Evan W. Weber, PhD

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Evan W. Weber, PhD, is a cell and gene therapy researcher with the Center for Childhood Cancer Research (CCCR) and the Center for Cellular and Molecular Therapeutics (CCMT) at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training


Postdoctoral Research Fellow - Stanford University School of Medicine, Stanford Cancer Institute, Stanford, CA

Undergraduate Degree

BS in Program in the Environment (PITE) - University of Michigan, College of Literature, Science, and the Arts, Ann Arbor, MI

Graduate Degree

PhD in Immunology - Northwestern University, Feinberg School of Medicine, Chicago, IL

Additional Training

Certificate in Management for Scientists and Engineers - Northwestern University, Kellogg School of Business, Evanston, IL

Titles and Academic Titles

Cell and Gene Therapy Researcher

Assistant Professor, Department of Pediatrics, Division of Oncology, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Gennert D.G., Lynn R.C., Granja J.M., Weber E.W., Mumbach M.R., Zhao Y., Duren Z., Sotillo E., Greenleaf W.J., Wong W.H., Satpathy A.T., Mackall C.L., Chang H.Y. Dynamic chromatin regulatory landscape of human CAR T cell exhaustion. PNAS. 2021 Jul 27;118(30)

Weber E.W., Parker K.R.*, Sotillo E.*, Lynn R.C., Anbunathan H., Lattin J., Good Z., Belk J.A., Daniel B., Klysz D., Malipatlolla M., Xu P., Bashti M., Heitzeneder S., Labanieh L., Vandris P., Majzner R.G., Qi Y., Sandor K., Chen L.C., Prabhu S., Gentles A.J., Wandless T.J., Satpathy A.T., Chang H.Y., Mackall C.L. Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. 2021. Science. Apr 2;372(6537):eaba1786


Lamarche C., Novakovsky G.E., Qi C.N., Weber E.W., Mackall C.L., Levings M.K. Repeated stimulation or tonicsignaling chimeric antigen receptors drive regulatory T cell exhaustion. bioRxiv 2020.06.27.175158

Dalal P., Sullivan D.P., Weber E.W., Sacks D., Gunzer M., Grumbach I, Brown J.H., Muller W.A. Spatiotemporal Restriction of Calcium Signaling in Endothelial Cells during Leukocyte Transmigration. 2020. J Exp Med. 218 (1): e20192378

Majzner R.G., Rietberg S., Sotillo E., Dong R., Vachharajani V., Labanieh L., Myklebust J., Kadapakkam M., Weber E.W., Tousley A., Richards R., Heitzeneder S., Nguyen S., Wiebking V., Theruvath J., Lynn R.C., Xu P., Dunn A., Vale R.D., Mackall C.L. Tuning the Antigen Density Requirement for CAR T Cell Activity. 2020. Cancer Discov. May;10(5):702-723

Weber E.W., Maus M.V., Mackall C.L. The Emerging Landscape of Immune Cell Therapies. 2020. Cell. Apr 2;181(1):46-62.


Lynn R.C., Weber E.W.*, Sotillo E.*, Gennert D., Xu P., Good Z., Anbunathan H., Lattin J., Jones R., Tieu V., Nagaraja S., Granja J., DeBourcy C., Majzner R., Satpathy A.T., Quake S.R., Chang H.Y., Mackall C.L. c-Jun Overexpression in CAR T Cells Induces Exhaustion-Resistance. 2019. Nature. 576(7786):293-300

Weber E.W., Lynn R.C., Sotillo E., Lattin J., Xu P., Mackall C.L. Pharmacologic Control of CAR T Cell Function Using Dasatinib. 2019. Blood Adv. 3(5):711-717. NOTE: Selected by Blood Adv as “Top Influential Article” in 2020


Weber E.W. and Muller W.A. Roles of Transient Receptor Potential Channels in Regulation of Vascular and Epithelial Barriers. 2017. Tissue Barriers. e1331722.


Winger R.C., Harp C.T., Chiang M.Y., Sullivan D.P., Watson R.L., Weber E.W., Miller S.D., Muller W.A. CD99 is a novel regulator of neuroinflammation. 2016. J Immunol. 196(4):1443-8


Rutledge N.S., Weber E.W., Winger R.C., Tourtellotte W., Park S.H., Muller W.A. CD99-like 2 (CD99L2)-deficient mice are defective in transendothelial migration. 2015. Exp Mol Pathol. 99(3):455-459

Weber E.W., Han F., Tauseef M., Birnbaumer L., Mehta D., Muller W.A. TRPC6 is the Endothelial Calcium Channel That Regulates Leukocyte Transendothelial Migration During the Inflammatory Response. 2015. J Exp Med. 212:1883-1899


Moricoli D., Muller W.A., Carbonella D.C., Balducci M.C., Dominici S., Watson R., Fiori V., Weber E., Cianfriglia M., Scotlandi K., Magnani M. Blocking monocyte transmigration in in vitro system by a human antibody scFv anti-CD99. Efficient large scale purification from periplasmic inclusion bodies in E. coli expression system. 2014. J Immunol Methods. 408:35-45


Cuda,C.M., Agrawal H., Misharin A.V., Haines G.K., 3rd, Hutcheson J., Weber E., Schoenfeldt J.A., Mohan C., Pope R.M., Perlman H. Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in mice. 2012. Arthritis Rheum. 64, 808-820.

Mavers M., Cuda C.M., Misharin A.V., Gierut A.K., Agrawal H., Weber E., Novack D.V., Haines G.K., 3rd, Balomenos D., Perlman H. Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis. 2012. Arthritis Rheum. 64, 141-152.

*contributed equally

Awards and Honors

2021, Society for Immunotherapy of Cancer (SITC) Rosenberg Scholars Award
2020, First-author paper selected by Blood Advances as “Top Influential Article”
2019, First place award, Immuno-oncology Young Investigators’ Forum (by SITC)
2015, Outstanding poster award, PISA
2015, American Society for Investigative Pathology Trainee Travel Award
2014, Driskill Graduate Program Travel Award
2014, Northwestern University TGS Travel Grant
2013, American Society for Investigative Pathology Trainee Travel Award

Leadership and Memberships

Memberships in Professional Organizations

2020-present, Society for Immunotherapy of Cancer (SITC)
2020-present, American Society of Hematology (ASH)
2018-present, American Association for Cancer Research (AACR)