Background

Dr. Lakshmi Srinivasan is an attending physician in the Division of Neonatology and the Pediatric Sepsis Program at Children’s Hospital of Philadelphia, and the Neonatal Intensive Care Units (NICUs) at Children’s Hospital of Philadelphia and Hospital of University of Pennsylvania.

Dr. Srinivasan attended medical school at Madras Medical College in Chennai, India. After receiving training in Pediatrics at Children’s Hospital of Michigan, she completed her neonatal-perinatal medicine fellowship at Children’s Hospital of Philadelphia. She joined the faculty of the Division of Neonatology after graduation from fellowship, and went on to complete a Masters in Translational Research with an emphasis on design and conduct of patient oriented research studies. Her specific areas of interest include improving sepsis recognition and response in the NICU discovery of biomarker signatures for neonatal sepsis.

Dr. Srinivasan is the CHOP physician leader hospital-wide for prevention of Central Line Associated Bloodstream infections (CLABSI). She also heads the CHOP NICU sepsis quality improvement workgroup, and has successfully led improvement work standardizing the response to sepsis and timely antibiotic administration in the NICU. She is currently guiding the development of a sepsis pathway to improve recognition and management of late-onset sepsis in the CHOP NICU. Along with Dr. Harris, she co-leads the NICU sepsis registry project (an ongoing automated repository of  clinical data surrounding sepsis evaluations in the NICU), and is a co-investigator on the project led by Drs. Harris and Grundmeier to develop an early warning system utilizing the NICU sepsis registry.

Her translational research investigations of biomarkers have included testing of broad range 16s rRNA bacterial PCR for diagnosis of neonatal infections, and development of diagnostic signatures using cytokines and Damage Associated Molecular Patterns. She has performed a pilot gene expression profiling study to better understand genetic risk and expression in neonatal sepsis. She was the lead investigator of the first genome-wide-association study of neonatal sepsis, performed through the NICHD Neonatal Research Network. She is presently performed a metaHer current research involves the investigation of integrated “omics” approaches for identification of diagnostic and prognostic tools in neonatal diseases. To this end, she is validating pilot data on transcriptomic profiles in neonatal sepsis, and embarking on a concurrent investigation of the metabolome in neonatal sepsis.

Education and Training

Medical School

MBBS - Madras Medical College, Chennai, India

Internship

Rotating Internship - Government General Hospital, Chennai, India

Residency

Pediatrics - Children's Hospital of Michigan, Detroit, MI

Fellowship

Neonatal-Perinatal Medicine - The Children's Hospital of Philadelphia, Philadelphia, PA

Additional Training

Clinical Research Certificate, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania

Patient Oriented Research Training Program - Institute for Translational Medicine and Therapeutics, University of Pennsylvania

Board Certification

Neonatal-Perinatal Medicine
Pediatrics

Graduate Degree

Masters in Translational Research - Institute for Translational Medicine and Therapeutics, University of Pennsylvania

Titles and Academic Titles

Attending Neonatologist

Departments and Services

Publications

Papers

2020

Gordon SM, Srinivasan L, Taylor DM, Master SR, Tremoglie, MA, Hankeova A, Flannery DD, Abbasi S, Fitzgerald JC, Harris MC. Derivation of a metabolic signature associated with bacterial meningitis in infants. 2020. Pediatr Res. 88, 184–191. https://doi.org/10.1038/s41390-020-0816-7

Gordon SM, Srinivasan L and Harris MC. Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics. 2017. Front. Pediatr. 5:139. https://doi.org/10.3389/fped.2017.00139

Coggins S, Harris MC, Grundmeier R, Kalb E, Nawab U, Srinivasan L. Performance of Pediatric Systemic Inflammatory Response Syndrome and Organ Dysfunction Criteria in Late-Onset Sepsis in a Quaternary Neonatal Intensive Care Unit: A Case-Control Study. J Pediatr. 2020 Feb 6. pii: S0022-3476(19)31743-3. doi: 10.1016/j.jpeds.2019.12.064. PMID: 32037153.

2019

Ostapenko S, Schmatz M, Srinivasan L, Elci OU, Weiss SL, Masino AJ, Tremoglie M, Harris MC, Grundmeier RW. Neonatal sepsis registry: Time to antibiotic dataset. Data Brief. 2019 Nov 11;27:104788. doi: 10.1016/j.dib.2019.104788. eCollection 2019 Dec. PMID: 31799346

Schmatz M, Srinivasan L, Grundmeier RW, Elci OU, Weiss SL, Masino AJ, Tremoglie M, Ostapenko S, Harris MC. Surviving Sepsis in a Referral Neonatal Intensive Care Unit: Association between Time to Antibiotic Administration and In-Hospital Outcomes. J Pediatr. 2019 Oct 8. pii: S0022-3476(19)31081-9. doi: 10.1016/j.jpeds.2019.08.023. [Epub ahead of print] PMID: 31604632 [PubMed - as supplied by publisher]

Masino AJ, Harris MC, Forsyth D, Ostapenko S, Srinivasan L, Bonafide CP, Balamuth F, Schmatz M, Grundmeier RW. Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data. PLoS One. 2019 Feb 22;14(2):e0212665. doi: 10.1371/journal.pone.0212665. eCollection 2019.

2018

Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris MC. Elevations of novel cytokines in bacterial meningitis in infants. PLoS One. 2018 Feb; 13(2):e0181449.

2017

Gordon SM, Srinivasan L, Harris MC. Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics. Front Pediatr. 2017 Jun; 5:139.

Srinivasan L, Page G, Kirpalani H, Murray JC, Das A, Higgins RD, Carlo WA, Bell EF, Goldberg RN, Schibler K, Sood BG, Stevenson DK, Stoll BJ, Van Meurs KP, Johnson KJ, Levy J, McDonald SA, Zaterka-Baxter KM, Kennedy KA, Sánchez PJ, Duara S, Walsh MC, Shankaran S, Wynn JL, Cotten CM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed. 2017 Mar 10. pii: fetalneonatal-2016-311545. [Epub ahead of print]

Srinivasan L, Swarr DT, Sharma M, Cotten CM, Kirpalani H.: Systematic Review and Meta-analysis: Gene Association Studies in Neonatal Sepsis. Am J Perinatol. 2017 Jun; 34(7):684-692.

2016

Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris MC. Cerebrospinal fluid cytokines in the diagnosis of bacterial meningitis in infants. Pediatr Res. 2016 Oct;80(4):566-72. doi: 10.1038/pr.2016.117. Epub 2016 May 26.

2014

Padula, MA; Dewan, ML; Shah, SS; Padula, AM; Srinivasan, L; McGowan, KL; Mahoney, KR; Harris, MC. Risk Factors Associated with Laboratory-confirmed Bloodstream Infections in a Tertiary Neonatal Intensive Care Unit. Pediatr Infect Dis J. 2014 Oct. 33 (10):1027-1032.

2013

Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, et a. Novel FOXF1 Mutations in Sporadic and Familial Cases of Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins Imply a Role for its DNA Binding Domain. Hum Mutat. 2013 Jun;34(6)801-11.

Srinivasan L, Shah SS, Abbasi S, Padula MA, Harris MC. Traumatic Lumbar Punctures in Infants Hospitalized in the Neonatal Intensive Care Unit. Pediatr Infect Dis J. 2013 Apr 25.

Srinivasan L, Harris MC, Shah SS. Lumbar puncture in the neonate: challenges in decision-making and interpretation. Semin Perinatol. 2012 Dec;36(6):445-53.

2012

Srinivasan L, Harris MC, Shah SS. Lumbar puncture in the neonate: challenges in decision-making and interpretation. Semin Perinatol 2012. Dec; 36(6): 445-453.

Srinivasan L, Pisapia JM, Shah SS, Halpern CH, Harris MC.
Can broad-range 16S ribosomal ribonucleic acid gene polymerase chain reactions improve the diagnosis of bacterial meningitis? A systematic review and meta-analysis. Ann Emerg Med. 2012 Nov; 60(5):609-620.e2.

Srinivasan L, Shah SS, Padula MA, Abbasi S, McGowan KL, Harris MC. Cerebrospinal fluid reference ranges in term and preterm infants in the neonatal intensive care unit. J Pediatr. 2012 Oct; 161(4):729-34.

Srinivasan L, Harris MC: New technologies for the rapid diagnosis of neonatal sepsis. Curr Opin Pediatr. 2012 Apr; 24(2): 165-171.

2011

Lorch SA, Srinivasan L, Escobar GJ. Epidemiology of apnea and bradycardia resolution in premature infants. Pediatrics. 2011 Aug; 128(2):e366-73.

Books

Chapters

2017

Srinivasan L, Evans JE.: Healthcare Associated Infections in the Nursery.  Avery's Diseases of the Newborn 10th ed. 2017.

Srinivasan L, Harris MC, Kilpatrick L.: Cytokines and Inflammatory Response in the Fetus and Neonate. Polin, Abman, Rowitch, Benitz and Fox, Fetal and Neonatal Physiology 5th ed. 2017.

Posters and Presentations

2018

Kalb E, Coggins S, Harris MC, Ursula Nawab, Grundmeier R, Srinivasan L: Applicability of systemic inflammatory response syndrome (SIRS) and severe sepsis definitions to late onset infections in a quaternary NICU. (Poster presentations at Society for Pediatric Research, Toronto, Canada 2018 and Eastern Society for Pediatric Research, Philadelphia 2018).

Schmatz M, Srinivasan L, Grundmeier R, Ostapenko S,  Chilutti M, Harris MC: Surviving Sepsis in the NICU: Delayed Antimicrobial Therapy Worsens Outcomes. (Poster presentations at Society for Pediatric Research, Toronto, Canada 2018 and Eastern Society for Pediatric Research, Philadelphia 2018).

Coggins S, Kalb E, Harris MC, Nawab U, Grundmeier R, Srinivasan L: Factors associated with delayed recognition of sepsis in a quarternary NICU. (Poster presentation at Eastern Society for Pediatric Research, Philadelphia 2018).

2017

Wu K, Srinivasan L, NICU Sepsis Workgroup at Children's Hospital of Philadelphia: Decreasing time to antibiotics in the neonatal intensive care unit. (Poster presentation at Eastern Society for Pediatric Research, Philadelphia, PA 2017).

Schmatz M, Srinivasan L, Davis D, Grundmeier G, Ostapenko S, Chilutti M, Harris M C: Culture Negative Sepsis in the NICU: What Drives the Decision to Extend Antibiotics? (Poster presentation at Society for Pediatric Research, San Francisco, CA 2017 and Eastern Society for Pediatric Research, Philadelphia, PA 2017).

Flannery D, Srinivasan L, Davis D, Schmatz M, Harris M C.: Challenges in Early recognition of Neonatal Fungal Sepsis. (Poster presentation at Society for Pediatric Research, San Francisco, CA 2017 and Eastern Society for Pediatric Research, Philadelphia, PA 2017).

Barkwell V, Bezpalko O, Frye A, Gibbons MA, Powell S, Snyder M, Srinivasan L. Using a Bundle Element Approach in Pediatric Central Line-Associated Bloodstream Infections: Focus on CHG Bathing.  (Poster presentation at Solutions for Patient Safety, Dallas, TX 2017).

2016

Wu K, Srinivasan L, NICU Sepsis Workgroup at Children's Hospital of Philadelphia: Decreasing time to antibiotics in the neonatal intensive care unit. (Poster presentation at Institute for Healthcare Improvement, Orlando, FL 2016).

Srinivasan L, Watson D, Zhang Z, Rappaport E, Harris MC. : Gene Expression Profiling in Diagnosis of Neonatal Sepsis. (Poster presentation at Society for Pediatric Research, Baltimore, MD 2016 and Eastern Society for Pediatric Research, Philadelphia, PA 2016).

Schmatz M, Srinivasan L, Tremoglie M, Grundmeier R, Perez A, Ostapenko S, Chilutti M, and Harris MC: Improvements in Timing of Antibiotic Administration in a Quaternary Care NICU: A One Year Perspective. (Poster presentation at Society for Pediatric Research, Baltimore, MD 2016 and Eastern Society for Pediatric Research, Philadelphia, PA 2016).

Schmatz M, Srinivasan L, Grundmeier R, Tremoglie M, Perez A, Chilutti M, Ostapenko S and Harris MC: Antibiotic Use in the NICU: Do Comorbidities Matter? (Poster presentation at Society for Pediatric Research, Baltimore, MD 2016 and Eastern Society for Pediatric Research, Philadelphia, PA 2016).

Srinivasan L, Gerhardt K, Rowan H, Rigby V, Minich C, Bodenstab H, Hadley S, Masten M, Schmucker K, Dysart K, Chuo J, Harris MC, Nawab U ,Munson D.  : Improving Time to Antibiotic Administration During Sepsis Evaluations in the NICU: Adopting a Culture of Urgency.  Poster presentation at Vermont Oxford Network, Chicago, IL 2016, Children's Hospital Neonatal Consortium, Kansas, MO 2016 and platform presentation at Patient Safety and Quality Day, Children's Hospital of Philadelphia, Philadelphia, PA 2016).

Gordon SM, Srinivasan L, Abbasi S, Perez A, Tremoglie M and Harris MC: Analysis of Cerebrospinal Fluid Reveals Derangement of Metabolism in Infants with Bacterial Meningitis. Society for Pediatric Research 2016 (Poster presentation at Society for Pediatric Research, Washington, DC 2016 and Eastern Society for Pediatric Research, Philadelphia, PA 2016).

Barkwell V, Bezpalko O, Frye A, Gibbons MA, Powell S, Snyder M, Srinivasan L.Using a Bundle Element Approach in Pediatric Central Line-Associated Bloodstream Infections. (Poster presentation at Institute for Healthcare Improvement, Orlando, FL 2016 and Patient Safety and Quality Day, Children's Hospital of Philadelphia, Philadelphia, PA 2016).

2015

Schmatz M, Srinivasan L, Grundmeier R, Chilutti M, Monk H, Ostapenko S, Perez A, Tremoglie M, Harris MC: Automated Neonatal Sepsis Registry: A Novel Approach to Understand Clinical Practice and Sepsis Related Outcomes. (Poster presentation at Society for Pediatric Research 2015).

Schmatz M, Perez A, Srinivasan L, Tremoglie M,  Ostapenko S, Grundmeier R, Chilutti M, Harris MC. Timing of antibiotic administration in neonatal sepsis: evaluating current practice and initiating quality improvement.  (Poster presentation at American Academy of Pediatrics, Washington, DC 2015).

Invited Lectures

2018

Srinivasan, L. “Sepsis Management in the NICU: adopting a culture of urgency”. Invited presentation (webinar) to New Jersey Health Association and the New Jersey Sepsis Learning Action Collaborative, Jan 2018.

2017

Srinivasan L. “Quality Improvement Strategies to Reduce Late-onset Infections in the NICU.” Invited presentation at joint EBNEO 2017 and Indian Academy of Pediatrics Neonatology conference (IAP Neocon) 2017, Hyderabad, India, Nov 2017.

Srinivasan L. “Culture negative sepsis: how much fact and how much fiction?” Invited presentation at Indian Academy of Pediatrics Neonatology conference (IAP Neocon) 2017 workshop on Neonatal Infections, Hyderabad, India, Nov 2017.

Srinivasan, L. "Pause, Reflect, Go: Developing a CLABSI site visit strategy for internal assessment and external learning." Invited presentation (leader of 3 hour breakout session) at the Solutions for Patient Safety National Conference, Dallas, TX, May 2017.

Srinivasan, L. "CLABSI Prevention: a revised approach and benchmarking summary." Invited presentation at the Solutions for Patient Safety Regional Conference, Children's Hospital of Pittsburgh, Pittsburgh, PA, Apr 2017.

2016

Srinivasan, L. "Improving Time to Antibiotic Administration During Sepsis Evaluations in the NICU: Adopting a Culture of Urgency." Invited presentation as a Top Ten finalist at Patient Safety and Quality Day, Children's Hospital of Philadelphia, Philadelphia, PA, May 2016

Awards and Honors

2017, Young Investigator Travel grant award, Perinatal Research Society

2016, Inducted as member, Society for Pediatric Research

2014, Faculty Honor Roll, Children’s Hospital of Philadelphia

2013, Faculty Honor Roll, Children’s Hospital of Philadelphia

2011, Junior Investigator Pilot Grant Award, Clinical and Translational Research Center and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania

2011, Foerderer Awards for Excellence, Children's Hospital of Philadelphia

2010, Institute for Translational Medicine and Therapeutics scholarship, University of Pennsylvania

2010, Travel Grant, American Academy of Pediatrics

2009, Travel Grant, Pediatric Academic Societies

2009, Travel Grant, Eastern Society for Pediatric Research

2007, Best Graduating Pediatric Critical Care Medicine Resident, Children's Hospital of Michigan, Detroit, MI

2006, Outstanding Pediatric Critical Care Medicine Resident, Children's Hospital of Michigan, Detroit, MI

2005, Travel Grant as AAP Resident Representative for the Children's Hospital of Michigan, American Academy of Pediatrics

2005, Tina Kelley Award for Pediatric Intern of the Year, Children's Hospital of Michigan, Detroit, MI

2002, Balfour Memorial Medal for Excellence in Obstetrics and Gynecology, Madras Medical College, Chennai, India

2002, Gangadram Prize in Obstetrics and Gynecology, Madras Medical College, Chennai, India

2001, Dr. Venugopal Silver Medal in Urology, Madras Medical College, Chennai, India

2000, Dr. Govindareddy Gold Medal in Pathology, Madras Medical College, Chennai, India

2000, Dr. Govindarajan Prize in Microbiology, Madras Medical College, Chennai, India

1999, Biochemistry Prize, Madras Medical College, Chennai, India

1997, Department of Biotechnology Award, Government of India

1996-1998, National Talent Scholarship, Government of India

Editorial and Academic Positions

Editorial Positions

Ad hoc Reviewer

British Medical Journal
Pediatrics
Journal of the Pediatric Infectious Diseases Society
Journal of Perinatology
Pediatric Research

Academic and Institutional Committees

2017-present, Member, Lines indicator harmonization committee

2015-present, Member and CLABSI indicator leader, Harm Prevention Program, Children's Hospital of Philadelphia

2015-present, Hospital-wide physician leader, Central Line Associated Bloodstream Infections Steering Committee, Children's Hospital of Philadelphia

2015-present, NICU team leader, CHOP Sepsis Outcomes Advisory Committee

2015-present, Member, Infection Prevention and Control Committee, The Children's Hospital of Philadelphia

2014-present, Leader, NICU Sepsis Workgroup, CHOP

2014-2017, Member, Institutional Review Board (Committee 6), University of Pennsylvania

2014-2015, NICU Fellowship Clinical Competency Committee

2012-present, Member, CHOP Sepsis Governance Committee

Leadership and Memberships

Memberships in Professional Organizations

2017, Member, Perinatal Research Society
2016, Member, Society for Pediatric Research
2015, Member, Eastern Society for Pediatric Research
2011-present, Associate member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania.
2007-present, Fellow, American Academy of Pediatrics