Stanley J. Stachelek, PhD
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PhD in Physiology - University of Massachusetts, Amherst, MA
Post-doctoral Fellow - The Children's Hospital of Philadelphia, Philadelphia, PA
Assistant Director, Cardiology NHLBI Training Program
Research Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Inamdar Vaishali V, Fitzpatrick Emmett, Alferiev Ivan, Nagaswami Chandrasekaran, Spruce Lynn A, Fazelinia Hossein, Bratinov George, Seeholzer Steven H, Levy Robert J, Fishbein Ilia, Stachelek Stanley J: Stability and bioactivity of pepCD47 attachment on stainless steel surfaces. Acta Biomaterialia 104: 231-240, Mar 2020.
Zhang Q, Stachelek SJ, Inamdar VV, Alferiev I, Nagaswami C, Weisel JW, Hwang JH, Meyerhoff ME: Studies of combined NO-eluting/CD47-modified polyurethane surfaces for synergistic enhancement of biocompatibility. Colloids and Surfaces B: Biointerfaces. Elsevier, 192: 111060, April 2020 Notes: Co-first author and corresponding author.
Slee JB, Alferiev IS, Nagaswami C, Weisel JW, Levy RJ, Fishbein I, Stachelek SJ: Enhanced biocompatibility of CD47-functionalized vascular stents. Biomaterials 87: 82-92, May 2016.
Josh Slee, Ivan Alferiev, Robert J. Levy, Stanley J. Stachelek: The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits. Journal of Visualized Experiments 90(1): e51871, Oct 2014.
Lee H-S, Stachelek SJ, Tomczyk N, Finley MJ, Composto RJ, Eckmann DM: Correlating macrophage morphology and cytokine production resulting from biomaterial contact. Journal of Biomedical Materials Research 101(1): 203-212, January 2013.
Finley MJ, Clark KA, Alferiev IS, Levy RJ, Stachelek SJ: Intracellular signaling mechanisms associated with CD47 modified surfaces. Biomaterials 34(34): 8640-9, Nov 2013.
Chen Chiu-Yu, Bertozzi Cara, Zou Zhiying, Yuan Lijun, Lee John S, Lu Minmin, Stachelek Stan J, Srinivasan Sathish, Guo Lili, Vincente Andres, Mericko Patricia, Levy Robert J, Makinen Taija, Oliver Guillermo, Kahn Mark L: Blood flow reprograms lymphatic vessels to blood vessels. Journal of Clinical Investigation 122(6): 2006-17, Jun 2012.
Finley MJ, Rauova L, Alferiev IS, Weisel JW, Levy RJ, Stachelek SJ. : Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces. Biomaterials 33(24): 5803-5811, August 2012.
Tsai IY, Kao C-C, Tomckzac N, Stachelek SJ, Composto RJ, Eckmann DM: Human macrophage adhesion on polysaccharaide patterned surfaces. Soft Matter 1(7): 3599-3606, January 2011.
Stachelek SJ*, Finley MJ, Alfereiev IS, Wang F, Tsai R, Eckells EC, Tomckzac N, Connolly JM, Discher DE, Eckmann DM, Levy RJ: The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials. Elsevior, 32(19): 4317-26, July 2011.
Masako Ueda, Ivan Alferiev, Stacey Simons, Robert P. Hebbel, Robert J. Levy, Stanley J. Stachelek: CD47-Dependent Molecular Mechanisms of Blood Outgrowth Endothelial Cell Attachment on Cholesterol-Modified Polyurethane. Biomaterials 31(25): 6394-9, September 2010.
Stanley J. Stachelek, Ivan Alferiev, Masako Ueda, Edward C. Eckels, Kevin T. Gleason, Robert J. Levy. (Corresponding author) : Prevention of polyurethane oxidative degradation with phenolic antioxidants covalently attached to the hard segments: structure function relationships. Journal of Biomedical Materials Research 3(94): 751-9, September 2010.
Uttayarat P, Perets A, Li M, Pimton P, Stachelek SJ, Alferiev I, Composto RJ, Levy RJ, Lelkes PI: Micropatterning of three-dimensional electrospun polyurethane vascular grafts. Acta Biomaterialia 6(11): 4229-37, November 2010.
Ilia Fishbein, Ivan Alferiev, Marina Bakay, Stanley J. Stachelek, Peter Sobolewski, Meizan Lai, Hoon Choi, I-W Chen, Robert J. Levy: Local Delivery of Gene Vectors From Bare-Metal Stents by Use of a Biodegradable Synthetic Complex Inhibits In-Stent Restenosis in Rat Carotid Arteries. Circulation 117(16): 2096-103, April 2008.
Stanley J. Stachelek, Ivan Alferiev, James Fulmer, Harry Ishiropoulos, Robert J Levy.: Biological Stability of polyurethane modified with covalent attachment of di-tert-butyl-phenol. Journal of Biomedical Materials Research 82(4): 1004, Sep 2007.
Alferiev IS, Connolly JM, Stachelek SJ, Ottey A, Rauova L, Levy RJ.: Surface heparinization of polyurethane via bromoalkylation of hard segment nitrogens. Biomacromolecules 7(1): 317-22, Jan-Feb 2006.
Stachelek SJ, Alferiev I, Connolly JM, Hebbel RP, Bianco R, Levy RJ.: Cholesterol-modified polyurethane heart valve leaflets seeded with blood outgrowth endothelial cells demonstrate cellular adhesion under high shear In Vitro and In Vivo. Annals of Thoracic Surger 81(1): 47-55, Jan 2006.
Stachelek SJ, Alferiev I, Choi H, Ottey A, Levy RJ.: Prevention of oxidative degradation of polyurethane by covalent attachment of di-tert-butylphenol residues. J Biomed Mater Res A 78(4): 653, Sep 2006.
Song CX, Zhang LH, Yang J, Stachelek SJ, Levy RJ: Animal study of intravascular gene therapy based on polyurethane implantable devices. Zhongguo Yi Xue Ke XueYuan Xue Bao 28(5): 682-685, October 2006.
Farwell AP, Dubord-Tomasetti SA, Pietrzykowski AZ, Stachelek SJ, Leonard JL.: Regulation of cerebellar neuronal migration and neurite outgrowth by thyroxine and 3,3',5'-triiodothyronine. Brain Res Dev Brain Res 154(1): 121-35, Jan 2005.
Stachelek SJ, Alferiev I, Choi H, Kronsteiner A, Uttayarat P, Gooch KJ, Composto RJ, Chen IW, Levy RJ.: Cholesterol-derivatized polyurethane: characterization and endothelial cell adhesion. J Biomed Mater Res A 72A(2): 200-12, Feb 2005.
Stachelek SJ, Song C, Alferiev I, Defelice S, Cui X, Connolly JM, Bianco RW, Levy RJ.: Localized gene delivery using antibody tethered adenovirus from polyurethane heart valve cusps and intra-aortic implants. Gene Ther 11(1): 15-24, Jan 2004.
Alferiev I, Stachelek SJ, Lu Z, Fu AL, Sellaro TL, Connolly JM, Bianco RW, Sacks MS, Levy RJ.: Prevention of polyurethane valve cusp calcification with covalently attached bisphosphonate diethylamino moieties. J Biomed Mater Res A 66A(2): 385-395, Aug 2003.
Vacanti MP, Leonard JL, Dore B, Bonassar LJ, Cao Y, Stachelek SJ, Vacanti JP, O'Connell F, Yu CS, Farwell AP, Vacanti CA.: Tissue-engineered spinal cord. Transplant Proc 33(1-2): 592-8, Feb-Mar 2001.
Stachelek SJ, Tuft RA, Lifschitz LM, Leonard DM, Farwell AP, Leonard JL.: Real-time visualization of processive myosin 5a-mediated vesicle movement in living astrocytes. J Biol Chem 276(38): 35652-9, Sep 2001.
Leonard DM, Stachelek SJ, Safran M, Farwell AP, Kowalik TF, Leonard JL.: Cloning, expression, and functional characterization of the substrate binding subunit of rat type II iodothyronine 5'-deiodinase. J Biol Chem 275: 25194-25201, Aug 2000.
Stachelek SJ, Kowalik TF, Farwell AP, Leonard JL.: Myosin V plays an essential role in the thyroid hormone-dependent endocytosis of type II iodothyronine 5'-deiodinase. J Biol Chem 275: 31701-31707, Oct 2000.
Zakharchenko A, Keeney S, Stachelek S, Alferiev I, Levy R: Polymer modification of bioprosthetic heart valves to mitigate structural degeneration. American Chemical Society National Meeting; March 22-26,2020. Philadelpha, PA. Abstract 3309668 March 2020.
Inamdar VV, Fitzpatrick E, Alferiev I, Nagaswami C, Levy RJ, Fishbein I, Stachelek SJ: Enhanced Biocompatibility of Stents via CD47 Surface Functionalization. Society for Biomaterials 2019 Annual Meeting, Seattle, WA April 2019 Notes: Oral Presentation.
Zakharchenko A, Keeney S, Stachelek S, Levy R, Ferrari G.: The Pro-inflammatory Role of Advanced Glycation End Products Accumulation in Bioprosthetic Heart Valves. BMES (Biomaterial Engineering Society) Annual Meeting 2019; October 17-19, Philadelphia, PA. Poster #P-TH-440, October 2019.
Frasca A, Rock C, Keeney S, Streeter M, Kibel J, Gorman J, Gorman RC, Grau JB, Stachelek S, Levy RJ, Ferrari G.: Advanced Glycation End Products and Structural Degeneration of Bioprosthetic Heart Valves: Clinical Explant Analyses and Mechanistic Studies. Heart Valve Society Meeting, New York, NY April 2018 Notes: Poster Presentation.
Stachelek SJ. "Pediatric Cardiology Research at CHOP: Student Research Opportunities", CHOP Summer Educational Program for High School Students, Virtual. July 2020.
Stachelek SJ. "Medical Device Research in the Cardiovascular Research Group", Medtronic Academic Research Collaboration, Santa Ana, CA. Mar 2018.
2009, Finalist for the Spring 2009 QED Proof of Concept Competition hosted by the University City Science Center
2004, Outstanding Poster Fellow's Research Poster Day at The Children's Hospital of Philadelphia
2014-present, Journal of Experimental Cell Research, Reviewer
2014-present, Biomechanics and Biomaterials, Reviewer
2014-present, Journal of Materials Chemistry, Reviewer
2013-present, BioMed Research International, Editorial Board Member
2013-present, Diabetes and Vascular Disease, Reviewer
2012-present, Annals of Thoracic Surgery, Reviewer
2011-present, Cardiovascular Pathology, Reviewer
2011-present, Biomaterials, Reviewer
2011-present, Cryobiology, Reviewer
2010-present, The Protein Journal, Reviewer
2010-present, Acta Biomaterialia, Reviewer
2001-present, Journal of Biomedical Materials Research Part B: Applied Biomaterials, Reviewer
2020-present, Co-Investigator/Clinical Scientific Advisory Committee, Philadelphia Pediatric Device Consortium
2015-present, Bioengineering Graduate Group, University of Pennsylvania School of Medicine
2013-present, Clinical Scientific and Advisory Committee, Pennsylvania Pediatric Device Consortium
2012-present, Reviewer for T32 CHOP Cardiology Fellowship Applications
2001-present, Society of Biomaterials
2015-present, National Institute of Health
- 2015-present, Special Emphasis Panel ZRG1 SBIB
- 2015-present, Ad Hoc Reviewer
2011-present, American Heart Association
- 2018-present, Reviewer, Career Development Awards in Basic Science
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