Jane E. Minturn, MD, PhD

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Jane E. Minturn, MD, PhD, is an attending physician at CHOP’s Cancer Center who specializes in treating children with brain tumors.

Areas of Expertise: Pediatric brain and spine tumors, Early phase clinical trials in neuro-oncology, International medicine

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

My clinical practice is limited to caring for patients with brain and spinal cord tumors as a member of the multidisciplinary Brain Tumor Program. Our team includes specialists in Neuro-Oncology,  Neurology, Neurosurgery, Radiation Oncology, and Neuropsychology along with skilled nurse practitioners. There is a broad spectrum of expertise that The Children's Hospital of Philadelphia brings to treating its patients with brain tumors.

Treating cancer is a team effort at Children's Hospital, and we consider patients and their families as part of the team. Since our young patients are dependent on their parents for medical decision-making, I try to give them a sense of some control over their disease, communicating in an age appropriate manner. Kids do much better when they are part of the treatment plan and "secrets" are not kept from them.

My research is focused on developing personalized and targeted therapeutics in tumors of the nervous system and understanding the late effects of our therapies in long-term survivors.

As part of our approach to identifying new treatments for children with brain tumors, we are members of the multi-institutional Pacific Pediatric Neuro-Oncology Consortium (PNOC) and a Children's Oncology Group (COG) Phase 1 Institution. These groups are involved in early phase clinical trials for relapsed and refractory brain tumors, with a particular focus on testing new, targeted treatments in children with brain tumors.

Our Children's Hospital team has partnered with drug development groups, and we are rapidly identifying drugs that show promise in patients with brain tumors who have no other curable option. There is a sense of urgency in our group — working collaboratively with laboratory scientists and drug development companies on rational, biologically-based therapies.

There is huge progress in getting promising drugs to children with cancer. Through our cooperative group consortia, the pace is much more rapid than in past years, and Children's Hospital is a major part of the effort to help bring new agents to children with brain tumors.

Education and Training

Medical School

MD - Yale University School of Medicine, New Haven, CT

Internship

Pediatrics - The Children’s Hospital, Boston, MA

Residency

Pediatrics - The Children's Hospital, Boston, MS

Fellowship

Hematology/Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pa.

Board Certification

Hematology-Oncology
Pediatrics

Undergraduate Degree

University of Southern California (BS, psychobiology), Los Angeles, Calif.

Graduate Degree

PhD in Neurobiology - Yale University, New Haven, CT
MPhil - Yale University, New Haven, CT

Titles and Academic Titles

Attending Physician

Medical Director for Oncology, International Patient Services

Clinical Associate Professor, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2015

Shah AC, Cole KA, Waanders AJ, Minturn JE, Fisher MJ, Hill-Kayser C. Proton radiation therapy effect mimicking radiologic relapse in two young adults with pure CNS germinoma.  Pediatric Blood and Cancer, 2015 (in review).

Frick M, Minturn JE, Li Y, Hill-Kayser CE.  Radiotherapy-related outcomes in pediatric patients with atypical teratoid rhabdoid tumor of the central nervous system. Journal of Pediatric Hematology/Oncology, 2015 (in review).

Shah AC, Minturn JE, Li Y, Belasco JB, Phillips PC, Kang TI, Cole KA, Waanders AJ, Pollack R, Didomenico C, Wildes C, Fisher MJ.  Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Pediatric Blood and Cancer, 2015 (in press).

Abstracts

2015

Hoffman L, Bartels U, Miles L, Hawkins C, Goldman S, Leary S, Hassal T, Minturn J, Packer R, Foreman N, Warren K, Broniscer A, Broxon E, Shih C-S, Leach J, Jones B, Baugh J, Hacker B, Lerme B, Jones C, Savage S, Kirkendall J, Doughman R, Wollman M, Millett L, O’Keefe R, Bouffet E, van Vuurden D, Fouladi M. Clinical, radiographic, and biologic characteristics of long-term survivors of diffuse intrinsic pontine glioma. 3rd Biennial Conference on Pediatric Neuro-Oncology Basic and Translational Research, May 7-8, 2015.  San Diego, CA.

2014

Hollander A, Lustig RA, Tochner Z, Paltin I, Both S, Zhai H, Fisher MJ, Minturn JE, Phillips P, Hill-Kayser CE.  Acute toxicities and treatment outcomes for pediatric medulloblastoma patients treated with proton-based craniospinal irradiation.  46th Congress of the International Society of Paediatric Oncology, October 22-25, 2014.  Toronto, Canada.

Paltin I, Hill-Kayser CE, Lustig RA, Minturn JE, Fisher MJ.  Relative differences in risk for neuropsychological late effects post proton radiation for infratentorial versus supratentorial pediatric brain tumors.  46th Congress of the International Society of Paediatric Oncology, October 22-25, 2014.  Toronto, Canada.

Hill-Kayser CE, Tochner Z, Fisher M, Minturn JE, Belasco J, Bagatell R, Balamuth N, Womer R, Reilly A, Phillips P, Lustig RA.  Proton radiation for treatment of children less than 18 months of age.  46th Congress of the International Society of Paediatric Oncology, October 22-25, 2014.  Toronto, Canada.

Hollander A, Both S, Zhai H, Lustig RA, Tochner Z, Fisher MJ, Minturn JE, Phillips P, Hill-Kayser CE.  Acute toxicities and treatment outcomes of a novel craniospinal irradiation (CSI) technique using double scattered proton therapy for medulloblastoma patients.  ASTRO’s 56th Annual Meeting, September 14-17, 2014.  San Francisco, CA.

Hill-Kayser CE, Lustig RA, Minturn JE, Both S, Waanders AJ, Belasco JB, Armstrong C, Phillips PC, Fisher MJ.  Outcomes after proton radiotherapy (RT) for infratentorial brain tumors in infants and very young children.   16th International Symposium on Pediatric Neuro-Oncology, 28 June-02 July 2014.  Singapore.

Hill-Kayser CE, Paltin I, Lustig RA, Fisher MJ, Both S, Belasco JB, Cole KA, Waanders AJ, Phillips PC, Minturn JE.  Proton radiation for treatment of localized ependymoma in children.  16th International Symposium on Pediatric Neuro-Oncology, 28 June-02 July 2014.  Singapore.

Paltin I, Hill-Kayser CE, Lustig RA, Fisher MJ, Belasco JB, Phillips PC, Cole KA, Minturn JE.  Neuropsychological functioning after proton radiation therapy for pediatric ependymoma.  12th Annual American Academy of Clinical Neuropsychology Conference, June 25-28, 2014.  New York, NY.

Hill-Kayser CE, Lustig RA, Minturn JE, Both S, Waanders AJ, Belasco JB, Armstrong CA, Phillips P, Fisher MJ.  Proton radiation for treatment of infratentorial brain tumors in infants and very young children.  2014 ASCO Annual Meeting, May 30-June 3, 2014.  Chicago, IL. 

Hill-Kayser CE, Paltin I, Lustig RA, Fisher MJ, Both S, Belasco JB, Cole KA, Waanders AJ, Phillips P, Minturn JE.  Outcomes after proton radiotherapy for localized childhood ependymoma (EP).  2014 ASCO Annual Meeting, May 30-June 3, 2014.  Chicago, IL.

Meany HJ, Dome J, Hinds PS, Bagatell R, Shusterman S, Widemann BC, Stern E, London WB, Kim A, Fox E, Rodriguez-Galindo C, Minturn JE.  Phase 1 study of sorafenib and irinotecan in pediatric patients with relapsed or refractory solid tumors.  2014 ASCO Annual Meeting, May 30-June 3, 2014.  Chicago, IL. 

2013

Doolin E, Redden RA, Brodeur GM, Minturn JE, Iyer R.  Use of a microgravity culture system to assess biological behavior in neuroblastoma (NB) cell lines.  99th Clinical Congress, American College of Surgeons, October 6-10, 2013.  Washington, D.C.

Paltin I, Minturn J, Fisher M, Barakat L.  Prospective case study of two 2 year olds with posterior fossa ependymoma treated with proton radiation therapy.  American Academy of Clinical Neuropsychology, June 19-22, 2013.  Chicago, IL.

Books

Chapters
2015

Minturn JE and Fisher MJ: Brain Tumors, In: Schwartz MW (ed), The 5-Minute Pediatric Consult, 7th Edition, Philadelphia: Wolters Kluwer, 2015, p.124-125.

2013

Zhi W, Minturn J, Rappaport E, Brodeur G, Li H:  Network-based analysis of multivariate gene expression data.  In: Statistical Methods for Microarray Data Analysis, vol 972, Yakovlev AY, Klebanov L, and Gaile D, (eds). Humana Press, Totowa, NJ, Pp. 121-139, 2013.

2012

Minturn JE: Teratoma, In Schwartz MW (ed), The 5-Minute Pediatric Consult, 6th Edition, Lippincott Williams & Wilkins, Philadelphia, PA.  Pp. 864-865, 2012.

2011

Sievert AJ, Minturn JE. Brain tumors. In: Florin TA, Ludwig S, editors. Netter's pediatrics. Philadelphia: Elsevier Publishing; 2011.

2008

Fisher MJ, Minturn J, Phillips PC. Brain tumors. In: Brodeur GM, Manno CS, editors. Pediatric hematology/oncology: the requisites in pediatrics. Philadelphia: C.V. Mosby Publishing; 2008.

Minturn JE. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2008. p. 840-41.

2005

Minturn JE. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 834-35.

2002

Minturn JE, Friedman DL. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 812-13.

Minturn JE. Idiopathic thrombocytopenic purpura. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 464-65.

Minturn JE, Kelly KM. Hemophilia. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 420-21.

Minturn JE, Kelly KM. Aplastic anemia. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 130-31.

Posters and Presentations

Invited Lectures

2015

From the Office through Treatment and Survivorship: Pediatric Brain Tumors. CME Lecture Series in Pediatric Oncology, Bridgewater NJ, March 2015.

2014

Neurocognitive effects of brain tumor therapy in children.  Pediatric Brain Tumor Foundation, Valley Forge Christian College, Phoenixville, PA, September 2014.

2013

Advances in Precision Medicine for Pediatric Brain Tumors.  Pediatric Brain Tumor Foundation Annual Ride for Kids Program, Valley Forge Christian College, Phoenixville, PA, September 2013.

Awards and Honors

2010, Hyundai Hope on Wheels, Hope Grant Award Winner
2010, Advances in Neuroblastoma Research Annual Meeting: Best Clinical Poster Award, Stockholm, Sweden
2006-2009, American Cancer Society Mentored Research Scholar Grant
2004-2006, Wolfson Scholar in Neuroblastoma Research
2003-2006, American Society of Clinical Oncology Career Development Award
2003, Florence R.C. Murray Program Fund Award
2002-2003, American Society of Clinical Oncology Young Investigator Award
2000, Selected Participant, American Association for Cancer Research Workshop, Molecular Biology in Clinical Oncology, The Given Institute, Aspen, CO
1989-1996, Pre-doctoral Fellowship, Howard Hughes Medical Institute
1988, Medical Student Research Fellowship, American Heart Association
1986, 1986 Phi Kappa Phi, University of Southern California
1986, 1986 Phi Beta Kappa, University of Southern California
1986, 1986 Summa Cum Laude, University of Southern California

Editorial and Academic Positions

Editorial positions

Reviewer

Clinical Cancer Research
Journal of Neuro-Oncology
Neuropediatrics
Pediatric Blood & Cancer
Pediatric Drugs 
Neuropsychiatric Disease and Treatment 

Academic and Institutional Committees

2015-present, Oncology Liaison, International Medicine
2013-present, Clinical Competency Committee
2011-present, Targeted Therapy Glioma Group
2010-present, Proton Therapy Triage Committee
2008-present, Pediatric Protocol Review Committee
2006-present, Pediatrics Residency Program Faculty Interviewer

Leadership and Memberships

Memberships in Professional Organizations

American Association for Cancer Research
American Society of Clinical Oncology
American Society of Pediatric Hematology/Oncology
Children’s Oncology Group (COG)
Pediatric Brain Tumor Consortium
Institutional Principal Investigator
Society for Neuro-Oncology
Pacific Pediatric Neuro-Oncology Consortium
 - Institutional Principal Investigator