Alanna Strong, MD, PhD
About Alanna Strong
Titles
Attending Physician
Awards and Honors
Saint Christopher’s Hospital For Children SEEDS Service Award
Junior Investigator Award for Women, ATVB 2012 Scientific Sessions
Edward Holmes Award in Bench Research – Dept. of Medicine, University of Pennsylvania
Trainee Award in Predoctoral-Translational Research, American Society of Human Genetics
Fellow, American Heart Association (AHA) Pre-doctoral Fellowship - Great Rivers Affiliate
Summa cum laude with University Honors, University of Pennsylvania
American Heart Association Grant
National Institutes of Health T32 Grant
Leadership and Memberships
Memberships in Professional Organizations
American Heart Association
American Society of Human Genetics
Education & training
Medical Degree
MD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Residency
Pediatrics - St. Christopher’s Hospital for Children, Philadelphia, PA
Fellowship
Human Genetics - Children's Hospital of Philadelphia, PA
Publications
Publications
2017
Strong A, Musunuru K. (2017) Genome editing in cardiovascular diseases. Nat Rev Cardiol. 14(1): 11-20.
2016
Strong A, Musunuru K. (2016) The (pro)renin receptor and LDL clearance: an old player joins a new game. Circ. Res.117: 187-9.
2015
Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, Millar JS, Kruth H, Rader DJ. (2015) Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis. Circ. Res. 116: 789-796
2014
Strong A, Patel K, Rader DJ. (2014) Sortilin and lipoprotein metabolism: making sense out of complexity. Curr. Opin. Lipidol. 25:350-7.
Bearden D, Strong A, Ehnot J, DiGiovine M, Dlugos D, Goldberg EM. (2014) Targeted treatment of migrating partial seizures of infancy with quinidine. Ann. Neurol. 76:457-61.
Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K. (2014) Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circ. Res. 115:488-92.
2012
Strong A, Ding Q, Edmondson AC, Millar JS, Sachs KV, Li X, Kumaravel A, Wang MY, Ai D, Guo L, Alexander ET, Nguyen D, Lund-Katz S, Phillips MC, Morales CR, Tall AR, Kathiresan S, Fisher EA, Musunuru K, Rader DJ. (2012) Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J. Clin. Invest. 122: 2807-16.
Strong A, Rader DJ (2012) Sortilin as a regulator of lipoprotein metabolism. Curr. Atheroscler. Rep. 14: 211-8.
Ai D, Baez JM, Jiang H, Conlon DM, Hernandez-Ono A, Frank-Kamenetsky M, Milstein S, Fitzgerald K, Murphy AJ, Woo CW, Strong A, Ginsberg HN, Tabas I, Rader DJ, Tall AR. (2012) Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. J. Clin. Invest. 122:1667-87.
2010
Musunuru K*, Strong A , Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ. (2010) From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466: 714-9.
Strong A, Rader DJ. (2010) Clinical Implications of Lipid Genetics for Cardiovascular Disease. Current Cardiovascular Risk Rep. 4:461-8.