Cancer Center News

Yael Mossé, MD, received the William Osler Patient Oriented Research Award, which was established in 1996 to honor Osler, a “Father of Clinical Medicine” who, in the 1800s, revolutionized clinical teaching and patient-oriented research at the Perelman School of Medicine at the University of Pennsylvania.

Made possible with a $4 million grant from the Brazilian Ministry of Health, CHOP cell therapy specialists will offer their expertise and resources to oversee this initiative.

Researchers at Children’s Hospital of Philadelphia (CHOP) have elucidated the significant role that alternative splicing – a process whereby a single gene produces multiple proteins by rearranging its messenger RNA segments in different combinations – plays in resistance to chemotherapy in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). The study published today in the journal Cancer Research.

This award will help research, validate and implement a new model for sharing and integrating data at a national level.

Evan Weber will use this “high risk, high reward” grant to fund research into improving CAR-T therapies.

Researchers at Children’s Hospital of Philadelphia (CHOP) revealed for the first time that children, adolescents and young adults may experience very rare neurological issues of paraparesis and quadriparesis following chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy used to treat B-cell Acute Lymphoblastic Leukemia (B-ALL). Additionally, these complications occurred without the type of inflammation typically seen in adults. The findings were published today in the journal Blood.

CHOP researchers are aiming to treat a wider range of cancers by reaching previously “unreachable” drug targets.

Researchers in the Children’s Oncology Group (COG) at Children’s Hospital of Philadelphia (CHOP) are highlighting key factors influencing survival rates after the first relapse of acute lymphoblastic leukemia (ALL) in children. The study, which is the largest of its kind to evaluate leukemia relapse in children, was published recently in the journal Leukemia.

Dr. Adam Wolpaw and Dr. Timothy Spear of Children's Hospital of Philadelphia (CHOP) received the Scholar Hope Award and Young Investigator Award respectively from Hyundai Hope On Wheels.

Researchers at Children’s Hospital of Philadelphia (CHOP) demonstrated a promising new approach in the fight against high-risk neuroblastoma, a common and potentially deadly childhood cancer that can occur within the peripheral nervous system. The study, recently published in Nature Communications, found that chimeric antigen receptor (CAR) T-cell therapy targeting two markers on neuroblastoma cancer cells simultaneously boosted overall immune response by engaging adaptive and innate immunity in preclinical models.