Mortimer Poncz, MD

Mortimer Poncz, MD

Mortimer Poncz, MD, is the Chief of the Division of Hematology at Children's Hospital of Philadelphia.

Areas of Expertise: Congenital platelet disorders, General hematology
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Pennsylvania School of Medicine, Philadelphia, PA


Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA


Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA


Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

American Board of Pediatrics
American Board of Pediatrics/Pediatric Hematology-Oncology,

Titles and Academic Titles

Chief, Division of Hematology

Jane Fishman Grinberg Endowed Chair in Stem Cell Research

Departments and Services



Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M. Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood. 2010 Aug 19. [Epub ahead of print] Read abstract.


Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity. 2010 Jul 23;33(1):106-17. Read abstract.

Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Marcos-Contreras OA, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood. 2010 Jun 24;115(25):5241-8. Epub 2010 Apr 21. Read abstract.


Gregory GD, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, Poncz M, Tong W, Blobel GA. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood. 2010 Mar 18;115(11):2156-66. Epub 2010 Jan 11. Read abstract


Kowalska MA, Rauova L, Poncz M. Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis. Thromb Res. 2010 Apr;125(4):292-6. Epub 2009 Dec 9. Review. Read abstract.

Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Bdeir K, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther. 2010 Mar;332(3):1022-31. Epub 2009 Dec 1. Erratum in: J Pharmacol Exp Ther. 2010 Jun;333(3):976. Zaitzev, Sergei [corrected to Zaitsev, Sergei]. Read abstract.

Miccio A, Wang Y, Hong W, Gregory GD, Wang H, Yu X, Choi JK, Shelat S, Tong W, Poncz M, Blobel GA. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J. 2010 Jan 20;29(2):442-56. Epub 2009 Nov 19. Read abstract.

Lambert MP, Wang Y, Bdeir KH, Nguyen Y, Kowalska MA, Poncz M. Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood. 2009 Sep 10;114(11):2290-8. Epub 2009 Jul 15. Read abstract.

Blue R, Kowalska MA, Hirsch J, Murcia M, Janczak CA, Harrington A, Jirouskova M, Li J, Fuentes R, Thornton MA, Filizola M, Poncz M, Coller BS. Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood. 2009 Jul 2;114(1):195-201. Epub 2009 May 4. Read abstract.

Basani RB, Zhu H, Thornton MA, Soto CS, Degrado WF, Kowalska MA, Bennett JS, Poncz M. Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. Blood. 2009 Jan 22;113(4):902-10. Epub 2008 Nov 5.  Read abstract.

Bougie DW, Birenbaum J, Rasmussen M, Poncz M, Aster RH. Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia. Blood. 2009 Jan 29;113(5):1105-11. Epub 2008 Oct 23. Read abstract.

Min SH, Oh SY, Karp GI, Poncz M, Zhao R, Goldman ID. The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption. J Pediatr. 2008 Sep;153(3):435-7. Read abstract.

Neyman M, Gewirtz J, Poncz M. Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots. Blood. 2008 Aug 15;112(4):1101-8. Epub 2008 Jun 16. Read abstract.