Christopher L. Smith, MD, PhD

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Christopher L. Smith, MD, PhD, is an attending cardiologist with the Division of Cardiology at Children's Hospital of Philadelphia.

Areas of Expertise: Developmental biology (cardiovascular and lymphatic), Interventional cardiology and lymphatic intervention
Locations: Main Hospital
Phone: 215-590-4040

Education and Training

Medical School

MD - University of Texas Southwestern Medical Center, Dallas, TX


Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA


Pediatric Cardiology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Cardiology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Graduate Degree

PhD - University of Texas Southwestern Medical Center, Dallas, TX

Titles and Academic Titles

Attending Cardiologist

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




O'Byrne ML, Kennedy KF, Steven JM, Hill KD, Chamberlain RC, Millenson ME, Smith CL, Dori Y, Gillespie MJ, Rome JJ, Glatz AC: Outcomes of Operator-Directed Sedation and Anesthesiologist Care in the Pediatric/Congenital Catheterization Laboratory: A Study Utilizing Data From the IMPACT Registry  Journal of the American Journal of Cardiology 14(4): 101-413, February 2021.

Li D, Sheppard SE, Peroutka C, Barnes C, Reid JR, Smith CL, Dori Y, Hakonarson H  : Expanded phenotypic spectrum of JAG1-associated diseases: Central conducting lymphatic anomaly with a pathogenic variant in JAG1  Clinical Genetics 2021 Notes: Online ahead of print.

Smith CL, : Liver Lymphatic Anatomy and Role in Systemic Lymphatic Disease. European Radiology Submitted 2021.


Barrera Christian A, Saul David, Rapp Jordan B, Smith Christopher L, White Ammie M, Biko David M, Otero Hansel J: Diagnostic performance of CT angiography to detect pulmonary vein stenosis in children. The international journal of cardiovascular imaging 36(1): 141-147, Jan 2020.

Smith Christopher L, Saul David, Goldfarb Samuel B, Biko David M, O'Byrne Michael L: Compression of the left mainstem bronchus by patent ductus arteriosus in neonates under consideration for ductal stenting. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Page: doi: 10.1002, Jan 2020 Notes: epub ahead of print.

Smith Christopher L, Hoffman Timothy M, Dori Yoav, Rome Jonathan J: Decompression of the thoracic duct: A novel transcatheter approach. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 95(2): E56-E61, Feb 2020.

Gokli A, Pinto E, Escobar FA, Krishnamurthy G, Smith CL, Biko DM.: Contrast-Enhanced Ultrasound: Use in the Management of Lymphorrhea in Generalized Lymphatic Anomaly. J Vasc Interv Radiol 31(9): 1511-1513, September 2020.

Pinto E, Dori Y, Smith C, DeWitt A, Williams C, Griffis H, Escobar F, Biko DM, Krishnamurthy G, Rome J, Glatz AC, Liu M, Ravishankar C, Zhang H, Taha D.: Neonatal lymphatic flow disorders: impact of lymphatic imaging and interventions on outcomes. J Perinatol September 2020.

Mejia EJ, Otero HJ, Smith CL, Shipman M, Liu M, Pinto E, DeWitt A, Rome JJ, Dori Y, Biko DM.: Use of Contrast-Enhanced Ultrasound to Determine Thoracic Duct Patency. J Vasc Interv Radiol 31(10): 1670-1674, October 2020.

Dori Y, Smith CL, Pinto E, Snyder K, March M, Hakonarson H, Belaso J.: Severe Lymphatic Disorder Resolved with MEK Inhibition in a Noonan Patient with SOS1 Mutation. Pediatrics 146(6): e20200167, December 2020.

O'Byrne ML, Huang J, Asztalos I, Smith CL, Dori Y, Gillespie MJ, Rome JJ, Glatz AC  : Pediatric/Congenital Cardiac Catheterization Quality: An Analysis of Existing Metrics  JACC Cardiovascular Interventions 13(24): 2853-2864, December 2020.

Tomasulo C, Chen JM, Smith CL, Maeda K, Rome JJ, Dori Y  : Lymphatic Disorders and Management in Patients with Congenital Heart Disease  The annals of thoracic surgery(20), December 2020 Notes: Online ahead of print.

Yoav Dori, MD PhD; Chris Smith, MD PhD; Aaron G. DeWitt, MD; Abhay Srinivasan, MD; Ganesh Krishnamurthy, MD; Fernando A. Escobar, MD; David M. Biko, MD: Intramesenteric Dynamic Contrast Pediatric MR Lymphangiography: Initial Experience and Comparison with Intranodal and Intrahepatic MR Lymphangiography. European Radiology Page: In press, 2020.


Biko DM, Smith CL, Otero HJ et al. Intrahepatic dynamic contrast MR lymphangiography: initial experience with a new technique for the assessment of liver lymphatics. Eur Radiol 2019.


Song, K, Nam, YJ, Luo, X, Qi, X, Tan, W, Huang, GN, Acharya, A, Smith, CL, Tallquist, MD, Neilson, EG, Hill, JA, Bassel-Duby, R and Olson, EN. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485, 599-604, 2012. PMID:  22660318


Smith, CL, Baek SB, Sung CY, Tallquist MD “Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling” Circ Res. 108:e15-e26, 2011.  This article won a Best manuscript award from Circulation Research for July 2010 - June 2011.  PMID:  21512159


Smith, CL, Tallquist, MD.  “PDGF function in diverse neural crest cell populations.”  Cell Adhesion and Migration.19;4(4), 2010.  Review  PMID:  20657170

Wu, M, Smith, CL, Hall, JA, Lee, I, Luby-Phelps, K, Tallquist, MD.  “Epicardial spindle orientation controls cell entry into the myocardium.” Developmental Cell. 19(1):114-25, 2010.   PMID:  20643355


Mellgren, AM*, Smith, CL*, Olsen, GS, Eskiocak, B, Zhou, B, Kazi, MN, Ruiz, FR, Pu, WT, and Tallquist, MD “PDGFR signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations.” Circulation Research.103:1393-1401, 2008 epub Oct 23, 2008. *Indicates equal contribution.  PMID:  18948621


Bhat, S, Tang, L, Krueger, AD, Smith, CL, Ford, S, Dickey, LF,  and Petracek, ME    "The Fed-1 (CAUU)4 element is a  5' UTR dark-responsive mRNA instability element that functions independently of dark-induced polyribosome dissociation." Plant Molecular. Biology. 56: 761-773, 2004.  PMID:  15803413

Bunce, RA, Smith, CL, Knight, CL  "N-(nitrophenyl)benzamide and benzenesulfonamide derivatives by nucleophilic aromatic substitution." Organic Preparations and Procedures International: The New Journal for Organic Synthesis. 36: 482-487, 2004.

Bunce, RA, Smith, CL, Lewis, JR "Tetrahydro-1,5-benzoxazepines and tetrahydro-1H-1,5-benzodiazepines by a tandem reduction-reductive amination reaction" Journal of Heterocyclic Chemistry. 41:  963-970, 2004.

Posters and Presentations


Chaszczewski KJ, Linder JR, Campbell MJ, Kozyak BW, Convery M, Wang Y, Smith CL, Quartermain MD: Novel Utilization of Ultrasound Enhancing Agents Following Superior Cavopulmonary Connection. American Society of Echocardiography, Virtual Conference, Poster Presentation June 2021.


Tomasulo CE, Dori Y and Smith CL: Outcomes After Lymphatic Intervention for Hepatopulmonary Connections. Society for Cardiovascular Angiography and Interventions (SCAI), Virtual Presention 2020.

Tomasulo CE, MD; Dori Y, PhD; Saravanan M, BS; Smith CL: Intramesenteric lymphatic imaging in patients with congenital heart disease. Pediatric and Adult Interventional Cardiac Symposium, Virtual Meeting 2020.

Zviman MM, Smith CL, Teson J, Birati E and Dori Y: Central Lymphatic Dysfunction is a Contributing Cause of Tissue Congestion in Heart Failure. American Heart Association, Virtual Presentation 2020.


Smith CL. Decompression of the Thoracic Duct:  A Novel Transcatheter Approach in a Patient with an LSVC to Atretic Coronary Sinus, SCAI Fall Fellows course, Las Vegas, NV, December 7-11, 2018.

Invited Lectures


Smith CL. "Challenges and Opportunities in Developing Catheter-based Lymphatic System Interventions" Cardiology 2021 Virtual Conference. Feb 20210.


Smith CL. "Extending Beyond Plastic Bronchitis and protein losing enteropathy", Pediatric and Adult Interventional Cardiac Symposium (PICS-AICS) Virtual Conference. Sept 2020.


Smith CL. "Liver lymphatics in development of chylothorax, plastic bronchitis, ascites, and protein losing enteropathy", World Congress of lymphology, Buenos Aires, Argentina. Sept 2019.

Smith CL. "Is Lymphatics Functional Failure Involved in Ascites Formation Due to Right Heart Failure?" North American Vascular Biology Organization, Austin, TX. June 2019.

Awards and Honors

2020, Kleinman Award, Pediatric and Adult Interventional Cardiac Symposium (PICS-AICS)
2016, Physician Partnering Award (cardiac center nomination)
2013, Kurt Ian Wey, M.D. Pediatrics Award (Outstanding Senior award in Pediatrics)
2012, Alpha Omega Alpha Medical Honor Society
2011, Best Manuscript Award from the Journal of Circulation Research
2010, Top 5 GSO poster session finalist
2009, Ruth L. Kirschstein NRSA, NIH Individual Fellowship (F30)
2009, American Heart Association Predoctoral Fellowship
2008, Cardiology Institutional Training Fellowship
2004, Honors College Degree – Arts and Sciences
2004, Honors College Degree – Agricultural Science and Natural Resources
2004, Outstanding Senior Award in Chemistry
2004, Chemistry Departmental Honors Award, OSU
2004, Summa Cum Laude, Oklahoma State University
2003-2004, Tom E. Moore Outstanding Senior Scholarship, OSU
2003, Pfizer Summer Undergraduate Research Fellow
2003, Paul F. Kruse Award for Excellence in Biochemistry, OSU
2003, Biochemistry Departmental Honors Award, OSU
2002-2003, Robert Schively Chemistry Scholarship, OSU 

Leadership and Memberships

Memberships in Professional Organizations

2018-present, Society of Cardiovascular Angiography and Interventions
2016-present, American College of Cardiology

Academic and Institutional Committees

2021-present, Cardiac Center Taskforce