(5): 1995-2005, Sep 2015.


Hughes, T.,  Briercheck, E. L.,  Freud, A. G.,  Trotta, R.,  McClory, S.,  Scoville, S. D.,  Keller, K.,  Deng, Y.,  Cole, J.,  Harrison, N.,  Mao, C.,  Zhang, J.,  Benson, D. M.,  Yu, J.,  Caligiuri, M. A.: The transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells. Cell Rep 8(1): 150-62, Jul 2014.


McClory, S.,  Hughes, T.,  Freud, A. G.,  Briercheck, E. L.,  Martin, C.,  Trimboli, A. J.,  Yu, J.,  Zhang, X.,  Leone, G.,  Nuovo, G.,  Caligiuri, M. A.: Evidence for a stepwise program of extrathymic T cell development within the human tonsil. J Clin Invest 122(4): 1403-15, Apr 2012.


Yu, J.,  Mao, H. C.,  Wei, M.,  Hughes, T.,  Zhang, J.,  Park, I. K.,  Liu, S.,  McClory, S.,  Marcucci, G.,  Trotta, R.,  Caligiuri, M. A.: CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets. Blood 115(2): 274-81, Jan 2010.

Hughes, T.,  Becknell, B.,  Freud, A. G.,  McClory, S.,  Briercheck, E.,  Yu, J.,  Mao, C.,  Giovenzana, C.,  Nuovo, G.,  Wei, L.,  Zhang, X.,  Gavrilin, M. A.,  Wewers, M. D.,  Caligiuri, M. A.: Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue. Immunity 32(6): 803-14, Jun 2010.

Male, V.,  Hughes, T.,  McClory, S.,  Colucci, F.,  Caligiuri, M. A.,  Moffett, A.: Immature NK cells, capable of producing IL-22, are present in human uterine mucosa. J Immunol 185(7): 3913-8, Oct 2010.


Hughes, T.,  Becknell, B.,  McClory, S.,  Briercheck, E.,  Freud, A. G.,  Zhang, X.,  Mao, H.,  Nuovo, G.,  Yu, J.,  Caligiuri, M. A.: Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22. Blood 113(17): 4008-10, Apr 2009.


Gowda, A.,  Roda, J.,  Hussain, S. R.,  Ramanunni, A.,  Joshi, T.,  Schmidt, S.,  Zhang, X.,  Lehman, A.,  Jarjoura, D.,  Carson, W. E.,  Kindsvogel, W.,  Cheney, C.,  Caligiuri, M. A.,  Tridandapani, S.,  Muthusamy, N.,  Byrd, J. C.: IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro. Blood 111(9): 4723-30, May 2008.

Posters and Presentations


Susan E. McClory, Oishi Bardhan, Kelly S. Rome, Lanwei Xu, Phyllis A. Gimotty, Martha S. Jordan, and Warren S. Pear: Trib1 Inhibition Promotes the KLR Effector State and Augments Checkpoint Blockade to Enhance T Cell Function during T Cell Exhaustion. American Society of Hematology Annual Meeting, Virtual 2022 Notes: Poster.

Susan McClory, MD, PhD; Oishi Bardhan; Kelly Rome, PhD; Warren Pear, MD, PhD; and Martha Jordan, PhD: Trib1 Inhibits Viral-specific T Cell Responses during Chronic Infection by Promoting Terminal Exhaustion. Keystone Symposium on Advances in Checkpoints Immunology from Autoimmunity to Oncology to Infectious Diseases, Virtual 2022 Notes: Poster.

Invited Lectures


McClory S. "Oncologic Emergencies", Congreso Colombiano de Pediatria. Barranquilla, Colombia. July 2023.

McClory S. "Improving T cell effector function: from mouse models to CAR T cells", Nationwide Children's Hospital, Columbus, OH. Feb 2023.


McClory S. "Trib1 Inhibits Viral-Specific T Cell Responses During Chronic Infection by Promoting Terminal Exhaustion", Keystone Symposia on Advances in Checkpoints Immunology from Autoimmunity to Oncology to Infectious Diseases, Whistler, Canada. June 2022.

Awards and Honors

2017, Senior Resident Humanitarian Award, Children's Hospital of Philadelphia
2017, Senior Resident Clinician Award, Children's Hospital of Philadelphia
2014, Pediatric Department Chairman's Award, Ohio State University and Nationwide Children's Hospital
2014, Medical Scientist Award, Ohio State University
2013, Outstanding Merit Scholarship, Ohio State University
2011, Second place winner for Professional Biological Sciences Oral Presentations, Hayes Graduate Research Forum, Ohio State University
2011-2012, Presidential Fellowship, Ohio State University
2010, Travel Award Recipient, American Physician Scientist Association
2009, MD, PhD Scientific Achievement Travel Award, Ohio State University
2008, Travel Award Recipient, OSUMC Research Day, Ohio State University
2007-2008, University Fellowship, Ohio State University
2007, 2013-2014, MD, PhD Leadership and Academic Achievement Scholarship, Ohio State University
2001-2005, Medalist Scholarship, Ohio State University

Editorial and Academic Positions

Editorial Positions

2022-present, Peer Reviewer for Pediatric Blood & Cancer

Academic and Institutional Committees

2022-present, Wellness Liaison, Pediatric Hematology/Oncology Fellowship Committee
2020-present, Cancer Center Diversity, Equity, and Inclusion Committee

Leadership and Memberships

Memberships in Professional Organizations




2022-present, Pediatric Transplant & Cell Therapy Consortium
2019-present, American Society of Pediatric Hematology/Oncology
2019-present, American Society of Hematology