Yimei Li, PhD

female silhouette icon

Yimei Li, PhD, is a research biostatistician with the Division of Oncology at The Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Undergraduate Degree

BS in Applied Mathematics - Peking University, Beijing, China

Graduate Degree

PhD in Biostatistics - University of Pennsylvania, Philadelphia, PA
MS in Biostatistics - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Research Biostatistician

Assistant Professor of Biostatistics, Perelman School of Medicine at the University of Pennsylvania
Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2016

Desai A, Seif A, Li Y, Getz K, Fisher B, Huang YV, Mante A, Aplenc R, Bagatell R (2016). Resource utilization and toxicities after carboplatin/etoposide/melphalan and busulfan/melphalan for autologous stem cell rescue in high-risk neuroblastoma using a national administrative database. Pediatr Blood Cancer. 2016 May;63(5):901-7. doi: 10.1002/pbc.25893. Epub 2016 Jan 21.

Daniel LC, Li Y, Kloss J, Reilly AF, Barakat LP (2016). The impact of dexamethasone and prednisone on sleep in children with acute lymphoblastic leukemia. 2016 Apr, Supportive Care in Cancer, DOI 10.1007/s00520-016-3234-y

Levin MH, Armstrong GT, Broad JH, Zimmerman R, Bilaniuk LT, Feygin T, Li Y, Liu GT, Fisher MJ. Risk of optic pathway glioma in children with neurofibromatosis type 1 and optic nerve tortuosity or nerve sheath thickening. Br J Ophthalmol. 2016 Apr;100(4):510-4. doi: 10.1136/bjophthalmol-2015-306958. Epub 2015 Aug 20.

Roth JJ, First T, Wanders A, Li Y, Biegel JA, Santi M (2016). Whole chromosome 7 gain predicts high risk of recurrence in pilocytic astrocytomas independently from BRAF-KIAA1549 fusion status. 2016 Mar, Journal of Neuropathology and Experimental Neurology.

DiNofia A, Salazar E, Seif AE, Li Y, Huang YS, Bagatell R, Fisher BT, Aplenc R (2016). Bortezomib inpatient prescribing practices in free-standing children’s hospitals in the United States. 2016 Mar, PLoS One, 11(3):e0151362. doi: 10.1371/journal.pone.0151362

Miller TP, Li Y, Kavcic M, Troxel A, Huang YV, Luger S, Alonzo T, Gerbing R, Hall M, Daves M, Horton TM, Pulsipher MA, Pollard J, Bagatell R, Seif AE, Fisher BT, Rubin D, Luger S, Gamis L, Adamson PC, Aplenc R (2016). Accuracy of adverse event ascertainment in clinical trials for pediatric acute myeloid leukemia. J Clin Oncol. 2016 May 1;34(13):1537-43. doi: 10.1200/JCO.2015.65.5860. Epub 2016 Feb 16.

Miller TP, Li Y, Kavcic M, Troxel A, Huang YV, Luger S, Alonzo T, Gerbing R, Hall M, Daves M, Horton TM, Pulsipher MA, Pollard J, Bagatell R, Seif AE, Fisher BT, Rubin D, Luger S, Gamis L, Adamson PC, Aplenc R. Accuracy of adverse event ascertainment in clinical trials for pediatric acute myeloid leukemia. J Clin Oncol. 2016 May 1;34(13):1537-43. doi: 10.1200/JCO.2015.65.5860. Epub 2016 Feb 16.

Babushok DV, Grignon AL, Li Y, Atienza J, Xie HM, Lam HS, Hartung H, Bessler M, Olson TS. Disrupted lymphocyte homeostasis in hepatitis-associated acquired aplastic anemia is associated with short telomeres. Am J Hematol. 2016 Feb;91(2):243-7. doi: 10.1002/ajh.24256.

Daniel LC, Kazak A, Li Y, Hobbie W, Ginsberg J, Butler E, Schwartz L. Relationship between sleep problems and psychological outcomes in adolescent and young adult cancer survivors and controls. Support Care Cancer. 2016 Feb;24(2):539-46. doi: 10.1007/s00520-015-2798-2. Epub 2015 Jul 1.

Miller TP, Getz KD, Kavcic M, Li Y, Huang YS, Sung L, Alonzo T, Gerbing R, Daves M, Horton T, Pulsipher M, Pollard J, Bagatell R, Seif AE, Fisher BT, Gamis A, Aplenc R (2016). A comparison of discharge strategies after chemotherapy completion in pediatric patients with acute myeloid leukemia: A report from the Children’s Oncology Group. 2016 Jan, Leukemia and Lymphoma

Infarinato N, Park J, Krytska K, Ryles H, Sano R, Szigety K, Li Y, Zou H, Lee N, Smeal T, Lemmon M, Mosse Y. The ALK/ROS1 inhibitor PF-06464922 overcomes primary resistance to crizotinib in ALK-driven neuroblastoma. Cancer Discov. 2016 Jan;6(1):96-107. doi: 10.1158/2159-8290.CD-15-1056. Epub 2015 Nov 10.

2015

Lee GE, Fisher BT, Xiao R, Coffin SE, Feemster K, Seif AE, Bagatell R, Li Y, Huang YV, Aplenc R. Burden of influenza-related hospitalizations and attributable mortality in pediatric acute lymphoblastic leukemia. J Pediatric Infect Dis Soc. 2015 Dec;4(4):290-6. doi: 10.1093/jpids/piu066. Epub 2014 Jul 22.

Getz KD, Li Y, Alonzo TA, Fisher BT, Gerbing RB, Hall M, Arnold S, Huang YS, Seif AE, Bagatell R, Sung L, Adamson PC, Gamis A, Keren R, Aplenc R. Comparison of in-patient costs for patients treated on the AAML0531 clinical trial: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2015 Oct;62(10):1775-81. doi: 10.1002/pbc.25569. Epub 2015 May 6.

Patterson CA, Chavez V, Mondestin V, Deatrick JA, Li Y, Barakat LP. Clinical trial decision-making in pediatric sickle cell disease: A qualitative study of perceived benefits and barriers to participation. J Pediatr Hematol Oncol. 2015 Aug;37(6):415-22. doi: 10.1097/MPH.0000000000000216. DOI: 10.1097/MPH.0000000000000216.

Miller TP, Troxel A, Li Y, Huang YV, Alonzo T, Gerbing R, Hall M, Fisher BT, Bagatell R, Seif AE, Sung L, Gamis L, Rubin D, Luger S, Aplenc R. Comparison of administrative/billing data to expected protocol-mandated chemotherapy exposures in children with acute myeloid leukemia: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2015 Jul;62(7):1184-9. doi: 10.1002/pbc.25475. Epub 2015 Mar 11.

Barakat LP, Li Y, Hobbie WL, Ogle S, Hardie T, Volpe E, Szabo MM, Reilly M, Deatrick JA: Health-related quality of life of adolescent and young adult survivors of childhood brain tumors. Psychooncology. 2015 Jul;24(7):804-11. doi: 10.1002/pon.3649. Epub 2014 Aug 11.

Li Y, Zhang Q. A Weibull multi-state model for the dependence of progression-free survival and overall survival. Pediatr Blood Cancer. 2015 Jul;62(7):1184-9. doi: 10.1002/pbc.25475. Epub 2015 Mar 11.

G Salazar E, Bernhardt MB, Li Y, Aplenc R, Adamson PC. Clinical trials and chemotherapy shortage in pediatric oncology: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2015 Jun;62(6):940-4. doi: 10.1002/pbc.25445. Epub 2015 Feb 19.

Griffith S, Shiffman S, Li Y, Heitjan DF. Model-based imputation of latent cigarette counts using data from a calibration study. Int J Methods Psychiatr Res. 2015 Jun 16. doi: 10.1002/mpr.1468. [Epub ahead of print]

Seif AE, Walker D, Li Y, Huang YV, Karvcic M, Torp K, Fisher BT, Aplenc R. Dexrazoxane exposure and risk of secondary acute myeloid leukemia in pediatric oncology patients. Pediatr Blood Cancer. 2015 Apr;62(4):704-9. doi: 10.1002/pbc.25043. Epub 2014 Mar 26.

2014

Miller SD, Li Y, Ginsberg JP, Meyers KEC, Caplan A, Miller VA. Fertility preservation in pediatric nephrology: results of a physician survey. J Ren Care. 2014 Dec;40(4):257-62. doi: 10.1111/jorc.12079. Epub 2014 Jul 1.

Fisher BT, Sammons JS, Li Y, Huang YV, Seif AE, Kavcic M, Kleiger S, Blank PD, Harris T, Torp K, Rheam D, Shah A, Aplenc R: Variation in risk of hospital-onset clostridium difficile infection across beta-lactam antibiotics in children with new onset acute lymphoblastic leukemia. J Pediatric Infect Dis Soc. 2014 Dec;3(4):329-35. doi: 10.1093/jpids/piu008. Epub 2014 Feb 16.

Goodman EK, Reilly A, Fisher BT, Fitzgerald JC, Li Y, Seif AE, Huang YV, Bagatell R, Aplenc R. Association of weekend admission with hospital length of stay, time to chemotherapy and risk of respiratory failure in pediatric patients with newly diagnosed leukemia at freestanding U.S. children's hospitals. JAMA Pediatr. 2014 Oct;168(10):925-31. doi: 10.1001/jamapediatrics.2014.1023.

Freedman JL, Faerber J, Kang TI, Dai D, Localio AR, Fisher BT, Huang YS, Li Y, Aplenc R, Feudtner C. Predictors of antiemetic alteration in pediatric acute myeloid leukemia. Pediatr Blood Cancer. 2014 Oct;61(10):1798-805. doi: 10.1002/pbc.25108. Epub 2014 Jun 17.

Deatrick JA, Hobbie WL, Ogle S, Fisher M, Barakat LP, Hardie T, Li Y, Ginsberg J. Competence in caregivers of adolescent and young adult childhood brain tumor survivors. Health Psychol. 2014 Oct;33(10):1103-12. doi: 10.1037/a0033756. Epub 2013 Aug 19.

Desai AV, Kavcic M, Huang YV, Herbst N, Fisher BT, Seif AE, Li Y, Hennessy S, Aplenc R, Bagatell R. Establishing a high-risk neuroblastoma cohort using the Pediatric Hospital Information System. Pediatr Blood Cancer. 2014 Jun;61(6):1129-31. doi: 10.1002/pbc.24930. Epub 2014 Jan 13.

Seif AE, Fisher BT, Li Y, Torp K, Rheam DP, Huang YV, Harris T, Shah A, Hall M, Fieldston E, Vujkovic M, Bailey LC, Kersun LS, Reilly AF, Rheingold SR, Walker DS, Aplenc R. Patient and hospital factors associated with induction mortality in acute lymphoblastic leukemia. Pediatr Blood Cancer. 2014 May;61(5):846-52. doi: 10.1002/pbc.24855. Epub 2013 Nov 19.

Maude SL, Fitzgerald JC, Fisher BT, Li Y, Huang YV, Torp K, Seif AE, Kavcic M, Walker D, Leckerman KH, Kilbaugh T, Rheingold SR, Sung L, Zaoutis TE, Berg R, Nadkarni VM, Thomas N, Aplenc R. Outcome of pediatric acute myeloid leukemia patients receiving intensive care interventions in the United States. Pediatr Crit Care Med. 2014 Feb;15(2):112-20. doi: 10.1097/PCC.0000000000000042.

Fisher BT, Kavcic M, Li Y, Seif AE, Bagatell R, Huang YV,  Zaoutis T, Torp K, Leckerman K, Aplenc R. Antifungal prophylaxis associated with decreased induction mortality rates and resource utilized in children with new onset acute myeloid leukemia. Clin Infect Dis. 2014 Feb;58(4):502-8. doi: 10.1093/cid/cit781. Epub 2013 Nov 23.

Fisher BT, Singh S, Huang YV, Li Y, Gregory J, Walker D, Seif AE, Kavcic M, Aplenc R. Induction mortality, ATRA administration, and resource utilization in a nationally representative cohort of children with acute promyelocytic leukemia in the United States from 1999 to 2009. Pediatr Blood Cancer. 2014 Jan;61(1):68-73. doi: 10.1002/pbc.24585. Epub 2013 Jul 18. Fisher BT and Singh S are co-first authors, and Huang YV and Li Y are co-second authors.

Fisher BT, Harris T, Torp K, Seif AE, Shah A, Huang YV, Bailey LC, Kersun LS, Reilly AF, Rheingold SR, Walker D, Li Y, Aplenc R. Establishment of an 11-year cohort of 8733 pediatric patients hospitalized at United States free-standing children's hospitals with de novo acute lymphoblastic leukemia. Med Care. 2014 Jan;52(1):e1-6. doi: 10.1097/MLR.0b013e31824deff9.

Babushok DV,  Xie HM, Roth JJ, Perdigones N, Olson TS, Cockroft J, Gai X, Perin JC, Li Y, Paessler ME, Hakonarson H, Mason PJ, Biegel JA, Bessler. Single nucleotide polymorphism array analysis of bone marrow failure patients reveals characteristic patterns of genetic changes. Br J Haematol. 2014 Jan;164(1):73-82. doi: 10.1111/bjh.12603. Epub 2013 Oct 14.

Abstracts

 

2014

DiNofia A, Seif AE, Devidas M, Li Y, Hall M, Huang YS, Bagatell R, Hunger SP, Carroll WL, Naomi J, Fisher BT, Larse EC, Aplenc R: Resource Utilization and Cost Analysis by Treatment Arm on the Children's Oncology Group AALL0232 Phase 3 High-Risk B-Acute Lymphoblastic Leukemia Trial. ASH Annual Meeting, San Francisco, CA Dec 2014.

Posters and Presentations

2016

Frick M, Minturn J, Li Y, Hill-Kayser C. Radiotherapy-related outcomes in pediatric patients with atypical teratoid rhabdoid tumor of the central nervous system. Contributed Poster, AACR Annual Meetings, New Orleans, LO, Apr 2016.

Seif AE, Li Y, Aplenc R, Barrett DM, Casper JT, Freedman JL, Grupp SA, Margolis DA, Olson TM, Teachey DT, Wang Y, Talano JM, Bunin NJ. Favorable chronic graft-versus-host-disease (GVHD), event-free (EFS), and overall survival (OS) rates following partially CD3-depleted alternative donor peripheral stem cell transplantation (PSCT) for pediatric hematologic malignancies. Oral Presentation. BMT Tandem Meetings, Honolulu, HI, Feb 2016.

Hudgins E, Li Y, Smith EC, Smith LT, Bunin NJ, Seif AE. Low body mass index and hypoalbuminemia predict high-grade acute graft-versus-host disease (aGVHD) and early mortality in pediatric allogeneic hematopoietic stem cell transplantation (alloHSCT). Contributed Poster. BMT Tandem Meetings, Honolulu, HI, Feb 2016.

2015

Arnold SD, Satwani P, Brazauskas R, He N, Li Y, Aplenc R, Jin Z, Hall M, Atsuta Y, Dalal J, Hahn T, Sales-Bonfim C, Khera N, Saber W. A study of predictors of clinical outcomes and healthcare utilization in children with sickle cell disease undergoing allogeneic hematopoietic cell transplantation. Oral Presentation, ASH Annual Meeting, Orlando, FL, Dec 2015.

Rao P, Li Y, Getz KD, Seif AE, Miller TP, Huang YS, Bagatell R, Fisher B, Aplenc R.: Patterns of Pregnancy Screening Prior to Induction Chemotherapy For Adolescents with Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia Within the Pediatric Health Information System. Contributed Poster. Women's Health The 23rd Annual Congress, Washington, DC. Apr 2015.

Stevens EM, Patterson CA, Li Y, Smith-Whitley K, Barakat LP. Factors related to mistrust of clinical trials research among adolescent/young adults with sickle cell disease (SCD) and caregivers of children with SCD. Oral Presentation, Sickle Cell Disease Association of American 43rd Annual Convention, Baltimore, MD Sept 2015.

Gurunathan A, Desai A, Bailey C, Li Y, Choi J, Rheingold SR. Identification of Patients with CNS 2 Status Post-Induction and Outcomes. Contributed Poster. ASCO Annual Meeting, Chicago, IL, Jun 2015.

Miller TP, Li Y, Kavcic M, Alonzo T, Hall M, Huang YV, Gerbing R, Fisher BT, Luger S, Rubin D, Troxel A, Gamis L, Aplenc R. Accuracy of adverse event reporting on a phase III clinical trial for pediatric acute myeloid leukemia: A report from The Children’s Oncology Group. Contributed Poster. ASCO Annual Meeting, Chicago, IL, Jun 2015.

Rao P, Li Y, Getz KD, Seif AE, Miller TP, Huang YS, Bagatell R, Fisher B, Aplenc R. Patterns of Pregnancy Screening Prior to Induction Chemotherapy For Adolescents with Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia Within the Pediatric Health Information System. Contributed Poster. Women’s Health The 23rd Annual Congress, Washington, DC, Apr 2015.

2014

Goodman E, Li Y, Fisher BT, Fitzgerald J, Seif AE, Huang YS, Bagatell R, Aplenc R. Treatment toxicity and supportive care utilization in children with down syndrome and acute lymphoid leukemia at free-standing pediatric hospitals in the United States. Oral Presentation, ASH Annual Meeting, San Francisco, CA, Dec 2014.

Rao P, Li Y, Alonzo T, Sung L, Gerbing RB, Getz KD, Seif AE, Miller TP, Huang YS, Bagatell R, Hall M, Fisher BT, Gamis AS, Aplenc R: Patient factor associated with enrollment on an acute myeloid leukemia phase III clinical trial: A Report from the Children's Oncology Group. Contributed Poster. ASH Annual Meeting, San Francisco, CA Dec 2014.

Goodman E, Li Y, Fisher BT, Fitzgerald J, Seif AE, Huang YS, Bagatell R, Aplenc R: Treatment toxicity and supportive care utilization in children with down syndrome and acute lymphoid leukemia at free-standing pediatric hospitals in the United States. Oral Presentation. ASH Annual Meeting, San Francisco, CA Dec 2014.

Daniel LC, Li Y, Smith K, Morrison M, Tarazi R, Robinson MR, Patterson CA, Smith-Whitley K, Stuart M, Barakat L: Family-based Problem-solving Intervention for School-age Children with SCD. Contributed poster. Sickle Cell Disease Association of America Annual Meeting, Baltimore, MD Oct 2014.

Li Y, Wileyto EP, Heitjan DF: Predicting smoking cessation outcomes beyond clinical trials. Oral Presentation. ICSA Applied Statistics Symposium, Portland, OR Jun 2014.

Bagatell R, Fisher BT, Seif AE, Huang YS, Li Y, Desai AV, London WB, Van Ryn C, Park JR, Richardson T, Hall M, Aplenc R.: Evaluation of resources used during care of children with high-risk neuroblastoma via merging of cooperative group trial data & administrative data. Contributed Poster. ASCO Annual Meeting, Chicago, IL Jun 2014.

Quillen J, Li Y, Demski M, Bradley H, Ginsberg J, Hobbie W: Comparison of treatment knowledge between childhood Cancer Survivors and their Parents. Oral presentation. 6th International Nursing Conference on Childhood and Adolescent Cancer Survivorship. Philadelphia, PA Apr 2014.

Daniel LC, Kazak A, Li Y, Hobbie W, Ginsberg J, Butler E, Schwartz L: Relationship between Sleep and Psychological Outcomes in Adolescent Cancer Survivors and Controls. Oral Presentation. 6th International Nursing Conference on Child and Adolescent Cancer Survivorship. Philadelphia, PA Apr 2014.

Invited Lectures

2016

Yimei L. A Bayesian Design for Phase I platform trial of targeted cancer therapies. 5th Early Phase Adaptive Trials Workshop; 2016 Sep; Turin, Italy.

2015

Yimei L. Treatment prioritization in Phase I umbrella protocol for targeted cancer therapies. Joint Statistical Meeting (JSM); 2015 Aug; Seattle, WA.

Yimei L. Prediction of individual long-term smoking outcomes based on a multivariate cure-mixture frailty model. Department of Biostatistics, Columbia University; 2015 Apr; New York, NY.

2014

Yimei L. Merging Children's Oncology Group clinical trial data with Pediatric Health Information System using indirect patient identifiers.: Children's Hospital Association Analytics Conference; 2014 Oct; Kansas, MO.

Yimei L. Predicting smoking cessation outcomes beyond clinical trials. ICSA Applied Statistics Symposium; 2014 Jun; Portland, OR.

Awards and Honors

2009, Student Scholarship Award, Society for Clinical Trials
2998, Jonathan Raz Award, Biostatistics Program, University of Pennsylvania
2006, GlaxoSmithKline Scholar Award, Biostatistics Program, University of Pennsylvania

Editorial and Academic Positions

Editorial Positions

2013-present, International Journal of Statistics and Probability, editorial board

Reviewer

2015-present, PLOS ONE
2015-present, Journal of National Cancer Institute
2015- present, Clinical Trials
2014-present, Journal of Clinical Oncology
2014-present, Journal of Biopharmaceutical Statistics
2014-present, Contemporary Clinical Trials
2013-present, Clinical Epidemiology
2013-present, Statistics in Medicine
2011-present, Computational Statistics and Data Analysis
2011-present, Addictive Behaviors
2010-present, Journal of Biometrics & Biostatistics
2009-present, Nicotine & Tobacco Research

Academic and Institutional Committees

2015-present, CCEB Appointments Committee, Department of Biostatistics and Epidemiology, University of Pennsylvania
2014-present, Chair, Biostatistics seminar series committee, Department of Biostatistics and Epidemiology, University of Pennsylvania
2014, Strategic Planning Research Programs in Biostatistics, Division of Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania
2013-present, Biostatistics junior faculty committee, Department of Biostatistics and Epidemiology, University of Pennsylvania
2013-2014, Biostatistics seminar series committee, Department of Biostatistics and Epidemiology, University of Pennsylvania
2010-present, Biostatistics seminar series committee, Department of Biostatistics and Epidemiology, University of Pennsylvania
2010-present, Clinical Research Quality Assurance Committee, Division of Oncology, CHOP
2010- present, Member, Pediatric Protocol Review Committee, Division of Oncology, CHOP
2010- present, Member, Pediatric Protocol Review Committee, Division of Oncology, CHOP

Leadership and Memberships

Memberships in Professional Organizations

International

2011-present, International Chinese Statistical Association

National

2007-present, Eastern North American Region, International Biometric Society
2007-present, American Statistical Association