CHOP Researchers Reveal How NSAIDs Worsen C. difficile Infections
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CHOP researchers have shown that NSAIDs disrupt epithelial cells in the colon and sensitize them to C. difficile toxins by perturbing cell mitochondria.
Division of Gastroenterology, Hepatology and Nutrition News and Updates
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CHOP Researchers Use Lab-Grown “Mini-Intestines” to Study Inner Lining of Gastrointestinal Tract for Crohn’s Disease Patients
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Researchers from Children’s Hospital of Philadelphia (CHOP) confirmed that “mini-intestines” generated from patient tissue samples and grown in a lab can accurately replicate certain features of Crohn’s disease, which will allow them to study the epithelium, the thin layer of cells lining the intestine, that is broken down in patients with inflammatory bowel disease.
Children’s Hospital of Philadelphia Establishes the Martha Escoll Lubeck Feeding and Swallowing Center
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$4 million gift from the Escoll-Lubeck Charitable Foundation will support innovative and high-quality care to children with feeding and swallowing disorders and their families.
The Next Frontier of Care for VEO-IBD
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Very early onset inflammatory bowel disease was virtually unheard of just a decade ago. Today, a variety of personalized therapies exist, and potential curative gene therapies are on the horizon.
Practice Variation and Guidelines for the Diagnosis and Treatment of Celiac Disease in Children
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Regional and local differences in the diagnosis and treatment of celiac disease affects outcomes for youth.
Promising Use for Antibody Treatment for EoE
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Two recent studies show dupilumab improves eosinophilic esophagitis symptoms and pathology for adolescents and young adults.
Motility Case Study
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When rumination and gastroparesis collide in patients at Children’s Hospital of Philadelphia, a personalized treatment plan is developed.
Pancreatic Case Study
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Continued surveillance after pancreatic solid pseudopapillary tumor and pancreatic insufficiency is important – even after treatment.
Growing Mini-Organs for Personalized GI Solutions
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Researchers from CHOP and Penn are working to perfect 3D models of GI disease and create more personalized treatments for patients.
CHOP-led Study Shows that Antibiotic-Resistant Microbes in the Gut Make C. difficile More Infectious
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CHOP researchers have found that Enterococcus – an antibiotic-resistant, opportunistic pathogen – works together with C. difficile, reshaping and enhancing the metabolic environment in the gut so that C. difficile can thrive.