Pediatric Concussion Research

CHOP's Concussion Program has a robust research arm that helps to inform the resources we share here, as well as fuel important advances in how we diagnose and manage pediatric and adolescent concussion. Through our research efforts, we seek to advance targeted interventions to prevent concussion and optimize treatments to shorten recovery time and improve individual outcomes.

See a selection of recent publications highlighted below, and visit our Minds Matter Concussion Research Program website for more details about our ongoing research.


Roby PR, Mozel AE, Arbogast KB, Buckley T, Caccese JB, Chrisman SP, Clugston JR, Eckner JT, Esopenko C, Hunt T, Kelly LA, McDevitt J, Perkins SM, Putukian M, Susmarski A, Broglio SP, Pasquina PF, McAllister TW, McCrea M, Master CL; CARE Consortium Investigators. Post-injury outcomes following non-sport related concussion: A CARE Consortium Study. J Athl Train. 2023 Sep 8. doi: 10.4085/1062-6050-0181.23. Epub ahead of print. PMID: 37681681.

Vernau BT, Haider MN, Fleming A, Leddy JJ, Willer BS, Storey EP, Grady MF, Mannix R, Meehan W, Master CL. Exercise-Induced Vision Dysfunction Early After Sport-Related Concussion Is Associated With Persistent Postconcussive Symptoms. Clin J Sport Med. 2023 Mar 30. doi: 10.1097/JSM.0000000000001145. Epub ahead of print. PMID: 37015066.

Corrado C, Willer BS, McPherson JI, Storey EP, Sisto SA, Master CL, Wiebe DJ, Grady MF, Mannix RC, Meehan WP, Leddy JJ, Haider MN. Adolescents With More Oculomotor and Vestibular Signs of Sport-Related Concussion Benefit from Aerobic Exercise: An Exploratory Analysis. J Neurotrauma. 2023 Aug;40(15-16):1718-1729. doi: 10.1089/neu.2022.0225. Epub 2023 Apr 20. PMID: 36884297.

Corwin DJ, Mandel F, McDonald CC, Mohammed FN, Margulies S, Barnett I, Arbogast KB, Master CL. Maximizing accuracy of adolescent concussion diagnosis using individual elements of common standardized clinical assessment tools. J Athl Train. 2023 Jan 16. doi: 10.4085/1062-6050-0020.22. Epub ahead of print. PMID: 36645832.

Huber CM, Patton DA, Rownd KR, Patterson Gentile C, Master CL, Arbogast KB. Neurophysiological Effects of Repeated Soccer Heading in Youth. J Biomech Eng. 2023 Sep 1;145(9):091005. doi: 10.1115/1.4062423. PMID: 37216312; PMCID: PMC10259471.

Roby PR, Podolak OE, Grady M, Arbogast KB, Master CL. The effect of a home exercise program on visio-vestibular function in concussed pediatric patients. Front Sports Act Living. 2023 Mar 3;5:1064771. doi: 10.3389/fspor.2023.1064771. PMID: 36935886; PMCID: PMC10020172.

Roby PR, Grimberg A, Master CL, Arbogast KB. Menstrual Cycle Patterns After Concussion in Adolescent Patients. J Pediatr. 2023 Feb 15;262:113349. doi: 10.1016/j.jpeds.2023.02.002. Epub ahead of print. PMID: 36796579; PMCID: PMC10423739.


Roby PR, Metzger KB, Storey EP, Master CL, Arbogast KB. Influence of concussion history and age of first concussion on visio-vestibular function. J Sci Med Sport. 2022 Sep;25(9):715-719. doi: 10.1016/j.jsams.2022.06.006. Epub 2022 Jun 21. PMID: 35821211; PMCID: PMC9489638.

Chizuk HM, Willer BS, Cunningham A, Bezherano I, Storey E, Master C, Mannix R, Wiebe DJ, Grady MF, Meehan WP, Leddy JJ, Haider MN. Adolescents with Sport-Related Concussion Who Adhere to Aerobic Exercise Prescriptions Recover Faster. Med Sci Sports Exerc. 2022 Sep 1;54(9):1410-1416. doi: 10.1249/MSS.0000000000002952. Epub 2022 Apr 28. PMID: 35482774; PMCID: PMC9378725.

Jain D, Arbogast KB, McDonald CC, Podolak OE, Margulies SS, Metzger KB, Howell DR, Scheiman MM, Master CL. Eye Tracking Metrics Differences among Uninjured Adolescents and Those with Acute or Persistent Post-Concussion Symptoms. Optom Vis Sci. 2022 Aug 1;99(8):616-625. doi: 10.1097/OPX.0000000000001921. Epub 2022 Jul 14. PMID: 35848958; PMCID: PMC9361745.

Corwin DJ, McDonald CC, Arbogast KB, Mohammed FN, Grady MF, Master CL. Visio-Vestibular Deficits in Healthy Child and Adolescent Athletes. Clin J Sport Med. 2022 Jul 1;32(4):376-384. doi: 10.1097/JSM.0000000000000955. Epub 2021 Jun 22. PMID: 34173781; PMCID: PMC8692490.

Corwin DJ, Root JM, Zonfrillo MR, Thomas DG. Concussion Referral and Practice Patterns by Pediatric Emergency Medicine Providers. Pediatr Emerg Care. 2022 Mar 1;38(3):e1133-e1138. doi: 10.1097/PEC.0000000000002523. PMID: 34432741.

Patton DA, Huber CM, Fedonni D, Margulies SS, Master CL, Arbogast KB. Quantifying head impact exposure, mechanisms and kinematics using instrumented mouthguards in female high school lacrosse. Res Sports Med. 2022 Feb 23:1-15. doi: 10.1080/15438627.2022.2042294. Epub ahead of print. PMID: 35195503; PMCID: PMC9921769.

Lempke LB, Lynall RC, Anderson MN, McCrea MA, McAllister TW, Broglio SP, Schmidt JD; CARE Consortium Investigators. Optimizing Order of Administration for Concussion Baseline Assessment Among NCAA Student-Athletes and Military Cadets. Sports Med. 2022 Jan;52(1):165-176. doi: 10.1007/s40279-021-01493-y. Epub 2021.


Patton  DA , Huber CM, Margulies SS, Master CL, Arbogast KB. Comparison of Video-Identified Head Contacts and Sensor-Recorded Events in High School Soccer. J Appl Biomech. 2021 Nov 15;1-5. doi: 10.1123/jab.2021-0191. Online ahead of print.

Roby PR, Metzger KB, McDonald CC, Corwin DJ, Huber CM, Patton DA, Margulies SS, Grady MF, Master CL, Arbogast KB. Pre- and post-season visio-vestibular function in healthy adolescent athletes. Phys Sportsmed. 2021 Sep 21;1-9. doi: 10.1080/00913847.2021.1980744. Online ahead of print.

Zimmerman SD, Vernau  BT, Meehan WP, Master CL. Sports-Related Concussions and the Pediatric Patient. Clin Sports Med. 2021 Jan;40(1):147-158. doi: 10.1016/j.csm.2020.08.010.

Huber CM, Patton DA, Jain D, Master CL, Margulies SS, McDonald CC, Arbogast KB. Variations in Head Impact Rates in Male and Female High School Soccer. Med Sci Sports Exerc. 2021 Jun 1;53(6):1245-1251.

Jain, D., Arbogast, K.B., Master, C.L., & McDonald, C.C. (2021). An integrative review of return to driving after concussion in adolescents. Journal of School Nursing, 37(1), 17-27.

Metzger KB, Corwin DJ, Wiebe DJ, Master CL, Grady MF, Arbogast KB, McDonald CC, Storey, E.P., Pfeiffer MR, Margulies SS, Grady MF. Assessment of Saccades and Gaze Stability in the Diagnosis of Pediatric ConcussionClinical Journal Of Sport Medicine, 2021.

Master CL, Arbogast KB, McDonald CC, Margulies SS, Huber, CM, Patton DA, Jain, D., Simmons, K, Lallo, V., Margulies, SS. Sport- and Gender-Based Differences in Head Impact Exposure and Mechanism in High School Sports. Orthopaedic Journal Of Sports Medicine. 2021.

Master, C.L. Arbogast KB, Podolak OE, Grady MF, Sleet, D. Pediatric Sports-Related Concussion: An Approach to Care. American Journal Of Lifestyle Medicine. 2021.

Haider, N., Arbogast KB, Patel, K., Willer, B., Videira, V., Wilber, C., Mayer AR, Master, C.L., Mariotti, B., Wertz, CJ, Storey, E.P., Park, G., Oglesbee, S., Bezherano, I., Aguiree, K., Fodero, J., Johnson, B., Mannix, R., Miecznikowski, J., Leddy, J. Symptoms upon postural change and orthostatic hypotension in adolescents with concussion. Brain Injury. 2021.

Feinberg C, Carr C, Master C, et al. Association of Pharmacological Interventions with Symptom Burden Reduction in Patients with Mild Traumatic Brain Injury: A Systematic Review. JAMA Neurology. Jan 2021. 


Mannix R, Levy R, Zemek R, Arbogast KB, Master C, et al. Fluid Biomarkers of Pediatric Mild Traumatic Brain Injury: A Systematic Review. Journal of Neurotrauma. Oct 2020.

McDonald, C.C., Jain, D., Storey, E.P., Gonzalez, M., Master, C.L., & Arbogast, K.B. Changes in driving behavior after concussion in adolescents. Journal of Adolescent Health. Dec. 2020.

Master CL, Podolak OE, Ciuffreda KJ, et al.  Utility of Pupillary Light Reflex Metrics as a Physiologic Biomarker for Adolescent Sport-Related Concussion.  JAMA Ophthalmol. 2020.

Master CL, Curry AE, Pfeiffer MR, et al. Characteristics of Concussion in Elementary School-Aged Children: Implications for Clinical Management. The Journal of Pediatrics. 2020.

Podolak O, Chaudhary S, Haarbauer-Krupa J, et al. Characteristics of Diagnosed Concussions in Children Aged 0 to 4 Years Presenting to a Large Pediatric Healthcare Network. Pediatric Emergency Care. 2020.

Howell DR, Mayer AR, Master CL, et al. Prognosis for Persistent Post Concussion Symptoms using a Multifaceted Objective Gait and Balance Assessment Approach. Gait Posture. 2020;79:53-59. 

McDonald CC, Pfeiffer MR, Robinson RL, Arbogast KB, Master CL. Telephone Triage in Pediatric Head Injury: Follow-up Patterns and Subsequent Diagnosis of Concussion. Clin Nurs Res. 2020. 

Hajiaghamemar M, Kilbaugh T, Arbogast KB, Master CL, Margulies SS. Using Serum Amino Acids to Predict Traumatic Brain Injury: A Systematic Approach to Utilize Multiple Biomarkers. Int J Mol Sci. 2020;21(5). 

Patton DA, Huber CM, McDonald CC, Margulies SS, Master CL, Arbogast KB. Video Confirmation of Head Impact Sensor Data From High School Soccer Players. Am J Sports Med. 2020.


Corwin DJ, McDonald CC, Arbogast KB, et al. Clinical and Device-based Metrics of Gait and Balance in Diagnosing Youth Concussion. Med Sci Sports Exerc. 2019.

Desai N, Wiebe DJ, Corwin DJ, Lockyer J, Grady MF, Master CL. Factors Affecting Recovery Trajectories in Pediatric Female Concussion. Clin J Sport Med. 2019;29(5):361-367.

Mannix R, Zemek R, Yeates KO, et al. Practice Patterns in Pharmacologic and Non-pharmacologic Therapies for Children with Mild Traumatic Brain Injury: A survey of 15 Canadian and United States Centers. J. Neurotrauma. 2019.

Mayer AR, Cohen DM, Wertz CJ, et al. Radiologic common data elements rates in pediatric mild traumatic brain injury. Neurology. 2019.

Curry AE, Arbogast KB, Metzger KB, et al. Risk of Repeat Concussion Among Patients Diagnosed at a Pediatric Care Network. J. Pediatr. 2019.


Mayer AR, Kaushal M, Dodd AB, et al. Advanced Biomarkers of Pediatric Mild Traumatic Brain Injury: Progress and Perils. Neurosci Biobehav Rev. 2018.

Corwin DJ, Zonfrillo MR, Wiebe DJ, Master CL, Grady MF, Arbogast KB. Vestibular and Oculomotor Findings in Neurologically-Normal, Non-Concussed children. Brain Inj. 2018;32(6):794-799.

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