MD - Medical College of Pennsylvania, Philadelphia, PA
Internal Medicine - Yale-New Haven Hospital, New Haven, CT
Internal Medicine - Yale-New Haven Hospital, New Haven, CT (chief resident)
Medical Staff Fellow in Molecular Disease Branch - National Heart, Lung, and Blood Institute, Bethesda, MD
Internal Medicine – American Board of Internal Medicine
Chief, Division of Human Genetics
Chief, Metabolic Disease Program
Seymour Gray Professor of Molecular Medicine, Perelman School of Medicine at the University of Pennsylvania
Chair, Department of Genetics, Perelman School of Medicine at the University of Pennsylvania
Chief, Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania
Small AM, Mehta NN, Rader DJ. : The Role of Emerging Biomarkers in Unraveling the Complex Biology Underlying Associations between HDL Cholesterol and Cardiovascular Diseases. Clin Chem. 63(1): 27-29, Jan 2017.
Chhatriwalla AK, Rader DJ.: Intracoronary Imaging, Reverse Cholesterol Transport, and Transcriptomics: Precision Medicine in CAD? J Am Coll Cardiol. 69(6): 641-643, Feb 2017.
Rader DJ, Bajaj A, Khetarpal SA.: Deep Apolipoprotein Proteomics to Uncover Mechanisms of Coronary Disease Risk. J Am Coll Cardiol. 69(7): 801-804, Feb 2017.
Rader DJ.: Mediterranean Approach to Improving High-Density Lipoprotein Function. Circulation. 135(7): 644-647, Feb 2017.
Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Rader DJ, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, et al. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. J Am Coll Cardiol. 69(7): 823-836, Feb 2017.
Emdin CA, Khera AV, Natarajan P, Klarin D, Baber U, Mehran R, Rader DJ, Fuster V, Kathiresan S: Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort. Am J Cardiol 119(6): 881-885, Mar 2017.
Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM : Non-Clinical Study Examining AAV8.TBG.hLDLR Vector-Associated Toxicity in Chow-Fed Wild-Type and LDLR(+/-) Rhesus Macaques. Hum Gene Ther Clin Dev. 28(1): 39-50, Mar 2017.
Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM. : Nonclinical Pharmacology/Toxicology Study of AAV8.TBG.mLDLR and AAV8.TBG.hLDLR in a Mouse Model of Homozygous Familial Hypercholesterolemia. Hum Gene Ther Clin Dev. 28(1): 28-38, Mar 2017.
Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Rader, DJ, Myocardial Infarction Genetics Consortium, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium, et al. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 317(9): 937-946, Mar 2017.
Bi X, Pashos EE, Cuchel M, Lyssenko NN, Hernandez M, Picataggi A, McParland J, Yang W, Liu Y, Yan R, Yu C, DerOhannessian SL, Phillips MC, Morrisey EE, Duncan SA, Rader DJ: ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion. EBioMedicine. 18: 139-145, Apr 2017.
Cayo MA, Mallanna SK, Di Furio F, Jing R, Tolliver LB, Bures M, Urick A, Noto FK, Pashos EE, Greseth MD, Czarnecki M, Traktman P, Yang W, Morrisey EE, Grompe M, Rader DJ, Duncan SA: A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia. Cell Stem Cell 20(4): 478-489, Apr 2017.
Cuchel M, Raper AC, Conlon DM, Pryma DA, Freifelder RH, Poria R, Cromley D, Li X, Dunbar RL, French B, Qu L, Farver W, Su CC, Lund-Katz S, Baer A, Ruotolo G, Akerblad P, Ryan CS, Xiao L, Kirchgessner TG, Millar JS, Billheimer JT, Rader DJ : A Novel Approach to Measuring Macrophage-specific Reverse Cholesterol Transport in Vivo in Humans. J Lipid Res 58(4): 752-762, Apr 2017.
Dunbar RL, Goel H, Tuteja S, Song WL, Nathanson G, Babar Z, Lalic D, Gelfand JM, Rader DJ, Grove GL : Measuring Physical Stigmata of Niacin-Associated Skin Toxicity by Colorimetry, White-Light Spectroscopy, Laser Doppler Flowmetry, and Thermometry in Combination with Symptom Perception Scoring: Methods to Aid Development of Niacin Mimetics. J Lipid Res 58(4): 783-797, Apr 2017.
Kuwano T, Bi X, Cipollari E, Yasuda T, Lagor WR, Szapary HJ, Tohyama J, Millar JS, Billheimer JT, Lyssenko NN, Rader DJ: Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport. J Lipid Res 58(4): 731-741, Apr 2017.
Pashos EE, Park Y, Wang X, Raghavan A, Yang W, Abbey D, Peters DT, Arbelaez J, Hernandez M, Kuperwasser N, Li W, Lian Z, Liu Y, Lv W, Lytle-Gabbin SL, Marchadier DH, Rogov P, Shi J, Slovik KJ, Stylianou IM, Wang L, Yan R, Zhang X, Kathiresan S, Duncan SA, Mikkelsen TS, Morrisey EE, Rader DJ, Brown CD, Musunuru K: Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell 20(4): 558-570, Apr 2017.
Saleheen D, Natarajan P, Armean IM, Zhao W, Rasheed A, Rader DJ, et al. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature 544(7649): 235-239, Apr 2017.
Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Rader DJ, PROMIS and Myocardial Infarction Genetics Consortium Investigators, et al. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol 69(16): 2054-2063, Apr 2017.
Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth AS, Rader DJ, Ford I, Sattar N, Kathiresan S. Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting. Circulation 135(22): 2091-2101, May 2017.
Ueda M, Dunbar RL, Wolska A, Sikora TU, Escobar MD, Seliktar N, deGoma E, DerOhannessian S, Morrell L, McIntyre AD, Burke F, Sviridov D, Amar M, Shamburek RD, Freeman L, Hegele RA, Remaley AT, Rader DJ.: A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency with Severe Triglyceridemia and Pancreatitis. J Clin Endocrinol Metab. J Clin Endocrinol Metab 102(5): 1454-1457, May 2017.
Khera AV, Demler O, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ,Mora S: Cholesterol Efflux Capacity, HDL Particle Number, and Incident Cardiovascular Events. An Analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). Circulation. 135(25): 2494-2504, Jun 2017.
Mehta MB, Shewale SV, Sequeira RN, Millar JS, Hand NJ, Rader DJ: Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis. J Biol Chem. 292(25): 1044-10454, Jun 2017.
Millar JS, Lassman ME, Thomas T, Ramakrishnan R, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Wagner JA, Holleran S, Obunike J, Liu Y, Aoujil S, Standiford T, Gutstein DE, Ginsberg HN, Rader DJ, Reyes-Soffer G : Effects of CETP Inhibition with Anacetrapib on Metabolism of VLDL TG and Plasma Apolipoproteins C-II, C-III, and E. J Lipid Res 58(6): 1214-1220, Jun 2017.
Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, Rader DJ, et al. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res 121(1): 81-88, Jun 2017.
Blom DJ, Averna MR, Meagher EA, du Toit Theron H, Sirtori CR, Hegele RA, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Larrey D, Bloedon LT, Foulds P, Rader DJ, Cuchel M. : Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia. Circulation 136(3): 332-335, Jul 2017.
Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Rader Dj, AFGen Consortium, et al. Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet 49(8): 1286, Jul 2017.
Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Rader DJ, et al. Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. N Engl J Med 377(3): 211-221, Jul 2017.
Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig LB, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers LJ, van Gorp RH, Ries C, Kusters PJH, van der Wal AC, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C: Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence from Mouse and Human Studies. Circulation. 136(4): 388-403, Jul 2017.
Howson JMM, Zhao W, Barnes DR, Ho WK, Young R, Rader DJ, et al. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nat Genet 49(7): 1113-1119, Jul 2017.
Knowles JW, Rader DJ, Khoury MJ: Cascade Screening for Familial Hypercholesterolemia and the Use of Genetic Testing. JAMA 318(4): 381-382, Jul 2017.
Saleheen D, Haycock PC, Zhao W, Rasheed A, Taleb A, Imran A, Abbas S, Majeed F, Akhtar S, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SN, Memon A, Mallick NH, Ishaq M, Rasheed SZ, Memon FU, Mahmood K, Ahmed N, Frossard P, Tsimikas S, Witztum JL, Marcovina S, Sandhu M, Rader DJ, Danesh J.: Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol 5(7): 524-533, Jul 2017 Notes:
Thomas T, Zhou H, Karmally W, Ramakrishnan R, Holleran S, Liu Y, Jumes P, Wagner JA, Hubbard B, Previs SF, Roddy T, Johnson-Levonas AO, Gutstein DE, Marcovina SM, Rader DJ, Ginsberg HN, Millar JS, Reyes-Soffer G: CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects. Arterioscler Thromb Vasc Biol Jul 2017.
Bajaj A, Damrauer SM, Anderson AH, Xie D, Budoff MJ, Go AS, He J, Lash JP, Ojo A, Post WS, Rahman M, Reilly MP, Saleheen D, Townsend RR, Chen J, Rader DJ: Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort). Arterioscler Thromb Vasc Biol Aug 2017 Notes: Epub ahead of print.
Dunbar RL, Movva R, Bloedon LT, Duffy D, Norris RB, Navab M, Fogelman AM, Rader DJ.: Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. Clin Transl Sci Aug 2017 Notes: Epub ahead of print.
Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AVH, Zanoni P, Landro JA, Barucci N, Zavadoski WJ, Sun Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M, Lund-Katz S, Phillips MC, Tall AR, Kathiresan S, DaSilva-Jardine P, Yates NA, Rader DJ : A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nat Med Aug 2017 Notes: Epub ahead of print.
Koekemoer AL, Codd V, Masca NGD, Nelson CP, Musameh MD, Kaess BM, Hengstenberg C, Rader DJ, Samani NJ: Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity. Arterioscler Thromb Vasc Biol Aug 2017 Notes: Epub ahead of print.
Small AM, Kiss DH, Zlatsin Y, Birtwell DL, Williams H, Guerraty MA, Han Y, Anwaruddin S, Holmes JH, Chirinos JA, Wilensky RL, Giri J, Rader DJ: Text mining applied to electronic cardiovascular procedure reports to identify patients with trileaflet aortic stenosis and coronary artery disease. J Biomed Inform 72: 77-84, Aug 2017.
Tuteja S, Wang L, Dunbar RL, Chen J, DerOhannessian S, Marcovina SM, Elam M, Lader E, Rader DJ: Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy. Pharmacogenet Genomics. 27(8): 285-293, Aug 2017.
Dron JS, Wang J, Low-Kam C, Khetarpal SA, Robinson JF, McIntyre AD, Ban MR, Cao H, Rhainds D, Dubé MP, Rader DJ, Lettre G, Tardif JC, Hegele RA: Polygenic determinants in extremes of high-density lipoprotein cholesterol. J Lipid Res Sep 2017 Notes: Epub ahead of print.
Ibrahim S, Somanathan S, Billheimer J, Wilson JM, Rader DJ : Stable Liver-specific Expression of Human IDOL in Humanized Mice Raises Plasma Cholesterol. Cardiovasc Res. Jan 2016 Notes: Epub ahead of print.
Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Rader DJ, et al. Genetic associations at 53 loci highlight cell types and biologic pathways relevant for kidney function. Nat Commun Page: 7, Jan 2016.
Wolf JH, Holmes MV, Fouraschen S, Keating BJ, Baker T, Emond J, Rader DJ, Shaked A, Olthoff KM: Serum lipid expression correlates with function and regeneration following living donor liver transplantation. Liver Transpl 22(1): 103-101, Jan 2016.
Keenan T, Zhao W, Rasheed A, Ho WK, Malik R, Rader DJ, et al. Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. J Am Coll Cardiol 67(4): 407-416, Feb 2016.
Nurnberg ST, Zhang H, Hand NJ, Bauer RC, Saleheen D, Reilly MP, Rader DJ: From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. Circ Res 118(4): 586-606, Feb 2016.
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators.: Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med 374(12): 1134-1144, Mar 2016.
Reyes-Soffer G, Millar JS, Ngai C, Jumes P, Coromilas E, Asztalos B, Johnson-Levonas AO, Wagner JA, Donovan DS, Karmally W, Ramakrishnan R, Holleran S, Thomas T, Dunbar RL, deGoma EM, Rafeek H, Baer AL, Liu Y, Lassman ME, Gutstein DE, Rader DJ, Ginsberg HN. : Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Decreases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholesteryl Ester Transfer Protein. Arterioscler Thromb Vasc Biol Mar 2016.
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Rader DJ, CHD Exome+ Consortium; CARDIoGRAM Exome Consortium; Global Lipids Genetics Consortium, et al. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science 351(6278): 1166-1171, Mar 2016.
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. : Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest 126(4): 1323-1336, Apr 2016.
Ibrahim S, Somanathan S, Billheimer J, Wilson JM, Rader DJ: Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol. Cardiovasc Res 110(1): 23-29, May 2016.
Kastelein JJ, Nissen SE, Rader DJ, Hovingh GK, Wang MD, Shen T, Krueger KA. : Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study. Eur Heart J 37(17): 1360-1369, May 2016.
Nioi P, Sigurdsson A, Thorleifsson G, Helgason H, Agustsdottir AB, Rader DJ, et al. Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease. N Engl J Med 374(22): 2131-2141, Jun 2016.
Peloso GM, Rader DJ, Gabriel S, Kathiresan S, Daly MJ, Neale BM: Phenotypic extremes in rare variant study designs. Eur J Hum Genet 24(6): 924-930, Jun 2016.
deGoma EM, Ahmad ZS, O'Brien EC, Kindt I, Shrader P, Newman CB, Pokharel Y, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW: Treatment Gaps in Adults with Heterozygous Familial Hypercholesterolemia in the United States: Data from the CASCADE-FH Registry. Circ Cardiovasc Genet 9(3): 240-249, Jun 2016.
Daugherty A, Hegele RA, Mackman N, Rader DJ, Schmidt AM, Weber C: Complying With the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility: Refutations. Arterioscler Thromb Vasc Biol 36(7): 1303-1304, Jul 2016.
Hsieh J, Koseki M, Molusky MM, Yakushiji E, Ichi I, Westerterp M, Iqbal J, Chan RB, Abramowicz S, Tascau L, Takiguchi S, Yamashita S, Welch CL, Di Paolo G, Hussain MM, Lefkowitch JH, Rader DJ, Tall AR: TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature 535(7611): 303-307, Jul 2016.
Lin J, Hu Y, Nunez S, Foulkes AS, Cieply B, Xue C, Gerelus M, Li W, Zhang H, Rader DJ, Musunuru K, Li M, Reilly MP: Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing. Arterioscler Thromb Vasc Biol 36(7): 1434-1447, Jul 2016.
Palmer EE, Jarrett KE, Sachdev RK, Al Zahrani F, Hashem MO, Ibrahim N, Sampaio H, Kandula T, Macintosh R, Gupta R, Conlon DM, Billheimer JT, Rader DJ, Funato K, Walkey CJ, Lee CS, Loo C, Brammah S, Elakis G, Zhu Y, Buckley M, Kirk EP, Bye A, Alkuraya FS, Roscioli T, Lagor WR. : Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy. Hum Mol Genet. 25(14): 3042-3054, Jul 2016.
Patel AP, Peloso GM, Pirruccello JP, Johansen CT, Dubé JB, Larach DB, Ban MR, Dallinge-Thie GM, Gupta N, Boehnke M, Abecasis GR, Kastelein JJ, Hovingh GK, Hegele RA, Rader DJ, Kathiresan S : Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution. Atherosclerosis 250: 63-68, Jul 2016.
Herzog E, Pragst I, Waelchli M, Gille A, Schenk S, Mueller-Cohrs J, Diditchenko S, Zanoni P, Cuchel M, Seubert A, Rader DJ, Wright SD : Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component. J Appl Toxicol 36(8): 1038-1047, Aug 2016.
Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Rader DJ, et al. Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. Cell Metab 24(2): 234-245, Aug 2016.
Ahmad ZS, Andersen RL, Andersen LH, O'Brien EC, Kindt I, Shrader P, Vasandani C, Newman CB, deGoma EM, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Kullo IJ, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW: US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry. J Clin Lipidol 10(5): 1223-1229, Sep-Oct 2016.
Quach D, Vitali C, La FM, Xiao AX, Millar JS, Tang C, Rader DJ, Phillips MC, Lyssenko NN: Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly. Biochim Biophys Acta 1861: 1968-1979, Sep 2016.
Saleheen D, Rader DJ, Voight BF: Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics. JAMA Cardiol 1(6): 631-633, Sep 2016.
Stroes E, Guyton JR, Lepor N, Civeira F, Gaudet D, Watts GF, Baccara-Dinet MT, Lecorps G, Manvelian G, Farnier M; ODYSSEY CHOICE II Investigators. : Efficacy and Safety of Alirocumab 150 mg Every 4 Weeks in Patients With Hypercholesterolemia Not on Statin Therapy: The ODYSSEY CHOICE II Study. J Am Heart Assoc 5(9): 407-416, Sep 2016.
Beheshtian A, Shitole SG, Segal AZ, Leifer D, Tracy RP, Rader DJ, Devereux RB, Kizer JR: Lipoprotein (a) level, apolipoprotein (a) size, and risk of unexplained ischemic stroke in young and middle-aged adults. Atherosclerosis 253: 47-53, Oct 2016.
Jacoby DS, Rader DJ: Improving cardiovascular outcomes by intensifying low density lipoprotein lowering therapy in high-risk patients. Eur Heart J Oct 2016.
van Capelleveen JC, Kastelein JJ, Zwinderman AH, van Deventer SJ, Collins HL, Adelman SJ, Round P, Ford J, Rader DJ, Hovingh GK. : Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses. J Clin Lipidol 10(5): 1137-1144.e3, Oct 2016.
Javaheri A, Molina M, Zamani P, Rodrigues A, Novak E, Chambers S, Stutman P, Maslanek W, Williams M, Lilly SM, Heeger P, Sayegh MH, Chandraker A, Briscoe DM, Daly KP, Starling R, Ikle D, Christie J, Rame JE, Goldberg LR, Billheimer J, Rader DJ : Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transplant 35(11): 1295-1302, Nov 2016.
Joshi AA, Lerman JB, Aberra TM, Afshar M, Teague HL, Rodante JA, Krishnamoorthy P, Ng Q, Aridi TZ, Salahuddin T, Natarajan B, Lockshin BN, Ahlman MA, Chen MY, Rader DJ, Reilly M, Remaley AT, Bluemke DA, Playford MP, Gelfand JM, Mehta NN: GlycA Is a Novel Biomarker of Inflammation and Subclinical Cardiovascular Disease in Psoriasis. Circ Res 119(11): 1242-1253, Nov 2016.
Mansouri B, Kivelevitch D, Natarajan B, Joshi AA, Ryan C, Benjegerdes K, Schussler JM, Rader DJ, Reilly MP, Menter A, Mehta NN.: Comparison of Coronary Artery Calcium Scores Between Patients With Psoriasis and Type 2 Diabetes. JAMA Dermatol 152(11): 1244-1253, Nov 2016.
Roth EM, Moriarty PM, Bergeron J, Langslet G, Manvelian G, Zhao J, Baccara-Dinet MT, Rader DJ; ODYSSEY CHOICE I investigators: A phase III randomized trial evaluating alirocumab 300 mg every 4 weeks as monotherapy or add-on to statin: ODYSSEY CHOICE I. Atherosclerosis 254: 254-262, Nov 2016.
Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Rader DJ, CHARGE-Heart Failure Consortium.; CARDIoGRAM Exome Consortium, et al. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J Am Coll Cardiol 68(25): 2761-2772, Dec 2016.
Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S.: Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl J Med 375(24): 2349-2358, Dec 2016.
Natarajan P, Bis JC, Bielak LF, Cox AJ, Dörr M, Rader DJ, CHARGE Consortium, et al. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet 9(6): 511-520, Dec 2016.
Rader DJ, Damrauer SM: "Pheno"menal value for human health. Science 354(6319): 1534-1536, Dec 2016.
Clapham KR, Chu AY, Wessel J, Natarajan P, Flannick J, Rivas MA, Sartori S, Mehran R, Baber U, Fuster V, Scott RA, Rader DJ, Boehnke M, McCarthy MI, Altshuler DM, Kathiresan S, Peloso GM. : A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans. BMC Endocr Disord 16(1): 7, Jan 2016.
Daugherty A, Tabas I, Rader DJ: Accelerating the pace of atherosclerosis research. Arterioscler Thromb Vasc Biol. 35(1): 11-12, Jan 2015.
Khera AV, Qamar A, Reilly MP, Dunbar RL, Rader DJ. : Effects of niacin, statin, and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 levels in patients with dyslipidemia. Am J Cardiol 115(2): 178-182, Jan 2015.
Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Rader DJ, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature 518(537): 102-106, Feb 2015.
Khetarpal SA, Rader DJ: Triglyceride-rich lipoproteins and coronary artery disease risk: new insights from human genetics. Arterioscler Thromb Vasc Biol 35(2): e3-9, Feb 2015.
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Rader DJ, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518(7538): 197-206, Feb 2015.
Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, Millar J, Kruth H, Rader DJ: Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis. Circ Res 116(5): 789-796, Feb 2015.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Rader DJ, et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 518(7538): 187-196, Feb 2015.
Thormaehlen AS, Schuberth C, Won HH, Blattmann P, Joggerst-Thomalla B, Theiss S, Asselta R, Duga S, Merlini PA, Ardissino D, Lander ES, Gabriel S, Rader DJ, Peloso GM, Pepperkok R, Kathiresan S, Runz H: Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction. PLoS Genet 11(2): e1004855, Feb 2015.
Bauer RC, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, Ou K, Paschos GK, Zheng XL, Parmacek MS, Rader DJ, Reilly MP: Knockout of adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation 131(13): 1202-1213, Mar 2015.
Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS; CARDIoGRAM, Assimes TL, Deloukas P, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Stewart AF: Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community. J Am Heart Assoc 4(3): e001544, Mar 2015.
Hovingh GK, Rader DJ, Hegele RA: HDL re-examined. Curr Opin Lipidol 26(2): 127-132, Apr 2015.
Interleukin 1 Genetics Consortium : Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol 3(4): 243-253, Apr 2015.
Nelson CP, Hamby SE, Saleheen D, Hopewell JC, Zeng L, Rader DJ, CARDIoGRAM+C4D Consortium, et al. Genetically determined height and coronary artery disease. N Engl J Med. 372(17): 1608-1618, Apr 2015.
Rader DJ: Human genetics of atherothrombotic disease and its risk factors. Arterioscler Thromb Vasc Biol 35(4): 741-747, Apr 2015.
Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Rader DJ, et al. Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet 8(2): 343-350, Apr 2015.
Luthi AJ, Lyssenko NN, Quach D, McMahon KM, Millar JS, Vickers KC, Rader DJ, Phillips MC, Mirkin CA, Thaxton CS: Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high-density lipoprotein. J Lipid Res 56(5): 972-985, May 2015.
deGoma EM, Salavati A, Shinohara RT, Saboury B, Pollan L, Schoen M, Torigian DA, Mohler ER, Dunbar RL, Litt HI, Woo J, Rader DJ, Alavi A, Mehta NN.: A Pilot Trial to Examine the Effect of High-Dose Niacin on Arterial Wall Inflammation Using Fluorodeoxyglucose Positron Emission Tomography. Acad Radiol 22(5): 600-609, May 2015.
Agarwala AP, Rodrigues A, Risman M, McCoy M, Trindade K, Qu L, Cuchel M, Billheimer J, Rader DJ. : High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease. Arterioscler Thromb Vasc Biol 35(6): 1515-1519, Jun 2015.
Millar JS, Reyes-Soffer G, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Pollan L, Tohyama J, Johnson-Levonas AO, Wagner JA, Holleran S, Obunike J, Liu Y, Ramakrishnan R, Lassman ME, Gutstein DE, Ginsberg HN, Rader DJ. : Anacetrapib lowers LDL by increasing apoB clearance in mildly hypercholesterolemic subjects. J Clin Invest 125(6): 2510-2522, Jun 2015.
Stefanutti C, Blom DJ, Averna MR, Meagher EA, Theron HD, Marais AD, Hegele RA, Sirtori CR, Shah PK, Gaudet D, Vigna GB, Sachais BS, Di Giacomo S, du Plessis AM, Bloedon LT, Balser J, Rader DJ, Cuchel M; Phase 3 HoFH Lomitapide Study Investigators. : The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - A post-hoc analysis of a Phase 3, single-arm, open-label trial. Atherosclerosis 240(2): 408-414, Jun 2015.
Zhang H, Xue C, Shah R, Bermingham K, Hinkle CC, Li W, Rodrigues A, Tabita-Martinez J, Millar JS, Cuchel M, Pashos E, Liu Y, Yan R, Yang W, Gosai SJ, VanDorn D, Chou S, Gregory BD, Morrisey E, Li M, Rader DJ, Reilly MP: Functional Analysis and Transcriptomic Profiling of iPSC-Derived Macrophages and Their Application in Modeling Mendelian Disease. Circ Res 117(1): 17-28, Jun 2015.
Auer PL, Nalls M, Meschia JF, Worrall BB, Longstreth WT Jr, Seshadri S, Kooperberg C, Burger KM, Carlson CS, Carty CL, Chen WM, Cupples LA, DeStefano AL, Fornage M, Hardy J, Hsu L, Jackson RD, Jarvik GP, Kim DS, Lakshminarayan K, Lange LA, Manichaikul A, Quinlan AR, Singleton AB, Thornton TA, Nickerson DA, Peters U, Rich SS; National Heart, Lung, and Blood Institute Exome Sequencing Project: Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. JAMA Neurol 72(7): 781-788, Jul 2015.
Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, Lukmanova D, Mucksavage ML, Luben R, Billheimer J, Kastelein JJ, Boekholdt SM, Khaw KT, Wareham N, Rader DJ. : Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. Lancet Diabetes Endocrinol. 3(7): 507-513, July 2015.
Winsvold BS, Nelson CP, Malik R, Gormley P, Anttila V, Rader DJ, CARDIoGRAM Consortium and the International Headache Genetics Consortium, et al. Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurol Genet 1(1): e10, Jul 2015.
Hovingh GK, Kastelein JJ, van Deventer SJ, Round P, Ford J, Saleheen D, Rader DJ, Brewer HB, Barter PJ. : Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidemia (TULIP): a randomized, double-blind, placebo-controlled phase 2 trial. Lancet 386(9992): 452-460, Aug 2015.
Qamar A, Khetarpal SA, Khera AV, Qasim A, Rader DJ, Reilly MP: Plasma Apolipoprotein C-III Levels, Triglycerides, and Coronary Artery Calcification in Type 2 Diabetics. Arterioscler Thromb Vasc Biol 35(8): 1880-1888, Aug 2015.
Shah R, Matthews GJ, Shah RY, McLaughlin C, Chen J, Wolman M, Master SR, Chai B, Xie D, Rader DJ, Raj DS, Mehta NN, Budoff M, Fischer MJ, Go AS, Townsend RR, He J, Kusek JW, Feldman HI, Foulkes AS, Reilly MP; CRIC Study Investigators. Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 66(2): 266-273, Aug 2015.
Asch DA, Rader DJ, Merchant RM: Mining the social mediome. Trends Mol Med. 21(9): 528-529, Sep 2015.
Khera AV, Qamar A, Murphy SA, Cannon CP, Sabatine MS, Rader DJ. : On-Statin Resistin, Leptin, and Risk of Recurrent Coronary Events After Hospitalization for an Acute Coronary Syndrome (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Study). Am J Cardiol. 116(5): 694-698, Sep 2015.
Peloso GM, Rader DJ, Gabriel S, Kathiresan S, Daly MJ, Neale BM.: Phenotypic extremes in rare variant study designs. Eur J Hum Genet. Sep 2015 Notes: [Epub ahead of print]
Rader DJ.: Lysosomal Acid Lipase Deficiency - A New Therapy for a Genetic Lipid Disease. N Engl J Med. 373(11): 1071-1073, Sep 2015.
Bauer RC, Sasaki M, Cohen DM, Cui J, Smith MA, Yenilmez BO, Steger DJ, Rader DJ.: Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPa. J Clin Invest. 125(10): 3809-3818, Oct 2015.
CARDIoGRAMplusC4D Consortium.: A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 47(10): 1121-1130, Oct 2015.
Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE.: Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. J Clin Invest. 125(10): 3819-3830, Oct 2015.
Iqbal J, Walsh MT, Hammad SM, Cuchel M, Tarugi P, Hegele RA, Davidson NO, Rader DJ, Klein RL, Hussain MM : Microsomal triglyceride transfer protein transfers and determines plasma concentrations of ceramide and sphingomyelin, but not glucosylceramide. J Biol Chem 290(43): 25863-25875, Oct 2015.
Lagor WR, Tong F, Jarrett KE, Lin W, Conlon DM, Smith M, Wang MY, Yenilmez BO, McCoy MG, Fields DW, O'Neill SM, Gupta R, Kumaravel A, Redon V, Ahima RS, Sturley SL, Billheimer JT, Rader DJ: Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure. Nutr Diabetes 5: e181, Oct 2015.
Goth CK, Halim A, Khetarpal SA, Rader DJ, Clausen H, Schjoldager KT: A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation. Proc Natl Acad Sci U S A 112(47): 14623-14628, Nov 2015.
Hegele RA, Gidding SS, Ginsberg HN, McPherson R, Raal FJ, Rader DJ, Robinson JG, Welty FK : Nonstatin Low-Density Lipoprotein-Lowering Therapy and Cardiovascular Risk Reduction-Statement From ATVB Council. Arterioscler Thromb Vasc Biol 35(11): 2269-2268, Nov 2015.
Khera AV, Millar JS, Ruotolo G, Wang MD, Rader DJ : Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. Eur Heart J 36(42): 3020-3022, Nov 2015.
Natarajan P, Kohli P, Baber U, Nguyen KD, Sartori S, Reilly DF, Mehran R, Muntendam P, Fuster V, Rader DJ, Kathiresan S: Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study. J Am Coll Cardiol 66(18): 2053-2055, Nov 2015.
Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ: Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. J Am Coll Cardiol 66(20): 2201-2210, Nov 2015.
Herzog E, Pragst I, Waelchli M, Gille A, Schenk S, Mueller-Cohrs J, Diditchenko S, Zanoni P, Cuchel M, Seubert A, Rader DJ, Wright SD: Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component. J Appl Toxicol. Dec 2015 Notes: Epub ahead of print.
Voight BF, Rader DJ: Human genetics shines a light on ischaemic stroke. Lancet Neurol. Dec 2015 Notes: Epub ahead of print.
Dichgans M, Malik R, König IR, Rosand J, Clarke R, Rader DJ, et al. Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants. Stroke 45(1): 24-36, Jan 2014.
Fruchart JC, Davignon J, Hermans MP, Al-Rubeaan K, Amarenco P, Rader DJ, et al. Residual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol 13(1): 26, Jan 2014 Notes: [Epub ahead of print]
Li RC, Krishnamoorthy P, Derohannessian S, Doveikis J, Wilcox M, Thomas P, Rader DJ, Reilly MP, Van Voorhees A, Gelfand JM, Mehta NN: Psoriasis is associated with decreased plasma adiponectin levels independently of cardiometabolic risk factors. Clin Exp Dermatol 39(1): 19-24, Jan 2014.
Rader DJ, Degoma EM: Future of cholesteryl ester transfer protein inhibitors. Annu Rev Med 14(65): 385-403, Jan 2014.
Lagor WR, Fields DW, Bauer RC, Crawford A, Abt MC, Artis D, Wherry EJ, Rader DJ: Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis. Atherosclerosis 233(1): 234-241, Mar 2014.
Miksztowicz V, Schreier L, McCoy M, Lucero D, Fassio E, Billheimer J, Rader DJ, Berg G: Role of SN1 Lipases on Plasma Lipids in Metabolic Syndrome and Obesity. Arterioscler Thromb Vasc Biol 34(3): 669-675, Mar 2014.
Gordon AS, Tabor HK, Johnson AD, Snively BM, Assimes TL, Auer PL, Ioannidis JP, Peters U, Robinson JG, Sucheston LE, Wang D, Sotoodehnia N, Rotter JI, Psaty BM, Jackson RD, Herrington DM, O'Donnell CJ, Reiner AP, Rich SS, Rieder MJ, Bamshad MJ, Nickerson DA; NHLBI GO Exome Sequencing Project: Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset. Hum Mol Genet 23(8): 1957-1963, Apr 2014.
Javaheri A, Rader DJ: Apolipoprotein a-I and cholesterol efflux: the good, the bad, and the modified. Circ Res. 114(11): 1681-1683, May 2014.
Javaheri A, Rader DJ, Javaheri S: Statin therapy in heart failure: is it time for a second look? Hypertension 63(5): 909-910, May 2014.
Mehta N, Qamar A, Qu L, Qasim AN, Mehta NN, Reilly MP, Rader DJ. : Differential Association of Plasma Angiopoietin-Like Proteins 3 and 4 With Lipid and Metabolic Traits. Arterioscler Thromb Vasc Biol 34(5): 1057-1063, May 2014.
Singh N, Jacobs F, Rader DJ, Vanhaecke J, Van Cleemput J, De Geest B: Impaired cholesterol efflux capacity and vasculoprotective function of high-density lipoprotein in heart transplant recipients. J Heart Lung Transplant 33(5): 499-506, May 2014.
Chirinos JA, Gurubhagavatula I, Teff K, Rader DJ, Wadden TA, Townsend R, Foster GD, Maislin G, Saif H, Broderick P, Chittams J, Hanlon AL, Pack AL: CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med 370(24): 2265-2275, Jun 2014.
Rosenson RS, Brewer HB, Rader DJ: Lipoproteins as biomarkers and therapeutic targets in the setting of acute coronary syndrome. Circ Res 114(12): 1880-1889, Jun 2014.
Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ: Lipidomic Analyses of Female Mice Lacking Hepatic Lipase and Endothelial Lipase Indicate Selective Modulation of Plasma Lipid Species. Lipids 49(6): 505-515, Jun 2014.
Rahman M, Yang W, Akkina S, Alper A, Anderson AH, Appel LJ, He J, Raj DS, Schelling J, Strauss L, Teal V, Rader DJ; CRIC Study Investigators. : Relation of Serum Lipids and Lipoproteins with Progression of CKD: The CRIC Study. Clin J Am Soc Nephrol 9(7): 1190-1198, Jul 2014.
Tuteja S, Rader DJ: High Density Lipoproteins in the Prevention of Cardiovascular Disease: Changing the Paradigm. Clin Pharmacol Ther 96(1): 48-56, Jul 2014.
Anthanont P, Polisecki E, Asztalos BF, Diffenderfer MR, Barrett PH, Millar JS, Billheimer J, Cuchel M, Rader DJ, Schaefer EJ: A novel ApoA-I truncation (ApoA-IMytilene) associated with decreased ApoA-I production. Atherosclerosis 235(2): 470-476, Aug 2014.
Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K. : Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing. Circ Res. 115(5): 488-492, Aug 2014.
Mehta NN, Matthews GJ, Krishnamoorthy P, Shah R, McLaughlin C, Patel P, Budoff M, Chen J, Wolman M, Go A, He J, Kanetsky PA, Master SR, Rader DJ, Raj D, Gadegbeku CA, Shah R, Schreiber M, Fischer MJ, Townsend RR, Kusek J, Feldman HI, Foulkes AS, Reilly MP; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.: Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study. Eur Heart J. 14(35): 2115 - 2122, Aug 2014.
Rader DJ: Spotlight on HDL biology: new insights in metabolism, function, and translation. Cardiovasc Res. 103(3): 337-340, Aug 2014.
Somanathan S, Jacobs F, Wang Q, Hanlon AL, Wilson JM, Rader DJ: AAV vectors expressing LDLR gain-of-function variants demonstrate increased efficacy in mouse models of familial hypercholesterolemia. A Circ Res 115(6): 591-599, Aug 2014.
Lassman ME, McAvoy T, Lee AY, Chappell D, Wong O, Zhou H, Reyes-Soffer G, Ginsberg HN, Millar JS, Rader DJ, Gutstein DE, Laterza O: Practical immunoaffinity-enrichment LC-MS for measuring protein kinetics of low-abundance proteins. Clin Chem 60(9): 1217-1224, Sep 2014.
Yang P, Belikova NA, Billheimer J, Rader DJ, Hill JS, Subbaiah PV : Inhibition of endothelial lipase activity by sphingomyelin in the lipoproteins. Lipids 49(10): 987-996, Oct 2014.
Myocardial Infarction Genetics Consortium Investigators, Stitziel NO, Won HH, Morrison AC, Peloso GM, Rader DJ, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med 371(22): 2072-2082, Nov 2014.
Tuteja S, Rader DJ: Dyslipidemia: prevention-end of the road for niacin? Nat Rev Endocrinol 10(11): 646-647, Nov 2014.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Rader DJ, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet 46(11): 1173-1186, Nov 2014.
Knowles JW, O'Brien EC, Greendale K, Wilemon K, Genest J, Sperling LS, Neal WA, Rader DJ, Khoury MJ : Reducing the burden of disease and death from familial hypercholesterolemia: A call to action. Am Heart J 168(6): 807-811, Dec 2014.
Agarwala A, Billheimer J, Rader DJ: Mighty minipig in fight against cardiovascular disease. Sci Transl Med 5(166): 166fs1, Jan 2013.
Cuchel M, Meagher EA, du Toit Theron H, Blom DJ, Marais AD, Hegele RA, Averna MR, Sirtori CR, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plessis AM, Propert KJ, Sasiela WJ, Bloedon LT, Rader DJ; Phase 3 HoFH Lomitapide Study investigators.: Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet. 5(381): 40-6, Jan 2013.
Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ; NHLBI Exome Sequencing Project, Akey JM: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature 493(7431): 216-2220, Jan 2013.
Guo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA, Keating BJ; IBC 50K SNP array BMI Consortium. : Gene-centric meta-analyses of 108,912 individuals confirm known body mass index loci and reveal three novel signals. Hum Mol Genet. 1(22): 184-201, Jan 2013.
Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJ : Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia. Hum Gene Ther 24(1): 19-26, Jan 2013.
Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Rader DJ, et al. Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India. Diabetes Jan 2013.
Kothapalli D, Castagnino P, Rader DJ, Phillips MC, Lund-Katz S, Assoian RK: Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222. Atherosclerosis 227(1): 65-71, Mar 2013.
Mohler ER 3rd, Sibley AA, Stein R, Davila-Roman V, Wyatt H, Badellino K, Rader DJ, Klein S, Foster GD: Endothelial function and weight loss: comparison of low-carbohydrate and low-fat diets. Obesity (Silver Spring) 21(3): 504-509, Mar 2013.
Cuchel M, Rader DJ: Lipid-lowering treatment for homozygous familial hypercholesterolaemia -- authors' reply. Lancet 381(9873): 1183, Apr 2013.
Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Rader DJ, et al. Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet 15(22): 1663-1678, Apr 2013.
Li H, Dhanasekaran P, Alexander ET, Rader DJ, Phillips MC, Lund-Katz S: Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. Arterioscler Thromb Vasc Biol 33(4): 687-693, Apr 2013.
Manolio TA, Chisholm RL, Ozenberger B, Roden DM, Williams MS, Wilson R, Bick D, Bottinger EP, Brilliant MH, Eng C, Frazer KA, Korf B, Ledbetter DH, Lupski JR, Marsh C, Mrazek D, Murray MF, O'Donnell PH, Rader DJ, Relling MV, Shuldiner AR, Valle D, Weinshilboum R, Green ED, Ginsburg GS. : Implementing genomic medicine in the clinic: the future is here. Genet Med 15(4): 258-267, Apr 2013.
Norton N, Li D, Rampersaud E, Morales A, Martin ER, Zuchner S, Guo S, Gonzalez M, Hedges DJ, Robertson PD, Krumm N, Nickerson DA, Hershberger RE; National Heart, Lung, and Blood Institute GO Exome Sequencing Project and the Exome Sequencing Project Family Studies Project Team: Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circ Cardiovasc Genet 6(2): 144-153, Apr 2013.
Kahn ML, Rader DJ: Lymphatics as a new active player in reverse cholesterol transport. Cell Metab 17(5): 627-628, May 2013.
Lieb W, Jansen H, Loley C, Pencina MJ, Nelson CP, Rader DJ, et al. Genetic predisposition to higher blood pressure increases coronary artery disease risk. Hypertension 61(5): 995-1001, May 2013.
Master SR, Rader DJ : Beyond LDL Cholesterol in Assessing Cardiovascular Risk: apo B or LDL-P? Clin Chem 59(5): 723-725, May 2013.
Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Rader DJ, et al. Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Diabetes 62(5): 1746-1755, May 2013.
Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J: Endothelial Lipase Is a Critical Determinant of High-Density Lipoprotein-Stimulated Sphingosine 1-Phosphate-Dependent Signaling in Vascular Endothelium. Arterioscler Thromb Vasc Biol [Epub ahead of print] , May 2013.
Cuchel M, Rader DJ: Microsomal transfer protein inhibition in humans. Curr Opin Lipidol 24(3): 246-250, Jun 2013.
Vickers KC, Rader DJ: Nuclear Receptors and microRNA-144 Coordinately Regulate Cholesterol Efflux. Circ Res 112(12): 1529-1531, Jun 2013.
Zhou H, Castro-Perez J, Lassman ME, Thomas T, Li W, McLaughlin T, Dan X, Jumes P, Wagner JA, Gutstein DE, Hubbard BK, Rader DJ, Millar JS, Ginsberg HN, Reyes-Soffer G, Cleary M, Previs SF, Roddy TP : Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry. Rapid Commun Mass Spectrom 27(12): 1294-1302, Jun 2013.
Khera AV, Rader DJ: Cholesterol efflux capacity: full steam ahead or a bump in the road? Arterioscler Thromb Vasc Biol 33(7): 1149-1451, Jul 2013.
O'Connor TD, Kiezun A, Bamshad M, Rich SS, Smith JD, Turner E; NHLBIGO Exome Sequencing Project; ESP Population Genetics, Statistical Analysis Working Group, Leal SM, Akey JM : Fine-scale patterns of population stratification confound rare variant association tests. PLoS One 8(7): e65834, Jul 2013.
Ferguson JF, Matthews GJ, Townsend RR, Raj DS, Kanetsky PA, Rader DJ, et al. Candidate Gene Association Study of Coronary Artery Calcification in Chronic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort Study. J Am Coll Cardiol 62(9): 789-798, Aug 2013.
Picataggi A, Lim GF, Kent AP, Millar JS, Rader DJ, Stylianou IM : A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice. Mamm Genome 24(7-8): 257-265, Aug 2013.
Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Rader DJ, et al. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Hum Mol Genet 22(16): 3381-3393, Aug 2013.
Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J : Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol 33(8): 1788-1794, Aug 2013.
Keenan TE, Rader DJ: Genetics of lipid traits and relationship to coronary artery disease. Curr Cardiol Rep 15(9): 396, Sep 2013.
Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Rader DJ, et al. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and Circulation 128(12): 1310-1324, Sep 2013.
Toth PP, Barter PJ, Rosenson RS, Boden WE, Chapman MJ, Cuchel M, D'Agostino RB Sr, Davidson MH, Davidson WS, Heinecke JW, Karas RH, Kontush A, Krauss RM, Miller M, Rader DJ: High-density lipoproteins: A consensus statement from the National Lipid Association. J Clin Lipidol 7(5): 484-525, Sep-Oct 2013.
van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Rader DJ, et al. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr 98(3): 668-676, Sep 2013.
Ho JE, Chen WY, Chen MH, Larson MG, McCabe EL,Rader DJ, et al. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. J Clin Invest 123(10): 4208-4218, Oct 2013.
Brown WV, Rader DJ, Kane J : JCL Roundtable: Diagnosis of severe familial hypercholesterolemia. J Clin Lipidol 7(6): 540-545, Nov-Dec 2013.
Chen SJ, Sanmiguel J, Lock M, McMenamin D, Draper C, Limberis M, Kassim S, Somathanan S, Bell P, Johnston J, Rader DJ, Wilson JM: Biodistribution of AAV8 vectors expressing human LDL receptor in a mouse model of homozygous familial hypercholesterolemia. Hum Gene Ther Clin Dev Page: [Epub ahead of print] Nov 2013.
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Rader DJ, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 45(11): 1345-1352, Nov 2013.
Global Lipids Genetics Consortium, Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Rader DJ, et al. Discovery and refinement of loci associated with lipid levels. Nat Genet 45(11): 1274-1283, Nov 2013.
Holmes MV, Simon T, Exeter HJ, Folkersen L, Asselbergs FW, Rader DJ, et al. Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study. J Am Coll Cardiol 62(21): 1966-1976, Nov 2013.
Khera AV, Patel PJ, Reilly MP, Rader DJ : The Addition of Niacin to Statin Therapy Improves High-density Lipoprotein Cholesterol Levels but not Metrics of Functionality. J Am Coll Cardiol 62(20): 1909-1910, Nov 2013.
Patel PJ, Khera AV, Wilensky RL, Rader DJ: Anti-oxidative and cholesterol efflux capacities of high-density lipoprotein are reduced in ischaemic cardiomyopathy. Eur J Heart Fail 15(11): 1215-1219, Nov 2013.
Richardson K, Schoen M, French B, Umscheid CA, Mitchell MD, Arnold SE, Heidenreich PA, Rader DJ, Degoma EM: Statins and cognitive function: a systematic review. Ann Intern Med 159(10): 688-697, Nov 2013.
Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, Rader DJ, et al. Dysfunctional nitric oxide signaling increases risk of myocardial infarction. Nature 504(7480): 432-436, Dec 2013.
Hurt-Camejo E, Gautier T, Rosengren B, Dikkers A, Behrendt M, Grass DS, Rader DJ, Tietge UJ: Expression of Type IIA Secretory Phospholipase A2 Inhibits Cholesteryl Ester Transfer Protein Activity in Transgenic Mice. Arterioscler Thromb Vasc Biol 33(12): 2707-2014, Dec 2013.
Javaheri A, Rader DJ : High-Density Lipoprotein: NO Failure in Heart Failure. Circ Res 113(12): 1275-1277, Dec 2013.
Lagor WR, Johnston JC, Lock M, Vandenberghe LH, Rader DJ: Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism. Methods Mol Biol 1027: 237-307, 2013.
Stitziel NO, Fouchier SW, Sjouke B, Peloso GM, Moscoso AM, Rader DJ, et al. Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol 33(12): 2909-2914, Dec 2013.
Rader DJ: IL-1 and atherosclerosis: a murine twist to an evolving human story. J Clin Invest. 122(1): 27-30, Jan 2012.
Stylianou IM, Bauer RC, Reilly MP, Rader DJ. : Genetic basis of atherosclerosis: insights from mice and humans. Circ Res. 110(2): 337-355, Jan 2012.
Davies RW, Wells GA, Stewart A FR, Erdmann J, Shah SH, Rader DJ, et al. A Genome Wide Association Study for Coronary Artery Disease Identifies a Novel Susceptibility Locus in the Major Histocompatibility Complex. Circ Cardiovasc Genet. 5(2): 217-225, Feb 2012.
Clarke R, Bennett DA, Parish S, Verhoef P, Dötsch-Klerk M, Lathrop M, Xu P, Nordestgaard BG, Holm H, Hopewell JC, Saleheen D, Tanaka T, Anand SS, Chambers JC, Kleber ME, Ouwehand WH, Yamada Y, Elbers C, Peters B, Stewart AF, Reilly MM, Thorand B, Yusuf S, Engert JC, Assimes TL, Kooner J, Danesh J, Watkins H, Samani NJ, Collins R, Peto R; MTHFR Studies Collaborative Group. : Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Med. 9(2): e1001177, Feb 2012.
Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Rader Dj, EUROSPAN consortium, et al. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. PLoS Genet. 8(2): e1002490, Feb 2012.
Ferguson JF, Hinkle CC, Mehta NN, Bagheri R, Derohannessian SL, Shah R, Mucksavage MI, Bradfield JP, Hakonarson H, Wang X, Master SR, Rader DJ, Li M, Reilly MP. : Translational studies of lipoprotein-associated phospholipase A in inflammation and atherosclerosis. J Am Coll Cardiol 59(8): 764-772, Feb 2012.
Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ.: The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 7(2): e31616, Feb 2012.
Rader DJ, Parmacek MS. : Secreted miRNAs suppress atherogenesis. Nat Cell Biol. 14(3): 233-235, Feb 2012.
Lee AY, Yates NA, Ichetovkin M, Deyanova E, Southwick K, Fisher TS, Wang W, Loderstedt J, Walker N, Zhou H, Zhao X, Sparrow CP, Hubbard BK, Rader DJ, Sitlani A, Millar JS, Hendrickson RC. : Measurement of fractional synthetic rates of multiple protein analytes by triple quadrupole mass spectrometry. Clin Chem. 58(3): 619-627, Mar 2012.
Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Rader DJ, et al. IL6R Genetics Consortium Emerging Risk Factors Collaboration. Lancet 379(9822): 1205-1213, Mar 2012.
Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Rader DJ, et al. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet. 90(3): 410-425, Mar 2012.
Ai D, Baez JM, Jiang H, Conlon DM, Hernandez-Ono A, Frank-Kamenetsky M, Milstein S, Fitzgerald K, Murphy AJ, Woo CW, Strong A, Ginsberg HN, Tabas I, Rader DJ, Tall AR. : Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. J Clin Invest. 122(5): 1677-1687, Apr 2012.
Davies RW, Wells GA, Stewart AF, Erdmann J, Shah SH, Ferguson JF, Hall AS, Anand SS, Burnett MS, Epstein SE, Dandona S, Chen L, Nahrstaedt J, Loley C, König IR, Kraus WE, Granger CB, Engert JC, Hengstenberg C, Wichmann HE, Schreiber S, Tang WH, Ellis SG, Rader DJ, Hazen SL, Reilly MP, Samani NJ, Schunkert H, Roberts R, McPherson R. : A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet. 5(2): 217-225, Apr 2012.
Diffenderfer MR, Brousseau ME, Millar JS, Barrett PH, Nartsupha C, Schaefer PM, Wolfe ML, Dolnikowski GG, Rader DJ, Schaefer EJ.: Effects of CETP inhibition on triglyceride-rich lipoprotein composition and apoB-48 metabolism. J Lipid Res. Apr 2012.
Rosenson RS, Brewer HB Jr, Davidson WS, Fayad ZA, Fuster V, Goldstein J, Hellerstein M, Jiang XC, Phillips MC, Rader DJ, Remaley AT, Rothblat GH, Tall AR, Yvan-Charvet L.: Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation. 125(15): 1905-1919, Apr 2012.
Strong A, Rader DJ: Sortilin as a Regulator of Lipoprotein Metabolism. Curr Atheroscler Rep. Apr 2012.
Annema W, Dikkers A, Freark de Boer J, Gautier T, Rensen PC, Rader DJ, Tietge UJ. : apoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma. J Lipid Res. 53(5):929-40. , May 2012.
Ashley EA, Hershberger RE, Caleshu C, Ellinor PT, Garcia JG, Herrington DM, Ho CY, Johnson JA, Kittner SJ, Macrae CA, Mudd-Martin G, Rader DJ, Roden DM, Scholes D, Sellke FW, Towbin JA, Van Eyk J, Worrall BB; on behalf of the American Heart Association Advocacy Coordinating Committee. : Genetics and Cardiovascular Disease: A Policy Statement From the American Heart Association. Circulation. 3;126(1):142-157. , May 2012.
Degoma EM, Knowles JW, Angeli F, Budoff MJ, Rader DJ. : The evolution and refinement of traditional risk factors for cardiovascular disease. Cardiol Rev 20(3):118-29. , May 2012.
Musunuru K, Romaine SP, Lettre G, Wilson JG, Volcik KA, Tsai MY, Taylor HA Jr, Schreiner PJ, Rotter JI, Rich SS, Redline S, Psaty BM, Papanicolaou GJ, Ordovas JM, Liu K, Krauss RM, Glazer NL, Gabriel SB, Fornage M, Cupples LA, Buxbaum SG, Boerwinkle E, Ballantyne CM, Kathiresan S, Rader DJ.: Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project PLoS One. 7(5): e36473, May 2012.
Elbers CC, Guo Y, Tragante V, van Iperen EP, Lanktree MB, Rader DJ, et al. Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. PLoS One 7(12): e50198, Jul 2012 Notes: Epub.
Strong A, Ding Q, Edmondson AC, Millar JS, Sachs KV, Li X, Kumaravel A, Wang MY, Ai D, Guo L, Alexander ET, Nguyen D, Lund-Katz S, Phillips MC, Morales CR, Tall AR, Kathiresan S, Fisher EA, Musunuru K, Rader DJ. : Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest. Jul 2012.
Usman MH, Qamar A, Gadi R, Lilly S, Goel H, Hampson J, Mucksavage ML, Nathanson GA, Rader DJ, Dunbar RL. : Extended-Release Niacin Acutely Suppresses Postprandial Triglyceridemia. Am J Med. Jul 2012.
Foster GD, Shantz KL, Vander Veur SS, Oliver TL, Lent MR, Virus A, Szapary PO, Rader DJ, Zemel BS, Gilden-Tsai A. : A randomized trial of the effects of an almond-enriched, hypocaloric diet in the treatment of obesity. Am J Clin Nutr. 96 (2): 249-254, Aug 2012.
Jin SY, Tohyama J, Bauer RC, Cao NN, Rader DJ, Zheng XL : Genetic ablation of adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model. Arterioscler Thromb Vasc Biol. 32(8):1817-23. , Aug 2012.
Larach DB, Degoma EM, Rader DJ: Targeting high density lipoproteins in the prevention of cardiovascular disease? Curr Cardiol Rep 14(6): 684-691, Dec 2012.
Qamar A, Rader DJ. : Effect of interleukin 1β inhibition in cardiovascular disease. Curr Opin Lipidol 23(6): 548-53, Dec 2012.
Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French BC, Phillips JA, Mucksavage ML, Wilensky RL, Mohler ER, Rothblat GH, Rader DJ: Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. The New England journal of medicine 364(2): 127-135, Jan 2011.
Lagor WR, Rader DJ: Phospholipidation of HDL -- how much is too much? Clinical chemistry 57(1): 4-6, Jan 2011.
Millar JS, Ikewaki K, Bloedon LT, Wolfe ML, Szapary PO, Rader DJ: Effect of rosiglitazone on HDL metabolism in subjects with metabolic syndrome and low HDL. Journal of lipid research 52(1): 136-142, Jan 2011.
Qasim AN, Budharaju V, Mehta NN, St Clair C, Farouk S, Braunstein S, Schutta M, Iqbal N, Rader DJ, Reilly MP: Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes. Clinical endocrinology 74(1): 44-50, Jan 2011.
Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Rader DJ, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet 377(9763): 383-392, Jan 2011.
Alexander ET, Vedhachalam C, Sankaranarayanan S, de la Llera-Moya M, Rothblat GH, Rader DJ, Phillips MC: Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice. Arteriosclerosis, thrombosis, and vascular biology 31(2): 320-7, Feb 2011.
He J, Wang K, Edmondson AC, Rader DJ, Li C, Li M: Gene-based interaction analysis by incorporating external linkage disequilibrium information. European journal of human genetics : EJHG 19(2): 164-72, Feb 2011.
Martin SS, Qasim AN, Wolfe M, St Clair C, Schwartz S, Iqbal N, Schutta M, Bagheri R, Mehta NN, Rader DJ, Reilly MP: Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistance. The American journal of cardiology 107(3): 393-398, Feb 2011.
Mehta NN, Krishnamoorthy P, Martin SS, St Clair C, Schwartz S, Iqbal N, Braunstein S, Schutta M, Rader DJ, Reilly MP: Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus. The American journal of cardiology 107(3): 406-411, Feb 2011.
Watson CE, Weissbach N, Kjems L, Ayalasomayajula S, Zhang Y, Chang I, Navab M, Hama S, Hough G, Reddy ST, Soffer D, Rader DJ, Fogelman AM, Schecter A: Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function. Journal of lipid research 52(2): 361-73, Feb 2011.
Nijstad N, Gautier T, Briand F, Rader DJ, Tietge UJF: Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice. Gastroenterology 140(3): 1043-51, Mar 2011.
Trott WM, Castañeda JN, Torczynski JR, Gallis MA, Rader DJ: An experimental assembly for precise measurement of thermal accommodation coefficients. Rev Sci Instrum 82(3): 035120, Mar 2011.
Bauer RC, Stylianou IM, Rader DJ: Functional validation of new pathways in lipoprotein metabolism identified by human genetics. Current opinion in lipidology 22(2): 123-8, Apr 2011.
Edmondson AC, Braund PS, Stylianou IM, Khera AV, Nelson CP, Wolfe ML, Derohannessian SL, Keating BJ, Qu L, He J, Tobin MD, Tomaszewski M, Baumert J, Klopp N, Döring A, Thorand B, Li M, Reilly MP, Koenig W, Samani NJ, Rader DJ: Dense Genotyping of Candidate Gene Loci Identifies Variants Associated With High-Density Lipoprotein Cholesterol. Circulation 4(2): 145-155, Apr 2011.
Nijstad N, de Boer JF, Lagor WR, Toelle M, Usher D, Annema W, der Giet M van, Rader DJ, Tietge UJF: Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. Biochimica et biophysica acta 1811(4): 294-9, Apr 2011.
Rak K, Rader DJ: Cardiovascular disease: the diet-microbe morbid union. Nature 472(7341): 40-41, Apr 2011.
Toh S-A, Millar JS, Billheimer J, Fuki I, Naik SU, Macphee C, Walker M, Rader DJ: PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI. Biochemical pharmacology 81(7): 934-941, Apr 2011.
Degoma EM, Rader DJ: Novel HDL-directed pharmacotherapeutic strategies. Nature reviews. Cardiology 8(5): 266-277, May 2011.
Magge SN, Stettler N, Koren D, Levitt Katz LE, Gallagher PR, Mohler ER 3rd, Rader DJ.: Adiponectin Is Associated with Favorable Lipoprotein Profile, Independent of BMI and Insulin Resistance, in Adolescents. J Clin Endocrinol Metab 96(5): 1549-1554, May 2011.
Potteaux S, Gautier EL, Hutchison SB, van Rooijen N, Rader DJ, Thomas MJ, Sorci-Thomas MG, Randolph GJ: Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of apoE-/- mice during disease regression. The Journal of clinical investigation 121(5): 2025-2036, May 2011.
Wang K, Edmondson AC, Li M, Gao F, Qasim AN, Devaney JM, Burnett MS, Waterworth DM, Mooser V, Grant S FA, Epstein SE, Reilly MP, Hakonarson H, Rader DJ. : Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation. Front Genet. 10.3389/fgene.2011.00041 , May 2011.
Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J. : VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. PLoS One. Jul 2011.
Martin SS, Qasim AN, Rader DJ, Reilly MP. : C-Reactive Protein modifies the Association of Plasma Leptin With Coronary Calcium in Asymptomatic Overweight Individuals. Obesity Jul 2011.
He J, Li H, Edmondson AC, Rader DJ, Li M : A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies. Biostatistic Sep 2011.
Ricardo AC, Lash JP, Fischer MJ, Lora CM, Budoff M, Keane MG, Kusek JW, Martinez M, Nessel L, Stamos T, Ojo A, Rahman M, Soliman EZ, Yang W, Feldman HI, Go AS; CRIC and HCRIC Investigators. : Cardiovascular disease among Hispanics and non-Hispanics in the chronic renal insufficiency cohort (CRIC) study. Clin J Am Soc Nephrol. 6(9): 2121-2131, Sep 2011.
Kimball AB, Szapary P, Mrowietz U, Reich K, Langley RG, You Y, Hsu MC, Yeilding N, Rader DJ, Mehta NN. : Underdiagnosis and undertreatment of cardiovascular risk factors in patients with moderate to severe psoriasis. J Am Acad Dermatol. Oct 2011.
Khetarpal SA, Edmondson AC, Raghavan A, Neeli H, Jin W, Badellino KO, Demissie S, Manning AK, Derohannessian SL, Wolfe ML, Cupples LA, Li M, Kathiresan S, Rader DJ. : Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol. PLoS Genet 7(12): e1002393, Dec 2011.
Budoff MJ, Rader DJ, Reilly MP, Mohler ER 3rd, Lash J, Yang W, Rosen L, Glenn M, Teal V, Feldman HI; CRIC Study Investigators. : Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis. 58(4):519-26, 2011.
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Rader DJ, et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 43(11):1131-8, 2011.
IBC 50K CAD Consortium. : Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet. 7(9):e1002260, 2011.
International Consortium for Blood Pressure Genome-Wide Association Studies. : Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 478(7367):103-9, 2011.
Kanetsky PA, Mitra N, Vardhanabhuti S, Vaughn DJ, Li M, Ciosek SL, Letrero R, D'Andrea K, Vaddi M, Doody DR, Weaver J, Chen C, Starr JR, Håkonarson H, Rader DJ, Godwin AK, Reilly MP, Schwartz SM, Nathanson KL. : A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. Hum Mol Genet. 20(15):3109-17, 2011.
Kassim SH, Vandenberghe LH, Hovhannisyan R, Wilson JM, Rader DJ. : Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques. Physiol Genomics. 43(15):911-6, 2011.
Lecker JL, Matthan NR, Billheimer JT, Rader DJ, Lichtenstein AH. : Changes in cholesterol homeostasis modify the response of F1B hamsters to dietary very long chain n-3 and n-6 polyunsaturated fatty acids. Lipids Health Dis. 10:186, 2011.
Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Rader DJ, et al. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS genetics 7(2): e1001300, 2011.
O'Connell DP, LeBlanc DF, Cromley D, Billheimer J, Rader DJ, Bachovchin WW. : Design and synthesis of boronic acid inhibitors of endothelial lipase. Bioorg Med Chem Lett. 22(3): 1397-1401, Dec 2011.
Patel PJ, Khera AV, Jafri K, Wilensky RL, Rader DJ. : The anti-oxidative capacity of high-density lipoprotein is reduced in acute coronary syndrome but not in stable coronary artery disease. J Am Coll Cardiol 58(20):2068-75, 2011.
Ricketts SL, Rensing KL, Holly JM, Chen L, Young EH, Luben R, Ashford S, Song K, Yuan X, Dehghan A, Wright BJ, Waterworth DM, Mooser V; GEMS Investigators, Waeber G, Vollenweider P, Epstein SE, Burnett MS, Devaney JM, Hakonarson HH, Rader DJ, Reilly MP, Danesh J, Thompson SG, Dunning AM, van Duijn CM, Samani NJ, McPherson R, Wareham NJ, Khaw KT, Boekholdt SM, Sandhu MS. : Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease. Int J Mol Epidemiol Genet. 2(3):261-85, 2011.
Townsend RR, Anderson AH, Chen J, Gadebegku CA, Feldman HI, Fink JC, Go AS, Joffe M, Nessel LA, Ojo A, Rader DJ, Reilly MP, Teal V, Teff K, Wright JT, Xie D. : Metabolic syndrome, components, and cardiovascular disease prevalence in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Nephrol. 33(6):477-84, 2011.
Weibel GL, Hayes S, Wilson A, Phillips MC, Billheimer J, Rader DJ, Rothblat GH. : Novel in vivo method for measuring cholesterol mass flux in peripheral macrophages. Arterioscler Thromb Vasc Biol. 31(12):2865-71, 2011.
Wensley F, Gao P, Burgess S, Kaptoge S, Di Angelantonio E, Shah T, Engert JC, Clarke R, Davey-Smith G, Nordestgaard BG, Saleheen D, Samani NJ, Sandhu M, Anand S, Pepys MB, Smeeth L, Whittaker J, Casas JP, Thompson SG, Hingorani AD, Danesh J: Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BMJ (Clinical research ed.) 342: d548, 2011.
Wild PS, Zeller T, Schillert A, Szymczak S, Sinning CR, Rader DJ, et al. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ Cardiovasc Genet. 4(4):403-12, 2011.
Yamamoto S, Tanigawa H, Li X, Komaru Y, Billheimer JT, Rader DJ. : Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport. Circulation. 124(12):1382-90, 2011.
Brown WV, Brewer HB, Rader DJ, Schaefer EJ: HDL as a treatment target. Journal of clinical lipidology 4(1): 5-16, Jan-Feb 2010.
Halbert SC, French B, Gordon RY, Farrar JT, Schmitz K, Morris PB, Thompson PD, Rader DJ, Becker DJ: Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance. The American journal of cardiology 105(2): 198-204, Jan 2010.
Khera AV, Rader DJ: Future therapeutic directions in reverse cholesterol transport. Current atherosclerosis reports 12(1): 73-81, Jan 2010.
Yaffe K, Ackerson L, Kurella TM, Le Blanc P, Kusek JW, Sehgal AR, Cohen D, Anderson C, Appel L, Desalvo K, Ojo A, Seliger S, Robinson N, Makos G, Go AS: Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study. Journal of the American Geriatrics Society 58(2): 338-45, Feb 2010.
Burke MF, Khera AV, Rader DJ: Polyphenols and cholesterol efflux: is coffee the next red wine? Circulation research 106(4): 627-9, Mar 2010.
Cuchel M, Lund-Katz S, de la Llera-Moya M, Millar JS, Chang D, Fuki I, Rothblat GH, Phillips MC, Rader DJ: Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages. Arterioscler Thromb Vasc Biol 30(3): 526-532, Mar 2010.
Li M, Reilly MP, Rader DJ, Wang LS: Correcting population stratification in genetic association studies using a phylogenetic approach. Bioinformatics 26(6): 798-806, Mar 2010.
Yasuda T, Grillot D, Billheimer JT, Briand F, Delerive P, Huet S, Rader DJ: Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arteriosclerosis, thrombosis, and vascular biology 30(4): 781-6, Apr 2010.
de la Llera-Moya M, Drazul-Schrader D, Asztalos BF, Cuchel M, Rader DJ, Rothblat GH: The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arterioscler Thromb Vasc Biol 30(4): 796-801, Apr 2010.
Nadeem S, Manjinder S, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt S, Matthijs OW, Watkins H, Samani NJ, Saleheen D, Lawlor D, Reilly MP, Hingorani AD, Talmud PJ, Danesh J: Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 375(9726): 1634-1639, May 2010.
Shah A, Rader DJ, Millar JS: The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans. Atherosclerosis 210(1): 35-40, May 2010.
Glessner JT, Reilly MP, Kim CE, Takahashi N, Albano A, Hou C, Bradfield JP, Zhang H, Sleiman PMA, Flory JH, Imielinski M, Frackelton EC, Chiavacci R, Thomas KA, Garris M, Otieno FG, Davidson M, Weiser M, Reichenberg A, Davis KL, Friedman JI, Cappola TP, Margulies KB, Rader DJ, Grant SFA, Buxbaum JD, Gur RE, Hakonarson H: Strong synaptic transmission impact by copy number variations in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 107(23): 10584-9, Jun 2010.
Musunuru K, Lettre G, Young T, Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q, Chen M-H, Lapchyk N, Crenshaw A, Ziaugra L, Rachupka A, Benjamin EJ, Cupples LA, Fornage M, Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh C, Nizzari MM, Paltoo DN, Papanicolaou GJ, Patel SR, Psaty BM, Rader DJ, Redline S, Rich SS, Rotter JI, Taylor HA, Tracy RP, Vasan RS, Wilson JG, Kathiresan S, Fabsitz RR, Boerwinkle E, Gabriel SB : Candidate gene association resource (CARe): design, methods, and proof of concept. Circulation. Cardiovascular genetics 3(3): 267-275, Jun 2010.
Burke MF, Dunbar RL, Rader DJ: Could exercise metabolomics pave the way for gymnomimetics? Science translational medicine 2(41): 41ps35, Jul 2010.
Nijjar PS, Burke FM, Bloesch A, Rader DJ: Role of dietary supplements in lowering low-density lipoprotein cholesterol: a review. J Clin Lipidol 4(4): 248-258, Jul-Aug 2010.
Brown RJ, Lagor WR, Sankaranarayanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ: Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circulation research 107(3): 357-64, Aug 2010.
Foster GD, Wyatt HR, Hill JO, Makris AP, Rosenbaum DL, Brill C, Stein RI, Mohammed BS, Miller B, Rader DJ, Zemel B, Wadden TA, Tenhave T, Newcomb CW, Klein S: Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Annals of internal medicine 153(3): 147-57, Aug 2010.
Khera AV, Wolfe ML, Cannon CP, Qin J, Rader DJ: On-statin cholesteryl ester transfer protein mass and risk of recurrent coronary events (from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 [PROVE IT-TIMI 22] study). The American journal of cardiology 106(4): 451-6, Aug 2010.
Millar JS, Ky B, Wolfe ML, Pruscino L, Baer A, Rader DJ: Short-term treatment with high-dose atorvastatin reduces LDL cholesterol but shows no anti-inflammatory effects in normolipidemic subjects with normal CRP levels. Clinical and translational science 3(4): 140-6, Aug 2010.
Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ: From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466(7307): 714-9, Aug 2010.
Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS: Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. The Journal of clinical investigation 120(8): 2889-99, Aug 2010.
Liu J, Afroza H, Rader DJ, Jin W: Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases. The Journal of biological chemistry 285(36): 27561-70, Sep 2010.
Lecker JL, Matthan NR, Billheimer JT, Rader DJ, Lichtenstein AH: Impact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster. Metabolism: clinical and experimental 59(10): 1491-501, Oct 2010.
Preuss M, König IR, Thompson JR, Erdmann J, Absher D, Assimes TL, Blankenberg S, Boerwinkle E, Chen L, Cupples LA, Hall AS, Halperin E, Hengstenberg C, Holm H, Laaksonen R, Li M, März W, McPherson R, Musunuru K, Nelson CP, Burnett MS, Epstein SE, O'Donnell CJ, Quertermous T, Rader DJ, Roberts R, Schillert A, Stefansson K, Stewart AFR, Thorleifsson G, Voight BF, Wells GA, Ziegler A, Kathiresan S, Reilly MP, Samani NJ, Schunkert H : Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circulation. Cardiovascular genetics 3(5): 475-83, Oct 2010.
Tong F, Billheimer J, Shechtman CF, Liu Y, Crooke R, Graham M, Cohen DE, Sturley SL, Rader DJ: Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. The Journal of biological chemistry 285(44): 33632-41, Oct 2010.
Li X, Millar JS, Brownell N, Briand F, Rader DJ: Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes. Biochemical pharmacology 80(9): 1450-7, Nov 2010.
Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Rader DJ, et al. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arteriosclerosis, thrombosis, and vascular biology 30(11): 2264-2276, Nov 2010.
Yasuda T, Ishida T, Rader DJ: Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis. Circulation journal : official journal of the Japanese Circulation Society 74(11): 2263-70, Nov 2010.
Burkhardt R, Toh S-A, Lagor WR, Birkeland A, Levin M, Li X, Robblee M, Fedorov VD, Yamamoto M, Satoh T, Akira S, Kathiresan S, Breslow JL, Rader DJ: Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. The Journal of clinical investigation 120(12): 4410-4, Dec 2010.
Kassim SH, Li H, Vandenberghe LH, Hinderer C, Bell P, Marchadier D, Wilson A, Cromley D, Redon V, Yu H, Wilson JM, Rader DJ: Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis. PloS one 5(10): e13424, 2010.
Shen H, Bielak LF, Ferguson JF, Streeten EA, Yerges-Armstrong LM, Liu J, Post W, O'Connell JR, Hixson JE, Kardia SLR, Sun YV, Jhun MA, Wang X, Mehta NN, Li M, Koller DL, Hakonarson H, Keating BJ, Rader DJ, Shuldiner AR, Peyser PA, Reilly MP, Mitchell BD: Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. Arteriosclerosis, thrombosis, and vascular biology 30(12): 2648-54, Dec 2010.
Gordon RY, Becker DJ, Rader DJ: Reduced efficacy of rosuvastatin by St. John's Wort. The American journal of medicine 122(2): e1-2, Feb 2009.
Neeli H, Gadi R, Rader DJ: Managing diabetic dyslipidemia: beyond statin therapy. Current diabetes reports 9(1): 11-7, Feb 2009.
Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P,Rader DJ, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 41(3): 342-347, Mar 2009.
Briand F, Naik SU, Fuki I, Millar JS, Macphee C, Walker M, Billheimer J, Rothblat G, Rader DJ: Both the peroxisome proliferator-activated receptor delta agonist, GW0742, and ezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterol. Clin Transl Sci 2(127): 127-33, Apr 2009.
Edmondson AC, Brown RJ, Kathiresan S, Cupples LA, Demissie S, Manning AK, Jensen MK, Rimm EB, Wang J, Rodrigues A, Bamba V, Khetarpal SA, Wolfe ML, Derohannessian S, Li M, Reilly MP, Aberle J, Evans D, Hegele RA, Rader DJ: Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. J Clin Invest 119(4): 1042-1050, Apr 2009.
Rader DJ, Alexander ET, Weibel GL, Billheimer J, Rothblat GH: The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis. Journal of lipid research 50 Suppl: S189-94, Apr 2009.
An G, Miwa T, Song WL, Lawson JA, Rader DJ, Zhang Y, Song WC: CD59 but not DAF deficiency accelerates atherosclerosis in female apoE knockout mice. Mol Immunol 46(8-9): 1702-1709, May 2009.
Brown RJ, Edmondson AC, Griffon N, Hill TB, Fuki IV, Badellino KO, Li M, Wolfe ML, Reilly MP, Rader DJ: A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis. Journal of lipid research May 2009.
Qasim Atif N, Metkus Thomas S, Tadesse Mahlet, Lehrke Michael, Restine Stephanie, Wolfe Megan L, Hannenhalli Sridhar, Cappola Thomas, Rader Daniel J, Reilly Muredach P: Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians. Clinical endocrinology 70(5): 698-705, May 2009.
Becker David J, Gordon Ram Y, Halbert Steven C, French Benjamin, Morris Patti B, Rader Daniel J: Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Annals of internal medicine 150(12): 830-9, W147-9, Jun 2009.
Griffon N, Jin W, Petty TJ, Millar J, Badellino KO, Saven JG, Marchadier DH, Kempner ES, Billheimer J, Glick JM, Rader DJ: Identification of the Active Form of Endothelial Lipase: A Homodimer in a Head-to-tail Conformation. The Journal of biological chemistry Jun 2009.
Tohyama Junichiro, Billheimer Jeffrey T, Fuki Ilia V, Rothblat George H, Rader Daniel J, Millar John S: Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice. Atherosclerosis 204(2): 418-23, Jun 2009.
Alexander Eric T, Tanaka Masafumi, Kono Momoe, Saito Hiroyuki, Rader Daniel J, Phillips Michael C: Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I. Journal of lipid research 50(7): 1409-19, Jul 2009.
Brousseau Margaret E, Millar John S, Diffenderfer Margaret R, Nartsupha Chorthip, Asztalos Bela F, Wolfe Megan L, Mancuso James P, Digenio Andres G, Rader Daniel J, Schaefer Ernst J: Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism. Journal of lipid research 50(7): 1456-62, Jul 2009.
Duffy Danielle, Rader Daniel J: Update on strategies to increase HDL quantity and function. Nature reviews. Cardiology 6(7): 455-63, Jul 2009.
Heffron SP, Parastatidis I, Cuchel M, Wolfe ML, Tadesse MG, Mohler ER, Ischiropoulos H, Rader DJ, Reilly MP: Inflammation induces fibrinogen nitration in experimental human endotoxemia. Free radical biology & medicine Jul 2009.
Jensen Majken K, Rimm Eric B, Mukamal Kenneth J, Edmondson Andrew C, Rader Daniel J, Vogel Ulla, Tjønneland Anne, Sørensen Thorkild I A, Schmidt Erik B, Overvad Kim: The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. European heart journal 30(13): 1584-9, Jul 2009.
Kanetsky Peter A, Mitra Nandita, Vardhanabhuti Saran, Li Mingyao, Vaughn David J, Letrero Richard, Ciosek Stephanie L, Doody David R, Smith Lauren M, Weaver Joellen, Albano Anthony, Chen Chu, Starr Jacqueline R, Rader Daniel J, Godwin Andrew K, Reilly Muredach P, Hakonarson Hakon, Schwartz Stephen M, Nathanson Katherine L: Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nature genetics 41(7): 811-5, Jul 2009.
Nishimoto T, Pellizzon MA, Aihara M, Stylianou IM, Billheimer JT, Rothblat G, Rader DJ: Fish Oil Promotes Macrophage Reverse Cholesterol Transport in Mice. Arteriosclerosis, thrombosis, and vascular biology Jul 2009.
Tanigawa Hiroyuki, Billheimer Jeffrey T, Tohyama Jun-ichiro, Fuki Ilia V, Ng Dominic S, Rothblat George H, Rader Daniel J: Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo. Circulation 120(2): 160-9, Jul 2009.
Khera AV, Rader DJ: Discovery and validation of new molecular targets in treating dyslipidemia: the role of human genetics. Trends in cardiovascular medicine 19(6): 195-201, Aug 2009.
Rader DJ: Lecithin: cholesterol acyltransferase and atherosclerosis: another high-density lipoprotein story that doesn't quite follow the script. Circulation 120(7): 549-52, Aug 2009.
Stylianou IM, Svenson KL, VanOrman SK, Langle Y, Millar JS, Paigen B, Rader DJ: Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein. PLoS One 4(8): e6521, Aug 2009.
Alexander ET, Weibel GL, Joshi MR, Vedhachalam C, de la Llera-Moya M, Rothblat GH, Phillips MC, Rader DJ: Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano. Arteriosclerosis, thrombosis, and vascular biology 29(10): 1496-501, Oct 2009.
Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Rader DJ, GIANT Consortium, et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 5(12): e1000768, Dec 2009.
Ali K, Lund-Katz S, Lawson J, Phillips MC, Rader DJ: Structure-function properties of the apoE-dependent COX-2 pathway in vascular smooth muscle cells. Atherosclerosis 196: 201-209, 2008.
Badellino KO, Wolfe ML, Reilly MP, Rader DJ: Endothelial lipase is increased in vivo by inflammation in humans. Circulation 117: 678-685, 2008.
Bloedon LT, Balikai S, Chittams J, Cunnane SC, Berlin JA, Rader DJ, Szapary PO: Flaxseed and cardiovascular risk factors: Results from a double blind, randomized, controlled clinical trial. J Amer Coll Nutr 27: 65-74, 2008.
Glassberg H and Rader DJ: Management of lipids in the prevention of cardiovascular events [Review] Ann Rev Med 59: 79-94, 2008.
Helgadottir A, Thorleifsson G, Magnusson KP, Gretarsdottir S, Steinthorsdottir V, Rader DJ, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nature Genetics 40: 217-224, 2008.
Hunter DJ, Altshuler D, Rader DJ: From Darwin's finches to canaries in the coal mine -- mining the genome for new biology. New Engl J Med 358: 2760-2763, 2008.
Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ: The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol 51: 1653-1662, 2008.
Liu Y, Millar JS, Cromley DA, Graham M, Crooke R, Billheimer JT, Rader DJ: Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and apoB secretion in mice. Biochimica et Biophysica Acta 1781: 97-104, 2008.
Marais AD, Raal FJ, Stein EA, Rader DJ, Blasetto J, Palmer M, Wilpshaar W: A dose-titration and comparative study of rosuvastatin and atorvastatin in patients with homozygous familial hypercholesterolaemia. Atherosclerosis 197: 400-406, 2008.
Millar JS, Brousseau ME, Diffenderfer MR, Barrett P, Pugh HR, Welty FK, Cohn JS, Wilson A, Wolfe ML, Nartsupha C, Schaefer PM, DiGenio AG, Mancuso JP, Dolnikowski GG, Schaefer EJ, Rader DJ: Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism. J Lipid Res 49: 543-549, 2008.
Rosas S, Joffe M, Wolfe M, Brayman K, Rader DJ: Effects of renal replacement therapy on plasma lipoprotein(a) levels. Am J Nephrol 28: 361-365, 2008.
Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, Pure E, FitzGerald GA: Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation 117: 1302-1309, 2008.
Zhao L, Lee E, Zukas AM, Middleton MK, Kinder M, Acharya PS, Hall JA, Rader DJ, Pure E: CD44 expressed on both bone marrow-derived and non-bone marrow-derived cells promotes atherogenesis in apoE-deficient mice. Arterioscl Thromb Vasc Biol 28: 1283-1289, 2008.
Adorni MP, Zimetti F, Billheimer JT, Wang N, Rader DJ, Phillips MC, Rothblat GH: The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res 48: 2453-2462, 2007.
Brown RJ, Miller GC, Griffon N, Long CJ, Rader DJ: Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo. J Lipid Res 48: 1132-1139, 2007.
Cuchel M and Rader DJ: Is the cholesteryl ester transfer protein proatherogenic or antiatherogenic in humans? J Am Coll Cardiol 50: 1956-1958, 2007.
Cuchel M, Bloedon LT, Szapary PO, Kolansky DM, Wolfe ML, Sarkis A, Millar JS, Ikewaki K, Siegelman ES, Gregg RE, Rader DJ: Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. New Engl J Med 356: 148-156, 2007.
Friedewald VE Jr, Brewer HB Jr, Grundy SM, Rader DJ, Roberts WC: The editor's roundtable: High-density lipoprotein cholesterol. Amer J Cardiol 99: 1698-1705, 2007.
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, Backman VM, Matthiasdottir S, Jonsdottir T, Palsson S, Einarsdottir H, Gunnarsdottir S, Gylfason A, Vaccarino V, Hooper WC, Reilly MP, Granger CB, Austin H, Rader DJ, Shah SH, Quyyumi AA, Gulcher JR, Thorgeirsson G, Thorsteinsdottir U, Kong A, Stefansson K: A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316: 1491-1493, 2007.
Helgason A, Palsson S, Thorleifsson G, Grant SF, Emilsson V, Gunnarsdottir S, Adeyemo A, Chen Y, Chen G, Reynisdottir I, Benediktsson R, Hinney A, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Schafer H, Faruque M, Doumatey A, Zhou J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Sigurdsson G, Hebebrand J, Pedersen O, Thorsteinsdottir U, Gulcher JR, Kong A, Rotimi C, Stefansson K: Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nature Genetics 39: 218-225, 2007.
Jin W, Wang X, Millar JS, Quertermous T, Rothblat, GH, Glick JM, Rader DJ: Hepatic proprotein convertases modulate HDL metabolism. Cell Metabol 6: 129-136, 2007.
Lebherz C, Sanmiguel J, Wilson JM, Rader DJ: Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent. Cardiovasc Diabetol 6: 15, 2007.
Lehrke M, Millington SC, Lefterova M, Cumaranatunge RG, Szapary P, Wilensky R, Rader DJ, Lazar MA, Reilly MP: CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. J Am Coll Cardiol 49: 442-449, 2007.
Pellizzon MA, Billheimer JT, Bloedon LT, Szapary PO, Rader DJ: Flaxseed reduces plasma cholesterol levels in hypercholesterolemic mouse models. J Am Coll Nutr 26: 66-75, 2007.
Rader DJ: Illuminating HDL -- is it still a viable therapeutic target? New Engl J Med 357: 2180-2183, 2007.
Rader DJ, Ischiropoulos H: Multipurpose oxidase' in atherogenesis. Nature Medicine 13: 1146-1147, 2007.
Reilly MP, Rohatgi A, McMahon K, Wolfe ML, Pinto SC, Rhodes T, Girman C, Rader DJ: Plasma cytokines, metabolic syndrome and atherosclerosis in humans. J Invest Med 55: 26-35, 2007.
Skropeta D, Settasatian C, McMahon MR, Shearston K, Caiazza D, McGrath KR, Jin W, Rader DJ, Barter PJ, Rye K-A: N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins. J Lipid Res 48: 2047-2057, 2007.
Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Rader Dj, et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nature Genetics 39: 770-775, 2007.
Tanigawa H, Billheimer JT, Tohyama J, Zhang YZ, Rothblat G, Rader DJ: Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport. Circulation 116: 1267-1273, 2007.
Wang X, Collins HL, Ranalletta M, Fuki IV, Billheimer JT, Rothblat GH, Tall AR, Rader DJ: Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 117: 2216-2224, 2007.
Wang X, Jin W, Rader DJ: Upregulation of macrophage endothelial lipase by toll-like receptors 4 and 3 modulates macrophage interleukin-10 and -12 production. Circulation Res 100: 1008-1015, 2007.
Weibel GL, Alexander ET, Joshi MR, Rader DJ, Lund-Katz S, Phillips MC, Rothblat GH: Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux. Arterioscl Thromb Vasc Biol 27: 2022-2029, 2007.
Zhao L, Hall JA, Levenkova N, Lee E, Middleton MK, Zukas AM, Rader DJ, Rux JJ, Pure E: CD44 regulates vascular gene expression in a proatherogenic environment. Arterioscl Thromb Vasc Biol 27: 886-892, 2007.
Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky J: High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: A candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circulation Res 98: 490-498, 2006.
Badellino KO, Wolfe ML, Reilly MP, Rader DJ: Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Medicine/Public Library of Science 3: e22, 2006.
Broedl UC, Jin W, Fuki IV, Millar JS, Rader DJ: Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II. J Lipid Res 47: 2191-2197, 2006.
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nature Genetics 38: 320-323, 2006.
Griffon N, Budreck EC, Long CJ, Broedl UC, Marchadier DH, Glick JM, Rader DJ: Substrate specificity of lipoprotein lipase and endothelial lipase: Studies of lipid chimeras. J Lipid Res 47: 1803-1811, 2006.
Helgadottir A, Manolescu A, Helgason A, Thorleifsson G, Thorsteinsdottir U, Gudbjartsson DF, Gretarsdottir S, Magnusson KP, Gudmundsson G, Hicks A, Jonsson T, Grant SF, Sainz J., O'Brien SJ, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Levey AI, Abramson JL, Reilly MP, Vaccarino V, Wolfe ML, Gudnason V, Quyyumi AA, Topol EJ, Rader DJ, Thorgeirsson G, Gulcher JR, Hakonarson H, Kong A, Stefansson K: A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nature Genet 38: 68-74, 2006.
Kitajima K, Marchadier DH, Burstein H, Rader DJ: Persistent liver expression of murine apoA-l using vectors based on adeno-associated viral vectors serotypes 5 and 1. Atherosclerosis 186: 65-73, 2006.
Kitajima K, Marchadier DH, Miller GC, Gao GP, Wilson JM, Rader DJ: Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8. Arterio Thromb Vasc Biol 26: 1852-1857, 2006.
Majdalawieh A, Zhang L, Fuki IV, Rader DJ, Ro HS: Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation. Proc Natl Acad Sci USA 103: 2346-2351, 2006.
Millar JS, Brousseau ME, Diffenderfer MR, Barrett PH, Welty FK, Faruqi A, Wolfe ML, Nartsupha C, Digenio AG, Mancuso JP, Dolnikowski GG, Schaefer EJ, Rader DJ: Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans. Arterioscl Thromb Vasc Biol 26: 1350-1356, 2006.
Millar JS, Stone SJ, Tietge UJ, Tow B, Billheimer JT, Wong JS, Hamilton RL, Farese RV Jr, Rader DJ: Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production. J Lipid Res 47: 2297-2305, 2006.
Naik SU, Wang X, Da Silva JS, Jaye M, Macphee CH, Reilly MP, Billheimer JT, Rothblat GH, Rader DJ: Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo [see Comment] Circulation 113: 90-97, 2006.
Paradis ME, Badellino KO, Rader DJ, Deshaies Y, Couture P, Archer WR, Bergeron N, Lamarche B: Endothelial lipase is associated with inflammation in humans. J Lipid Res 47: 2808-2813, 2006.
Paradis ME, Badellino KO, Rader DJ, Tchernof A, Richard C, Luu-The V, Deshaies Y, Bergeron J, Archer WR, Couture P, Bergeron N, Lamarche B: Visceral adiposity and endothelial lipase. J Clin Endocr Metabol 91: 3538-3543, 2006.
Reilly M and Rader DJ: Apolipoprotein E and coronary disease: A puzzling paradox [Comment] PLoS Medicine/Public Library of Science 3: e258, 2006.
Samaha FF, Szapary PO, Iqbal N, Williams MM, Bloedon LT, Kochar A, Wolfe ML, Rader DJ: Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome. Arterio Thromb Vasc Biol 26: 624-630, 2006.
Seetharam D, Mineo C, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW: High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circulation Res 98: 63-72, 2006.
Szapary PO, Bloedon LT, Samaha FF, Duffy D, Wolfe ML, Soffer D, Reilly MP, Chittams J, Rader DJ: Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome. Arterio Thromb Vasc Biol 26: 182-188, 2006.
Ali K, Middleton M, Pure E, Rader DJ: Apolipoprotein E suppresses the type I inflammatory response in vivo. Circulation Res 97: 922-927, 2005.
Broedl UC, Jin W, Marchadier D, Secreto A, Rader DJ: Tissue-specific expression pattern of human endothelial lipase in transgenic mice. Atherosclerosis 181: 271-274, 2005.
Brousseau ME, Diffenderfer MR, Millar JS, Nartsupha C, Asztalos BF, Welty FK, Wolfe ML, Rudling M, Bjorkhem I, Angelin B, Mancuso JP, Digenio AG, Rader DJ, Schaefer EJ: Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion. Arterio Thromb Vasc Biol 25: 1057-1064, 2005.
Cain WJ, Millar JS, Himebauch AS, Tietge UJ, Maugeais C, Usher D, Rader DJ: Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a] J Lipid Res 46: 2681-2691, 2005.
Foulkes AS, Reilly M, Zhou L, Wolfe M, Rader DJ: Mixed modelling to characterize genotype-phenotype associations. Statistics in Medicine 24: 775-789, 2005.
Jahangiri A, Rader DJ, Marchadier D, Curtiss LK, Bonnet DJ, Rye KA: Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I. J Lipid Res 46: 896-903, 2005.
Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ: Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase [Erratum appears in J Biol Chem. 2005 Dec 9; 280(49): 41124] J Biol Chem 280: 36551-36559, 2005.
Kratky D, Zimmermann R, Wagner EM, Strauss JG, Jin W, Kostner GM, Haemmerle G, Rader DJ, Zechner R: Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue. J Clin Invest 115: 161-167, 2005.
Ky B and Rader DJ: The effects of statin therapy on plasma markers of inflammation in patients without vascular disease. Clin Cardiol 38: 67-70, 2005.
Lehrke M, Lebherz C, Millington SC, Guan HP, Millar J, Rader DJ, Wilson JM, Lazar MA: Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXR alpha. Cell Metab 1: 297-308, 2005.
Li Z, Qiao H, Lebherz C, Choi SR, Zhou X, Gao G, Kung HF, Rader DJ., Wilson JM, Glickson JD, Zhou R: Creatine kinase, a magnetic resonance-detectable marker gene for quantification of liver-directed gene transfer. Human Gene Therapy 16: 1429-1438, 2005.
Madaio MP, Ahima RS, Meade R, Rader DJ, Mendoza A, Peng M, Tomaszewski JE, Hancock WW, Gasser DL: Glomerular and tubular epithelial defects in kd/kd mice lead to progressive renal failure. Am J Nephrol 25: 604-610, 2005.
Millar JS, Cromley DA, McCoy MG, Rader DJ, Billheimer JT: Determining hepatic triglyceride production in mice: Comparison of poloxamer 407 with Triton WR-1339. J Lipid Res 46: 2023-2028, 2005.
Millar JS, Maugeais C, Ikewaki K, Kolansky DM, Barrett PH, Budreck EC, Boston RC, Tada N, Mochizuki S, Defesche JC, Wilson JM, Rader DJ: Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production. Arterioscl Thromb Vasc Biol 25: 560-565, 2005.
Moore RE, Navab M, Millar JS, Zimetti F, Hama S, Rothblat GH, Rader DJ: Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation. Circulation Res 97: 763-771, 2005.
Rader DJ: Gene therapy for genetic lipid disorders: Lipoprotein lipase deficiency as a paradigm. Netherlands J Med 63: 2-3, 2005.
Rader DJ: Gain-of-function mutations and therapeutic implications: Lipoprotein lipase S447X to the rescue. Arterio Thromb Vasc Biol 25: 2018-2019, 2005.
Reilly MP, Foulkes AS, Wolfe ML, Rader DJ: Higher order lipase gene association with plasma triglycerides. J Lipid Res 46: 1914-1922, 2005.
Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ: Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111: 932-939, 2005.
Rosas SE, Mensah K, Weinstein RB, Bellamy SL, Rader DJ: Coronary artery calcification in renal transplant recipients. Amer J Transplant 5: 1942-1947, 2005.
Sachais BS, Katz J, Ross J, Rader DJ: Long-term effects of LDL apheresis in patients with severe hypercholesterolemia. J Clin Apheresis 20: 252-255, 2005.
Sovic A, Panzenboeck U, Wintersperger A, Kratzer I, Hammer A, Levak-Frank S, Frank S, Rader DJ, Malle E, Sattler W: Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood-brain barrier. J Neurochem 94: 109-119, 2005.
Zhang Y, Da Silva JR, Reilly M, Billheimer JT, Rothblat GH, Rader DJ: Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest 115: 2870-2874, 2005.
Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chretien M, Prat A, Seidah NG: NARC-1/PCSK9 and its natural mutants: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem 279: 48865-48867, 2004.
Broedl UC, Jin W, Fuki IV, Glick JM, Rader DJ: Structural basis of endothelial lipase tropism for HDL. FASEB J 18: 1891-1893, 2004.
Broedl UC, Maugeais C, Millar JS, Jin W, Moore RE, Fuki IV, Marchadier D, Glick JM, Rader DJ: Endothelial lipase promotes the catabolism of apoB-containing lipoproteins. Circulation Res 94: 1554-1561, 2004.
Brousseau ME, Schaefer EJ, Wolfe ML, Bloedon LT, Digenio AG, Clark RW, Mancuso JP, Rader DJ: Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med 350: 1505-1515, 2004.
Caiazza D, Jahangiri A, Rader DJ, Marchadier D, Rye KA: Apolipoproteins regulate the kinetics of endothelial lipase-mediated hydrolysis of phospholipids in reconstituted high-density lipoproteins. Biochemistry 43: 11898-11905, 2004.
Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R, Joyal SV, Hill KA, Pfeffer MA, Skene AM: Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 350: 1495-1504, 2004.
Duong M, Psaltis M, Rader DJ, Marchadier D, Barter PJ, Rye KA: Evidence that hepatic lipase and endothelial lipase have different substrate specificities for high-density lipoprotein phospholipids. Biochemistry 42: 13778-13785, 2004.
Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, FitzGerald GA: COX-2-derived prostacyclin confers atheroprotection on female mice. Science Page: 1954-1957, 2004.
Ikewaki K, Cain W, Thomas F, Shamburek R, Zech LA, Usher D, Brewer HB Jr, Rader DJ: Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE-deficiency. J Lipid Res 45: 1302-1311, 2004.
Kothapalli, D, Fuki, I, Ali K, Stewart SA, Zhao, L, Yahil R, Kwiatkowski D, Hawthorne EA, FitzGerald GA, Phillips MC, Lund-Katz S, Pure E, Rader DJ, Assoian RK: Antimitogenic effects of HDL and apoE-mediated by Cox-2-dependent IP activation. J Clin Invest 113: 609-618, 2004.
Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, Lazar MA: An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med 1: e45, 2004.
Miller GC, Long CJ, Bojilova ED, Marchadier D, Badellino KO, Blanchard N, Fuki IV, Glick JM, Rader DJ: Role of N-linked glycosylation in the secretion and activity of endothelial lipase. J Lipid Res 45: 2080-2087, 2004.
Reilly MP, Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, Rader DJ, Kimmel SE: Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab 89: 3872-3878, 2004.
Reilly MP, Wolfe ML, Dykhouse J, Reddy K, Localio AR, Rader DJ: Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels. J Invest Med 52: 515-522, 2004.
Reilly MP, Wolfe ML, Localio AR, Rader DJ: Coronary artery calcification and cardiovascular risk factors: Impact of the analytic approach. Atherosclerosis 173: 69-78, 2004.
Reilly MP, Wolfe ML, Rhodes T, Girman C, Mehta N, Rader DJ: Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis. Circulation 110: 803-809, 2004.
Seshadri P, Iqbal N, Stern L, Williams M, Chicano KL, Daily DA, McGrory J, Gracely EJ, Rader DJ, Samaha FF: A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity. Am J Med 117: 398-405, 2004.
Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ: Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 89: 2963-2972, 2004.
Wolfe ML and Rader DJ: Cholesteryl ester transfer protein and coronary artery disease: An observation with therapeutic implications. Circulation 110: 1338-1340, 2004.
Yancey PG, Kawashiri MA, Moore R, Glick JM, Williams DL, Connelly MA, Rader DJ, Rothblat GH: In vivo modulation of HDL phospholipids has opposing effects on SR-BI and ABCA1-mediated cholesterol efflux. J Lipid Res 45: 337-346, 2004.
Zhao L, Moos MPW, Gräbner R, Pédrono F, Fan J, Kaiser B, John N, Schmidt S, Spanbroek R, Loetzer K, Huang L, Cui J, Rader DJ, Evans JF, Habenicht AJR, Funk CD: The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nature Medicine 10: 966-973, 2004.
Broedl UC, Maugeais C, Marchadier D, Glick JM, Rader DJ: Effects of nonlipolytic ligand function of endothelial lipase on high-density lipoprotein metabolism in vivo. J Biol Chem 278: 40688-40693, 2003.
Foster GD, Wyatt HR, Hill J, McGuckin BG, Brill C, Mohammed BS, Szapary P, Rader DJ, Edman JS, Klein S: A multicenter, randomized, controlled trial of a low-carbohydrate diet for obesity. N Engl J Med 348: 2082-2092, 2003.
Fuki IV, Blanchard N, Jin W, Marchadier D, Millar JS, Glick JM, Rader DR: Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via HSPG-mediated pathway. J Biol Chem 278: 34331-34338, 2003.
Jin W, Gwo-Shing S, Marchadier D, Octtavani E, Glick JM, Rader DJ: Endothelial cells secrete triglyceride lipase and phospholipase activities due to endothelial lipase in response to inflammatory cytokines. Circ Res 92: 644-650, 2003.
Jin W, Millar JS, Broedl U, Glick JM, Rader DJ: Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo. J Clin Invest 111: 357-362, 2003.
Kothapalli D, Stewart SA, Smyth EM, Azonobi I, Rader DJ, Puré E, Assoian RK: Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin A gene expression. Mol Pharmacol 64: 1-10, 2003.
Maugeais C, Tietge UJ, Broedl UC, Marchadier D, Cain W, McCoy MG, Lund-Katz S, Glick JM, Rader DJ: Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase. Circulation 108: 2121-2126, 2003.
Moore RE, Kawashiri MA, Kitajima K, Secreto A, Millar JS, Pratico D, Rader DJ: Apolipoprotein A-I deficiency results in markedly increased atherosclerosis in mice lacking the LDL receptor. Arterio Thromb Vasc Biol 23: 1914-1920, 2003.
Rader DJ, Davidson M, Caplan R, Pears J: Lipid and apolipoprotein in ratios: Association with coronary artery disease and effects of rosuvastatin compared with atorvastatin, pravastatin, and simvastatin. Am J Cardiol 91(5A): 20C-23C; Discussion 23C-24C, 2003.
Rashid S, Trinh DK, Uffelman KD, Cohn JS, Rader DJ, Lewis GF: Expression of human hepatic lipase in the rabbit model preferentially enhances the clearance of triglyceride-enriched versus native HDL apolipoprotein A-I. Circulation 107: 3066-3072, 2003.
Reilly MP, Wolfe ML, Localico AR, Rader DJ: C-reactive protein and coronary artery calcification: The study of inherited risk of coronary atherosclerosis (SIRCA). Arterio Thromb Vasc Biol 23: 1851-1856, 2003.
Szapary PO, Wolfe ML, Bloedon LT, Cucchiaria AJ, DerMarderosian AH, Cirigliano MD, Rader DJ: Guggulipid for the treatment of hypercholesterolemia: A randomized, controlled trial. JAMA 290: 765-772, 2003.
Tietge UJF, Kozarsky KF, Donahee MH, Rader DJ: A tetracycline-regulated adenoviral expression system for in vivo delivery of transgenes to lung and liver. Gene Therapy 5: 567-675, 2003.
Tietge UJF, Maugeais C, Cain W, Grass D, deBeer FC, Rader DJ: Acute inflammation increases the selective uptake of HDL-cholesteryl esters into adrenals of mice overexpressing human secretory phospholipase A2 (sPLA2). Am J Physiol Endocrinol Metabol 285: E403-E411, 2003.
Zhang Y, Zanotti I, Reilly M, Glick JM, Rothblat GH, Rader DJ: Overexpression of apoA-I promotes reverse transport of cholesterol from macrophages to feces. Circulation 108: 661-663, 2003.
Ziouzenkova O, Perrey S, Asatryan L, Hwang J, MacNaul KL, Moller DE, Rader DJ, Sevanian A, Zechner R, Hoefler G, Plutzky J: Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: Evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci 100: 2730-2735, 2003.
Cuchel M, Wolfe ML, DeLemos AS, Rader DJ: The frequency of the cholesteryl ester transfer protein - TaqI B2 allele is lower in African Americans than in Caucasians. Atherosclerosis 163: 169-174, 2002.
Ikewaki K, Zech LA, Brewer HB Jr, Rader DJ: Comparative in vivo metabolism of apolipoproteins E2 and E4 in heterozygous apoE2/4 subjects. J Lab Clin Med 140: 1924-1928, 2002.
Jin W, Broedl U, Monajemi H, Glick JM, Rader DJ: Lipase H, a new member of the triglyceride lipase gene family synthesized in the intestine. Genomics 80: 268-273, 2002.
Kawashiri M, Zhang Y, Puré E, Rader DJ: Combined effects of cholesterol reduction and apolipoprotein A-I expression on atherosclerosis in LDL receptor mice. Atherosclerosis 165: 15-22, 2002.
McCoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ: Characterization of the lipolytic activity of endothelial lipase. J Lipid Res 43: 921-929, 2002.
Millar JS, Maugeais C, Fuki IV, Rader DJ: Normal production rate of apolipoprotein B in LDL receptor-deficient mice. Arterio Thromb Vasc Biol 22: 989-994, 2002.
Tietge UJF, Maugeais C, Lund-Katz S, Grass D, deBeer FC, Rader DJ: Human secretory phospholipase A2 (sPLA2) mediates decreased plasma levels of HDL-cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice. Arterio Thromb Vasc Biol 22: 1213-1218, 2002.
Valdes AM, Wolfe ML, O'Brien EJ, Spurr NK, Gefter W, Rut A, Groot PHE, Rader DJ: Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification. Arterio Thromb Vasc Biol 22: 1924-1928, 2002.
Wolfe ML, Iqbal N, Gefter W, Mohler ER, Rader DJ, Reilly M: Coronary artery calcification at electron beam CT is increased in asymptomatic type 2 diabetics independent of traditional risk factors. J Cardiovasc Risk 9: 369-376, 2002.
Yu YH, Zhang Y, Oelkers P, Sturley SL, Rader DJ, Ginsberg HN: Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes. J Biol Chem 277: 50876-50884, 2002.
Zhao L, Cuff CA, Moss E, Wille U, Cyrus T, Klein EA, Pratico D, Rader DJ, Hunter CA, Pure E, Funk CD: Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia. J Biol Chem 277: 35350-35356, 2002.
deLemos AS, Wolfe ML, Long CJ, Sivapackianathan R, Rader DJ: Identification of genetic variants in endothelial lipase in persons with elevated high sensity lipoprotein cholesterol. Circulation 106: 1321-1326, 2002.
Cuff CA, Kothapalli D, Azonobi I, Chun S, Zhang Y, Belkin R, Yeh C, Secreto A, Assosian RK, Rader DJ, Pure E: The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and activation of vascular cells. J Clin Invest 108: 1031-1040, 2001.
Cyrus T, Pratico D, Zhao L, Witztum J, Rader DJ, Rokach J, FitzGerald G, Funk C: Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice. Circulation 103: 2277-2282, 2001.
Grundy SM, D'Agostino RB, Mosca L, Burke GL, Wilson PWF, Rader DJ, Cleeman JI, Roccella EJ, Cutler JA, Friedman LM: Cardiovascular risk assessment based on US cohort studies. Circulation 104: 491-496, 2001.
Kawashiri M, Zhang Y, Usher D, Reilly M, Pure' E, Rader DJ: Effects of co-expression of the LDL receptor on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice. J Lipid Res 42: 943-950, 2001.
Meagher E and Rader DJ: Antioxidant therapy and atherosclerosis: Animal and human studies. Trends Cardiovasc Med 11: 162-165, 2001.
Rader DJ: Gene therapy for familial hypercholesterolemia. Nutr Metab Cardiovasc Dis Suppl 5: 40-44, 2001.
Rader DJ: A new feature on the cholesterol-lowering landscape. Nature Med 7: 1282-1284, 2001.
Reilly MP and Rader DJ: Clinical decision-making in the management of lipid disorders. Disease Management and Clinical Outcomes 3: 30-37, 2001.
Snyder PJ, Peachey H, Berlin JA, Rader DJ, Usher D, Loh L, Hannoush P, Dlewati A, Holmes JH, Santanna J, Strom BL: Effect of transdermal testosterone treatment on serum lipid and apolipoprotein levels in men more than 65 years of age. Am J Med 111: 255-260, 2001.
Tangirala RK, Pratico D, FitzGerald GA, Chun S, Tsukamoto K, Maugeais C, Usher DC, Pure' E, Rader DJ: Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E. J Biol Chem 276: 216-266, 2001.
Tietge UJF, Sun G, Czarnecki S, Yu QC, Lohse P, Du H, Grabowski GA, Glick JM, Rader DJ: Phenotypic correction of lipid storage and growth arrest in Wolman disease fibroblasts by gene transfer of lysosomal acid lipase. Human Gene Therapy 12: 279-289, 2001.
Valdes AM, Wolfe M, Tate HC, Rut A, Rader DR: Association of traditional risk factors with coronary calcification in persons with a family history of premature coronary heart disease: Study of the inherited risk of coronary atherosclerosis. J Invest Med 49: 353-361, 2001.
Wolfe ML, Vartanian SF, Ross JL, Bansavich LL, Mohler ER III, Meagher E, Friedrich CA, Rader DJ: Safety and effectiveness of Niaspan when added sequentially to a statin for treatment of dyslipidemia. Am J Cardiol 87: 476-479, 2001.
Chen SJ, Rader DJ, Tazelaar J, Kawashiri M, Gao GP, Wilson JM: Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expression VLDL receptor. Molecular Therapy 2: 256-261, 2000.
DeNofrio D, Desai S, Rader DJ, Chang G, Kelly MP, Acker MA, Loh E: Changes in lipoprotein(a) concentrations following orthotopic heart transplantation. Am Heart J 139: 729-733, 2000.
Detmers PA, Hernandez M, Mudgett J, Hassing H, Burton C, Mundt S, Chun S, Fletcher D, Card DJ, Lisnock JM, Weikel R, Bergstrom JD, Shevell DE, Hermanowski-Vosatka A, Sparrow C, Chao YS, Rader DJ, Wright SD, Pure E: Deficiency in inducible nitric oxide synthase (iNOS) results in reduced atherosclerosis in apoE-deficient mice. J Immunology 165: 3430-3435, 2000.
Higazi AA, Nassar T, Ganz T, Rader DJ, Udassin R, Bdeir K, Hiss E, Sachais BS, Williams KJ, Leitersdorf E, Cines DB: The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: A new class of inflammatory apolipoprotein and a possible contributor to atherogenesis. Blood 96: 1393-1398, 2000.
Kozarsky KF, Donahee MH, Glick JM, Krieger M, Rader DJ: Hepatic overexpression of the HDL receptor SR-BI inhibits atherosclerosis despite reducing HDL cholesterol levels in mice. Arterio Thromb Vasc Biol 20: 721-727, 2000.
Maugeais C, Tietge UJF, Tsukamoto K, Glick JM, Rader DJ: Hepatic apoE expression promotes VLDL-apoB production in mice. J Lipid Res 41: 1673-1679, 2000.
Tsukamoto K, Maugeais C, Glick JM, Rader DJ: Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient mice. J Lipid Res 41: 253-259, 2000.
Tsukamoto K, Tangirala RK, Chun S, Usher D, Pure' E, Rader DJ: Hepatic expression of apolipoprotein E inhibits progression of atherosclerosis in LDL receptor deficient mice. Molecular Therapy 1: 189-194, 2000.
Barnhart KT, Freeman E, Grisso JA, Rader DJ, Sammel M, Kapoor S, Nestler JE: The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J Clin Endo Metab 84: 3896-3902, 1999.
Cyrus T, Witztum JL, Rader DJ, Tangirala R, Fazio S, Linton MF, Witztum JL, Funk CD: Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apoE-deficient mice. J Clin Invest 103: 1597-1604, 1999.
Hobbs HH and Rader DJ: ABC1: connecting yellow tonsils, neuropathy, and very low HDL. J Clin Invest 104: 1015-1018, 1999.
Hosoai H, Webb NR, Glick J, Purdom MS, de Beer FC, Rader DJ: Expression of serum amyloid A protein in the absence of the acute phase response is not sufficient to reduce HDL cholesterol or apoA-I levels in mice. J Lipid Res 40: 648-653, 1999.
Jaye M, Lynch KL, Krawiec J, Marchadier D, Maugeais C, Doan K, South V, Amin D, Perrone M, Rader DJ: A novel endothelial-derived lipase that modulates HDL metabolism. Nature Genetics 21: 424-428, 1999.
Tangirala R, Tsukamoto K, Chun SH, Usher D, Pure' E, Rader DJ: Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice. Circulation 100: 1816-1822, 1999.
Tietge U, Tsukamoto K, Maugeais C, Bakillah A, Hussain M, Rader DJ: Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo production of VLDL triglycerides and apolipoprotein B. J Lipid Res 40: 2134-2139, 1999.
Tietge UJF, Maugeais C, Cain W, Grass D, Glick J, deBeer FC, Rader DJ: Overexpression of secretory phospholipase A2 causes rapid catabolism and altered tissue uptake of HDL cholesteryl ester and apolipoprotein A-I. J Biol Chem 275: 10077-10084, 1999.
Tsukamoto K, Tangirala R, Chun SH, Pure' E, Rader DJ: Rapid regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein E in apoE-deficient mice. Arterio Thromb Vasc Biol 19: 2162-2170, 1999.
Chang G, DeNofrio D, Desai S, Kelley MP, Rader DJ, Acker MA, Loh E: Lipoprotein(a) levels and heart transplantation atherosclerosis. Am Heart J 136: 329-334, 1998.
Kindy MS and Rader DJ: Reduction in amyloid A amyloid formation in apolipoprotein E-deficient mice. Am J Pathol 152: 1387-1395, 1998.
Pratico D, Tangirala RK, Rader DJ, Rokach J, FitzGerald GA: Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in apoE-deficient mice. Nature Medicine 4: 1189-1192, 1998.
Reilly MP, Pratico D, Delanty N, DiMinno G, Tremoli E, Rader DJ, Kapoor S, Lawson J, FitzGerald GA: Increased biosynthesis of distinct F2 isoprostanes in hypercholesterolemia. Circulation 98: 2822-2828, 1998.
Traber M, Rader DJ, Acuff R, Ramakrishnan R, Brewer HB Jr, Kayden H: Vitamin E dose response studies in humans using deuterated RRR-alpha-tocopherol. Am J Clin Nutr 68: 847-853, 1998.
Daugherty A, Pure E, Butteiger D, Chen S, Leferovich J, Roselaar S, Rader DJ: The effect of total lymphocyte deficiency on extent of atherosclerosis in apolipoprotein E-/- mice. J Clin Invest 100: 1575-1580, 1997.
Higazi A, Lavi E, Ulrich A, Jamieson D, Rader DJ, Usher D, Cain W, Ganz T, Cines D: Defensin stimulates the binding of lipoprotein(a) to human vascular endothelial and smooth muscle cells. Blood 89: 4290-4298, 1997.
Tsukamoto K, Hiester K, Smith P, Usher D, Glick J, Rader DJ: Comparison of human apoA-I expression in mouse models of atherosclerosis after gene transfer using a second generation adenovirus. J Lipid Res 38: 1869-1876, 1997.
Tsukamoto K, Smith P, Glick J, Rader DJ: Liver-directed gene transfer and prolonged expression of three major human apoE isoforms in apoE-deficient mice. J Clin Invest 100: 107-114, 1997.
Webb NR, de Beer MC, van der Westhuyzen DR, Kindy MS, Banka CL, Tsukamoto K, Rader DJ, de Beer FC: Adenoviral vector-mediated over-expression of serum amyloid A in apoA-I deficient mice. J Lipid Res 38: 1583-1590, 1997.
Ikewaki K, Zech L, Brewer HB Jr, Rader DJ: ApoA-II kinetics in humans using endogenous labeling with stable isotopes: Slower turnover of apoA-II compared with the exogenous radiotracer method. J Lipid Res 37: 399-407, 1996.
Jamieson D, Usher D, Rader DJ, Lavi E: Apolipoprotein(a) deposition in atherosclerotic plaques of cerebral vessels: A potential role for endothelial cells in lesion formation. Am J Pathol 147: 1567-1574, 1996.
Raper SE, Grossman M, Rader DJ, Thoene JG, Clark BJ, Kolansky DM, Muller D, Wilson JM: Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia. Annals of Surgery 223: 116-126, 1996.
Aguie G, Rader DJ, Clavey V, Traber M, Torpier G, Kayden H, Fruchart JC, Brewer HB Jr, Castro G: Lipoproteins containing apolipoprotein B isolated from patients with abetalipoproteinemia: Identification and characterization. Atherosclerosis 118: 183-191, 1995.
Bartens W, Rader DJ, Talley G, Kindt M, Brewer HB Jr: Lipoprotein(a) in patients with combined hyperlipidemia: Effect of triglycerides. Eur J Clin Invest 25: 647-653, 1995.
Duverger N, Rader DJ, Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Nagano M, Nakamura H, Brewer HB Jr: Characterization of high-density apolipoprotein particles A-I and A-I:A-II isolated from humans with cholesteryl ester transfer protein deficiency. Eur J Biochem 227: 123-129, 1995.
Grossman M, Rader DJ, Muller D, Kolansky D, Kozarsky K, Clark BJ, Stein E, Lupien P, Brewer HB Jr, Raper S, Wilson JM: A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolemia. Nature Med 1: 1148-1154, 1995.
Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Fairwell T, Zech L, Nagano M, Nakamura H, Brewer HB Jr, Rader DJ: Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency. J Clin Invest 96: 1573-1581, 1995.
Ikewaki K, Zech L, Kindt M, Brewer HB Jr, Rader DJ: Apolipoprotein A-II production rate is a major factor regulating the distribution of apolipoprotein A-I among HDL subclasses LpA-I and LpA-I:A-II in normolipidemic humans. Arterio Thromb Vasc Biol 15: 306-312, 1995.
Rader DJ, Mann WA, Cain W, Kraft HG, Usher D, Zech LA, Hoeg JM, Davignon J, Lupien P, Grossman M, Wilson JM, Brewer HB Jr: The LDL receptor is not required for normal catabolism of Lp(a) in humans. J Clin Invest 95: 1403-1408, 1995.
Ricci B, Sharp D, O'Rourke E, Kienzle B, Blinderman L, Gordon D, Smith-Monroy C, Robinson G, Gregg R, Rader D, Wetterau J: A 30 amino acid truncation of the microsomal triglyceride transfer protein large subunit disrupts its interaction with protein disulfide isomerase and causes abetalipoproteinemia. J Biol Chem 270: 14281-14285, 1995.
Skarlatos S, Duverger N, Rader DJ, Kruth H: Cholesterol efflux from human monocyte-derived macrophages in the presence of LpA-I:A-II. Biochim Biophys Acta 1270: 19-25, 1995.
Bartens W, Rader DJ, Talley G, Brewer HB Jr: Decreased plasma levels of lipoprotein(a) in patients with hypertriglyceridemia. Atherosclerosis 108: 149-157, 1994.
Benvenga S, Cahnmann HJ, Rader DJ, Kindt M, Facchiano A, Robbins J: Thyroid hormone binding to isolated human apolipoproteins A-II, C-I, C-II, and C-III: Homology in thyroxine binding sites. Thyroid 4: 261-269, 1994.
Duverger N, Rader DJ, Brewer HB Jr: Distribution of subclasses of human HDL containing apolipoprotein A-I without apolipoprotein A-II (LpA-I) in normolipidemic men and women. Arteriosclerosis and Thrombosis 14: 1594-1599, 1994.
Gilligan D, Sack M, Guetta V, Casino P, Quyyumi A, Rader DJ, Panza J, Cannon RO III: The effect of antioxidant vitamins on low-density lipoprotein oxidation and impaired endothelium-dependent vasodilatation in patients with hypercholesterolemia. J Am Coll Cardiol 24: 1611-1617, 1994.
Gorin MB, Paul TO, Rader DJ: Angioid streaks associated with abetalipoproteinemia. Ophthalmic Genetics 15: 151-159, 1994.
Ikewaki K, Rader DJ, Zech LA, Brewer HB Jr: Abnormal in vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: Implications for the roles of apolipoproteins B and E in HDL metabolism. J Lipid Res 35: 1809-1819, 1994.
Rader DJ, Cain W, Ikewaki K, Talley G, Zech LA, Usher D, Brewer HB Jr: The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate. J Clin Invest 93: 2758-2763, 1994.
Rader DJ, Ikewaki K, Duverger N, Schmidt H, Pritchard H, Frohlich J, Clerc M, Dumon MF, Fairwell T, Zech L, Santamarina-Fojo S, Brewer HB Jr: Rapid catabolism of apolipoprotein A-II and high density lipoproteins containing apoA-II in classic LCAT deficiency and fish-eye disease. J Clin Invest 93: 321-330, 1994.
Sack M, Rader DJ, Cannon RO III: Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet 343: 269-270, 1994.
Traber MG, Rader DJ, Acuff R, Brewer HB Jr, Kayden HJ: Discrimination between RRR- and all racemic-alpha-tocopherols labeled with deuterium by patients with abetalipoproteinemia. Atherosclerosis 108: 27-37, 1994.
Usher DC, Swanson C, Rader DJ, Krämer J, Brewer HB Jr: A comparison of Lp(a) levels in fresh and frozen plasma using ELISAs with either anti-apo(a) or anti-apoB reporting antibodies. Chemistry and Physics of Lipids 67-68: 243-248, 1994.
Verges B, Rader DJ, Schaefer J, Zech L, Kindt M, Fairwell T, Gambert P, Brewer HB Jr: In vivo metabolism of apolipoprotein A-IV in severe hypertriglyceridemia: a combined radiotracer and stable isotope study. J Lipid Res 35: 2280-2291, 1994.
Duchateau P, Rader DJ, Duverger N, Theret N, De Geitere C, Brewer HB Jr, Fruchart JC, Castro G: Tangier disease: Isolation and characterization of LpA-I, LpA-I:A-II, LpA-II, and LpA-IV particles from plasma. Biochim Biophys Acta 1182: 30-36, 1993.
Duverges N, Rader DJ, Duchateau P, Fruchart JC, Castro G, Brewer HB Jr: Biochemical characterization of the three major subclasses of lipoprotein A-I (LpA-I) preparatively isolated from human plasma. Biochemistry 32: 12372-12379, 1993.
Emmerich J, Verges B, Tauveron I, Rader DJ, Santamarina-Fojo S, Schaefer J, Ayault-Jarrier M, Thieblot P, Brewer HB Jr: Familial high density lipoprotein deficiency due to marked hypercatabolism of normal apolipoprotein A-I. Arteriosclerosis and Thrombosis 13: 1299-1306, 1993.
Ikewaki K, Rader DJ, Sakamoto T, Nishiwaki M, Wakimoto N, Schaefer J, Ishikawa T, Fairwell T, Zech L, Nakamura H, Nagano M, Brewer HB Jr: Delayed catabolism of high density lipoprotein apolipoproteins A-I and A-II in human cholesteryl ester transfer protein deficiency. J Clin Invest 92: 1650-1658, 1993.
Ikewaki K, Rader DJ, Schaefer J, Fairwell T, Zech LA, Brewer HB Jr: Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer labeling methods. J Lipid Res 34: 2207-2215, 1993.
Klein HG, Lohse P, Duverger N, Albers JJ, Rader DJ, Zech LA, Santamarina-Fojo S, Brewer HB Jr: Two different allelic mutations in the lecithin-cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (Tyr83->Stop) and LCAT (Tyr156->Asn). J Lipid Res 34: 49-58, 1993.
Rader DJ and Brewer HB Jr: A[beta]lipoproteinemia: New insights into lipoprotein assembly and vitamin E metabolism from a rare genetic disease. JAMA 270: 865-869, 1993.
Rader DJ, Cain W, Zech LA, Usher D, Brewer HB Jr: Variation in Lp(a) concentrations among individuals with the same apo(a) isoform is determined by the rate of Lp(a) production. J Clin Invest 91: 443-447, 1993.
Rader DJ, Ikewaki K, Duverger N, Feuerstein I, Zech LA, Connor W, Brewer HB Jr: Markedly decreased plasma high density lipoprotein levels without premature coronary atherosclerosis caused by rapid catabolism of apolipoproteins A-I and A-II. Lancet 342: 1455-1458, 1993.
Rader DJ, Schaefer JR, Lohse P, Ikewaki K, Thomas F, Harris WA, Zech LA, Dujovne CA, Brewer HB Jr: Increased production of apolipoprotein A-I associated with elevated levels of high density lipoproteins and apolipoprotein A-I in a patient with familial hyperalphalipoproteinemia. Metabolism 42: 1429-1434, 1993.
Rader DJ, Schaefer JR, Lohse P, Verges B, Kindt M, Zech LA, Steinmetz A, Brewer HB Jr: Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein. J Clin Invest 92: 1009-1017, 1993.
Sharp D, Blinderman L, Combs KA, Kienzle B, Ricci B, Wagner-Smith K, Gil CM, Turck CW, Bouma ME, Rader DJ, Aggerbeck LP, Gregg RE, Gordon DA, Wetterau JR: Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinemia. Nature 365: 65-69, 1993.
Wanner C, Rader DJ, Bartens W, Kraemer J, Brewer HB Jr, Schollmeyer P, Wieland H: Elevated plasma lipoprotein(a) in patients with the nephrotic syndrome. Ann Int Med 199: 263-269, 1993.
Benvenga S, Cahnmann HJ, Rader DJ, Kindt M, Robbins J: Thyroxine binding to the apolipoproteins of high density lipoproteins HDL2 and HDL3. Endocrinology 131: 2805-2811, 1992.
Lohse P, Rader DJ, Brewer HB Jr: Heterozygosity for apolipoprotein E-4Philadelphia (Glu13->Lys,Arg145->Cys) is associated with incomplete dominance of Type III hyperlipoproteinemia. J Biol Chem 267: 13642-13646, 1992.
Mautner SL, Sanchez JA, Rader DJ, Mautner GC, Ferrans VJ, Fredrickson DS, Brewer HB Jr, Roberts WC: The heart in Tangier disease: Severe coronary atherosclerosis with near absence of high-density lipoprotein cholesterol. Am J Clin Path 98: 191-198, 1992.
Rader DJ and Brewer HB Jr: Lipoprotein(a): Clinical approach to a unique atherogenic lipoprotein. JAMA 267: 1109-1112, 1992.
Rader DJ, Gregg RE, Meng MS, Schaefer JR, Zech LA, Benson MD, Brewer HB Jr: In vivo metabolism of a mutant apolipoprotein, ApoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis. J Lipid Res 33: 755-763, 1992.
Reblin T, Rader DJ, Beisiegel U, Greten H, Brewer HB Jr: Correlation of apolipoprotein(a) Isoproteins with Lp(a) density and distribution in fasting plasma. Atherosclerosis 94: 223-232, 1992.
Schaefer JR, Rader DJ, Ikewaki K, Fairwell T, Zech LA, Kindt MR, Davignon J, Gregg RE, Brewer HB Jr: In vivo metabolism of apolipoprotein A-I in a patient with homozygous familial hypercholesterolemia. Arteriosclerosis and Thrombosis 12: 843-848, 1992.
Schaefer JR, Rader, DJ, Brewer HB Jr: Investigation of lipoprotein kinetics using endogenous labeling with stable isotopes. Curr Opin Lipidology 3: 227-232, 1992.
Shibusawa Y, Ito Y, Ikewaki K, Rader DJ, Brewer HB Jr: Counter-current chromatography of lipoproteins with a polymer phase system using the cross-axis synchronous coil planet centrifuge. J Chromatography 596: 118-122, 1992.
Weiss JS, Rodrigues M, Kruth HS, Rajagopalan S, Rader DJ, Kachadoorian H: Panstromal Schnyder's corneal dystrophy: Ultrastructural and histochemical studies. Ophthalmology 99: 1072-1081, 1992.
Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M, Schmitz J, Gay G, Rader DJ, Gregg RE: Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science 258: 999-1001, 1992.
Charnas LR, Bernardini I, Rader DJ, Hoeg JM, Gahl WA: Clinical and laboratory findings in the oculocerebrorenal syndrome of Lowe, with special reference to growth and renal function. N Engl J Med 324: 1318-1325, 1991.
Lohse P, Kindt MR, Rader DJ, Brewer HB Jr: Three genetic variants of human plasma apolipoprotein A-IV. J Biol Chem 266: 13513-13518, 1991.
Novotny WF, Brown SG, Miletich JP, Rader DJ, Broze GJ Jr: Plasma antigen levels of the lipoprotein associated coagulation inhibitor in patient samples. Blood 78: 387-393, 1991.
Rader DJ, Castro G, Zech LA, Fruchart JC, Brewer HB Jr: Metabolism of apolipoprotein A-I in high density lipoprotein particles LpA-I and LpA-I,A-II. J Lipid Res 32: 1849-1859, 1991.
Lohse P, Kindt MR, Rader DJ, Brewer HB Jr: Human plasma apolipoproteins A-IV-0 and A-IV-3: Molecular basis for two rare variants of apolipoprotein A-IV-1. J Biol Chem 265: 12734-12739, 1990.
Lohse P, Kindt MR, Rader DJ, Brewer HB Jr: Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene. J Biol Chem 265: 10061-10064, 1990.
Sparks CE, Rader DJ, Marsh JB: Metabolism of two forms of apolipoprotein B of VLDL by rat liver. J Lipid Res 24: 156-166, 1983.
Rader DJ: Plasma high density lipoproteins and atherogenesis. Atherothrombosis and Coronary Artery Disease, 2nd Edition. Fuster V, Topol EJ, Nabel EG (eds.). Lippincott Williams and Wilkins, Philadelphia, PA, Page: 95-110, 2005.
Tershakovec AM and Rader DJ: Disorders of lipoprotein metabolism and transport. Nelson Textbook of Pediatrics, 17th edition. Behrman RE, Kliegman RM, Jenson HB (eds.). WB Saunders, Philadelphia, PA, 2004.
Rader DJ and Hobbs HH: Disorders of lipoprotein metabolism. Harrison's Principles of Internal Medicine, 16th Edition. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (eds.). McGraw-Hill, New York, NY, 2004.
Badellino K, Jin W, Rader DJ: Endothelial lipase: A novel drug target for HDL and atherosclerosis? Lipases and Phospholipases in Drug Development. Muller G and Petry S (eds.). Wiley-VCH GmbH & Co. KGaA, Weinheim, Germany, Page: 139-153, 2004.
Rader DJ: Lipid disorders. Cardiovascular Medicine, Second Edition. Topol EJ (eds.). Lippincott-Raven, Page: 43-73, 2002 Notes: Published in New York, NY.
Rader DJ, Raper SE, Wilson JM: Gene therapy for metabolic disease. Diabetes Mellitus: A Fundamental and Clinical Text, 2nd Edition. LeRoith D, Olefsky J, Taylor S (eds.). JB Lippincott Co., Philadelphia, PA, Page: 526-534, 2000.
Liang BT, Rader DJ, Mao CA: Reducing cardiovascular risk. Geriatric Secrets, 2nd Edition. Forciea MA, Lavizzo-Mourey R and Schwab EP (eds.). Hanley & Belfus, Inc., Philadelphia, PA, Page: 70-76, 2000.
Tershakovec AM and Rader DJ: Disorders of lipoprotein metabolism and transport. Nelson Textbook of Pediatrics, 16th edition. Behrman RE, Kliegman RM, Jenson HB (eds.). WB Saunders, Philadelphia, PA, Page: 387-397, 1999.
Rader DJ: Lipid disorders. Cardiovascular Medicine. Topol EJ (eds.). Lippincott-Raven, New York, NY, Page: 59-90, 1997.
Rader DJ, Hark L, Burke F: Nutrition and Pathophysiology: Cardiovascular Disease. Medical Nutrition and Disease. Morrison G and Hark L (eds.). Blackwell Science, Cambridge, UK, Page: 175-203, 1996.
Rader DJ and Wilson JM: Gene therapy for familial hypercholesterolemia. Gene Delivery Systems: State-of-the-art Review. OECD Documents, Paris, Page: 229-236, 1996.
Rader DJ: Genetic dyslipoproteinemias: Inborn errors of lipoprotein metabolism. Physician's Guide to Laboratory Diagnosis of Inherited Metabolic Disease. Blau N, Duran M, Blaskovics M (eds.). Chapman and Hall, London, UK, 1996.
Rader DJ: Approaches to hypercholesterolemia and other abnormal lipid profiles. Textbook of Internal Medicine. Kelley WN (eds.). JB Lippincott Co., Philadelphia, PA, Page: 183-191, 1996.
Rader DJ: Disorders of lipid metabolism. Textbook of Internal Medicine. Kelley WN (eds.). JB Lippincott Co., Philadelphia, PA, Page: 72-89, 1996.
Rader DJ and Wilson JM: Gene therapy for lipid disorders. Molecular Cardiovascular Medicine. Haber E (eds.). Scientific American Medicine, New York, NY, Page: 97-114, 1995.
Rader DJ and Brewer HB Jr: Lipids, apolipoproteins, and lipoproteins. Genetic Factors in Coronary Heart Disease. Goldbaurt U, de Faire U, Berg K (eds.). Kluwer Academic Publishers, Dordrecht, The Netherlands, Page: 83-104, 1994.
Rader DJ, Patterson A, Eggerman T, Hoeg JM, Brewer HB Jr: Apolipoprotein [beta] mRNA editing: Modulation and clinical implications. Hormones in Lipoprotein Metabolism. Steinmetz A (eds.). Springer-Verlag, Heidelberg, Germany, Page: 17-21, 1993.
Rader DJ, Ikewaki K, Schaefer J, Brewer HB Jr: Metabolism of HDL particles LpA-I and LpA-I,A-II in normal and hyperalphalipoproteinemia subjects. Atherosclerosis Reviews: High Density Lipoproteins - Pathophysiology and Clinical Relevance. Catapano A, Bernini F, Corsini A (eds.). Raven Press, New York, NY, Page: 43-55, 1993.
Brewer HB Jr, Rader DJ, Fojo SS, Hoeg JM: Frontiers in the analysis of HDL structure, function, and metabolism. Disorders of HDL. Carlson LA (eds.). Smith-Gordan, Page: 51-58, 1990.
Rader DJ. "Is it Time to Retire the HDL Hypothesis?" - Diabetes and Metabolism Seminar at the University of Washington - Seattle, WA, May 2015.
Rader DJ. "New therapeutic targets for dyslipidemia and atherosclerosis revealed through human genetics", DEUEL Conference on Lipids, San Diego, CA, March 2014.
Rader DJ. "Genomic Medicine: Its Time Has Arrived" - University of South Carolina's School of Medicine - Columbia, SC, February 2014.
Rader DJ. "Genomic Medicine in Cardiovascular Disease: Lipid Metabolism as a Paradigm", Grand Rounds Presentation at the Medical University of South Carolina, Charleston, SC, February 2014.
Rader DJ. "Update on Role of Sortilin in Lipoprotein Metabolism and Atherosclerosis" - Vascular Biology Seminar at Harvard - Boston, MA, January 2014.
2012, American Heart Association's Clinical Research Prize
2011, Peter Kuo Lecture, University of Medicine and Dentistry of New Jersey
2011, Louis Dinon Lecture, Jefferson University School of Medicine
2011, Election to the Institute of Medicine (IOM)
2010, Banting Lecture, University of Toronto
2009, Bondy Lecture, Yale University
2009, Dewitt Goodman Lecture, Columbia University
2009, MERIT (Merthod to Extend Research in Time) Award from the NIH-NHLBI
2007, International Atherosclerosis Society Distinguished Fellow
2007, Election to Association of American Physicians
2007, Named Associate Editor, Journal of Clinical Investigation (JCI)
2007, Named Associate Editor, Journal of Clinical Investigation (JCI)
2005-present, Bristol Myers Squibb "Freedom to Discover" Unrestricted Cardiovascular Research Grant
2005, Jeffrey M. Hoeg Award for Basic Science and Clinical Research, Arteriosclerosis, Thrombosis and Vascular Biology from Council of the American Heart Association
2005, William Osler Patient Oriented Research Award, University of Pennsylvania School of Medicine
2005-present, Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure Professor of Medicine, University of Pennsylvania School of Medicine
2005, 8th Annual Gill Heart Institute Award for Outstanding Contributions to Cardiovascular Research
2005, Bristol Myers Squibb "Freedom to Discover" Unrestricted Cardiovascular Research Award
2004, Chair, Gordon Conference on Lipid and Lipoprotein Metabolism
2002, Doris Duke Charitable Foundation Distinguished Clinical Investigator Award
2002-present, Listing in "Top Doctors of Philadelphia", Philadelphia Magazine
2000, Burroughs Wellcome Trust Clinician-Scientist Award in Translational Research
2000, Established Investigator, American Heart Association
1999, Election to American Society of Clinical Investigation
1997, Donald B. Martin Outstanding Teacher Award, University of Pennsylvania School of Medicine
1996, Outstanding Faculty Award, Department of Medicine, University of Pennsylvania School of Medicine
1995, W.W. Smith Charitable Trust Awardee
1984, Dean's Award, Medical College of Pennsylvania
1983, Alpha Omega Alpha
1979, Phi Beta Kappa
2012-present, Deputy Editor, Arteriosclerosis Thrombosis and Vascular Biology
2005-present, Editorial Board, Journal of Lipid Research
2002-present, Editorial Board, Circulation
2002-present, Editorial Board, Circulation Research
2001-present, Editorial Board, American Journal of Physiology (Endocrinology and Metabolism)
2000-present, Editorial Board, Arteriosclerosis, Thrombosis and Vascular Biology
1999-present, Editorial Board, Trends in Molecular Medicine
2014-present, Chair, Department of Genetics, Perelman School of Medicine at The University of Pennsylvania
2013-present, Director, PennMedicine BioBank, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
2013-present, Chair, Deuel Conference
2013-present, Co-Chair, Gordon Conference on Atherosclerosis
2011-present, Chief, Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania
2009-present, Scientific Director, Clinical and Translational Research, Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania
2008-present, Committee on Appointments and Promotions, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania
2007-present, Bridge Funding Program Committee, Perelman School of Medicine at the University of Pennsylvania
2005-present, Director, Cardiovascular Metabolism Unit, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine
2005-present, Associate Director, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
2005-present, Program Director, General Clinical Research Center, University of Pennsylvania Medical Center
2004-present, Chair, Gordon Conference on Lipid and Lipoprotein Metabolism
2003-present, Chair, Scientific Advisory Committee, Molecular Diagnostics and Genotyping Core Laboratory, University of Pennsylvania School of Medicine
2002-present, Member, Faculty Advisory Committee, University Office of Human Research
1997-present, Member, Gene Therapy Track, Graduate Group in Cell and Molecular Biology, School of Medicine
1994-present, Director, Preventive Cardiovascular Medicine and Lipid Clinic, University of Pennsylvania Health System
American Association for the Advancement of Science
American College of Physicians
American Federation for Medical Research
American Heart Association
- 1998-present, Thrombosis and Vascular Biology Council
American Society for Clinical Investigation
National Committee for Quality Assurance
- 1998-present, Member of Cardiovascular Measurement Advisory Panel
National Institutes of Health