Congenital Hyperinsulinism Center News and Updates

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Guidelines for Managing HI in School

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Both medical management and neurodevelopmental conditions may require accommodations for your child with hyperinsulinism at school.

Welcome Emily Wilkinson!

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Nurse practitioner Emily Wilkinson, MSN, CRNP, CPNP-PC, is the newest member of the Congenital Hyperinsulinism Center team. Get to know Emily. [short teaser] Meet nurse practitioner Emily Wilkinson, MSN, who will see children in CHOP’s Congenital Hyperinsulinism Center.

Two Focal Lesions: Extra Rare Cases Not so Rare at CHOP

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The Congenital Hyperinsulinism Center at Children’s Hospital of Philadelphia, with a high volume of approximately 80 congenital hyperinsulinism (HI) cases a year, sees a large share of unusual cases.

Neurodevelopmental Outcomes in HI

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Unrecognized or inadequately treated hyperinsulinism (HI) poses a high risk of adverse neurodevelopmental outcomes due to the combined insult of hypoglycemia and lack of alternate brain fuels.

When Hyperinsulinism is a Family Affair

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Three Generations Under CHOP’s Care for HI - Rian

Inactivating mutations in the beta cell KATP channels are the most common cause of congenital hyperinsulinism (HI), accounting for approximately 60% of all cases with known genotype. The beta cell KATP channels play a very important role in the regulation of insulin secretion by coupling the metabolic state of the cell to membrane potential.

Radiology: Key Member of the HI Team

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For the children with focal hyperinsulinism, the radiologist’s interpretation of a 18F-DOPA PET/CT scan guides the surgeon, leading to a cure in 97% of cases.

Meet the HI Center’s Nurse Coordinators

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Nurse coordinators at the Congenital Hyperinsulinism Center assist patient families before the first appointment and through admission and follow-up.