Most Recent Articles
Management of Congenital Diaphragmatic Hernia
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Congenital diaphragmatic hernia (CDH) is a complex and challenging anomaly. Learn about CHOP’s efforts to advance care and improve survival in severely affected children.
Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left CDH
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Despite advances in care, there remain high rates of morbidity and mortality in cases of severe CDH. Read about CHOP’s FDA-approved study of fetoscopic endoluminal tracheal occlusion (FETO).
Beyond Therapy: Long-term Follow-up Facilitates Early Recognition and Support for CDH Complications
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Neonates with congenital diaphragmatic hernia (CDH) often require intensive treatment after birth and have prolonged hospitalizations, and may suffer a variety of complications after discharge. Comprehensive interdisciplinary follow-up care is critical for long-term well being.
Research Update: 8- to 13-Year Study of Neurodevelopmental Outcomes in Children with Pulmonary Hypoplasia
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The Pulmonary Hypoplasia Program at The Children’s Hospital of Philadelphia is committed to tracking outcomes of children with pulmonary hypoplasia in an effort to improve understanding and care. A recent review of neurodevelopmental outcomes at 5 years of age found that CDH survivors are at increased risk for developing emotionally reactive and pervasive developmental problems.
Fetal Myelomeningocele Repair: The Post-MOMS Experience
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The CFDT Center at CHOP recently reviewed outcomes for fetal MMC repair since the MOMS results were reported, from referral and evaluation through surgery, delivery and neonatal discharge.
Tissue Engineering Strategies for Fetal MMC Repair
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While the MOMS trial has demonstrated conclusively that open fetal surgery for repair of myelomeningocele improves outcomes, open fetal surgery for MMC is not a cure.
Urologic Results After Fetal Myelomeningocele Repair in Pre-MOMS Patients
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Before the start of the Management of Myelomeningocele Study (MOMS) in 2003, an initial group of 58 patients at CHOP underwent in utero repair of their myelomeningocele between 21 and 25 weeks' gestation. Urologic results after fMMC repair are discussed here.
Diagnostic Imaging of Myelomeningocele
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Myelomeningocele (MMC) poses a diagnostic and therapeutic challenge. A thorough and detailed examination of the entire fetus, with visualization of every spinal segment, is necessary.
Fetal Myelomeningocele Closure: Technical Considerations
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Fetal closure of an MMC is technically more challenging than the standard postnatal closure. The access is smaller, the structures are smaller and more delicate, the placode must be handled with more care, avoiding blood loss is critical, and the surgery must be performed quickly to limit the exposure of the fetus to the extrauterine environment.
The Role of Echocardiography in Intraoperative Management of Fetal MMC Repair
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The Children's Hospital of Philadelphia has initiated a standard practice of continuous intraoperative echocardiographic monitoring for all fetuses undergoing myelomeningocele repair.