Lubica Rauova, MD, PhD Lubica Rauova, MD, PhD, is a researcher in the Division of Hematology at The Children's Hospital of Philadelphia. Locations: Main Campus Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467) Education and Training Medical SchoolMD - Masaryk University, Brno, Czech Republic InternshipInternal Medicine - Research Institute of Rheumatic Diseases, Piestany, Slovakia ResidencyRheumatology - Research Institute of Rheumatic Diseases, Piestany, Slovakia FellowshipPostdoctoral Fellow in Hematology, The Children's Hospital of Philadelphia ,Division of Hematology, Philadelphia, PAPostdoctoral Fellow in Autoimmunity - Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel Graduate DegreePhD in Internal Medicine - Commenius University, Bratislava, Slovakia Titles and Academic Titles ResearcherResearch Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania Departments and Services Division of Hematology Publications Papers2016 Khandelwal S, Lee GM, Hester CG, Poncz M, McKenzie S, Sachais BS, Rauova L, Kelsoe G, Cines DB, Frank M, Arepally GM: The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21). Blood July 2016 Notes: epub ahead of print. Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M and Rauova L: Platelet transactivation by monocytes promotes the prothrombotic state in heparin-induced thrombocytopenia. Blood 127(4): 464, Feb 2016. Parker ZF, Rux AH, Riblett AM, Lee FH, Rauova L, Cines DB, Poncz M, Sachais BS, Doms RW.: Platelet-Factor 4 (PF4) inhibits and enhances HIV-1 infection in a concentration-dependent manner by modulating viral attachment. AIDS Res Hum Retroviruses Feb 2016 Notes: Epub ahead of print. 2015 Zhou J, Wu Y, Wang L, Rauova L,Hayes VM, Poncz M, and Essex DW: The second CGHC motif of protein disulfide isomerase mediates thrombosis. Journal of Clinical Investigation 25(12): 4391, Nov 2015. Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB, Greene MI: Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nature Communications 6(8277): 9277, Sep 2015. Joglekar M, Khandelwal S, Cines DB, Poncz M, Rauova L, Arepally GM.: Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. J Thromb Haemost. 13(8): 1416-27, Aug 2015. 2014 Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW.: The disulfide isomerase ERp57 is required for fibrin deposition in vivo. J Thromb Haemost 12(11): 1890-1897, Nov 2014. Skewis LR, Lebedeva T, Papkov V, Thayer EC, Massefski W, Cuker A, Nagaswami C, Litvinov RI, Kowalska MA, Rauova L, Poncz M, Weisel JW, Lowery TJ, Cines DB: T2 Magnetic Resonance: A Diagnostic Platform for Studying Integrated Hemostasis in Whole Blood-Proof of Concept. Clin Chem 60(9): 1174-82, September 2014. Cuker A, Rauova L, Bolgiano D, Matthai WH Jr, Poncz M, Konkle BA.: Atherosclerosis is not a risk factor for anti-platelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery. Thromb Haemost 111(6): 1191-3, Jun 2014. Cines DB, Lebedeva T, Nagaswami C, Hayes V, Massefski W, Litvinov RI, Rauova L, Lowery TJ, Weisel JW.: Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin. Blood 123(10): 1596-1603, Mar 2014. BooksChapters 2012 Rauova L, Arepally GM, Cines DB, Poncz M: Cellular and molecular immunopathogenesis of heparin induced thrombocytopenia. Heparin Induced Thrombocytopenia 5th Ed. Theodore E Warkentin and Andreas Greinacher (eds.). Informa Healthcare, Page: 230-251, Oct 2012. Arepally GM, Sachais BS , Cines DB , Poncz M , Rauova L, McKenzie SM: : Murine models of heparin-induced thrombocytopenia. Heparin Induced Thrombocytopenia 5th Ed. Theodore E Warkentin and Andreas Greinacher (eds.). Informa Healthcare, Page: 252-71, Oct 2012. 2002 Gilburd B, Rauova L, Nesher Y, Shoenfeld Y. : Evaluation study on a new anti-ß2-glycoprotein I screening EIA. Autoantigens and Autoantibodies: Diagnostic Tools and Clues to Understanding Autoimmunity. K. Conrad, R.-L. Humbel, M. Meurer, Y. Shoenfeld, E. M. Tan. (eds.). Pabst Science Publishers, 2002. 2001 Rauova L, Chapman J, and Shoenfeld Y: Brain vasculitis and antiphospholipid syndrome. Brain Disease: Therapeutic Strategies and Repair. Oded Abramsky, D Alastair S Compston, Ariel Miller, Gerard Said (eds.). Taylor & Francis, A Martin Dunitz Book, Page: 193, 2001. 2000 Rauova L.: [Primary Immunodeficiency Syndromes]. Klinicka reumatologia [Clinical Rheumatology]. Rovensky J. and Pavelka K. (eds.). Osveta Martin Page: 629-635, 2000 Notes: In Slovak. Rauova L, Rovensky J: [Immunodeficiency and Arthritis]. Klinicka reumatologia [Clinical Rheumatology]. Rovesnky J. and Pavelka K. (eds.). Osveta Martin 2000, Page: 635-641, 2000 Notes: In Slovak. 1993 Rovensky J, Pekarek J, Lukac J, Rauova L, Niepel G, Cech K, Blazickova S: Immunoterapeutische Beeinfussung verschiedener Vaskulitisformen. Erkrankungen mit Immunpathogenese. Neue Therapiemöglichkeiten. Metzner, G., Wissler, J. H. (eds.). München, Bern, Wien, New York, W. Zuckschwerdt Verlag Page: 89-93, 1993 Notes: In German. 1991 Rauova, L., Pekarek, J. : DLE in the therapy of juvenile chronic arthritis. Recent advances in Transfer Factor and Dialyzable Leukocyte Extracts. Fujisawa T, Saskawa S, Iikkura Y, Komatsu F, Yamaguchi Y. (eds.). Tokyo, Japan: Maruzen Co. Ltd. Page: 323-325, 1991. Posters and Presentations2015 Junsong Zhou, Yi Wu, Lu Wang, Lubica Rauova, Vincent M Hayes, Mortimer Poncz, David W Essex: The Second CGHC Motif of Protein Disulfide Isomerase Mediates Thrombosis. Blood (ASH Annual Meeting Abstracts) 126: 3461, December 2015 Notes: Poster Presentation. Izabella Andrianova, Vincent M Hayes, Daria Madeeva, Rustem I. Litvinov, Douglas B. Cines, Mortimer Poncz, John W. Weisel, Lubica Rauova: Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia. Blood (ASH Annual Meeting Abstracts) 126: 2244, December 2015 Notes: Poster Presentation. Grace M. Lee, Manali Joglekar, Sanjay Khandelwal, Rui Qi, Lubica Rauova, Gowthami M Arepally: Characterization of Human and Murine Anti-Protamine/Heparin Antibodies. Blood (ASH Annual Meeting Abstracts) 126: 3461, December 2015 Notes: Poster Presentation. 2014 Zheng Cai, Serge V. Yarovoi, Zhiquiang Zhu, Lubica Rauova, Tatiana Lebedeva, Mortimer Poncz, Gowthami M Arepally, Douglas B. Cines, Mark I. Greene: Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT). Blood (ASH Annual Meeting Abstracts) 124(21): 465, December 2014 Notes: Oral Presentation. Yulia V. Skibo, Alia R. Fathullina, Elvira V. Romanova, Lubica Rauova, Rustem I. Litvinov: Anti-Apoptotic Effects of Platelet Factor 4 on Human T-Lymphocytes. Blood (ASH Annual Meeting Abstracts) Poster Presentation, 124(21): 1418, December 2014 Notes: Poster. Vincent Hayes, Ian Johnston, Douglas B. Cines, Lubica Rauova, Mortimer Poncz: New Insights into the Prothrombotic State of Heparin-Induced Thrombocytopenia (HIT) Using a Novel Microfluidic System: The Endothelial Lining and "Rolling Barrage" of Activation. Blood (ASH Annual Meeting Abstracts) 124(21): 574, December 2014 Notes: Oral Presentation. Manali V. Joglekar, Sanjay Khandelwal, Mortimer Poncz, Lubica Rauova, Gowthami M Arepally: Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells. Blood (ASH Annual Meeting Abstracts) 124(21): 4197, December 2014 Notes: Poster Presentation. Daria Madeeva, Valerie Tutwiler, Douglas B. Cines, Mortimer Poncz, Lubica Rauova: FcγRIIA Mediates the Prothrombotic Role of Monocytes in HIT. Blood (ASH Annual Meeting Abstracts) 124(21): 575, December 2014 Notes: Oral Presentation. Awards and Honors 2005, ASH Travel Award2003-2005, American Heart Association Postdoctoral Fellowship Research Award2003, ASH Travel Award1992, Slovak Medical Society Award for the best publication in Rheumatology1991, Slovak Medical Society Award for the best publication in immunology1985, Pathophysiology Department Award, School of Medicine, University of J.E. Purkyne, Brno Editorial and Academic Positions Editorial Positions Reviewer 2016-present, Science Translational Medicine2015-present, Biosensors2014-present, Hematology Reports2013-present, J Thromb Haemost2010-present, Platelets2008-present, Blood Leadership and Memberships Memberships in Professional Organizations International 2009-present, International Society of Thrombosis and Hemostasis (member) National 2013-present, American Heart Association- 2015-present, AHA Peer Review Committee on Thrombosis BSci 2006-present, American Society of Hematology- 2015-present, Scientific Committee on Thrombosis & Vascular Biology 2002-present, Slovak Medical Chamber (member) 1990-present, Slovak Rheumatology Society (member) 1989-present, Slovak Immunology Society 1988-present, Slovak Medical Society Patient Experience Ratings About the Patient Experience Rating System The Patient Experience Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. 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