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Research Studies Finder

Research Studies Finder

Use this finder to find a study or trial that is the right fit for your child. Also, filter results by phase — which are the specific steps researchers take throughout the trial to find answers, solutions and cures.

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Showing 1 - 10 of 35 results

Phenotyping Congenital Hyperinsulinism

The Congenital Hyperinsulinism Center at the Childrens Hospital of Philadelphia is working on a research study to better understand how people with hyperinsulinism may have different blood sugar responses to certain tests (like fasting or drinking a high-protein shake) when compared to people without hyperinsulinism. This study will involve a screening visit where we will ask you about your medical history and any known episodes of low blood sugar. Depending on your responses during the interview, you will be asked to complete up to five tests at our outpatient research center. These tests include fasting, drinking a high-protein shake, drinking a high-sugar drink, eating a regular meal, and exercising on a stationary bike. We will collect blood samples from an IV throughout the tests to measure certain blood levels like glucose and insulin. You will be compensated for some or all of your travel costs and you will receive payment for your time. If you are interested in learning more, please contact us at HIResearch@chop.edu.

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children, Healthy Controls

Conditions: Congenital Hyperinsulinism

Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia (HI/HA) Syndrome

Our team is working on a study to see if children with HI/HA Syndrome tolerate Vitamin E supplementation. This is an experimental, non-FDA approved use of Vitamin E which will lead to further studies to evaluate if Vitamin E can be used as a treatment for HI/HA. The study involves taking Vitamin E once a day for two weeks at home, completing a tolerability questionnaires, and two, one-day visits to the CHOP outpatient Center for Human Phenomic Science (one visit before and one visit after taking the Vitamin E supplement for two weeks). During each study visit, fasting oral protein tolerance will be performed and blood samples will be drawn.

Phase: Pilot

Actively recruiting: No

Category: Adults, Children, One-Time Visit Studies

Conditions: Congenital Hyperinsulinism

MRI Assessment of NAD+

NAD+ (nicotinamide adenine dinucleotide) is an important substance found in the body that plays a role in energy metabolism and overall health. The purpose of this research study is to test the performance of a new magnetic resonance imaging (MRI) technique (spectroscopy) to measure NAD+ metabolism in brain and skeletal muscle. MRI provides pictures of the inside of the body and information about chemicals the body makes.We are seeking to enroll males and females with Friedrichs Ataxia (FA) as well as healthy matched volunteers, 18 years of age and above. Pregnant females excluded for safety purposes.

Phase: N/A

Actively recruiting: Yes

Category: Adults, Healthy Controls, MRI/Imaging Studies

Designate - Siplizumab in T1DM

The goal of this study is to identify a safe dosing regimen for siplizumab in participants with type 1 diabetes. Siplizumab is a drug used to help treat recent onset type 1 diabetes mellitus (T1DM). This study is interested in participants aged 18-45 years with T1DM, who are within 18 months of receiving their diagnosis. Participants will be randomized (selected at random by the study team) to one of four possible treatment groups. All groups will receive weekly siplizumab doses administered subcutaneously (injected into the body through the skin) for a total of 12 weeks.

Phase: Phase I

Actively recruiting: Yes

Category: Adults

Canagliflozin in Children with Type 2 Diabetes

The goal of this study is to investigate the efficacy and safety of Canagliflozin (which is experimental) in children and adolescents ages 10 to 18 years old with Type 2 diabetes and poor control (i.e., an HbA1c of 6.5% to 10.5%). Study drug or placebo would be taken alone or with metformin or insulin as needed. Monitoring tests include blood, urine, physical exams, vital signs, blood sugar and ketone monitoring, diabetes management counseling.

Phase: Phase III

Actively recruiting: No

Category: Children

Medtronic 780G System

This study will evaluate the safety and effectiveness of the MiniMed 780G insulin pump system used in combination with the DS5 CGM in type 1 diabetic pediatric participants in a home setting.

Phase: Phase III

Actively recruiting: No

Category: Children

NCGD

The purpose of this research study is to learn more about Graves disease and PTC/Hypothyroidism, How it effects brain function and brain function changes after starting medical treatment.

Phase: N/A

Actively recruiting: No

Category: Adults, Children, MRI/Imaging Studies

The Charisma Study

We are currently enrolling adolescents ages 15-21 of South Asian ancestry, African American ancestry, and European American or "White" ancestry. This study is looking to better understand ancestry related differences in risks for developing cardiovascular disease and type 2 diabetes. The study involves 2 visits to the CHOP Main Hospital in Philadelphia, and participants will be compensated for their efforts.

Phase: N/A

Actively recruiting: No

Category: Adults, Children, Healthy Controls

MRI Muscle Metabolism in Different Age Groups

The purpose of the study is to determine changes in lactate and creatine in calf muscle of healthy adult volunteers. Males and females of different ages (18 - 30 years, 45-55 years, and 70-80 years) will be asked to attend a single in-person study visit. Prior to the completing the MRI scan, the study team will review the health status of individuals.

Phase: N/A

Actively recruiting: Yes

Category: Adults, Healthy Controls, MRI/Imaging Studies, One-Time Visit Studies

Exercise in Craniopharyngioma

The main goal of this study is to learn more from patients and their families about potential barriers of exercise and receptiveness to various interventional trial designs in survivors of childhood craniopharyngioma. Young adult survivors (ages 18 to 26) and/or parents/adult caregivers of elementary school-age children (5-11 years old) and adolescents (12-17 years old) who have had craniopharyngiomas will be invited to participate in a focus group session. Individuals with craniopharyngiomas must be at least 6 months since diagnosis and not currently undergoing active treatment for their tumors (e.g., radiation).

Phase: N/A

Actively recruiting: Yes

Category: Adults, One-Time Visit Studies, Remote (Online / Phone Call Only) Studies

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