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Children’s Hospital of Philadelphia Researchers Identify Instances of SYNGAP1-Related Disorders Caused by Inherited Genetic Variants
Researchers have found that in rare instances, variants responsible for SYNGAP1-related disorders – a group of disorders characterized by developmental delay and often associated with epilepsy – can be inherited from a parent, which could help influence family planning, genetic variant interpretation, and other aspects of clinical care.

John Simpkins Named Recipient of the Alex’s Lemonade Stand 2025 Pitcher of Hope Award
John Simpkins, Chief Administrative Officer of the Cancer Center at Children’s Hospital of Philadelphia, is this year’s recipient of the Alex’s Lemonade Stand Pitcher of Hope Award.
Advancing Care for Complex Childhood Lung Diseases
Experts from Children’s Hospital of Philadelphia’s Division of Pulmonary and Sleep Medicine discuss innovations in clinical care and diagnostics for respiratory disease.
Children’s Hospital of Philadelphia Researchers Show Quality Improvement Initiative in the Emergency Department Improved Family Engagement Around Firearm Safety Resources
Researchers in the Center for Violence Prevention (CVP) at Children’s Hospital of Philadelphia (CHOP) embarked on a quality improvement (QI) initiative with behavioral health patients at CHOP’s Philadelphia and King of Prussia emergency departments with the goal of improving firearm safety conversations.
"Just the Vax" Trivia Corner
Which vaccine-preventable disease can occur when a wound or cut is exposed to soil that contains bacteria? Find out.
Feature Article: What We Know and How We Feel — Can You Recognize the Difference? Try It!
Read why it’s important to separate knowledge-based statements from feelings-based ones. Learn about considerations related to misinformation, and see if you can tell the difference between knowledge, feelings and misinformation in the “Try it” section of the article.
Vaccine News & Notes — June 2025
Find out if children should get vaccinated early during a measles outbreak; hear or read the 2025 Hilleman winning essays; find info about recent changes to COVID-19 vaccine recommendations and more.

Children's Hospital of Philadelphia Hosts 29th Annual Fetal Surgery Family Reunion at Philadelphia Zoo
Now in its second year as the Lori J. Howell Fetal Family Reunion, the event honors the late Lori J. Howell, a pioneering nurse leader, mentor, and longtime executive director of the CFDT whose vision continues to shape fetal medicine worldwide.
Newsweek and Forbes Recognize CHOP
Newsweek and Forbes have included CHOP on their 2025 “best of” lists, which recognize our commitment to providing exceptional care and making CHOP a great place to work.
CHOP hosts 7th Annual Immune Dysregulation Symposium
CHOP hosts the 7th Annual Immune Dysregulation Symposium on April 30 for clinicians and researchers who care for patients with complex, multi-organ immune diseases.