Kim Smith-Whitley, MD

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Kim Smith-Whitley, MD, is an attending physician in the Division of Hematology and the Former Director of the Comprehensive Sickle Cell Center at Children's Hospital of Philadelphia.

Areas of Expertise: Bone marrow failure, General hematology, Sickle cell disease
Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


Kim Smith-Whitley, MD, is an Attending Physician in the Division of Hematology and the Former Director of the Comprehensive Sickle Cell Center at Children's Hospital of Philadelphia.

Her clinical and research focus is on sickle cell survivorship: predicting and preventing long-term, chronic, and life-threatening complications of the disease. She initiated two innovative programs at CHOP:

  • A short-stay Hematology Acute Care Unit
  • The Blue Tie Tag program to recruit blood donors for pediatric transfusions

She received the 2010 Blockley-Osler Award for excellence in teaching clinical medicine at the bedside.

Education and Training

Medical School

MD - George Washington University School of Medicine, Washington, DC


Children's National Medical Center, Washington, DC


The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Hematology-Oncology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Graduate Degree

Master of Clinical Epidemiology and Biostatistics - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician, Division of Hematology

Former Director, Comprehensive Sickle Cell Center

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services




Dougherty KA, Schall JI, Bertolaso C, Smith-Whitley K, Stallings VA. Vitamin D Supplementation Improves Health-Related Quality of Life and Physical Performance in Children with Sickle Cell Disease and in Healthy Children. J Pediatr Health Care. 2020 Sep-Oct;34(5):424-434. Epub 2020 Jun 5. PMID: 32507538.

Dong A, Ghiaccio V, Motta I, Guo S, Peralta R, Freier SM, Watt A, Damle S, Ikawa Y, Jarocha D, Chappell M, Stephanou C, Delbini P, Chen C, Christou S, Kleanthous M, Smith-Whitley K, Manwani D, Casu C, Abdulmalik O, Cappellini MD, Rivella S, Breda L. 2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance. Haematologica. 2020 May 21:haematol.2019.226852. Epub ahead of print. PMID: 32439726.

Brownell JN, Schall JI, Mcanlis CR, Smith-Whitley K, Norris CF, Stallings VA. Effect of High-dose Vitamin A Supplementation in Children With Sickle Cell Disease: A Randomized, Double-blind, Dose-finding Pilot Study. J Pediatr Hematol Oncol. 2020 Mar;42(2):83-91. PMID: 31764511.

Schultz CL, Tchume-Johnson T, Jackson T, Enninful-Eghan H, Schapira MM, Smith-Whitley K. Reproductive intentions in mothers of young children with sickle cell disease. Pediatr Blood Cancer. 2020 May;67(5):e28227. Epub 2020 Feb 17. PMID: 32065500.

Kaur M, Brown M, Love TW, Thompson A, Treadwell M, Smith-Whitley K. Understanding sickle cell disease: impact of surveillance and gaps in knowledge. Blood Adv. 2020 Feb 11;4(3):496-498. PMID: 32027743.


Smith-Whitley K. Complications in pregnant women with sickle cell disease. Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):359-366. PMID: 31808864.

Stevens EM, Patterson CA, Tchume-Johnson T, Antiel RM, Flake A, Smith-Whitley K, Barakat LP. Parental Attitudes Towards Prenatal Genetic Testing For Sickle Cell Disease. J Pediatr Hematol Oncol. 2019 Nov;41(8):579-585. PMID: 31568178.

Smaldone A, Manwani D, Aygun B, Smith-Whitley K, Jia H, Bruzzese JM, Findley S, Massei J, Green NS. HABIT efficacy and sustainability trial, a multi-center randomized controlled trial to improve hydroxyurea adherence in youth with sickle cell disease: a study protocol. BMC Pediatr. 2019 Oct 15;19(1):354. PMID: 31615480.

Lee L, Smith-Whitley K, Banks S, Puckrein G. Reducing Health Care Disparities in Sickle Cell Disease: A Review. Public Health Rep. 2019 Nov/Dec;134(6):599-607. Epub 2019 Oct 10. PMID: 31600481.

Allen KY, Jones S, Jackson T, DeCost G, Stephens P, Hanna BD, Cohen MS, Smith-Whitley K, Mercer-Rosa L, Natarajan SS. Echocardiographic Screening of Cardiovascular Status in Pediatric Sickle Cell Disease. Pediatr Cardiol. 2019 Dec;40(8):1670-1678. Epub 2019 Sep 21. PMID: 31542803.

Ruhl AP, Sadreameli SC, Allen JL, Bennett DP, Campbell AD, Coates TD, Diallo DA, Field JJ, Fiorino EK, Gladwin MT, Glassberg JA, Gordeuk VR, Graham LM, Greenough A, Howard J, Kato GJ, Knight-Madden J, Kopp BT, Koumbourlis AC, Lanzkron SM, Liem RI, Machado RF, Mehari A, Morris CR, Ogunlesi FO, Rosen CL, Smith-Whitley K, Tauber D, Terry N, Thein SL, Vichinsky E, Weir NA, Cohen RT, Klings ES. Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2019 Sep;16(9):e17-e32. PMID: 31469310.


Naik RP, Smith-Whitley K, Hassell KL, Umeh NI, de Montalembert M, Sahota P, Haywood C Jr, Jenkins J, Lloyd-Puryear MA, Joiner CH, Bonham VL, Kato GJ. Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review. Ann Intern Med. 2018 Nov 6;169(9):619-627. Epub 2018 Oct 30. PMID: 30383109.

Dougherty KA, Bertolaso C, Schall JI, Smith-Whitley K, Stallings VA. Muscle Strength, Power, and Torque Deficits in Children With Type SS Sickle Cell Disease. J Pediatr Hematol Oncol. 2018 Jul;40(5):348-354. PMID: 29621064.

Psihogios AM, Daniel LC, Tarazi R, Smith-Whitley K, Patterson CA, Barakat LP. Family Functioning, Medical Self-Management, and Health Outcomes Among School-Aged Children With Sickle Cell Disease: A Mediation Model. J Pediatr Psychol. 2018 May 1;43(4):423-433. PMID: 29048590.

Ellison AM, Smith Whitley K, Kittick M, Schast A, Norris C, Hartung H, McKnight T, Coyne E, Lavelle J. A Standardized Clinical Pathway to Decrease Hospital Admissions Among Febrile Children With Sickle Cell Disease. J Pediatr Hematol Oncol. 2018 Mar;40(2):111-115.PMID: 29252940.

Sontag MK, Sarkar D, Comeau AM, Hassell K, Botto LD, Parad R, Rose SR, Wintergerst KA, Smith-Whitley K, Singh S, Yusuf C, Ojodu J, Copeland S, Hinton CF. Case Definitions for Conditions Identified by Newborn Screening Public Health Surveillance. Int J Neonatal Screen. 2018;4(2):16. Epub 2018 May 9. PMID: 29862374.


Hulihan M, Hassell KL, Raphael JL, Smith-Whitley K, Thorpe P. CDC Grand Rounds: Improving the Lives of Persons with Sickle Cell Disease. MMWR Morb Mortal Wkly Rep. 2017 Nov 24;66(46):1269-1271. PMID: 29166365.

Panepinto JA, Paul Scott J, Badaki-Makun O, Darbari DS, Chumpitazi CE, Airewele GE, Ellison AM, Smith-Whitley K, Mahajan P, Sarnaik SA, Charles Casper T, Cook LJ, Leonard J, Hulbert ML, Powell EC, Liem RI, Hickey R, Krishnamurti L, Hillery CA, Brousseau DC; Pediatric Emergency Care Applied Research Network (PECARN). Determining the longitudinal validity and meaningful differences in HRQL of the PedsQL™ Sickle Cell Disease Module. Health Qual Life Outcomes. 2017 Jun 12;15(1):124. PMID: 28606098.

Antiel RM, Halpern SD, Stevens EM, Vrecenak JD, Patterson CA, Tchume-Johnson T, Smith-Whitley K, Peranteau WH, Flake AW, Barakat LP. Acceptability of In Utero Hematopoietic Cell Transplantation for Sickle Cell Disease. Med Decis Making. 2017 Nov;37(8):914-921. Epub 2017 May 10. PMID: 28490230.


Bride KL, Vincent T, Smith-Whitley K, Lambert MP, Bleesing JJ, Seif AE, Manno CS, Casper J, Grupp SA, Teachey DT. Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial. Blood. 2016 Jan 7;127(1):17-28.