Having your child diagnosed with an adrenal disorder or condition that affects your child’s sexual development can be distressing. Because these disorders can have a lasting impact on your child’s overall health and well-being, it’s important to find an experienced team of specialists that can create a customized care plan to treat your child.
The Adrenal and Puberty Center (APC) at The Children’s Hospital of Philadelphia provides streamlined, coordinated care for children and adolescents with adrenal disorders and conditions that may affect puberty and gonadal function. The program brings together experts from several pediatric specialties who tailor your child’s treatment to his unique needs. Our goal is to provide comprehensive, integrated care as your child grows and develops.
Conditions we treat
The Adrenal and Puberty Center at CHOP cares for children and adolescents with:
- Disorders of the adrenal glands, which produce hormones that are essential to life, such as cortisol and aldosterone.
- Disorders related to puberty that may affect your child’s sexual development and growth.
- Amenorrhea (absence of menstruation)
- Delayed puberty
- Disorders of sex development (DSD)
- Precocious puberty — this may include early breast development (thelarche) or early development of pubic hair, body odor or axillary hair (adrenarche)
- Genetic disorders associated with early or delayed puberty
- Gonadal disorders
- Kallman syndrome
- Klinefelter syndrome
- Lack of menstruation and puberty problems associated with anorexia nervosa, eating disorders or other chronic disorders such as Crohn's disease or inflammatory bowel disease
- Puberty problems associated with McCune-Albright syndrome
- Children born with ambiguous genitalia
Our Programs and Services
The APC offers both inpatient and outpatient services to help manage these complex conditions.
Our programs and services include:
- Comprehensive care program for patients and families with congenital adrenal hyperplasia
- Comprehensive care program for patients and families with Klinefelter’s syndrome
- Medical management of children with adrenal or gonadal disorders.
- Program for children with steroid-induced adrenal insufficiency. Many children with an underlying disease that requires treatment with high doses of steroids, such as prednisone or hydrocortisone, may develop adrenal suppression. Our team works with the patients’ primary medical team to taper patients off steroids and ensure normal adrenal function as patients improve and are weaned off steroids.
- Surgical consultations and treatment for genital reconstruction.
- Psychosocial support, including social work services and family counseling.
- Nutritional counseling and weight management.
- Genetic counseling to help with future family planning.
- Transition to adult care and referrals to adult specialists to address any health challenges that arise as your child grows and develops (i.e. reproductive issues and fertility preservation).
Our research in congenital adrenal hyperplasia (CAH) focuses in determining the long term outcomes in CAH including quality of life, effect of CAH on fertility in both males and females and understanding metabolic changes in CAH.
Additional research efforts focus on understanding the metabolic effects of high dose steroids in critically ill patients.