FAST-BOLUS
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Description
This study measures plasma biomarkers in children enrolled in PRoMPT BOLUS with existing stored samples which were collected at randomization in order to assess the for differential effects of fluid assignment on MAKE30 across risk strata using two distinct biomarker-based mortality prediction models (Aim 1) and separately across two different biomarker-defined inflammatory sub-phenotypes (Aim 2). The study will also leverage this biobank to investigate potential mechanisms between fluid choice and MAKE30 by measuring markers of endothelial cell and endothelial glycocalyx damage (Aim 3).
Eligibility and criteria
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