Immune Dysregulation: The Local Storm

May 20, 2022 from 8 a.m. - 3 p.m. (ET)

Join us for a free symposium

You’re invited to our 4th annual Immune Dysregulation Symposium as we explore how immune dysregulation affects blood and bone marrow, the brain, lungs and gastrointestinal tract. The symposium will include provocative cases for amplification of key concepts. Children’s Hospital of Philadelphia is hosting this full-day virtual event for clinicians, researchers and others who care for patients with complex immune disorders.

This event will explore immune dysregulation disorders related to:

  • Gastrointestinal system
  • Neurological system
  • Pulmonary system
  • Blood and bone marrow
  • Systemic diseases

** Approved for 6.25 AMA PRA Category 1 Credits.™ See below for details.

Register now

*Registration is free and includes all syllabus materials. The link to join the online symposium via BlueJeans will be sent out after registration.


8 a.m. – Welcome and Introduction. Edward M. Behrens, MD

8:05 a.m. – Keynote Address I: Diagnosis of Immune Dysregulation Syndromes - a DIRTy job! Megan Cooper, MD, PhD

Gastrointestinal focus

8:35 a.m. – The Gut Reaction in Immune Dysregulation. Judith R. Kelsen, MD

9 a.m. – The Pathology of Indeterminate Pediatric Acute Liver Failure. Portia A. Kreiger, MD

Neurology focus

9:25 a.m. – Effects of Systemic Inflammation on the Developing Brain. Jennifer McGuire, MD, MSCE

9:50 a.m. – Role of TREX1 Mutations in RVCL, a Hereditary Cerebroretinal Vasculopathy. Jonathan Miner, MD, PhD

10:15 a.m. – Role of the Blood-Brain Barrier in Neuroimmune Mechanisms of Disease. Jorge I. Alvarez, PhD, BSc

10:40 a.m. – BREAK

Pulmonary focus

11 a.m. – Lung Remodeling and the Emergence of Tuft Cells after Viral Pneumonia. Andrew Vaughan, PhD, BS

11:25 a.m. – Old Diseases, New Drugs and Nasty Lungs: What George Still Didn’t See Coming. Scott W. Canna, MD

11:50 a.m. – Hermansky Pudlak Syndrome: Lung Disease, Colitis and Immune Dysfunction. Lisa R. Young, MD

Provocative Cases

12:15 p.m. – Unexpected Systemic Inflammation with Complement Degradation. Julia Rood, MD, PhD

12:35 p.m. – Unexpected Cause of Encephalitis. Whitney Reid, MD

12:55 p.m. – BREAK

Focus on blood and bone marrow

1:15 p.m. – Langerhans Cell Histiocytosis: An Inflammatory Myeloid Disorder. Michael D. Hogarty, MD

1:40 p.m. – Immune Dysfunction in Pediatric Sepsis: The Path Towards Precision Immunotherapy. R. Brad Lindell, MD

2:05 p.m. – Immune Mechanisms and Genetic Etiologies of Bone Marrow Failure. Daria V. Babushok, MD, PhD

2:30 p.m. – Keynote Address II: Organ-Specific Effects of ALPS. V. Koneti Rao, MD, FRCPA

2:55 p.m. – Closing Remarks, Kathleen E. Sullivan, MD, PhD


Course Planners: Kathleen E. Sullivan, MD, PhD; Hamid Bassiri, MD, PhD; Edward M. Behrens, MD; Scott W. Canna, MD; Michele P. Lambert, MD SMTR; Whitney L. Petrosa, MSN, CRNP-AC; and David T. Teachey, MD

Course Faculty: Michael D. Hogarty, MD; Judith R. Kelsen, MD; Portia A. Kreiger, MD; R. Brad Lindell, MD; Jennifer McGuire, MD, MSCE; Whitney Reid, MD; Julia Rood, MD PhD; and Lisa R. Young, MD

Guest Faculty: Jorge I. Alvarez, PhD, BSc; Daria V. Babushok, MD, PhD; Megan Cooper, MD, PhD; Jonathan Miner, MD, PhD; V. Koneti Rao, MD, FRCPA; and Andrew Vaughan, PhD BS


ACCME Accreditation Statement: Children’s Hospital of Philadelphia is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

** AMA Credit Designation Statement: Children’s Hospital of Philadelphia designates this live activity for a maximum of 6.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


If you have any questions or need more information, please contact Adriana Deverlis at

Related specialty: allergy and immunology