Mortimer Poncz, MD

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Mortimer Poncz, MD, is an attending physician with the Division of Hematology at Children's Hospital of Philadelphia.

Areas of Expertise: Congenital platelet disorders, General hematology
Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Pennsylvania School of Medicine, Philadelphia, PA

Internship

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Hematology-Oncology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Jane Fishman Grinberg Endowed Chair in Stem Cell Research

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Professor of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2019

Lyde RB, Ahn HS, Vo KK, Jarocha DJ, Tkaczynski J, Treffeisen E, Sullivan SK, Camire RM, Sabatino DE, French DL, Poncz M. Infused factor VIII-expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A. Blood Adv. 3(9):1368-1378; May 2019. PMID: 31036722

Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability. Scanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS.  Thromb Haemost. 2019 Mar 12. PMID: 30861547

Lyde RB, Ahn HS, Vo KK, Jarocha DJ, Tkaczynski J, Treffeisen E, Sullivan SK, Camire RM, Sabatino DE, French DL, Poncz M. Infused factor VIII-expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A. Blood Adv. 3(9):1368-1378; May 2019. PMID: 31036722

Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability. Scanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS.  Thromb Haemost. 2019 Mar 12. PMID: 30861547

2018

Khandelwal S, Ravi J, Rauova L, Johnson A, Lee GM, Gilner JB, Gunti S, Notkins AL, Kuchibhatla M, Frank M, Poncz M, Cines DB, Arepally GM. Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway. Blood. 2018 Oct 11. pii: blood-2018-03-834598. PMCID: 628421

Gollomp K, Kim M, Johnston I, Hayes V, Welsh J, Arepally GM, Kahn M, Lambert MP, Cuker A, Cines DB, Rauova L, Kowalska MA, Poncz M. Neutrophil accumulation and NET release contribute to thrombosis in HIT.    JCI Insight. 3(18). pii: 99445; Sept 2018. PMCID: 6237233

Revel-Vilk S, Shai E, Turro E, Jahshan N, Hi-Am E, Spectre G, Daum H, Kalish Y, Althaus K, Greinacher A, Kaplinsky C, Izraeli S, Mapeta R, Deevi SVV, Jarocha D, Ouwehand WH, Downes K, Poncz M, Varon D, Lambert MP. GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting. Blood. pii: blood-2018-04-845545, 2018 Aug. PMID: 30171045

Dai J, Madeeva D, Hayes V, Ahn HS, Tutwiler V, Arepally GM, Cines DB, Poncz M, Rauova L. Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. Blood. 132(7):727-734, Aug 2018. PMCID: PMC6097133

Tkaczynski E, Arulselvan A, Tkaczynski J, Avery S, Xiao L, Torok-Storb B, Abrams K, Rao NV, Johnson G, Kennedy TP, Poncz M, Lambert MP: 2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia. Blood Advances 2(7): 754-761, Apr 2018. PMCID: PMC5894257

Khandelwal S, Ravi J, Rauova L, Johnson A, Lee GM, Gilner JB, Gunti S, Notkins AL, Kuchibhatla M, Frank M, Poncz M, Cines DB, Arepally GM. Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway. Blood. 2018 Oct 11. pii: blood-2018-03-834598. PMCID: 6284214

Gollomp K, Kim M, Johnston I, Hayes V, Welsh J, Arepally GM, Kahn M, Lambert MP, Cuker A, Cines DB, Rauova L, Kowalska MA, Poncz M. Neutrophil accumulation and NET release contribute to thrombosis in HIT.    JCI Insight. 3(18). pii: 99445; Sept 2018. PMCID: 6237233

Revel-Vilk S, Shai E, Turro E, Jahshan N, Hi-Am E, Spectre G, Daum H, Kalish Y, Althaus K, Greinacher A, Kaplinsky C, Izraeli S, Mapeta R, Deevi SVV, Jarocha D, Ouwehand WH, Downes K, Poncz M, Varon D, Lambert MP. GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting. Blood. pii: blood-2018-04-845545, 2018 Aug. PMID: 30171045

Dai J, Madeeva D, Hayes V, Ahn HS, Tutwiler V, Arepally GM, Cines DB, Poncz M, Rauova L. Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. Blood. 132(7):727-734, Aug 2018. PMCID: PMC6097133

Tkaczynski E, Arulselvan A, Tkaczynski J, Avery S, Xiao L, Torok-Storb B, Abrams K, Rao NV, Johnson G, Kennedy TP, Poncz M, Lambert MP: 2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia. Blood Advances 2(7): 754-761, Apr 2018. PMCID: PMC5894257

Jarocha D, Vo KK, Lyde RB, Hayes V, Camire RM, Poncz M: Enhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors. Blood Advances 2(6): 597-606, Mar 2018. PMCID: PMC5873227

Villa CH, Pan DC, Johnston IH, Greineder CF, Walsh LR, Hood ED, Cines DB, Poncz M, Siegel DL, Muzykantov VR: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. Blood Advances 2(3): 165-176, Feb 2018. PMCID: PMC5812327

2017

Rao AK, Poncz M: Defective acid hydrolase secretion in RUNX1 haplodeficiency: Evidence for a global platelet secretory defect. Haemophilia 23(5): 784-792, Sep 2017. PMCID: PMC5623153

Hanby HA, Bao J, Noh J-Y, Jarocha D, Poncz M, Weiss MJ, Marks MS: Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation. Blood advances 1(19): 1478-1490, Aug 2017. PMCID: PMC5604861

Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T, Liu J, Essex DW. The disulfide isomerase ERp72 supports arterial thrombosis in mice. Blood 130(6): 817-828, Aug 2017. PMCID: PMC5553574

Vo KK, Jarocha DJ, Lyde RB, Hayes V, Thom CS, Sullivan SK, French DL, Poncz M: FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology. Blood 129(26): 3486-3494, Apr 2017. PMCID: PMC5492092

Sim X, Jarocha D, Hayes V, Hanby HA, Marks MS, Camire RM, French DL, Poncz M, Gadue P: Identifying and enriching the platelet-producing human stem cell-derived megakaryocytes using factor V uptake. Blood 130(2): 192-204, Apr 2017. PMCID: PMC5510789

Hayes V, Johnston Ian, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M: Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. The Journal of Clinical Investigation 127(3): 1090-1098, Mar 2017. PMCID: PMC5330743

2016

Bdeir K, Gollomp K, Stasiak M, Mei J, Papiewska-Pajak I, Zhao G, Worthen GS, Cines DB, Poncz M, Kowalska MA: Platelet-specific chemokines contribute to the pathogenesis of acute lung injury. American Journal of Respiratory Cell and Molecular Biology 56(2): 261-270, Oct 2016. PMCID: PMC5455412

Wang Q, You T, Fan H, Wang Y, Chu T, Poncz M, Zhu L: Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis. Platelets 28(1): 1-8, Aug 2016

Ostertag EM, Bdeir K, Kacir S, Thiboutot M, Gulendran G, Yunk L, Hayes VM, Motto DG, Poncz M, Zheng XL, Cines DB, Siegel DL: ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model. Transfusion 56(7): 1775-1785, Jul 2016. PMCID: PMC4938757

Khandelwal S, Lee GM, Hester CG, Poncz M, McKenzie S, Sachais BS, Rauova L, Kelsoe G, Cines DB, Frank M, Arepally GM: The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21). Blood 128(14): 1789-1799, Jul 2016. PMCID: PMC5054694

Zhang N, Zhi H, Curtis BR, Rao S, Jobaliya C, Poncz M, French DL, Newman PJ: CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. Blood 127(6): 675-680, Feb 2016. PMCID: PMC4751021

Parker ZF, Rux AH, Riblett AM, Lee F-H, Rauova L, Cines DB, Poncz M, Sachais BS, Doms RW: Platelet-Factor 4 (PF4) inhibits and enhances HIV-1 infection in a concentration-dependent manner by modulating viral attachment. AIDS Research and Human Retroviruses 32(7): 705-717, Feb 2016. PMCID: PMC4931766

Greineder CF, Hood ED, Yao A, Khoshnejad M, Brenner JS, Johnston IH, Poncz M, Gottstein C, Muzykantov VR: Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans. Journal of Controlled Release 226: 229-237, Feb 2016. PMCID: PMC4964279

Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M, Rauova L: Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia. Blood 127(4): 464-472, Jan 2016. PMCID: PMC4731847

Sim X, Poncz M, Gadue P, French DL: Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. Blood 127(10): 1227-1233, Jan 2016. PMCID: PMC4786833

2015

Zhou J, Wu Y, Wang L, Rauova L, Hayes V, Poncz M, Essex DW: The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. The Journal of Clinical Investigation 125(12): 4391-4406, Dec 2015. PMCID: PMC4665788

Fuentes RE, Zaitsev S, Ahn HS, Hayes V, Kowalska MA, Lambert MP, Wang Y, Siegel DL, Bougie DW, Aster RH, Myers DD, Stepanova V, Cines DB, Muzykantov VR, Poncz M: A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. The Journal of Clinical Investigation 126(2): 483-494, Dec 2015. PMCID: PMC4731161

Lambert MP, Meng R, Xiao L, Harper DC, Marks MS, Kowalska MA, Poncz M: Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules. Journal of Thrombosis and Haemostasis 13(10): 1888-1899, Oct 2015. PMCID: PMC4638179

Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally GM, Cines DB, Greene MI: Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nature Communications 6: 8277, Sep 2015. PMCID: PMC4580983

Chacko A-M, Han J, Greineder CF, Zern BJ, Mikitsh JL, Nayak M, Menon D, Johnston IH, Poncz M, Eckmann DM, Davies PF, Muzykantov VR: Collaborative enhancement of endothelial targeting of nanocarriers by modulating platelet-endothelial cell adhesion molecule-1/CD31 epitope engagement. ACS Nano 9(7): 6785-6793, Jul 2015. PMCID: PMC4761649

Noh J-Y, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ: Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. The Journal of Clinical Investigation 125(6): 2369-2374, Jun 2015. PMCID: PMC4497743

Joglekar M, Khandelwal S, Cines DB, Poncz M, Rauova L, Arepally GM: Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. Journal of Thrombosis and Haemostasis 13(8): 1416-1427, May 2015. PMCID: PMC4516590

Wang Y, Hayes V, Jarocha D, Sim X, Harper DC, Fuentes R, Sullivan SK, Gadue P, Chou ST, Torok-Storb BJ, Marks MS, French DL, Poncz M: Comparative analysis of human ex vivo-generated platelets vs. megakaryocyte-generated platelets in mice: A cautionary tale. Blood 125(23): 3627-3636, Apr 2015. PMCID: PMC4458801

Pickens B, Mao Y, Li D, Siegel DL, Poncz M, Cines DB, Zheng XL: Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents murine models of thrombotic thrombocytopenic purpura. Blood 125(21): 3326-3334, Mar 2015. PMCID: PMC4440884

Meng R, Wu J, Harper DC, Wang Y, Kowalska MA, Abrams CS, Brass LF, Poncz M, Stalker TJ, Marks MS: Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood 125(10): 1623-1632, Mar 2015. PMCID: PMC4351507

2014

Zhou J, Wu Y, Wang L, Rauova L, Hayes V M, Poncz M, Essex D W: The disulfide isomerase ERp57 is required for fibrin deposition in vivo. Journal of Thrombosis and Haemostasis 12(11): 1890-1897, Nov 2014. PMCID: PMC4229395

Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS: Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nature Medicine 20(11): 1315-1320, Nov 2014. PMCID: PMC4258871

Greene TK, Lyde RB, Bailey SC, Lambert MP, Zhai L, Sabatino DE, Camire RM, Arruda VR, Poncz M: Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy. Journal of Thrombosis and Haemostasis 12(12): 2102-2112, Oct 2014.

Skewis LR, Lebedeva T, Papkov V, Thayer EC, Massefski W, Cuker A, Nagaswami C, Litvinov RI, Kowalska MA, Rauova L, Poncz M, Weisel JW, Lowery TJ, Cines DB: T2 magnetic resonance: A diagnostic platform for studying integrated hemostasis in whole blood-proof of concept. Clinical Chemistry 60(9): 1174-1182, Jun 2014.

Cuker A, Rauova L, Bolgiano D, Matthai WH, Poncz M, Konkle BA: Atherosclerosis is not a risk factor for anti-platelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery. Thrombosis and Haemostasis 111(6): 1191-1193, Jun 2014. PMCID: PMC4043923

Lian L, Suzuki A, Hayes V, Saha S, Han X, Xu T, Yates JR, Poncz M, Kashina A, Abrams CS: Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation. Haematologica 99(3): 554-560, Mar 2014. PMCID: PMC3943321

Shi G, Field DJ, Ko K-A, Ture S, Srivastava K, Levy S, Kowalska MA, Poncz M, Fowell DJ, Morrell CN: Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. The Journal of Clinical Investigation 124(2): 543-552, Feb 2014. PMCID: PMC3904624

Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh E Z, Lambert MP, Wilcox DA, French DL, Poncz M, Gadue P: High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood 123(5): 753-757, Jan 2014. PMCID: PMC3907760

2013

Kowalska MA, Zhao G, Zhai Li, David G, Marcus S, Krishnaswamy S, Poncz M: Modulation of Protein C activation by histones, Platelet Factor 4, and heparinoids: new insights into activated Protein C formation. Arteriosclerosis, Thrombosis, and Vascular Biology 34(1): 120-126, Oct 2013

Suzuki A, Shin J-W, Wang Y, Min SH, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS: RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation. PloS one 8(7): e69315, July 2013. PMCID: PMC3720647

Siner JI, Iacobelli NP, Sabatino DE, Ivanciu L, Zhou S, Poncz M, Camire RM, Arruda VR: Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. Blood 121(21): 4396-4403, May 2013. PMCID: PMC3663432

Lambert MP, Sullivan SK, Fuentes R, French DL, Poncz M: Challenges and promises for the development of donor-independent platelet transfusions. Blood 121(17): 3319-3324, Apr 2013. PMCID: PMC3976218

Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ: Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood 121(10): 1858-67, Mar 2013. PMCID: PMC3591804

2012

Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding BS, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR: Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood 119: 4779-4785, 2012.

Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC: Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host and Microbe 12(6): 815-23, Dec 2012. PMCID: PMC3638032

Ono Y, Wang Y, Suzuki H, Okamoto S, Ikeda Y, Murata M, Poncz M, Matsubara Y: Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. Blood 120(18): 3812-3821, Nov 2012. PMCID: PMC3488891

Sachais BS, Litvinov RI, Yarovoi SV, Rauova L, Hinds JL, Rux AH, Arepally GM, Poncz M, Cuker A, Weisel JW, Cines DB: Dynamic antibody-binding properties in the pathogenesis of HIT. Blood 120(5): 1137-1142, Aug 2012. PMCID: PMC3412334

Meng R, Wang Y, Yao Y, Zhang Z, Harper DC, Heijnen HFG, Sitaram A, Li W, Raposo G, Weiss MJ, Poncz M, Marks MS: SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Blood 120(2): 404-414, Jul 2012. PMCID: PMC3398753

Lambert MP, Reznikov A, Grubbs A, Nguyen Y, Xiao L, Aplenc R, Rauova L, Poncz M: Platelet factor 4 platelet levels are inversely correlated with steady-state platelet counts and with platelet transfusion needs in pediatric leukemia patients. Journal of Thrombosis and Haemostasis 10(7): 1442-1446, Jul 2012. PMCID: PMC3389572

Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding B-S, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR: Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood 119(20): 4779-4785, May 2012. PMCID: PMC3367878

2011

Wang Y, Meng R, Hayes V, Fuentes R, Yu X, Abrams CS, Heijnen HFG, Blobel GA, Marks MS, Poncz M: Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction. Blood 118(23): 6183-6191, Dec 2011. PMCID: PMC3234671

Ahmad F, Boulaftali Y, Greene T K, Ouellette T D, Poncz M, Feske S, Bergmeier W: Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis. Journal of Thrombosis and Haemostasis 9(10): 2077-2086, Oct 2011. PMCID: PMC3184355

Kowalska MA, Krishnaswamy S, Rauova L, Zhai L, Hayes V, Amirikian K, Esko JD, Bougie DW, Aster RH, Cines DB, Poncz M: Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. Blood 118(10): 2882-2888, Sep 2011. PMCID: PMC3172804

Lambert MP, Xiao L, Nguyen Y, Kowalska MA, Poncz M: The role of platelet factor 4 in radiation-induced thrombocytopenia. International Journal of Radiation Oncology, Biology, Physics 80(5): 1533-1540, Aug 2011. PMCID: PMC3134787

DiCarlo AL, Poncz M, Cassatt DR, Shah JR, Czarniecki CW, Maidment BW: Medical countermeasures for platelet regeneration after radiation exposure. Report of a workshop and guided discussion sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22-23, 2010. Radiation Research 176(1): e0001-15, Jul 2011.

DiCarlo AL, Poncz M, Cassatt DR, Shah JR, Czarniecki CW, Maidment BW: Development and licensure of medical countermeasures for platelet regeneration after radiation exposure. Radiation Research 176(1): 134-137, Jul 2011.

Stolla M, Stefanini L, Roden RC, Chavez M, Hirsch J, Greene T, Ouellette TD, Maloney SF, Diamond SL, Poncz M, Woulfe DS, Bergmeier W: The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy. Blood 117(3): 1005-1013, Jan 2011. PMCID: PMC3035063

2010

Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M: Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood 116(23): 5021-5031, Dec 2010. PMCID: PMC3012595

Greene TK, Wang C, Hirsch JD, Zhai L, Gewirtz J, Thornton MA, Miao HZ, Pipe SW, Kaufman RJ, Camire RM, Arruda VR, Kowalska MA, Poncz M: In vivo efficacy of platelet-delivered, high specific activity factor VIII variants. Blood 116(26): 6114-6122, Dec 2010. PMCID: PMC3031396

Greene TK, Schiviz A, Hoellriegl W, Poncz M, Muchitsch E-M: Towards a standardization of the murine tail bleeding model. Journal of Thrombosis and Haemostasis 8(12): 2820-2822, Dec 2010.

Fuentes R, Wang Y, Hirsch J, Wang C, Rauova L, Worthen GS, Kowalska MA, Poncz M: Infusion of mature megakaryocytes into mice yields functional platelets. The Journal of Clinical Investigation 120(11): 3917-3922, Nov 2010. PMCID: PMC2964983

Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS: CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity 33(1): 106-117, Jul 2010. PMCID: PMC3748840

Zaitsev S, Spitzer D, Murciano J-C, Ding B-S, Tliba S, Kowalska MA, Marcos-Contreras OA, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR: Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood 115(25): 5241-5248, Jun 2010. PMCID: PMC2892950

Zaitsev S, Spitzer D, Murciano J-C, Ding B-S, Tliba S, Kowalska MA, Bdeir K, KA, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR: Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. The Journal of Pharmacology and Experimental Therapeutics 332(3): 1022-1031, Mar 2010. PMCID: PMC2835436

Gregory GD, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, Poncz M, Tong W, Blobel GA: FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood 115(11): 2156-2166, Mar 2010. PMCID: PMC2844012

Miccio A, Wang Y, Hong W, Gregory GD, Wang H, Yu X, Choi JK, Shelat S, Tong W, Poncz M, Blobel GA: NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. The EMBO Journal 29(2): 442-456, Jan 2010. PMCID: PMC2824460

2009

Lambert MP, Wang Y, Bdeir KH, Nguyen Y, Kowalska MA, Poncz M: Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood 114(11): 2290-8, Sep 2009. PMCID: PMC2745847

Rauova L, Arepally GM, McKenzie S E, Konkle B A, Cines D B, Poncz M: Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT). Journal of Thrombosis and Haemostasis 7 Suppl 1: 249-252, Jul 2009. PMCID: PMC3711938

Blue R, Kowalska MA, Hirsch J, Murcia M, Janczak CA, Harrington A, Jirouskova M, Li J, Fuentes R, Thornton MA, Filizola M, Poncz M, Coller BS: Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood 114(1): 195-201, Jul 2009. PMCID: PMC2710948

Bougie DW, Birenbaum J, Rasmussen M, Poncz M, Aster RH: Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia. Blood 113(5): 1105-1111, Jan 2009. PMCID: PMC2635075

Basani R B, Zhu H, Thornton MA, Soto CS, Degrado WF, Kowalska MA, Bennett JS, Poncz M: Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. Blood 113(4): 902-910, Jan 2009. PMCID: PMC2630275

2008

Min SH, Oh SY, Karp GI, Poncz M, Zhao R, Goldman ID: The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption. The Journal of Pediatrics 153(3): 435-437, Sep 2008. PMCID: PMC3835188

Neyman M, Gewirtz J, Poncz M: Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots. Blood 112(4): 1101-1108, Aug 2008. PMCID: PMC2515146

Gewirtz J, Thornton MA, Rauova L, Poncz M: Platelet-delivered factor VIII provides limited resistance to anti-factor VIII inhibitors. Journal of Thrombosis and Haemostasis 6(7): 1160-1166, Jul 2008.

2007

Suvarna S, Espinasse B, Qi R, Rauova L, Poncz M, Cines DB, Wiesner Mark R, Arepally GM: Determinants of PF4/heparin immunogenicity. Blood 110(13): 4253-4260, Dec 2007. PMCID: PMC2234783

Motto D, Roltsch M, Poncz M: Mechanisms for mentored career development: the NIH research career awards and other national awards. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program Page: 504-8, 2007

Kowalska MA, Mahmud SA, Lambert MP, Poncz M, Slungaard A: Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge. Blood 110(6): 1903-1905, Sep 2007. PMCID: PMC1976343

Lambert MP, Rauova L, Bailey M, Sola-Visner MC, Kowalska MA, Poncz M: Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood 110(4): 1153-1160, Aug 2007. PMCID: PMC1976471

Muntean AG, Pang L, Poncz M, Dowdy SF, Blobel GA, Crispino JD: Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood 109(12): 5199-5207, Jun 2007. PMCID: PMC1890844

Lee MK, Kang SJ, Poncz M, Song K-J, Park KS: Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine. Experimental and Molecular Medicine 39(3): 376-384, Jun 2007.

Cines DB, Rauova L, Arepally GM, Reilly MP, McKenzie SE, Sachais BS, Poncz M: Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. Journal of Clinical Apheresis 22(1): 31-36, Feb 2007.

2006

Pang L, Xue H-H, Szalai G, Wang X, Wang Y, Watson DK, Leonard WJ, Blobel GA, Poncz M: Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood 108(7): 2198-2206, Oct 2006. PMCID: PMC1895561

Rauova L, Zhai L, Kowalska MA, Arepally GM, Cines DB, Poncz M: Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood 107(6): 2346-2353, Mar 2006. PMCID: PMC1895727

2005

Schlachterman A, Schuettrumpf J, Liu J-H, Furlan Freguia C, Freguia CF, Toso R, Poncz M, Camire RM, Arruda VR: Factor V Leiden improves in vivo hemostasis in murine hemophilia models. Journal of Thrombosis and Haemostasis 3(12): 2730-2737, Dec 2005.

Pang L, Weiss MJ, Poncz M: Megakaryocyte biology and related disorders. The Journal of Clinical Investigation 115(12): 3332-3338, Dec 2005. PMCID: PMC1297258

Suvarna Shayela, Rauova Lubica, McCracken Emily K E, Goss Christina M, Sachais Bruce S, McKenzie Steven E, Reilly Michael P, Gunn Michael Dee, Cines Douglas B, Poncz Mortimer, Arepally Gowthami: PF4/heparin complexes are T cell-dependent antigens. Blood 106(3): 929-31, Aug 2005. PMCID: PMC1895158

Lian L, Wang Y, Draznin J, Eslin D, Bennett JS, Poncz M, Wu D, Abrams CS: The relative role of PLCbeta and PI3Kgamma in platelet activation. Blood 106(1): 110-117, Jul 2005. PMCID: PMC1895115

Yarovoi H, Nurden AT, Montgomery RR, Nurden P, Poncz M: Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII. Blood 105(12): 4674-4676, Jun 2005.

Song J-W, Song K-J, Baek L-J, Frost B, Poncz M, Park KS: In vivo characterization of the integrin beta3 as a receptor for Hantaan virus cellular entry. Experimental and Molecular Medicine 37(2): 121-127, Apr 2005.

Rauova L, Poncz M, McKenzie SE, Reilly MP, Arepally GM, Weisel JW, Nagaswami C, Cines DB, Sachais BS: Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood 105(1): 131-138, Jan 2005.

2004

Eslin DE, Zhang C, Samuels KJ, Rauova L, Zhai L, Niewiarowski S, Cines DB, Poncz M, Kowalska MA: Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin. Blood 104(10): 3173-3180, Nov 2004.

2003

Yarovoi HV, Kufrin B, Eslin DE, Thornton MA, Haberichter SL, Shi Q, Zhu H, Camire R, Fakharzadeh SS, Kowalska MA, Wilcox DA, Sachais BS, Montgomery RR, Poncz M: Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Blood 102(12): 4006-4013, Dec 2003.

Rozmyslowicz T, Majka M, Kijowski J, Murphy SL, Conover DO, Poncz M, Ratajczak J, Gaulton GN, Ratajczak MZ: Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS 17: 33-42, 2003.

Poncz M, Iannone Robert, Werner Ellen M: Hematology grants workshop. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program Page: 590-6, 2003.

Pitsilos S, Hunt J, Mohler ER, Prabhakar AM, Poncz M, Dawicki J, Khalapyan TZ, Wolfe ML, Fairman R, Mitchell M, Carpenter J, Golden MA, Cines DB, Sachais BS: Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. Thrombosis and Haemostasis 90(6): 1112-1120, Dec 2003.

Kufrin D, Eslin DE, Bdeir K, Murciano J-C, Kuo A, Kowalska MA, Degen JL, Sachais BS, Cines DB, Poncz M: Anti-thrombotic thrombocytes: Ectopic expression of urokinase-type plasminogen activator in platelets. Blood 102: 926-933, 2003.

Nassar T, Sachais BS, Akkawi S, Kowalska MA, Bdeir K, Leitersdorf E, Hiss E, Ziporen L, Aviram M, Cines DB, Poncz M, Higazi AA-R: Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells. The Journal of Biological Chemistry 278(8): 6187-6193, Feb 2003.

Rozmyslowicz T, Majka M, Kijowski J, Murphy SL, Conover DO, Poncz M, Ratajczak J, Gaulton GN, Ratajczak MZ: Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS 17(1): 33-42, Jan 2003.

2002

Wang X, Crispino JD, Orkin SH, Poncz M, Blobel G: Cooperativity between GATA-1, FOG-1 and FLI1 during activation of a megakaryocyte-specific gene ĄIIb in vivo. EMBO J 21: 5225-34, 2002.

Thornton MA, Zhang C, Kowalska MA, Poncz M: Identification of distal regulatory regions in the human alpha IIb gene locus necessary for consistent, high-level megakaryocyte expression. Blood 100(10): 3588-3596, Nov 2002.

Wang X, Crispino JD, Letting DL, Nakazawa M, Poncz M, Blobel GA: Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. The EMBO Journal 21(19): 5225-5234, Oct 2002. PMCID: PMC129049

Sachais BS, Kuo A, Nassar T, Morgan J, Kariko K, Williams KJ, Feldman M, Aviram M, Shah N, Jarett L, Poncz M, Cines DB, Higazi AA-R: Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface. Blood 99(10): 3613-3622, May 2002.

Fang J, Hsu BY, MacMullen CM, Poncz M, Smith TJ, Stanley CA: Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. The Biochemical Journal 363(Pt 1): 81-87, Apr 2002. PMCID: PMC1222454

Li ZQ, Liu W, Park KS, Sachais BS, Arepally GM, Cines DB, Poncz M: Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. Blood 99(4): 1230-1236, Feb 2002.

2001

Reilly MP, Taylor SM, Hartman NK, Arepally GM, Sachais BS, Cines DB, Poncz M, McKenzie SE: Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA. Blood 98(8): 2442-2447, Oct 2001.

Derrick JM, Shattil SJ, Poncz M, Gruppo RA, Gartner TK: Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide. Thrombosis and Haemostasis 86(3): 894-901, Sep 2001.

Zhang C, Thornton MA, Kowalska MA, Sachis BS, Feldman M, Poncz M, McKenzie SE, Reilly MP: Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus. Blood 98(3): 610-617, Aug 2001.

Konkle BA, Bauer TL, Arepally GM, Cines DB, Poncz M, McNulty S, Edie RN, Mannion JD: Heparin-induced thrombocytopenia: bovine versus porcine heparin in cardiopulmonary bypass surgery. The Annals of Thoracic Surgery 71(6): 1920-1924, Jun 2001.

Basani RB, D'Andrea G, Mitra N, Vilaire G, Richberg M, Kowalska MA, Bennett JS, Poncz M: RGD-containing peptides inhibit fibrinogen binding to platelet alpha(IIb)beta3 by inducing an allosteric change in the amino-terminal portion of alpha(IIb). The Journal of Biological Chemistry 276(17): 13975-13981, Apr 2001.

2000

Basani RB, French, DL, Vilaire G, Brown DL, Chen F, Coller BS, Gartner TK, Bennett JS, Poncz M: A platelet alphaIIb mutation site defines a new region Involved in ligand binding by the fibrinogen receptor. Blood 95: 180-189, 2000.

Arepally GM, Park KS, Kamei S, Kamei A, Li ZQ, Liu W, Kisiel W, Cines D, Poncz M: A murine monoclonal antibody that mimics heparin-induced thrombocytopenia (HIT) antibodies. Blood 95: 1533-1540, 2000.

Majka M, Janowska-Wieczorek A, Ratajczak J, Kowalska MA, Vilaire S, Pan ZK, Honczarenko M, Marquez LA, Poncz M, Ratajczak MZ: Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. Blood 96: 4142-4151, 2000.

Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR: The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. The Journal of Biological Chemistry 275(41): 32129-32134, Oct 2000.

Yang J, Wu J, Kowalska MA, Dalvi A, Prevost N, O'Brien PJ, Manning D, Poncz M, Lucki I, Blendy JA, Brass LF: Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proceedings of the National Academy of Sciences of the United States of America 97(18): 9984-9989, Aug 2000. PMCID: PMC27645

Kowalska MA, Ratajczak MZ, Majka M, Jin J, Kunapuli S, Brass LF, Poncz M: Stromal cell-derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets. Blood 96(1): 50-57, Jul 2000.

Stanley CA, Fang J, Kutyna K, Hsu BY, Ming JE, Glaser B, Poncz M: Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. Diabetes 49(4): 667-673, Apr 2000.

Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ: Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nature Genetics 24(3): 266-270, Mar 2000.

Arepally GM, Kamei S, Park KS, Kamei K, Li ZQ, Liu W, Siegel DL, Kisiel W, Cines DB, Poncz M: Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. Blood 95(5): 1533-1540, Mar 2000.

Basani RB, French DL, Vilaire G, Brown DL, Chen F, Coller BS, Derrick JM, Gartner TK, Bennett JS, Poncz M: A naturally occurring mutation near the amino terminus of alphaIIb defines a new region involved in ligand binding to alphaIIbbeta3. Blood 95(1): 180-188, Jan 2000.

1999

Thornton MA, Korostishevsky, M, Yakobson E, Usher S, Seligsohn U, Poncz M, Peretz H: The human platelet alphaIIb gene Is not closely linked to its integrin partner beta3. Blood 94: 2039-2047, 1999.

Thornton MA, Poncz M: Characterization of the murine platelet alphaIIb gene and encoded cDNA. Blood 94: 3947-3949, 1999.

Basani RB, Richberg M, Poncz M: Molecular biological identification and characterization of inherited platelet receptor disorders. Methods in Molecular Medicine 31: 313-336, 1999.

Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, Ratajczak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, Willman C, Gewirtz AM, Speck NA, Bushweller JH, Li FP, Gardiner K, Poncz M, Maris JM, Gilliland DG: Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nature Genetics 23(2): 166-175, Oct 1999.

Thornton MA, Poncz M, Korostishevsky M, Yakobson E, Usher S, Seligsohn U, Peretz H: The human platelet alphaIIb gene is not closely linked to its integrin partner beta3. Blood 94(6): 2039-2047, Sep 1999.

Kowalska MA, Ratajczak J, Hoxie J, Brass L F, Gewirtz A, Poncz M, Ratajczak M Z: Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets. British Journal of Haematology 104(2): 220-229, Feb 1999.

1998

Arepally GM, Maris JM, Rebbeck TR, Song W, Gilliland G, Poncz M: Evidence for genetic homogeneity in a familial platelet disorder with predisposition to acute myelogenous leukemia. Blood 98: 2600-2602, 1998.

Ziporen L, Li ZQ, Park KS, Sabnekar P, Liu WY, Arepally GM, Shoenfeld Y, Kieber-Emmons T, Cines DB, Poncz M: Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. Blood 92(9): 3250-3259, Nov 1998.

Arepally GM, Rebbeck T R, Song W, Gilliland G, Maris J M, Poncz M: Evidence for genetic homogeneity in a familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML). Blood 92(7): 2600-2602, Oct 1998.

Stanley CA, Lieu YK, Hsu BY, Burlina AB, Greenberg CR, Hopwood NJ, Perlman K, Rich BH, Zammarchi E, Poncz M: Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. The New England Journal of Medicine 338(19): 1352-1357, May 1998.

Shou Y, Baron S, Poncz M: An Sp1-binding silencer element is a critical negative regulator of the megakaryocyte-specific alphaIIb gene. The Journal of Biological Chemistry 273(10): 5716-5726, Mar 1998.

1997

Zhang C, Gadue P, Scott E, Atchison M, Poncz M: Activation of the megakaryocyte-specific gene platelet basic protein (PBP) by the Ets family factor PU.1. The Journal of Biological Chemistry 272(42): 26236-26246, Oct 1997.

Basani R B, Brown DL, Vilaire G, Bennett JS, Poncz M: A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface. Blood 90(8): 3082-3088, Oct 1997.

Bauer TJ, Arepally GM, Konkle BA, Mestichelli B, Shapiro SS, Cines DB, Poncz M, McNulty S, Amiral J, Hauck WW, Edie RN, Mannion JD: Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. Circulation 95(5): 1242-1246, Mar 1997.

Arepally GM, McKenzie SE, Jiang XM, Poncz M, Cines DB: Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis. Blood 89(2): 370-375, Jan 1997

1996

Poncz M, Cohen AR: Long-term treatment of congenital folate malabsorption. The Journal of Pediatrics 129(6): 948, Dec 1996.

Kahn MJ, Kieber-Emmons T, Vilaire G, Murali R, Poncz M, Bennett JS: Effect of mutagenesis of GPIIb amino acid 273 on the expression and conformation of the platelet integrin GPIIb-IIIa. Biochemistry 35(45): 14304-14311, Nov 1996.

Jiang XM, Arepally GM, Poncz M, McKenzie SE: Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). Journal of Immunological Methods 199(1): 55-59, Nov 1996.

Block KL, Shou Y, Poncz M: An Ets/Sp1 interaction in the 5'-flanking region of the megakaryocyte-specific alpha IIb gene appears to stabilize Sp1 binding and is essential for expression of this TATA-less gene. Blood 88(6): 2071-2080, Sep 1996.

Jackson DE, Poncz M, Holyst MT, Newman PJ: Inherited mutations within the calcium-binding sites of the integrin alpha IIb subunit (platelet glycoprotein IIb). Effects of the amino acid side chain and the amino acid position on cation binding. European Journal of Biochemistry / FEBS 240(1): 280-287, Aug 1996.

Basani RB, Vilaire G, Shattil SJ, Kolodziej MA, Bennett JS, Poncz M: Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3. Blood 88(1): 167-173, Jul 1996.

Amiral J, Marfaing-Koka A, Wolf M, Alessi M C, Tardy B, Boyer-Neumann C, Vissac AM, Fressinaud E, Poncz M, Meyer D: Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia. Blood 88(2): 410-416, Jul 1996.

1995

Arepally GM, Reynolds C, Tomaski A, Amiral J, Jawad A, Poncz M, Cines D B: Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. American Journal of Clinical Pathology 104(6): 648-654, Dec 1995.

Gewirtz AM, Zhang J, Ratajczak J, Ratajczak M, Park KS, Li C Yan Z, Poncz M: Chemokine regulation of human megakaryocytopoiesis. Blood 86(7): 2558-2567, Oct 1995.

Loh E, Beaverson K, Vilaire G, Qi W, Poncz M, Bennett JS: Agonist-stimulated ligand binding by the platelet integrin alpha IIb beta 3 in a lymphocyte expression system. The Journal of Biological Chemistry 270(31): 18631-18636, Aug 1995.

1994

Block KL, Ravid K, Phung QH, Poncz M: Characterization of regulatory elements in the 5'-flanking region of the rat GPIIb gene by studies in a primary rat marrow culture system. Blood 84(10): 3385-3393, Nov 1994.

Yan Z, Zhang J, Holt JC, Stewart G J, Niewiarowski S, Poncz M: Structural requirements of platelet chemokines for neutrophil activation. Blood 84(7): 2329-2339, Oct 1994.

Poncz M, Rifat S, Coller BS, Newman PJ, Shattil SJ, Parrella T, Fortina P, Bennett JS: Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. The Journal of Clinical Investigation 93(1): 172-9, Jan 1994. PMCID: PMC293750

1993

Poncz M, Rifat S, Coller BS, Newman PJ, Shattil SJ, Parrella T, Fortina P, Bennett JS: Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. The Journal of Clinical Investigation 93(1): 172-9, Jan 1994. PMCID: PMC293750

Brass LF, Hoxie JA, Kieber-Emmons T, Manning DR, Poncz M, Woolkalis MA: Agonist receptors and G proteins as mediators of platelet activation. Advance Experimental Medicine and Biology 344: 17-36, 1993.

Cieutat AM, Rosa JP, Letourneur F, Poncz M, Rifat S: A comparative analysis of cDNA-derived sequences for rat and mouse beta 3 integrins (GPIIIA) with their human counterpart. Biochemical and Biophysical Research Communications 193(2): 771-778, Jun 1993.

Lounsbury KM, Schlegel B, Poncz M, Brass LF, Manning DR: Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation. The Journal of Biological Chemistry 268(5): 3494-3498, Feb 1993.

1992

Tunnacliffe A, Majumdar S, Yan B, Poncz M: Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4. Blood 79(11): 2896-2900, Jun 1992.

1991

Kolodziej MA, Vilaire G, Gonder D, Poncz M, Bennett JS: Study of the endoproteolytic cleavage of platelet glycoprotein IIb using oligonucleotide-mediated mutagenesis. The Journal of Biological Chemistry 266(34): 23499-23504, Dec 1991.

Cornelius AS, Campbell D, Schwartz E, Poncz M: Elevated common acute lymphoblastic leukemia antigen expression in pediatric immune thrombocytopenic purpura. The American Journal of Pediatric Hematology Oncology 13(1): 57-61, 1991.

Kolodziej MA, Vilaire G, Rifat S, Poncz M, Bennett JS: Effect of deletion of glycoprotein IIb exon 28 on the expression of the platelet glycoprotein IIb/IIIa complex. Blood 78(9): 2344-2353, Nov 1991.

Gagnon AW, Manning DR, Catani L, Gewirtz A, Poncz M, Brass LF: Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes. Blood 78(5): 1247-1253, Sep 1991.

Goldberger A, Kolodziej M, Poncz M, Bennett JS, Newman PJ: Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes. Blood 78(3): 681-687, Aug 1991.

Majumdar S, Gonder D, Koutsis B, Poncz M: Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. The Journal of Biological Chemistry 266(9): 5785-5789, Mar 1991.

Burk CD, Newman PJ, Lyman S, Gill J, Coller BS, Poncz M: A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia. The Journal of Clinical Investigation 87(1): 270-276, Jan 1991. PMCID: PMC295042

Brass LF, Manning DR, Williams AG, Woolkalis MJ, Poncz M: Receptor and G protein-mediated responses to thrombin in HEL cells. The Journal of Biological Chemistry 266(2): 958-965, Jan 1991

1990

Ryo R, Adachi M, Sugano W, Yasunaga M, Yoshida A, Jikai J, Saigo K, Yamaguchi N, Akita H, Yokoyama M, Konaka Y, Poncz M: Platelet factor 4 mRNA expression in cells from a patient with megakaryoblastic crisis of chronic myelogenous leukemia. Cancer 67: 960-964, 1990.

Ramachandran B, Rappaport EF, Surrey S, Poncz M, Schwartz E: Polymerase chain reaction (PCR) for detection of PstI polymorphism in the human PF4 gene. Nucleic Acids Research 18(19): 5919, Oct 1990. PMCID: PMC332366

Williams AG, Woolkalis MJ, Poncz M, Manning DR, Gewirtz AM, Brass LF: Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells. Blood 76(4): 721-730, Aug 1990.

Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M: Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. Blood 76(2): 336-344, Jul 1990.

Puck JM, Siminovitch KA, Poncz M, Greenberg CR, Rottem M, Conley ME: Atypical presentation of Wiskott-Aldrich syndrome: diagnosis in two unrelated males based on studies of maternal T cell X chromosome inactivation. Blood 75(12): 2369-2374, Jun 1990.

Zimrin AB, Gidwitz S, Lord S, Schwartz E, Bennett J S, White G C, Poncz M: The genomic organization of platelet glycoprotein IIIa. The Journal of Biological Chemistry 265(15): 8590-8595, May 1990.

Park KS, Rifat S, Eck H, Adachi K, Surrey S, Poncz M: Biologic and biochemic properties of recombinant platelet factor 4 demonstrate identity with the native protein. Blood 75(6): 1290-1295, Mar 1990.

Poncz M, Newman PJ: Analysis of rodent platelet glycoprotein IIb: evidence for evolutionarily conserved domains and alternative proteolytic processing. Blood 75(6): 1282-1289, Mar 1990.

Heidenreich R, Eisman R, Surrey S, Delgrosso K, Bennett J S, Schwartz E, Poncz M: Organization of the gene for platelet glycoprotein IIb. Biochemistry 29(5): 1232-1244, Feb 1990.

1988

Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kao F-T, Schwartz E, Phillips D, Bennett JS, Fitzgerald LA, Poncz M: Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa. Journal of Clinical Investigation 81: 1993-1998, 1988. PMCID: PMC442653

Sharon B, Poncz M, Surrey S, Schwartz E: Non-random association of the Rsa I polymorphic site 5' to the beta-globin gene with major sickle cell haplotypes. Hemoglobin 12(2): 115-124, 1988.

Poncz M, Henthorn P, Stoeckert C, Surrey S: Globin gene expression in hereditary persistence of fetal haemoglobin and (delta beta) (0)-thalassaemia. Oxford Surveys on Eukaryotic Genes 5: 163-203, 1988.

Fortina P, Delgrosso K, Rappaport E, Poncz M, Ballas SK, Schwartz E, Surrey S: A large deletion encompassing the entire alpha-like globin gene cluster in a family of northern European extraction. Nucleic Acids Research 16(23): 11223-11235, Dec 1988. PMCID: PMC339006

Burk C, Ingram C, Weiner M, Rappaport E F, Schwartz E, Poncz M: A Taq 1 polymorphism for the human platelet glycoprotein IIIa gene (GP3A). Nucleic Acids Research 16(14B): 7216, Jul 1988. PMCID: PMC338396

Zimrin AB, Eisman R, Vilaire G, Schwartz E, Bennett JS, Poncz M: Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors. The Journal of Clinical Investigation 81(5): 1470-1475, May 1988. PMCID: PMC442579

1987

Griffin AC, Emanuel SB, LaRocco P, Schwartz E, Poncz M: Human platelet factor 4 gene is mapped to 4q11q21. Cytogenetics and Cell Genetics 45: 67-69, 1987.

Fitzgerald LA, Poncz M, Steiner B, Rall SC, Bennett JS, Phillips DR: Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb. Biochemistry 26: 8158-8165, 1987.

Fitzgerald LA, Poncz M, Steiner B, Rall SC, Bennett JS, Phillips R: Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb. Biochemistry 26(25): 8158-8165, Dec 1987.

Poncz M, Sutton M, Delgrosso K, Schwartz E, Surrey S: DNA methylation in hereditary persistence of fetal hemoglobin (HPFH-2). Nucleic Acids Research 15(13): 5169-5179, Jul 1987. PMCID: PMC305954

Poncz M, Eisman R, Heidenreich R, Silver S M, Vilaire G, Surrey S, Schwartz E, Bennett J S: Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors. The Journal of Biological Chemistry 262(18): 8476-8482, Jun 1987.

Poncz M, Surrey S, LaRocco P, Weiss MJ, Rappaport EF, Conway TM, Schwartz E: Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. Blood 69(1): 219-223, Jan 1987.

Guzzo C, Weiner M, Rappaport E, LaRocco P, Surrey S, Poncz M, Schwartz E: An Eco R1 polymorphism of a human platelet factor 4 (PF4) gene. Nucleic Acids Research 15(1): 380, Jan 1987. PMCID: PMC340433

1985

Poncz M, Kane E, Gill F M: Acute chest syndrome in sickle cell disease: etiology and clinical correlates. The Journal of Pediatrics 107(6): 861-6, Dec 1985.

Poncz M, Greenberg J, Gill F M, Cohen AR: Hematologic changes during acute chest syndrome in sickle cell disease. The American Journal of Pediatric Hematology Oncology 7(1): 96-99, 1985.

1984

Rappaport E F, Schwartz E, Poncz M, Surrey S: Frequent occurrence of a zeta-globin-region deletion in American blacks accounts for a previously-described restriction site polymorphism. Biochemical and Biophysical Research Communications 125(2): 817-823, Dec 1984.

Semenza G L, Delgrosso K, Poncz M, Malladi P, Schwartz E, Surrey S: The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions. Cell 39(1): 123-128, Nov 1984.

Semenza G L, Malladi P, Surrey S, Delgrosso K, Poncz M, Schwartz E: Detection of a novel DNA polymorphism in the beta-globin gene cluster. The Journal of Biological Chemistry 259(10): 6045-6048, May 1984.

1983

Poncz M, Schwartz E, Ballantine M, Surrey S: Nucleotide sequence analysis of the delta beta-globin gene region in humans. The Journal of Biological Chemistry 258(19): 11599-11609, Oct 1983.

1982

Poncz M, Solowiejczyk D, Ballantine M, Schwartz E, Surrey S: "Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method. Proceedings of the National Academy of Sciences of the United States of America 79(14): 4298-4302, Jul 1982. PMCID: PMC346658

Poncz M, Ballantine M, Solowiejczyk D, Barak I, Schwartz E, Surrey S: beta-Thalassemia in a Kurdish Jew. Single base changes in the T-A-T-A box. The Journal of Biological Chemistry 257(11): 5994-5996, Jun 1982.

1981

Poncz M, Colman N, Herbert V, Schwartz E, Cohen A: Congenital folate malabsorption. The Journal of Pediatrics 99(5): 828-829, Nov 1981.

Schmidt W F, Poncz M, Russell MO, Schwartz E: Unusual manifestations of chronic granulomatous disease. American Journal of Diseases of Children (1960) 135(4): 376-377, Apr 1981.

Poncz M, Colman N, Herbert V, Schwartz E, Cohen AR: Therapy of congenital folate malabsorption. The Journal of Pediatrics 98(1): 76-79, Jan 1981.

1978

Poncz M, Schwartz MW: Vocal cord paralysis and mediastinal mass: an unusual esophageal foreign body presentation. Clinical Pediatrics 17(2): 196-198, Feb 1978.

1973

Sederoff R, Clynes R, Poncz M, Hachtel S: RNA synthesis by exogenous RNA polymerase on cytological preparations of chromosomes. Journal Cell Biology 57(2): 538-550, May 1973.

Books

Chapters

2012

Lambert MP, Spencer SK, Poncz M: Making Platelets Ex Vivo. in Platelets Michelson AD (eds.). Elsevier Science, 2012.

Lambert MP, Poncz M: Inherited Thrombocytopenias in Michelson AD (ed) 3rd ed. Platelets. Michelson AD (eds.). Elsevier Science, 2012.

2001

Kaluzhny Y, Poncz M, Ravid K: Transcription factors involved in lineage-specific gene expression during megakaryopoiesis. in Transcription factors involved in lineage-specific gene expression in megakaryocytes. (Wiley-Liss, Inc., Hew York, NY) Ravid K, Licht JD (eds.). Page: 31-50, 2001.

French DL, Newman PJ, Poncz M: Inherited Platelet Disorders. in The Metabolic Basis of Inherited Disease. (McGraw-Hill Inc., New York, NY, 8th ed.) Scriver CR, Beaudet AL, WS Sly, Valle D (eds.). Page: 4473-4504, 2001.

2000

Arepally GM, Poncz M, Cines DB: Immune vascular injury in heparin-induced thrombocytopenia. In: Heparin-Induced Thrombocytopenia. Marcel-Decker, New York, N.Y. Warkentin T, Greinacher A (eds.). Page: 195-211, 2000

1995

Newman P, Poncz M: Inherited Platelet Disorders. in The Metabolic Basis of Inherited Disease. (McGraw-Hill Inc., New York, NY, 7th ed, 1995 ) Scriver CR, Beaudet AL, WS Sly, Valle D (eds.). Page: 3335-3366, 1995.

Bennett JS, Poncz M: Platelet Glycoprotein IIb and IIIa. in Molecular Biology of Thrombosis and Hemostasis. (Marcel Dekker, Inc., New York, NY, 1995) High KA, Roberts H (eds.). Page: 579-602, 1995.

1990

Kahn M, Bennett JS, Brass LF, Poncz M: Platelet Membranes and Their Disorders. in BLOOD: Principles and Practice of Hematology. (Lippincott Williams & Wilkins). Handin RI, Lux SE, Stossel TP (eds.), 1990

Poncz M: Inherited Platelet Disorders in Hematology of Infancy and Childhood. (Harcourt Health Science, 6th ed) (in press). Nathan D, Ginsburg D, Orkin S, Look T (eds.), 1990.

Gewirtz A, Poncz M: Platelet Production and Survival in Hematology: Basic Principles and Practice. (Churchill Livingstone, London,1990) R Hoffman, EJ Benz, SJ Shattil, B Furie and HJ Cohen (eds.). Page: 1148-56, 1990.

1989

Poncz M, Henthorn PS, Stoeckert C, Surrey S: Globin Gene Expression. in Hereditary Persistence of Fetal Hemoglobin and Delta-Beta Thalassemia. in Oxford Surveys on Eukaryotic Genes. Vol 5. (Oxford University Press, Oxford,1989) Maclean N (eds.). Page: 163-203, 1989.

Poncz M: M13-Dideoxy Sequencing. in Methods in Hematology. (Churchill Livingstone, London, 1989). Benz E (eds.). 1989.

1987

Poncz M: Purpura. in Schwartz MW, Curry TA, Charney Principles and Practice of Clinical Pediatrics. (Yearbook Med Pub, Chicago, 1987) EB, Ludwig S (eds.). Page: 274-77, 1987.

Poncz M: Anemia. in Schwartz MW, Curry TA, Charney Principles and Practice of Clinical Pediatrics. (Yearbook Med Pub, Chicago, 1987) EB, Ludwig S (eds.). Page: 303-309, 1987.

Poncz M: Pallor. in Schwartz MW, Curry TA, Charney Principles and Practice of Clinical Pediatrics. (Yearbook Med Pub, Chicago, 1987) EB, Ludwig S (eds.). Page: 268-73, 1987.

Posters and Presentations

Invited Lectures

2019

Poncz M. “The role of NETs in heparin-induced thrombocytopenia and thrombosis”, American Heart Association, Philadelphia, PA. November, 2019.

Poncz M. “Drug targeted therapy for the thrombocytopenia in FPD/AML”, RUNX1 Foundation, Aspen, CO. October, 2019.

Poncz M. "Lessons learned from heparin-induced thrombocytopenia (HIT):Turning a HIT sword into a Sepsis plowshare", University of Michigan, Ann Arbor, MI. January, 2019.

2018

Poncz M. "PF4 interactions with neutrophil extracellular traps (NETs) in endotoxemia & heparin-induced thrombocytopenia (HIT)", Temple University, Philadelphia, PA. May, 2018.

Poncz M. "Neutrophil/Endothelial Interactions in HIT", International Society on Thrombosis and Haemostasis, Ramat Gan, Israel. Apr, 2018.

Poncz M. "Neutrophils and NETS in HIT and more…", Blood Center of Wisconsin, Milwaukee, WI. Feb, 2018.

Poncz M. "Heparin-Induced Thrombocytopenia (HIT): The Endothelial-Neutrophil Prothrombotic Axis", McMaster Hamilton, Ontario. Feb, 2018.

2017

Poncz M. "Heparin-Induced Thrombocytopenia (HIT): The Endothelial Neutrophil Prothrombotic Axis" New York School of Medicine, New York, NY. May, 2017.

Poncz M. "Heparin-Induced Thrombocytopenia (HIT): The Endothelial Neutrophil Prothrombotic Axis", St. Jude, Memphis, TN. May, 2017.

Poncz M. "The Endothelial/Neutrophil Axis in Inflammatory Thrombosis: New Insights from Heparin-Induced Thrombocytopenia", University of Pennsylvania. May, 2017.

Awards and Honors

2017, Investigator Recognition Awards, International Society on Thrombosis and Haemostasis (ISTH), Biennial Awards for Contributions (BACH)
2010, American Heart Association, ATVB Special Recognition Award in Thrombosis
2009, The Mary Rodes Gibson Memorial Award in Hemostasis and Thrombosis to my trainee Rudy Fuentes over an ASH grant
2009, Mentor Award, The Children's Hospital of Philadelphia
2009, Association of American Physicians (AAP)
1996-2002, Chair, Philadelphia Workshop on Hemostasis, Thrombosis and Atherosclerosis
1988, American Society for Clinical Investigation
1976, Pharmacology Prize, University of Pennsylvania School of Medicine
1976, Alpha Omega Alpha
1971, Phi Beta Kappa
1968-1972, Pulitzer Scholar at Columbia University

Editorial and Academic Positions

Editorial Positions

Ad Hoc Editor

2002-present, Blood Advance
2002-present, The Journal of Clinical Investigation
2002-present, The Journal of Biological Chemistry
2002-present, Biochemistry
2002-present, The Journal of Pediatrics
2002-present, Journal of Thrombosis and Haemostasis
2002-present, Atherosclerosis
2002-present, Thrombosis and Vascular Biology
2002-present, New England Journal of Medicine
2002-present, Nature
2002-present, Science
2002-present, Cell

Academic and Institutional Committees

2002-present, Cardiovascular Center Advisory Committee, PENN
1996-present, PENN Biomedical Research Grants
1998-present, MD Short-Term Research Committee
1997-present, MD/PhD Admissions Committee
1995-present, Recombinant Biology Subcommittee for the Biological Hazard Committee
1999-present, Hematology/Oncology Fellowship Committee 

Leadership and Memberships

Memberships in Professional Organizations

American Association for the Advancement of Science
American Federation for Clinical Research
American Society for Clinical Investigation
Association of American Physicians
NCRR (K12 ad hoc chair (2002))
Society for Experimental Biology and Medicine
Society for Pediatric Research