Alanna Strong, MD, PhD

Alanna Strong, MD, PhD

Alanna Strong, MD, PhD, is fellow in the Division of Human Genetics at Children's Hospital of Philadelphia. 

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Residency

Pediatrics - St. Christopher’s Hospital for Children, Philadelphia, PA

Fellowship

Human Genetics - Children's Hospital of Philadelphia, PA

Titles and Academic Titles

Fellow, Human Genetics Fellowship Program

Departments and Services

Publications

Papers

2017

Strong A, Musunuru K. (2017) Genome editing in cardiovascular diseases. Nat Rev Cardiol. 14(1): 11-20. 

2016

Strong A, Musunuru K. (2016) The (pro)renin receptor and LDL clearance: an old player joins a new game. Circ. Res.117: 187-9.

2015

Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, Millar JS, Kruth H, Rader DJ. (2015) Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis. Circ. Res. 116: 789-796

2014

Strong A, Patel K, Rader DJ. (2014) Sortilin and lipoprotein metabolism: making sense out of complexity. Curr. Opin. Lipidol. 25:350-7.

Bearden D, Strong A, Ehnot J, DiGiovine M, Dlugos D, Goldberg EM. (2014)  Targeted treatment of migrating partial seizures of infancy with quinidine. Ann. Neurol. 76:457-61.

Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K. (2014) Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circ. Res. 115:488-92.

2012

Strong A, Ding Q, Edmondson AC, Millar JS, Sachs KV, Li X, Kumaravel A, Wang MY, Ai D, Guo L, Alexander ET, Nguyen D, Lund-Katz S, Phillips MC, Morales CR, Tall AR, Kathiresan S, Fisher EA, Musunuru K, Rader DJ. (2012) Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J. Clin. Invest. 122: 2807-16.

Strong A, Rader DJ (2012) Sortilin as a regulator of lipoprotein metabolism. Curr.  Atheroscler. Rep.  14: 211-8.

Ai D, Baez JM, Jiang H, Conlon DM, Hernandez-Ono A, Frank-Kamenetsky M, Milstein S, Fitzgerald K, Murphy AJ, Woo CW, Strong A, Ginsberg HN, Tabas I, Rader DJ, Tall AR. (2012) Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. J. Clin. Invest. 122:1667-87.

2010

Musunuru K*, Strong A , Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ. (2010) From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466: 714-9.

Strong A, Rader DJ. (2010) Clinical Implications of Lipid Genetics for Cardiovascular Disease. Current Cardiovascular Risk Rep. 4:461-8.

Awards and Honors

Saint Christopher’s Hospital For Children SEEDS Service Award
Junior Investigator Award for Women, ATVB 2012 Scientific Sessions
Edward Holmes Award in Bench Research – Dept. of Medicine, University of Pennsylvania
Trainee Award in Predoctoral-Translational Research, American Society of Human Genetics
Fellow, American Heart Association (AHA) Pre-doctoral Fellowship - Great Rivers Affiliate
Summa cum laude with University Honors, University of Pennsylvania
American Heart Association Grant
National Institutes of Health T32 Grant

Leadership and Memberships

Memberships in Professional Organizations

American Heart Association
American Society of Human Genetics