Most Recent Articles
Guidelines for Managing HI in School
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Both medical management and neurodevelopmental conditions may require accommodations for your child with hyperinsulinism at school.
Learning and Sharing at Family Conference
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The 2023 Congenital Hyperinsulinism Family Conference, held at CHOP in April, was a roaring success, with more than 225 attendees.
Congenital Hyperinsulinism Center Frontier Program Highlights
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CHOP’s HI Center, a Frontier Program, continues to set the standard for caring for children with congenital hyperinsulinism.
Q&A with Pediatric Endocrinologist Julia Crowley, MD
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New pediatric endocrinologist Julia Crowley, MD, will see children in CHOP’s Congenital Hyperinsulinism Center. Meet her in this Q&A. [short teaser] Meet Julia Crowley, MD, will see children in CHOP’s Congenital Hyperinsulinism Center.
Nutrition Corner: Simplifying the Complex Topic of Carbohydrates
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For children with hyperinsulinism, especially GCK HI, eating carbohydrates plays an important role in managing blood sugar levels.
Tips for Getting Through Medication Shortages
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Advance planning and working closely with your pharmacist can help families manage through medication shortages.
Two Focal Lesions: Extra Rare Cases Not so Rare at CHOP
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The Congenital Hyperinsulinism Center at Children’s Hospital of Philadelphia, with a high volume of approximately 80 congenital hyperinsulinism (HI) cases a year, sees a large share of unusual cases.
Neurodevelopmental Outcomes in HI
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Unrecognized or inadequately treated hyperinsulinism (HI) poses a high risk of adverse neurodevelopmental outcomes due to the combined insult of hypoglycemia and lack of alternate brain fuels.
When Hyperinsulinism is a Family Affair
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Inactivating mutations in the beta cell KATP channels are the most common cause of congenital hyperinsulinism (HI), accounting for approximately 60% of all cases with known genotype. The beta cell KATP channels play a very important role in the regulation of insulin secretion by coupling the metabolic state of the cell to membrane potential.
Radiology: Key Member of the HI Team
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For the children with focal hyperinsulinism, the radiologist’s interpretation of a 18F-DOPA PET/CT scan guides the surgeon, leading to a cure in 97% of cases.