Dr. Sengupta is a neonatologist and physician scientist with a long-standing interest in lung health. She studies the mechanisms of circadian regulation of lung inflammation, injury, and repair; and the effect of early life exposures on development and function of pulmonary circadian networks in adulthood.

Expanded bio.

Education and Training

Medical School

MB, BS - All-India Institute of Medican Sciences, New Delhi, India


Pediatrics - University of Buffalo, State University of New York, Buffalo, NY


Neonatology - The Children's Hospital of Philadelphia, Philadelphia, PA

Graduate Degree

MPH - Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

Titles and Academic Titles

Attending Neonatologist

Assistant Professor, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Stefanovski D, Tapia IE, Lioy J, Sengupta S, Mukhopadhyay S, Corcoran A, Cornaglia MA, Cielo CM. Respiratory indices during sleep in healthy infants: A prospective longitudinal study and meta-analysis. Sleep Med. 2022 Nov;99:49-57. doi: 10.1016/j.sleep.2022.07.010. Epub 2022 Jul 31. PMID: 35963199.


Issah Y, Naik A, Tang SY, Forrest K, Mermigos, M, Brooks TG, Lahens N, Theken KN, Sehgal A, Worthen GS, FitzGerald GA, Sengupta S.: Loss of circadian Protection against Influenza Infection in Adult mice Exposed to Hyperoxia as neonates. eLife 2021 Mar 2;10:e61241. PMCID: PMC7924938

Felt SA,Sun Y, Jozwik A, Paras A, Habibi MS, Nickle D, Anderson L, Achouri E, Feemster KM, C.rdenas AM, Turi KN, Chang M, Hartert TV, Sengupta S, Chiu C, L.pez CB.: Detection of copy-back defective viral genomes in nasal secretions predicts RSV disease2 severity in children and adults. Nature Microbiology 2021 Apr 1. doi: 10.1038/s41564-021-00882-3


Sengupta S, Brooks TG, Grant GR, FitzGerald GA.: Accounting for Time: Circadian Rhythms in the Time of COVID-19. J Biol Rhythms Sep 2020 Notes: doi: 10.1177/0748730420953335.


Sengupta S, Tang SY, Devine JC, Anderson ST, Nayak S, Zhang SL, Valenzuela A, Fisher DG, Grant GR, López CB, FitzGerald GA. Circadian control of lung inflammation in influenza infection. Nat Commun. 2019 Sep 11;10(1):4107. doi: 10.1038/s41467-019-11400-9.


Mukhopadhyay S, Sengupta S, Puopolo KM. Challenges and opportunities for antibiotic stewardship among preterm infants. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 13. pii: fetalneonatal-2018-315412. doi: 10.1136/archdischild-2018-315412. [Epub ahead of print] Review. PMID: 30425110


Sengupta S, Yang G, O'Donnell JC, Hinson MD, McCormack SE, Falk MJ, La P, Robinson MB, Williams ML, Yohannes MT, Polyak E, Nakamaru-Ogiso E, Dennery PA. The circadian gene rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med. 2016 Feb 5. pii: S0891-5849(16)00047-2. doi: 10.1016/j.freeradbiomed.2016.02.004. [Epub ahead of print]. PMID: 26855417. Read the abstract.