Evan W. Weber, PhD

Papers

2021

Gennert D.G., Lynn R.C., Granja J.M., Weber E.W., Mumbach M.R., Zhao Y., Duren Z., Sotillo E., Greenleaf W.J., Wong W.H., Satpathy A.T., Mackall C.L., Chang H.Y. Dynamic chromatin regulatory landscape of human CAR T cell exhaustion. PNAS. 2021 Jul 27;118(30)

Weber E.W., Parker K.R.*, Sotillo E.*, Lynn R.C., Anbunathan H., Lattin J., Good Z., Belk J.A., Daniel B., Klysz D., Malipatlolla M., Xu P., Bashti M., Heitzeneder S., Labanieh L., Vandris P., Majzner R.G., Qi Y., Sandor K., Chen L.C., Prabhu S., Gentles A.J., Wandless T.J., Satpathy A.T., Chang H.Y., Mackall C.L. Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. 2021. Science. Apr 2;372(6537):eaba1786

2020

Lamarche C., Novakovsky G.E., Qi C.N., Weber E.W., Mackall C.L., Levings M.K. Repeated stimulation or tonicsignaling chimeric antigen receptors drive regulatory T cell exhaustion. bioRxiv 2020.06.27.175158

Dalal P., Sullivan D.P., Weber E.W., Sacks D., Gunzer M., Grumbach I, Brown J.H., Muller W.A. Spatiotemporal Restriction of Calcium Signaling in Endothelial Cells during Leukocyte Transmigration. 2020. J Exp Med. 218 (1): e20192378

Majzner R.G., Rietberg S., Sotillo E., Dong R., Vachharajani V., Labanieh L., Myklebust J., Kadapakkam M., Weber E.W., Tousley A., Richards R., Heitzeneder S., Nguyen S., Wiebking V., Theruvath J., Lynn R.C., Xu P., Dunn A., Vale R.D., Mackall C.L. Tuning the Antigen Density Requirement for CAR T Cell Activity. 2020. Cancer Discov. May;10(5):702-723

Weber E.W., Maus M.V., Mackall C.L. The Emerging Landscape of Immune Cell Therapies. 2020. Cell. Apr 2;181(1):46-62.

2019

Lynn R.C., Weber E.W.*, Sotillo E.*, Gennert D., Xu P., Good Z., Anbunathan H., Lattin J., Jones R., Tieu V., Nagaraja S., Granja J., DeBourcy C., Majzner R., Satpathy A.T., Quake S.R., Chang H.Y., Mackall C.L. c-Jun Overexpression in CAR T Cells Induces Exhaustion-Resistance. 2019. Nature. 576(7786):293-300

Weber E.W., Lynn R.C., Sotillo E., Lattin J., Xu P., Mackall C.L. Pharmacologic Control of CAR T Cell Function Using Dasatinib. 2019. Blood Adv. 3(5):711-717. NOTE: Selected by Blood Adv as “Top Influential Article” in 2020

2017

Weber E.W. and Muller W.A. Roles of Transient Receptor Potential Channels in Regulation of Vascular and Epithelial Barriers. 2017. Tissue Barriers. e1331722.

2016

Winger R.C., Harp C.T., Chiang M.Y., Sullivan D.P., Watson R.L., Weber E.W., Miller S.D., Muller W.A. CD99 is a novel regulator of neuroinflammation. 2016. J Immunol. 196(4):1443-8

2015

Rutledge N.S., Weber E.W., Winger R.C., Tourtellotte W., Park S.H., Muller W.A. CD99-like 2 (CD99L2)-deficient mice are defective in transendothelial migration. 2015. Exp Mol Pathol. 99(3):455-459

Weber E.W., Han F., Tauseef M., Birnbaumer L., Mehta D., Muller W.A. TRPC6 is the Endothelial Calcium Channel That Regulates Leukocyte Transendothelial Migration During the Inflammatory Response. 2015. J Exp Med. 212:1883-1899

2014

Moricoli D., Muller W.A., Carbonella D.C., Balducci M.C., Dominici S., Watson R., Fiori V., Weber E., Cianfriglia M., Scotlandi K., Magnani M. Blocking monocyte transmigration in in vitro system by a human antibody scFv anti-CD99. Efficient large scale purification from periplasmic inclusion bodies in E. coli expression system. 2014. J Immunol Methods. 408:35-45

2012

Cuda,C.M., Agrawal H., Misharin A.V., Haines G.K., 3rd, Hutcheson J., Weber E., Schoenfeldt J.A., Mohan C., Pope R.M., Perlman H. Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in mice. 2012. Arthritis Rheum. 64, 808-820.

Mavers M., Cuda C.M., Misharin A.V., Gierut A.K., Agrawal H., Weber E., Novack D.V., Haines G.K., 3rd, Balomenos D., Perlman H. Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis. 2012. Arthritis Rheum. 64, 141-152.

*contributed equally