Eosinophilic Disorders Research Publications


Dellon ES, Gonsalves N, Hirano I, Furuta GT, Liacouras CA, Katzka DA. ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE). Am J Gastroenterol. 2013 May;108(5):679-92. doi: 10.1038/ajg.2013.71. Epub 2013 Apr 9. Read the abstract.

Garrett JP, Apter AJ, Hoffstad O, Spergel JM, Margolis DJ. Asthma and frequency of wheeze: risk factors for the persistence of atopic dermatitis in children. Ann Allergy Asthma Immunol. 2013 Mar;110(3):146-9. doi: 10.1016/j.anai.2012.12.013. Epub 2013 Jan 16. Read the abstract.

Lee J, Garrett JP, Brown-Whitehorn T, Spergel JM. Biphasic reactions in children undergoing oral food challenges. Allergy Asthma Proc. 2013 May;34(3):220-6. doi: 10.2500/aap.2013.34.3669. Read the abstract.

Muir AB, Lim DM, Benitez AJ, Modayur Chandramouleeswaran P, Lee AJ, Ruchelli ED, Spergel JM, Wang ML. Esophageal epithelial and mesenchymal cross-talk leads to features of epithelial to mesenchymal transition in vitro. Exp Cell Res. 2013 Apr 1;319(6):850-9. doi: 10.1016/j.yexcr.2012.12.002. Epub 2012 Dec 10. Read the abstract.


Cianferoni A, Garrett JP, Naimi DR, Khullar K, Spergel JM. Predictive values for food challenge-induced severe reactions: development of a simple food challenge score. Isr Med Assoc J. 2012 Jan;14(1):24-8. Read the abstract.

Fung I, Spergel JM. Administration of influenza vaccine to pediatric patients with egg-induced anaphylaxis. J Allergy Clin Immunol. 2012 Apr;129(4):1157-9. doi: 10.1016/j.jaci.2011.11.038. Epub 2012 Jan 10. Read the abstract.

Greenhawt MJ, Spergel JM, Rank MA, Green TD, Masnoor D, Sharma H, Bird JA, Chang JE, Parikh DS, Teich E, Kelso JM, Sanders GM. Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy. Ann Allergy Asthma Immunol. 2012 Dec;109(6):426-30. doi: 10.1016/j.anai.2012.09.011. Epub 2012 Oct 24. Read the abstract.

Keller MD, Shuker M, Heimall J, Cianferoni A. Severe malnutrition resulting from use of rice milk in food elimination diets for atopic dermatitis. Isr Med Assoc J. 2012 Jan;14(1):40-2. Read the abstract.

Kurzweil V, Tarangelo A, Oliver PM. Gastrointestinal microbiota do not significantly contribute to T cell activation or GI inflammation in Ndfip1-cKO mice. PLoS One. 2012;7(4):e34478. Epub 2012 Apr 10. PubMed PMID: 22506022; PubMed Central PMCID: PMC3323617. Read the abstract.

Ramon HE, Beal AM, Liu Y, Worthen GS, Oliver PM. The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J Immunol. 2012 Apr 15;188(8):4023-31. Epub 2012 Mar 7. PubMed PMID: 22403444. Read the abstract.

Rothenberg ME, Aceves S, Bonis PA, Collins MH, Gonsalves N, Gupta SK, Hirano I, Liacouras CA, Putnam PE, Spergel JM, Straumann A, Wershil BK, Furuta GT. Working with the US Food and Drug Administration: Progress and timelines in understanding and treating patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2012 Sep;130(3):617-9. PubMed PMID: 22935588. Read the abstract.

Saltzman RW, Brown-Whitehorn TF. Gastrointestinal syndromes associated with food allergies. Curr Probl Pediatr Adolesc Health Care. 2012 Aug;42(7):164-90. doi: 10.1016/j.cppeds.2012.03.007. Read the abstract.

Spergel JM, Brown-Whitehorn TF, Cianferoni A, Shuker M, Wang ML, Verma R, Liacouras CA. Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J Allergy Clin Immunol. 2012 Aug;130(2):461-467.e5. Epub 2012 Jun 27. PubMed PMID: 22743304. Read the abstract.


Liacouras CA. Clinical presentation and treatment of pediatric patients with eosinophilic esophagitis. Gastroenterol Hepatol (N Y). 2011 Apr;7(4):264-7. PubMed PMID: 21857826; PubMed Central PMCID: PMC3127030. Read the article.

Liacouras CA, Furuta GT, Hirano I, Atkins D, Attwood SE, Bonis PA, Burks AW, Chehade M, Collins MH, Dellon ES, Dohil R, Falk GW, Gonsalves N, Gupta SK, Katzka DA, Lucendo AJ, Markowitz JE, Noel RJ, Odze RD, Putnam PE, Richter JE, Romero Y, Ruchelli E, Sampson HA, Schoepfer A, Shaheen NJ, Sicherer SH, Spechler S, Spergel JM, Straumann A, Wershil BK, Rothenberg ME, Aceves SS. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011 Jul;128(1):3-20.e6; quiz 21-2. Epub 2011 Apr 7. Review. PubMed PMID: 21477849. Read the abstract.

Lim DM, Wang ML. Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells. Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G91-9. Epub 2011 Apr 7. PubMed PMID: 21474651; PubMed Central PMCID: PMC3129934. Read the article.

Ramon HE, Riling CR, Bradfield J, Yang B, Hakonarson H, Oliver PM. The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility. Mucosal Immunol. 2011 May;4(3):314-24. Epub 2010 Oct 20. PubMed PMID: 20962770.Read the abstract.

Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF, Comeau MR, Artis D. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature. 2011 Aug 14;477(7363):229-33. doi: 10.1038/nature10329. PubMed PMID: 21841801; PubMed Central PMCID: PMC3263308. Read the article.

Spergel JM, Book WM, Mays E, Song L, Shah SS, Talley NJ, Bonis PA. Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States. J Pediatr Gastroenterol Nutr. 2011 Mar;52(3):300-6. PubMed PMID: 21057327. Read the abstract.


Brown-Whitehorn TF, Spergel JM. The link between allergies and eosinophilic esophagitis: implications for management strategies. Expert Rev Clin Immunol. 2010 Jan;6(1):101-9. Review. PubMed PMID: 20161677; PubMed Central PMCID: PMC2821054. Read the article.

Franciosi JP, Fiorino K, Ruchelli E, Shults J, Spergel J, Liacouras CA, Leonard M. Changing indications for upper endoscopy in children during a 20-year period. J Pediatr Gastroenterol Nutr. 2010 Oct;51(4):443-7. PubMed PMID: 20562722; PubMed Central PMCID: PMC2946469. Read the article.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91. Epub 2010 Mar 7. PubMed PMID: 20208534. Read the abstract.

Shaffer MH, Huang Y, Corbo E, Wu GF, Velez M, Choi JK, Saotome I, Cannon JL, McClatchey AI, Sperling AI, Maltzman JS, Oliver PM, Bhandoola A, Laufer TM, Burkhardt JK. Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice. PLoS One. 2010 Aug 27;5(8):e12404. PubMed PMID: 20806059; PubMed Central PMCID: PMC2929185. Read the article.

Spergel JM. New genetic links in eosinophilic esophagitis. Genome Med. 2010 Sep 7;2(9):60. PubMed PMID: 20822553; PubMed Central PMCID: PMC3092111. Read the article.


Franciosi JP, Liacouras CA. Eosinophilic esophagitis. Immunol Allergy Clin North Am. 2009 Feb;29(1):19-27, viii. Review. PubMed PMID: 19141338. Read the abstract.

Franciosi JP, Tam V, Liacouras CA, Spergel JM. A case-control study of sociodemographic and geographic characteristics of 335 children with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2009 Apr;7(4):415-9. Epub 2008 Oct 15. PubMed PMID: 19118642. Read the abstract.

Jyonouchi S, Brown-Whitehorn TA, Spergel JM. Association of eosinophilic gastrointestinal disorders with other atopic disorders. Immunol Allergy Clin North Am. 2009 Feb;29(1):85-97, x. Review. PubMed PMID: 19141344. Read the abstract.

Lim DM, Narasimhan S, Michaylira CZ, Wang ML. TLR3-mediated NF-{kappa}B signaling in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1172-80. Epub 2009 Sep 24. PubMed PMID: 19779021; PubMed Central PMCID: PMC2850089. Read the article.

Smith LP, Chewaproug L, Spergel JM, Zur KB. Otolaryngologists may not be doing enough to diagnose pediatric eosinophilic esophagitis. Int J Pediatr Otorhinolaryngol. 2009 Nov;73(11):1554-7. Epub 2009 Sep 3. PubMed PMID: 19732967. Read the abstract.

Spergel JM, Brown-Whitehorn TF, Beausoleil JL, Franciosi J, Shuker M, Verma R, Liacouras CA. 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr. 2009 Jan;48(1):30-6. PubMed PMID: 19172120. Read the abstract.

Spergel J. Diagnosis and treatment of eosinophilic esophagitis. F1000 Med Rep. 2009 Jun 9;1. pii: 46. PubMed PMID: 20948735; PubMed Central PMCID: PMC2924731. Read the article.


Gay DL, Ramón H, Oliver PM. Cbl- and Nedd4-family ubiquitin ligases: balancing tolerance and immunity. Immunol Res. 2008;42(1-3):51-64. PubMed PMID: 18827983. Read the abstract.

Liacouras CA. Eosinophilic esophagitis. Gastroenterol Clin North Am. 2008 Dec;37(4):989-98, xi. PubMed PMID: 19028328. Read the abstract.

Liacouras CA. Pharmacologic treatment of eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008 Jan;18(1):169-78; xi. PubMed PMID: 18061110. Read the abstract.

Spergel JM, Shuker M. Nutritional management of eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008 Jan;18(1):179-94; xi. PubMed PMID: 18061111. Read the abstract.

Yang B, Gay DL, MacLeod MK, Cao X, Hala T, Sweezer EM, Kappler J, Marrack P,Oliver PM. Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol. 2008 Dec;9(12):1356-63. Epub 2008 Oct 19. PubMed PMID: 18931680; PubMed Central PMCID: PMC2935464. Read the abstract.


Brown-Whitehorn T, Liacouras CA. Eosinophilic esophagitis. Curr Opin Pediatr. 2007 Oct;19(5):575-80. PubMed PMID: 17885478. Read the abstract.

Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis P, Hassall E, Straumann A, Rothenberg ME; First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007 Oct;133(4):1342-63. Epub 2007 Aug 8. PubMed PMID: 17919504. Read the abstract.

Spergel JM, Brown-Whitehorn T, Beausoleil JL, Shuker M, Liacouras CA. Predictive values for skin prick test and atopy patch test for eosinophilic esophagitis. J Allergy Clin Immunol. 2007 Feb;119(2):509-11. PubMed PMID: 17291865. Abstract not available.

Spergel JM. Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients. Curr Opin Allergy Clin Immunol. 2007 Jun;7(3):274-8. Review. PubMed PMID: 17489048. Read the abstract.


Liacouras CA. Eosinophilic esophagitis: treatment in 2005. Curr Opin Gastroenterol. 2006 Mar;22(2):147-52. Review. PubMed PMID: 16462171. Read the abstract.

Liu B, Fan YJ, Wang ML, Lü XD, Jiang JL, Wang TY, Fan ZM, Wang JK, Wang LD. Genetic polymorphisms in glutathione S-transferases T1, M1 and P1 and susceptibility to reflux esophagitis. Dis Esophagus. 2006;19(6):477-81. PubMed PMID: 17069592. Read the abstract.

Markowitz JE, Liacouras CA. Ten years of eosinophilic oesophagitis: small steps or giant leaps? Dig Liver Dis. 2006 Apr;38(4):251-3. Epub 2006 Feb 7. PubMed PMID: 16458086. Abstract not available.


Liacouras CA, Spergel JM, Ruchelli E, Verma R, Mascarenhas M, Semeao E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005 Dec;3:1198-206. PubMed PMID: 16361045.Read the abstract.

Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, Liacouras CA. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005 Oct;95:336-43. PubMed PMID: 16279563. Read the abstract.

Spergel JM. Eosinophilic oesophagitis and pollen. Clin Exp Allergy. 2005 Nov;35(11):1421-2. PubMed PMID: 16297136. Abstract not available.

Spergel J, Rothenberg ME, Fogg M. Eliminating eosinophilic esophagitis. Clin Immunol. 2005 May;115(2):131-2. PubMed PMID: 15885634. Abstract not available.  


Liacouras CA, Ruchelli E. Eosinophilic esophagitis. Curr Opin Pediatr. 2004 Oct;16(5):560-6. Review. PubMed PMID: 15367851. Read the abstract.


Fogg MI, Ruchelli E, Spergel JM. Pollen and eosinophilic esophagitis. J Allergy Clin Immunol. 2003 Oct;112:796-7. PubMed PMID:14564365. Abstract not available. 

Markowitz JE, Spergel JM, Ruchelli E, Liacouras CA. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol. 2003 Apr;98:777-82. PubMed PMID:12738455. Read the abstract.

Markowitz JE, Liacouras CA. Eosinophilic esophagitis. Gastroenterol Clin North Am. 2003 Sep;32:949-66. PubMed PMCID: PMC2650237.
Read the article.  


Spergel JM, Beausoleil JL, Mascarenhas M, Liacouras CA. The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol. 2002 Feb;109:363-8. PubMed PMID:11842310. Read the abstract.


Liacouras CA, Wenner WJ, Brown K, Ruchelli E. Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr. 1998 Apr;26:380-5. PubMed PMID:9552132. Read the abstract.

Updated: May 2013