Education and Training

Medical School

MD - Masaryk University, Brno, Czech Republic 


Internal Medicine - Research Institute of Rheumatic Diseases, Piestany, Slovakia


Rheumatology - Research Institute of Rheumatic Diseases, Piestany, Slovakia


Postdoctoral Fellow in Hematology, The Children's Hospital of Philadelphia ,Division of Hematology, Philadelphia, PA
Postdoctoral Fellow in Autoimmunity - Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel

Graduate Degree

PhD in Internal Medicine - Commenius University, Bratislava, Slovakia 

Titles and Academic Titles


Research Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania 

Departments and Services




Khandelwal S, Lee GM, Hester CG, Poncz M, McKenzie S, Sachais BS, Rauova L, Kelsoe G, Cines DB, Frank M, Arepally GM: The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21). Blood July 2016 Notes: epub ahead of print.

Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M and Rauova L: Platelet transactivation by monocytes promotes the prothrombotic state in heparin-induced thrombocytopenia. Blood 127(4): 464, Feb 2016.

Parker ZF, Rux AH, Riblett AM, Lee FH, Rauova L, Cines DB, Poncz M, Sachais BS, Doms RW.: Platelet-Factor 4 (PF4) inhibits and enhances HIV-1 infection in a concentration-dependent manner by modulating viral attachment. AIDS Res Hum Retroviruses Feb 2016 Notes: Epub ahead of print.


Zhou J, Wu Y, Wang L, Rauova L,Hayes VM, Poncz M, and Essex DW: The second CGHC motif of protein disulfide isomerase mediates thrombosis. Journal of Clinical Investigation 25(12): 4391, Nov 2015.

Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB, Greene MI: Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nature Communications 6(8277): 9277, Sep 2015.

Joglekar M, Khandelwal S, Cines DB, Poncz M, Rauova L, Arepally GM.: Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. J Thromb Haemost. 13(8): 1416-27, Aug 2015.


Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW.: The disulfide isomerase ERp57 is required for fibrin deposition in vivo. J Thromb Haemost 12(11): 1890-1897, Nov 2014.

Skewis LR, Lebedeva T, Papkov V, Thayer EC, Massefski W, Cuker A, Nagaswami C, Litvinov RI, Kowalska MA, Rauova L, Poncz M, Weisel JW, Lowery TJ, Cines DB: T2 Magnetic Resonance: A Diagnostic Platform for Studying Integrated Hemostasis in Whole Blood-Proof of Concept. Clin Chem 60(9): 1174-82, September 2014.

Cuker A, Rauova L, Bolgiano D, Matthai WH Jr, Poncz M, Konkle BA.: Atherosclerosis is not a risk factor for anti-platelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery. Thromb Haemost 111(6): 1191-3, Jun 2014.

Cines DB, Lebedeva T, Nagaswami C, Hayes V, Massefski W, Litvinov RI, Rauova L, Lowery TJ, Weisel JW.: Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin. Blood 123(10): 1596-1603, Mar 2014.




Rauova L, Arepally GM, Cines DB, Poncz M: Cellular and molecular immunopathogenesis of heparin induced thrombocytopenia.  Heparin Induced Thrombocytopenia 5th Ed. Theodore E Warkentin and Andreas Greinacher (eds.). Informa Healthcare, Page: 230-251, Oct 2012.

Arepally GM, Sachais BS , Cines DB , Poncz M , Rauova L, McKenzie SM: : Murine models of heparin-induced thrombocytopenia.  Heparin Induced Thrombocytopenia 5th Ed. Theodore E Warkentin and Andreas Greinacher (eds.). Informa Healthcare, Page: 252-71, Oct 2012.


Gilburd B, Rauova L, Nesher Y, Shoenfeld Y. : Evaluation study on a new anti-ß2-glycoprotein I screening EIA.  Autoantigens and Autoantibodies: Diagnostic Tools and Clues to Understanding Autoimmunity.   K. Conrad, R.-L. Humbel, M. Meurer, Y. Shoenfeld, E. M. Tan.  (eds.). Pabst Science Publishers, 2002.


Rauova L, Chapman J, and Shoenfeld Y: Brain vasculitis and antiphospholipid syndrome. Brain Disease: Therapeutic Strategies and Repair. Oded Abramsky, D Alastair S Compston, Ariel Miller, Gerard Said  (eds.). Taylor & Francis, A Martin Dunitz Book, Page: 193, 2001.


Rauova L.: [Primary Immunodeficiency Syndromes].  Klinicka reumatologia [Clinical Rheumatology].  Rovensky J. and Pavelka K. (eds.). Osveta Martin  Page: 629-635, 2000 Notes: In Slovak.

Rauova L, Rovensky J: [Immunodeficiency and  Arthritis].  Klinicka reumatologia [Clinical Rheumatology].  Rovesnky J. and Pavelka K. (eds.). Osveta Martin 2000, Page: 635-641, 2000 Notes: In Slovak.


Rovensky J, Pekarek J, Lukac J, Rauova L, Niepel G, Cech K, Blazickova S: Immunoterapeutische Beeinfussung verschiedener  Vaskulitisformen. Erkrankungen  mit Immunpathogenese. Neue Therapiemöglichkeiten.  Metzner, G., Wissler, J. H. (eds.). München, Bern,  Wien, New York, W. Zuckschwerdt Verlag  Page: 89-93, 1993 Notes: In German.


Rauova, L., Pekarek, J. : DLE  in the therapy of juvenile chronic arthritis.  Recent advances in Transfer Factor and Dialyzable Leukocyte Extracts.  Fujisawa T, Saskawa S, Iikkura Y, Komatsu F, Yamaguchi Y. (eds.). Tokyo, Japan: Maruzen Co. Ltd. Page: 323-325, 1991.

Posters and Presentations


Junsong Zhou, Yi Wu, Lu Wang, Lubica Rauova, Vincent M Hayes, Mortimer Poncz, David W Essex: The Second CGHC Motif of Protein Disulfide Isomerase Mediates Thrombosis. Blood (ASH Annual Meeting Abstracts)  126: 3461, December 2015 Notes: Poster Presentation.

Izabella Andrianova, Vincent M Hayes, Daria Madeeva, Rustem I. Litvinov, Douglas B. Cines, Mortimer Poncz, John W. Weisel, Lubica Rauova: Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia. Blood (ASH Annual Meeting Abstracts)  126: 2244, December 2015 Notes: Poster Presentation.

Grace M. Lee, Manali Joglekar, Sanjay Khandelwal, Rui Qi, Lubica Rauova, Gowthami M Arepally: Characterization of Human and Murine Anti-Protamine/Heparin Antibodies. Blood (ASH Annual Meeting Abstracts)  126: 3461, December 2015 Notes: Poster Presentation.


Zheng Cai, Serge V. Yarovoi, Zhiquiang Zhu, Lubica Rauova, Tatiana Lebedeva, Mortimer Poncz, Gowthami M Arepally, Douglas B. Cines, Mark I. Greene: Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT). Blood (ASH Annual Meeting Abstracts)  124(21): 465, December 2014 Notes: Oral Presentation.

Yulia V. Skibo, Alia R. Fathullina, Elvira V. Romanova, Lubica Rauova, Rustem I. Litvinov: Anti-Apoptotic Effects of Platelet Factor 4 on Human T-Lymphocytes. Blood (ASH Annual Meeting Abstracts)  Poster Presentation, 124(21): 1418, December 2014 Notes: Poster.

Vincent Hayes, Ian Johnston, Douglas B. Cines, Lubica Rauova, Mortimer Poncz: New Insights into the Prothrombotic State of Heparin-Induced Thrombocytopenia (HIT) Using a Novel Microfluidic System: The Endothelial Lining and "Rolling Barrage" of Activation. Blood (ASH Annual Meeting Abstracts)  124(21): 574, December 2014 Notes: Oral Presentation.

Manali V. Joglekar, Sanjay Khandelwal, Mortimer Poncz, Lubica Rauova, Gowthami M Arepally: Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells. Blood (ASH Annual Meeting Abstracts)  124(21): 4197, December 2014 Notes: Poster Presentation.

Daria Madeeva, Valerie Tutwiler, Douglas B. Cines, Mortimer Poncz, Lubica Rauova: FcγRIIA Mediates the Prothrombotic Role of Monocytes in HIT. Blood (ASH Annual Meeting Abstracts)  124(21): 575, December 2014 Notes: Oral Presentation.

Awards and Honors

2005, ASH Travel Award
2003-2005,  American Heart Association Postdoctoral Fellowship Research Award
2003, ASH Travel Award
1992,  Slovak Medical Society Award for the best publication in Rheumatology
1991, Slovak Medical Society Award for the best publication in immunology
1985, Pathophysiology Department Award, School of Medicine, University of J.E. Purkyne, Brno

Editorial and Academic Positions

Editorial Positions


2016-present, Science Translational Medicine
2015-present, Biosensors
2014-present, Hematology Reports
2013-present, J Thromb Haemost
2010-present, Platelets
2008-present, Blood

Leadership and Memberships

Memberships in Professional Organizations


2009-present, International Society of Thrombosis and Hemostasis  (member)


2013-present, American Heart Association
- 2015-present, AHA Peer Review Committee on Thrombosis BSci

2006-present, American Society of Hematology
- 2015-present, Scientific Committee on Thrombosis & Vascular Biology

2002-present, Slovak Medical Chamber  (member)

1990-present, Slovak Rheumatology Society  (member)

1989-present, Slovak Immunology Society  

1988-present, Slovak Medical Society