Dr. Whitworth is a pediatric hematologist with a clinical interest in pediatric thrombosis and hemostasis. Her clinical research focuses on the prevention and treatment of pediatric thrombosis.
Education and Training
MD - Emory University School of Medicine, Atlanta, GA
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatric Hematology and Oncology - Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatrics – American Board of Pediatrics
MSCE - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Titles and Academic Titles
Instructor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Whitworth H, Beslow LA, Hubbard RA, Leonard CE, Scobell R, Witmer C, Raffini L. Outcomes in infants with unprovoked venous thromboembolism: A retrospective cohort study. Res Pract Thromb Haemost. 2023. In press. doi: 10.1016/j.rpth.2023.100174
Whitworth H, Amankwah EK, Betensky M, Castellucci LA, Cuker A, Goldenberg NA, Male C, Rinzler E, Zia A, Raffini L. Updated guidance for efficacy and safety outcomes for clinical trials in venous thromboembolism in children: Communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis. J Thromb Haemost. 2023 Jun;21(6):1666-1673. PMID: 36921919.
Whitworth H, Clark HH, Hubbard RA, Witmer C, Leonard CE, Raffini L. High rate of recurrent venous thromboembolism in children with unprovoked venous thromboembolism. J Thromb Haemost. 2023 Jan;21(1):47-56. PMID: 36695395.
Roe AH, McAllister A, Kete C, Pishko A, Whitworth H, Schreiber CA, Sayani FA. Sex as an independent risk factor for venous thromboembolism in sickle cell disease: A cross-sectional study. J Women's Health (Larchmt). 2022 Jun 8. doi: 10.1089/jwh.2022.0046. Epub ahead of print. PMID: 35675680.
Dain AS, Raffini L, Whitworth H. Thrombotic events in critically ill children with COVID-19 or MIS-C. Curr Opin Pediatr. 2022;34(3):261-267. PMID: 35634699
Whitworth H, Raffini L. Practical Considerations for Use of Direct Oral Anticoagulants in Children. Front Pediatr. 2022 Apr 1;10:860369. PMID: 35433559; PMCID: PMC9010784
Clark HH, Ballester L, Whitworth H, Raffini L, Witmer C. Prevention of Recurrent Thrombotic Events in Children with Central Venous Catheter-Associated Venous Thrombosis. Blood. 2022 Jan 20;139(3):452-460. PMID: 34727184
Strong A, March ME, Cardinale CJ, Kim SE, Merves J, Whitworth H, Raffini L, Larosa C, Copelovitch L, Hou C, Slater D, Vaccaro C, Watson D, Zackai EH, Billheimer J, Hakonarson H. A novel MBTPS2 variant associated with BRESHECK syndrome impairs sterol-regulated transcription and the endoplasmic reticulum stress response. Am J Med Genet A. 2022 Feb;188(2):463-472. PMID: 34655156
Clark HH, Ballester L, Whitworth HB, Raffini L, Witmer C. Prevention of Recurrent Thrombotic Events in Children with Central Venous Catheter-Associated Venous Thrombosis. Blood. 2021 Nov 2:blood.2021013453. doi: 10.1182/blood.2021013453. Epub ahead of print. PMID: 34727184.
Strong A, March ME, Cardinale CJ, Kim SE, Merves J, Whitworth H, Raffini L, Larosa C, Copelovitch L, Hou C, Slater D, Vaccaro C, Watson D, Zackai EH, Billheimer J, Hakonarson H. A novel MBTPS2 variant associated with BRESHECK syndrome impairs sterol-regulated transcription and the endoplasmic reticulum stress response. Am J Med Genet A. 2021 Oct 15. doi: 10.1002/ajmg.a.62537. Epub ahead of print. PMID: 34655156.
Whitworth HB, Sartain SE, Kumar R, Armstrong K, Ballester L, Betensky M, Cohen C, Diaz R, Diorio C, Goldenberg NA, Jaffray J, Keegan J, Malone K, Randolph A, Rifkin-Zenenberg S, Leung WS, Sochet AA, Srivaths L, Zia A, Raffini L. Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C. Blood. 2021;138(2):190-198. doi:10.1182/blood.2020010218. PMID: 33895804; PMCID: PMC8079262.
Neese JM, Yum S, Matesanz S, Raffini LJ, Whitworth HB, Loomes KM, Mayer OH, Alcamo AM. Intracranial hemorrhage secondary to vitamin K deficiency in X-linked myotubular myopathy. Neuromuscul Disord. 2021 Jul;31(7):651-655. doi: 10.1016/j.nmd.2021.04.009. Epub 2021 May 11. PMID: 34120822.
Doshi, BS, Rogers, RS, Whitworth, HB, Stabnick, EA, Britton, J, Butler, RB, Obstfeld, AE, Witmer, CM. Utility of repeat testing in the evaluation for von Willebrand disease in pediatric patients. J Thromb Haemost. 2019; 17: 1838– 1847. PMID: 31350816
Ta HQ, Whitworth H, Yin Y, Conaway M, Frierson H, Campbell MJ, Raj G, Gioeli D. Discovery of a novel long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth. Mol Cancer. 2019;18(113):1-15. PMID: 31253147
Candy V, Whitworth H, Grabell J, Thibeault L, Harpell L, Bowman M, Good D, Hopman WM, Sidonio RF, James PD. A decreased and less sustained desmopressin response in hemophilia A carriers contributes to bleeding. Blood Advances. 2018; 2(20), 2629-2636. PMID: 30327371
Whitworth H, Bhadel S, Ivey M, Conaway M, Spencer A, Hernan R, Holemon H, Gioeli D. Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen. PLoS ONE. 2012;7(6):e38950. PMID: 22761715
Posters and Presentations
Whitworth, H, Hubbard R, Leonard CE, Witmer C, Raffini L. “High rate of recurrent thrombosis in children with unprovoked venous thromboembolism” Oral presentation at the International Society on Thrombosis and Haemostasis Congress; London, England, U.K. July 2022.
Whitworth, H, Hubbard R, Leonard CE, Witmer C, Raffini L. “Rate of recurrent venous thromboembolism in infants with unprovoked venous thromboembolism” Poster presentation at the International Society on Thrombosis and Haemostasis Congress; London, England, U.K. July 2022.
Whitworth, H “Coagulopathy in children with COVID: When to start anticoagulation” Invited lecture to the Al-Qassimi Women’s and Children’s Hospital International Pediatric Conference; Sharjah, United Arab Emirates (October 2021)
Whitworth, H “Thrombosis in children and adolescents hospitalized with SARS-CoV-2 related illness” Children’s Hospital of Philadelphia Department of Pediatrics Grand Rounds; Philadelphia, PA (June 2021)
Whitworth, H “Thrombosis in children and adolescents hospitalized with SARS-CoV-2 related illness” Oral presentation at Children’s Hospital of Philadelphia Division of Hematology Research Seminar; Philadelphia, PA (April 2021)
Doshi BS, Rogers RS, Whitworth H, Stabnick E, Britton J, Butler R, Witmer CM. “Utility of Repeat Testing in the Evaluation for von Willebrand Disease in Pediatric Patients” Oral presentation by Dr. Doshi at the American Society of Hematology 60th Annual Meeting and Exposition; San Diego, CA (December 2018)
Whitworth, H “Coagulopathy in children with COVID: When to start anticoagulation” Invited speaker to the Al-Qassimi Women’s and Children’s Hospital International Pediatric Conference; Sharjah, United Arab Emirates (October 2021)
Awards and Honors
2022, International Society of Thrombosis and Haemostasis Early Career Travel Award
2020, NIH/NHLBI T32 Training Grant in Hemostasis and Thrombosis, University of Pennsylvania/Children’s Hospital of Philadelphia
2020, Hematology Fellows Consortium
2016, Cum Laude, Emory University School of Medicine
2015, Alpha Omega Alpha Honor Medical Society
2012, Segal AmeriCorps Education Award
2011, University of Virginia Distinguished Majors Program, Awarded a degree with High Distinction
2011, Harrison Undergraduate Research Award, University of Virginia
Leadership and Memberships
Memberships in Professional Organizations
2021-present, American Society of Pediatric Hematology/Oncology
2020-present, American Society of Hematology
2020-present, Hemostasis and Thrombosis Research Society
2020-present, International Society on Thrombosis and Haemostasis
- 2020-present, Pediatric/Neonatal Thrombosis and Hemostasis subcommittee
2019-present, Children’s Oncology Group
Patient Experience Ratings
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