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Researchers Find Potential Neurodevelopmental Outcomes Linked to Brain Tissue Differences in Newborns Exposed to HIV
Researchers at Children’s Hospital of Philadelphia (CHOP) in collaboration with the Botswana Harvard Health Partnership identified measurable differences in brain tissue patterns between newborns exposed to HIV during pregnancy but not infected and those with no HIV exposure.
Breakthrough Discovery Reveals How Connection Between Mitochondrial Vulnerability and Neurovasculature Function Impacts Neuropsychiatric Disease
Researchers found that mitochondrial dysfunction in the blood-brain barrier (BBB) may lead to neuropsychiatric disease in some patients with 22qDS. The researchers also demonstrated that a class of FDA-approved cholesterol drugs could potentially be repurposed to treat this dysfunction.
Children’s Hospital of Philadelphia Researchers Find Promising Preclinical Data for Expanding Use of Drug for Primary Mitochondrial Diseases
Researchers found that a new drug therapy currently in clinical trials for a form of primary mitochondrial disease – Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) syndrome – was safe and effective in multiple preclinical zebrafish models.
Children’s Hospital of Philadelphia, FAB Youth Philly, Philadelphia Parks & Recreation, West Philadelphia YMCA and Partners Host Enhanced Summer Program Offering Paid Swim Lessons and Lifeguard Certificate Training
Children’s Hospital of Philadelphia’s (CHOP) Healthier Together, Fab Youth Philly (FYP), Philadelphia Parks & Recreation, the West Philadelphia YMCA and other local organizations joined forces to support a paid learn-to-swim and paid lifeguard skill-building and lifeguard certificate programs for local youth.
Children’s Hospital of Philadelphia and Children’s Hospital Colorado Researchers Conduct First Prospective Study of Pediatric EoE Patients and Disease Progression
Researchers have found that better control of chronic eosinophilic esophagitis (EoE)-associated inflammation during childhood leads to less stiffening of the esophagus, resulting in fewer disease complications.
Children’s Hospital of Philadelphia Researchers Find that Missing Messenger RNA Fragments Could be Key to New Immunotherapy for Hard-to-Treat Tumors
A new study, led by researchers CHOP, identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues. Preclinical research indicates that these missing RNA fragments can make difficult-to-treat tumors more responsive to immunotherapy. The findings were recently published in the journal Cell Reports.
Children’s Hospital of Philadelphia Launches Inaugural I ♥ CHOP Event with Official Champion Saquon Barkley
Today, Children’s Hospital of Philadelphia (CHOP) announced the launch of the I ♥ CHOP Run, Walk & Virtual Challenge, presented by Philadelphia Insurance Companies, with Saquon Barkley, running back for the Philadelphia Eagles, as the Official Champion of the event.
Children’s Hospital of Philadelphia, Clinic for Special Children Discover Ultra Rare Form of Neuroinflammatory Disease is Much More Common in Old Order Amish than General Population
Researchers found that complement factor I (CFI) deficiency, an ultra-rare genetic disorder that can cause debilitating neuroinflammation, is more than 4500 times more likely to be found in individuals of Old Order Amish ancestry than the rest of the global population.
Study Uncovers Critical Connections Between Neighborhood Violence, Youth Aggression and Perceived Access to Firearms
A new study by the Center for Violence Prevention (CVP) at Children’s Hospital of Philadelphia, in collaboration with principal investigator Jungwon Min, PhD, MS from the University of Pennsylvania School of Nursing.
Children’s Hospital of Philadelphia Researchers Lead Largest Comparative Study of Surgical Interventions for Children and Adolescents with Kidney Stones
Researchers at Children’s Hospital of Philadelphia (CHOP), along with several academic partners, announced the primary results of the Pediatric KIDney Stone (PKIDS) trial, the largest comparative effectiveness study of surgical interventions for children and adolescents with kidney stones.