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CHOP researchers found that a series of “liquid biopsies” could less invasively and more accurately identify tumor changes in patients with high-risk neuroblastoma.
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Four CHOP researchers are part of a world-class research team that will receive $25 million to study solid tumors in children, funded by Cancer Grand Challenges.
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More than 250 experts gathered in Philadelphia and virtually to discuss the latest scientific advancements and breakthroughs in pediatric precision medicine oncology.
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CHOP researchers have shown that linking a tumor-killing prodrug to a macromolecular carrier of the Poloxamer family improves retention of the drug in treatment-resistant neuroblastoma tumors.
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CHOP researchers have developed a novel cancer therapy that targets proteins inside cancer cells that are essential for tumor growth and survival but have been historically impossible to reach.
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The award was presented to the St. Baldrick’s Foundation-Stand Up 2 Cancer Pediatric Cancer Dream Team, co-led by CHOP, at the annual AACR conference.
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CHOP researchers will receive funds to discover a new drug that targets MYCN, a transcription factor involved in some pediatric cancers.
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The CHOP physician-researcher’s investigation into cause of and treatment for neuroblastoma has been supported by Conquer Cancer grants.
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Read this case study about a patient who received treatment for osteosarcoma and underwent limb salvage surgery at Children’s Hospital of Philadelphia.
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The CHOP-engineered therapy overcomes common drug resistance and has potential to elicit fewer toxicities than most cancer treatments.