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CHOP Biobank: Unlocking the Secrets to Childhood Health and Disease

Imagine a world where we can identify disease markers specific to pediatric illnesses; find patterns between medical history, cellular findings, and diseases; and develop new treatments and diagnostic tools. That's the potential power of the Children's Hospital of Philadelphia Biobank.

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Children’s Hospital of Philadelphia Researchers Secure Funding to Explore Progesterone Therapy Response Mechanisms in Fetuses with Hypoplastic Left Heart Syndrome (HLHS)

A research team in the Cardiac Center at Children’s Hospital of Philadelphia (CHOP) in collaboration with Boston Children’s Hospital and the Perelman School of Medicine at the University of Pennsylvania was awarded a $660,000 grant over three years by Additional Ventures through its Single Ventricle Research Fund to accelerate research and develop therapies for fetuses with hypoplastic left heart syndrome (HLHS).

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Children’s Hospital of Philadelphia Researchers Find Children with IBD Have Hidden Risk to Bone Health

A new study from researchers at Children’s Hospital of Philadelphia (CHOP) found that children and young adults living with inflammatory bowel disease (IBD may face a hidden threat – weakened bones. Researchers showed that a significant number of young patients with IBD have low bone mineral density (BMD), putting them at a higher risk for fractures and long-term bone complications.

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New Tool Developed by Children’s Hospital of Philadelphia Researchers Decodes Complex DNA Methylation

Researchers in the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia (CHOP) developed a new tool called the Methylation Screening Array (MSA) to better understand how changes in DNA methylation-mediated regulation of genes, rather than changes in the genes themselves, affect complex human traits like aging and disease risk. This is the first data set to dissect the two forms of DNA methylation---5-methylcytosine and 5-hydroxymethylcytosine---to associate characteristics such as cell composition, gene regulatory mechanism, and epigenetic age in diverse human cell lines and tissues.

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