Robert N. Baldassano, MD

Robert N. Baldassano, MD

Robert N. Baldassano, MD, is a Pediatric Gastroenterologist and Director of the Center for Pediatric Inflammatory Bowel Disease at Children’s Hospital of Philadelphia.

Areas of Expertise: Diet and inflammatory bowel disease, Crohn's disease, Ulcerative colitis
Locations: Main Campus

Phone: 215-590-3630

Background

Robert N. Baldassano, MD, is a board-certified pediatric gastroenterologist and director of the Center for Pediatric Inflammatory Bowel Disease at Children’s Hospital of Philadelphia. He specializes in diagnosing and treating children with Crohn’s disease and ulcerative colitis, and is actively researching new treatments for these gastrointestinal disorders.

Dr. Baldassano became a doctor and chose gastroenterology as a specialty for a very personal reason: He has Crohn’s disease. “I was in my 20s and working as a systems analyst when I was diagnosed. I felt drawn to medicine as a career. I thought maybe I’d be able to help create new therapies or cures that could help others, as well as myself.”

His philosophy of care is simple: “Every child deserves a perfect life. I try to make that happen.”

Because of his own 30-year battle with Crohn’s disease, Dr. Baldassano understands the challenges of symptom flare-ups, repeated endoscopies, and frequent hospitalizations.

“I guess I have empathy for my patients. I’ve lived their lives,” Dr. Baldassano says. “I understand their struggles and I’m working to improve treatment for all.”

Education and experience

Dr. Baldassano earned his bachelor’s degree from the State University of New York (SUNY) at Albany, and his medical degree from the College of Medicine at SUNY Health Science Center in Brooklyn, NY. He completed his pediatric residency training at The Children’s Hospital of Philadelphia, then served two-year terms as a clinical fellow, then a research fellow in gastroenterology at CHOP.

After his intensive training, Dr. Baldassano worked at Geisinger Medical Center in Danville, PA, for several years. In 1996, he returned to CHOP as a senior pediatric gastroenterologist and director of CHOP’s Center for Pediatric Inflammatory Bowel Disease.

Since then, Dr. Baldassano has continued his clinical and research work with children who have inflammatory bowel diseases. He served as associate medical director of CHOP’s Clinical Research Institute for five years.

Currently, Dr. Baldassano also holds the titles of Colman Family Chair in Pediatric Inflammatory Bowel Disease, medical director of the CHOP Specialty Care Center in Abington, PA, and co-director of the Penn/CHOP Microbiome Program.

Dr. Baldassano is actively involved in numerous professional and scientific societies including the Crohn’s and Colitis Foundation of America, the American Gastroenterological Association and the IBD Family Research Council. He has published hundreds of papers, presented at regional, national and international meetings, and received dozens of awards.

Research

In addition to his clinical work, Dr. Baldassano oversees a large team of researchers at CHOP. The team has more than 30 ongoing studies. Doctors and scientists are working together to translate discoveries in the laboratory into direct patient care for children.

One promising area of current research is investigating the intestinal microbiomes of children with inflammatory bowel diseases.

“Intestinal diseases are driven by the organisms that live inside us, and our diet — what we eat — greatly influences that,” Dr. Baldassano said. “We’re studying how diet changes can alter an individual’s microbiome so that it promotes health, instead of disease.”

Education and Training

Medical School

MD - SUNY Health Science Center at Brooklyn, College of Medicine, Brooklyn, NY

Residency

Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Gastroenterology and Nutrition (clinical and research fellowships) - Children's Hospital of Philadelphia

Board Certification

Diplomate, National Board of Medical Examiners
Pediatric Gastroenterology and Nutrition
Pediatrics

Undergraduate Degree

BS - State University at Albany, Albany, NY

Titles and Academic Titles

Director, Center for Pediatric Inflammatory Bowel Disease

Co-Director, PennCHOP Microbiome Program

Director, CHOP Microbiome Center

Colman Family Endowed Chair in Pediatric Inflammatory Bowel Disease

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Pediatric inflammatory bowel disease

Publications

Papers

2016

Conrad Máire A, Stein Ronen E, Maxwell Elizabeth C, Albenberg Lindsey, Baldassano Robert N, Dawany Noor, Grossman Andrew B, Mamula Petar, Piccoli David A, Kelsen Judith R: Vedolizumab Therapy in Severe Pediatric Inflammatory Bowel Disease. Inflammatory bowel diseases 22(10): 2425-31, Oct 2016.

Brant Steven R, Okou David T, Simpson Claire L, Cutler David J, Haritunians Talin, Bradfield Jonathan P, Chopra Pankaj, Prince Jarod, Begum Ferdouse, Kumar Archana, Huang Chengrui, Venkateswaran Suresh, Datta Lisa W, Wei Zhi, Thomas Kelly, Herrinton Lisa J, Klapproth Jan-Micheal A, Quiros Antonio J, Seminerio Jenifer, Liu Zhenqiu, Alexander Jonathan S, Baldassano Robert N, Dudley-Brown Sharon, Cross Raymond K, Dassopoulos Themistocles, Denson Lee A, Dhere Tanvi A, Dryden Gerald W, Hanson John S, Hou Jason K, Hussain Sunny Z, Hyams Jeffrey S, Isaacs Kim L, Kader Howard, Kappelman Michael D, Katz Jeffry, Kellermayer Richard, Kirschner Barbara S, Kuemmerle John F, Kwon John H, Lazarev Mark, Li Ellen, Mack David, Mannon Peter, Moulton Dedrick E, Newberry Rodney D, Osuntokun Bankole O, Patel Ashish S, Saeed Shehzad A, Targan Stephan R, Valentine John F, Wang Ming-Hsi, Zonca Martin, Rioux John D, Duerr Richard H, Silverberg Mark S, Cho Judy H, Hakonarson Hakon, Zwick Michael E, McGovern Dermot P B, Kugathasan Subra: Genome-wide Association Study Identifies African-Specific Susceptibility Loci in African Americans with Inflammatory Bowel Disease. Gastroenterology Sep 2016.

Li Jin, Wei Zhi, Chang Xiao, Cardinale Christopher J, Kim Cecilia E, Baldassano Robert N, Hakonarson Hakon: Pathway-based Genome-wide Association Studies Reveal the Association Between Growth Factor Activity and Inflammatory Bowel Disease. Inflammatory bowel diseases 22(7): 1540-51, Jul 2016.

Stein Ronen, Lee Dale, Leonard Mary B, Thayu Meena, Denson Lee A, Chuang Emil, Herskovitz Rita, Kerbowski Theresa, Baldassano Robert N: Serum Infliximab, Antidrug Antibodies, and Tumor Necrosis Factor Predict Sustained Response in Pediatric Crohn's Disease. Inflammatory bowel diseases 22(6): 1370-7, Jun 2016.

Leonard Mary B, Shults Justine, Long Jin, Baldassano Robert N, Brown J Keenan, Hommel Kevin, Zemel Babette S, Mahboubi Soroosh, Whitehead Krista Howard, Herskovitz Rita, Lee Dale, Rausch Joseph, Rubin Clinton T: Effect of Low Magnitude Mechanical Stimuli on Bone Density and Structure in Pediatric Crohn's Disease: A Randomized Placebo Controlled Trial. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 31(6): 1177-88, Jun 2016 Notes: doi: 10.1002/jbmr.2799. Epub 2016 March 31.

Turner Dan, Levine Arie, Walters Thomas D, Focht Gili, Otley Anthony, López Victor Navas, Koletzko Sibylle, Baldassano Robert, Mack David, Hyams Jeffrey, Griffiths Anne M: Which PCDAI Version Best Reflects Intestinal Inflammation in Pediatric Crohn's Disease? Journal of pediatric gastroenterology and nutrition Apr 2016.

DeBoer Mark D, Thayu Meena, Griffin Lindsay M, Baldassano Robert N, Denson Lee A, Zemel Babette S, Denburg Michelle R, Agard Hannah E, Herskovitz Rita, Long Jin, Leonard Mary B: Increases in Sex Hormones during Anti-Tumor Necrosis Factor α Therapy in Adolescents with Crohn's Disease. The Journal of pediatrics 171: 146-152.e2, Apr 2016.

Withers David R, Hepworth Matthew R, Wang Xinxin, Mackley Emma C, Halford Emily E, Dutton Emma E, Marriott Clare L, Brucklacher-Waldert Verena, Veldhoen Marc, Kelsen Judith, Baldassano Robert N, Sonnenberg Gregory F: Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells. Nature medicine 22(3): 319-23, Mar 2016.

Wang Feng, Kaplan Jess L, Gold Benjamin D, Bhasin Manoj K, Ward Naomi L, Kellermayer Richard, Kirschner Barbara S, Heyman Melvin B, Dowd Scot E, Cox Stephen B, Dogan Haluk, Steven Blaire, Ferry George D, Cohen Stanley A, Baldassano Robert N, Moran Christopher J, Garnett Elizabeth A, Drake Lauren, Otu Hasan H, Mirny Leonid A, Libermann Towia A, Winter Harland S, Korolev Kirill S: Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota. Cell reports 14(4): 945-55, Feb 2016.

Cleynen Isabelle, Boucher Gabrielle, Jostins Luke, Schumm L Philip, Zeissig Sebastian, Ahmad Tariq, Andersen Vibeke, Andrews Jane M, Annese Vito, Brand Stephan, Brant Steven R, Cho Judy H, Daly Mark J, Dubinsky Marla, Duerr Richard H, Ferguson Lynnette R, Franke Andre, Gearry Richard B, Goyette Philippe, Hakonarson Hakon, Halfvarson Jonas, Hov Johannes R, Huang Hailang, Kennedy Nicholas A, Kupcinskas Limas, Lawrance Ian C, Lee James C, Satsangi Jack, Schreiber Stephan, Théâtre Emilie, van der Meulen-de Jong Andrea E, Weersma Rinse K, Wilson David C, Parkes Miles, Vermeire Severine, Rioux John D, Mansfield John, Silverberg Mark S, Radford-Smith Graham, McGovern Dermot P B, Barrett Jeffrey C, Lees Charlie W: Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. Lancet (London, England) 387(10014): 156-67, Jan 2016 Notes: Co-Author: International Inflammatory Disease Genetics Consortium (Robert N. Baldassano, M.D).

2015

Kelsen Judith R, Dawany Noor, Martinez Alejandro, Grochowski Christopher M, Maurer Kelly, Rappaport Eric, Piccoli David A, Baldassano Robert N, Mamula Petar, Sullivan Kathleen E, Devoto Marcella: Erratum to: A de novo whole gene deletion of XIAP detected by exome sequencing analysis in very early onset inflammatory bowel disease: a case report. BMC gastroenterology 15(1): 179, Dec 2015.

Kelsen Judith R, Dawany Noor, Moran Christopher J, Petersen Britt-Sabina, Sarmady Mahdi, Sasson Ariella, Pauly-Hubbard Helen, Martinez Alejandro, Maurer Kelly, Soong Joanne, Rappaport Eric, Franke Andre, Keller Andreas, Winter Harland S, Mamula Petar, Piccoli David, Artis David, Sonnenberg Gregory F, Daly Mark, Sullivan Kathleen E, Baldassano Robert N, Devoto Marcella: Exome Sequencing Analysis Reveals Variants in Primary Immunodeficiency Genes in Patients With Very Early Onset Inflammatory Bowel Disease. Gastroenterology 149(6): 1415-24, Nov 2015 Notes: doi. 10.1053/j.gastro.2015.07.006. Epub 2015 July 17.

Kelsen Judith R, Dawany Noor, Martinez Alejuandro, Grochowski Christopher M, Maurer Kelly, Rappaport Eric, Piccoli David A, Baldassano Robert N, Mamula Petar, Sullivan Kathleen E, Devoto Marcella: A de novo whole gene deletion of XIAP detected by exome sequencing analysis in very early onset inflammatory bowel disease: a case report. BMC gastroenterology 15: 160, Nov 2015.

Huang Chengrui, Haritunians Talin, Okou David T, Cutler David J, Zwick Michael E, Taylor Kent D, Datta Lisa W, Maranville Joseph C, Liu Zhenqiu, Ellis Shannon, Chopra Pankaj, Alexander Jonathan S, Baldassano Robert N, Cross Raymond K, Dassopoulos Themistocles, Dhere Tanvi A, Duerr Richard H, Hanson John S, Hou Jason K, Hussain Sunny Z, Isaacs Kim L, Kachelries Kelly E, Kader Howard, Kappelman Michael D, Katz Jeffrey, Kellermayer Richard, Kirschner Barbara S, Kuemmerle John F, Kumar Archana, Kwon John H, Lazarev Mark, Mannon Peter, Moulton Dedrick E, Osuntokun Bankole O, Patel Ashish, Rioux John D, Rotter Jerome I, Saeed Shehzad, Scherl Ellen J, Silverberg Mark S, Silverman Ann, Targan Stephan R, Valentine John, Wang Ming-Hsi, Simpson Claire L, Bridges S Louis, Kimberly Robert P, Rich Stephen S, Cho Judy H, Di Rienzo Anna, Kao Linda W H, McGovern Dermot P B, Brant Steven R, Kugathasan Subra: Characterization of Genetic Loci That Affect Susceptibility to Inflammatory Bowel Diseases in African Americans. Gastroenterology 149(6): 1575-86, Nov 2015 Notes: doi: 10.1053/j.gastro.2015.07.065. Epub 2015 Aug 14.

Li Yun R, Zhao Sihai D, Li Jin, Bradfield Jonathan P, Mohebnasab Maede, Steel Laura, Kobie Julie, Abrams Debra J, Mentch Frank D, Glessner Joseph T, Guo Yiran, Wei Zhi, Connolly John J, Cardinale Christopher J, Bakay Marina, Li Dong, Maggadottir S Melkorka, Thomas Kelly A, Qui Haijun, Chiavacci Rosetta M, Kim Cecilia E, Wang Fengxiang, Snyder James, Flatø Berit, Førre Øystein, Denson Lee A, Thompson Susan D, Becker Mara L, Guthery Stephen L, Latiano Anna, Perez Elena, Resnick Elena, Strisciuglio Caterina, Staiano Annamaria, Miele Erasmo, Silverberg Mark S, Lie Benedicte A, Punaro Marilynn, Russell Richard K, Wilson David C, Dubinsky Marla C, Monos Dimitri S, Annese Vito, Munro Jane E, Wise Carol, Chapel Helen, Cunningham-Rundles Charlotte, Orange Jordan S, Behrens Edward M, Sullivan Kathleen E, Kugathasan Subra, Griffiths Anne M, Satsangi Jack, Grant Struan F A, Sleiman Patrick M A, Finkel Terri H, Polychronakos Constantin, Baldassano Robert N, Luning Prak Eline T, Ellis Justine A, Li Hongzhe, Keating Brendan J, Hakonarson Hakon: Genetic sharing and heritability of paediatric age of onset autoimmune diseases. Nature communications 6: 8442, Oct 2015.

Lewis James D, Chen Eric Z, Baldassano Robert N, Otley Anthony R, Griffiths Anne M, Lee Dale, Bittinger Kyle, Bailey Aubrey, Friedman Elliot S, Hoffmann Christian, Albenberg Lindsey, Sinha Rohini, Compher Charlene, Gilroy Erin, Nessel Lisa, Grant Amy, Chehoud Christel, Li Hongzhe, Wu Gary D, Bushman Frederic D: Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn's Disease. Cell host & microbe 18(4): 489-500, Oct 2015.

Liu Jimmy Z, van Sommeren Suzanne, Huang Hailiang, Ng Siew C, Alberts Rudi, Takahashi Atsushi, Ripke Stephan, Lee James C, Jostins Luke, Shah Tejas, Abedian Shifteh, Cheon Jae Hee, Cho Judy, Daryani Naser E, Franke Lude, Fuyuno Yuta, Hart Ailsa, Juyal Ramesh C, Juyal Garima, Kim Won Ho, Morris Andrew P, Poustchi Hossein, Newman William G, Midha Vandana, Orchard Timothy R, Vahedi Homayon, Sood Ajit, Sung Joseph J Y, Malekzadeh Reza, Westra Harm-Jan, Yamazaki Keiko, Yang Suk-Kyun, Barrett Jeffrey C, Franke Andre, Alizadeh Behrooz Z, Parkes Miles, B K Thelma, Daly Mark J, Kubo Michiaki, Anderson Carl A, Weersma Rinse K: Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nature genetics 47(9): 979-86, Sep 2015.

Kelsen Judith R, Baldassano Robert N, Artis David, Sonnenberg Gregory F: Maintaining intestinal health: the genetics and immunology of very early onset inflammatory bowel disease. Cellular and molecular gastroenterology and hepatology 1(5): 462-476, Sep 2015.

Li Yun R, Li Jin, Zhao Sihai D, Bradfield Jonathan P, Mentch Frank D, Maggadottir S Melkorka, Hou Cuiping, Abrams Debra J, Chang Diana, Gao Feng, Guo Yiran, Wei Zhi, Connolly John J, Cardinale Christopher J, Bakay Marina, Glessner Joseph T, Li Dong, Kao Charlly, Thomas Kelly A, Qiu Haijun, Chiavacci Rosetta M, Kim Cecilia E, Wang Fengxiang, Snyder James, Richie Marylyn D, Flatø Berit, Førre Øystein, Denson Lee A, Thompson Susan D, Becker Mara L, Guthery Stephen L, Latiano Anna, Perez Elena, Resnick Elena, Russell Richard K, Wilson David C, Silverberg Mark S, Annese Vito, Lie Benedicte A, Punaro Marilynn, Dubinsky Marla C, Monos Dimitri S, Strisciuglio Caterina, Staiano Annamaria, Miele Erasmo, Kugathasan Subra, Ellis Justine A, Munro Jane E, Sullivan Kathleen E, Wise Carol A, Chapel Helen, Cunningham-Rundles Charlotte, Grant Struan F A, Orange Jordan S, Sleiman Patrick M A, Behrens Edward M, Griffiths Anne M, Satsangi Jack, Finkel Terri H, Keinan Alon, Prak Eline T Luning, Polychronakos Constantin, Baldassano Robert N, Li Hongzhe, Keating Brendan J, Hakonarson Hakon: Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nature medicine Aug 2015.

Lee Dale, Baldassano Robert N, Otley Anthony R, Albenberg Lindsey, Griffiths Anne M, Compher Charlene, Chen Eric Z, Li Hongzhe, Gilroy Erin, Nessel Lisa, Grant Amy, Chehoud Christel, Bushman Frederic D, Wu Gary D, Lewis James D: Comparative Effectiveness of Nutritional and Biological Therapy in North American Children with Active Crohn's Disease. Inflammatory bowel diseases 21(8): 1786-93, Aug 2015.

Kelsen Judith, Bittinger Kyle, Pauly-Hubbard Helen, Posivak Leah, Grunberg Stephanie, Baldassano Robert, Lewis James D, Wu Gary D, Bushman Frederic D: Alterations of the Subgingival Microbiota in Pediatric Crohn's Disease Studied Longitudinally in Discovery and Validation Cohorts. Inflammatory bowel diseases Aug 2015.

Chehoud Christel, Albenberg Lindsey G, Judge Colleen, Hoffmann Christian, Grunberg Stephanie, Bittinger Kyle, Baldassano Robert N, Lewis James D, Bushman Frederic D, Wu Gary D: Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease. Inflammatory bowel diseases 21(8): 1948-56, Aug 2015.

Hommel Kevin A, Gray Wendy N, Hente Elizabeth, Loreaux Katherine, Ittenbach Richard F, Maddux Michele, Baldassano Robert, Sylvester Francisco, Crandall Wallace, Doarn Charles, Heyman Melvin B, Keljo David, Denson Lee A: The Telehealth Enhancement of Adherence to Medication (TEAM) in pediatric IBD trial: Design and methodology. Contemporary clinical trials 43: 105-13, Jul 2015.

Cutler David J, Zwick Michael E, Okou David T, Prahalad Sampath, Walters Thomas, Guthery Stephen L, Dubinsky Marla, Baldassano Robert, Crandall Wallace V, Rosh Joel, Markowitz James, Stephens Michael, Kellermayer Richard, Pfefferkorn Marian, Heyman Melvin B, LeLeiko Neal, Mack David, Moulton Dedrick, Kappelman Michael D, Kumar Archana, Prince Jarod, Bose Promita, Mondal Kajari, Ramachandran Dhanya, Bohnsack John F, Griffiths Anne M, Haberman Yael, Essers Jonah, Thompson Susan D, Aronow Bruce, Keljo David J, Hyams Jeffrey S, Denson Lee A, Kugathasan Subra: Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping. PloS one 10(6): e0128074, Jun 2015.

Griffin LM, Thayu M, Baldassano RN, DeBoer MD, Zemel BS, Denburg MR, Denson LA, Shults J, Herskovitz R, Long J, Leonard MB. Improvements in bone density and structure during anti-TNF-α therapy in pediatric Crohn’s disease. J Clin Endocrinol Metab, April 28, 2015.  jc20144152 [Epub ahead of print].  PMID: 25919459.

Hepworth MR, Fung TC, Masur SH, Kelsen JR, McConnell FM, Dubrot J, Withers DR, Hugues S, Farrar MA, Reith W, Eberl G, Baldassano RN, Laufer TM, Elson CO, Sonenberg GF.  Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ Tcells. Science, April 23, 2015.  pii:aaa4812. [Epub head of print].  PMID: 25908663.

Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA. Corrigendum. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest, 125(3):1363, March 2 2015. doi: 10.1172/JC179657. Epub March 2 2015.  PMID: 25729854.

Lee D, Albenberg L, Compher C, Baldassano RN, Piccoli D, Lewis JD, Wu GD.  Diet in the pathogenesis and treatment of inflammatory bowel diseases.  Gastroenterology, 15 Jan 2015.  Pii: S0016-5085(15)00069-4. Doi: 10.1053/j.gastro.2015.01.007. [Epub ahead of print]. PMID: 25597840.

Gray WN, Boyle SL, Graef DM, Janicke DM, Jolley CD, Denson LA, Baldassano RN, Hommel KA. Health-related quality of life in youth with Crohn’s disease.  J Pediatr Gastroenterol Nutr, 5 Jan 2015. [Epub  ahead of print]. PMID: 25564807.

Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S; International Inflammatory Bowel Disease Genetics Consortium; Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium; Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium; United Kingdom IBDGC; Wellcome Trust Case Control Consortium; Quebec IBD Genetics Consortium; Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DP, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A, Rioux JD, [Collaborators 168: Baldassano RN].  High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.  Nat Genet, 47(2):172-9, Feb 2015.  doi: 10.1038/ng.3176.  Epub Jan 5 2015.  PMID: 25559196.

2014

Kelsen JR, Grossman AB, Pauly-Hubbard H, Gupta K, Baldassano RN, Mamula P. Infliximab therapy in pediatric patients 7 years of age and younger.  J Pediatr Gastroenterol Nutr, 59(6):758-62,Dec 2014.  doi: 10.1097/MPG.  PMID: 25419596.

Turner D, Doveh E, Cohen A, Wilson ML, Grossman AB, Rosh JR, Lu Y, Bousvaros A, Deslandres C, Noble A, Baldassano RN, Levine A, Lerner A, Wilson DC, Griffths AM. Efficacy of oral methotrexate in paediatric Crohn’s disease: a multicenter propensity score study. Gut, Nov 21, 2014, pii:gutjnl-2014-307964. doi: 10.1136/gutjnl-2014-307964. [Epub ahead of print].  PMID: 25416066.

Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA.  Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest, 124(8):3617-33, Aug 2014, doi: 10.1172/JC175436. Epub Jul 8 2014. Erratum in: J Clin Invest,125(3):1363, March 2, 2015.  PMID: 25003194.

Boyle BM, Kappelman MD, Colletti RB, Baldassano RN, Milov DE, Crandall WV. Routine use of thiopurines in maintaining remission in pediatric Crohn’s disease.  World J Gastroenterol, 20(27):9185-90, July 21, 2014, doi. 10.3748/wjg.v20.i27.9185. PMID 25083093.

Albenberg L, Esipova TV, Judge CP, Bittinger K, Chen J, Laughlin A, Grunberg S, Baldassano RN, Lewis JD, Li H, Thom SR, Bushman FD, Vinogradov SA, Wu GD.  Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota in humans and mice.  Gastroenterology, Jul 18 2014, pii: S0016-5085(14)00916-0, doi: 10.1053/j.gastro.2014.07.020. [Epub ahead of print]. PMID: 25046162.

Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME, Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM, Baker SS, Hyams JS, Kugathasan S, Denson LA. Utility of neutrophil Fcy receptor l (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn’s disease. Inflamm Bowel Dis, 20(6):1037-48, June 2014.  PMID: 24788216.

Cardinale CJ, Wei Z, Li J, Zhu J, Gu M, Baldassano RN, Grant SF, Hakonarson H: Transcriptome profiling of human ulcerative colitis mucosa reveals altered expression of pathways enriched in genetic susceptibility loci. PLoS One, 9(5): May 1, 2014, e96153.doi:10.1371/journal.pone.0096153. eCollection 2014. PMID 24788701; PMCID: PMC4006814.

Tsampalieros A, Berkenstock MK, Zemel BS, Griffin L, Shults J, Burnham JM, Baldassano RN, Leonard MB.  Changes in trabecular bone density in incident pediatric Crohn disease: A comparison of imaging methods.  Osteoporosis Int., 25(7):1875-83, Jul 2014, doi: 10.1007/s00198-014-2701-x. Epub 2014 April 24. PMID: 24760243.

Gevers D, Kugathasan S, Denson LA, Vazquez-Baeza Y, Van Treuren W…Baldassano RN, et al. The treatment-naïve microbiome in new-onset Crohn’s disease.  Cell Host Microbe, 15(3):382-392, March 12, 2014.  doi:10.1016/j.chom.2014.02.005. PMID: 24629344.

Augustine MV, Leonard MB, Thayu M, Baldassano RN, et al.  Changes in Vitamin-D-related mineral metabolism after induction with anti-tumor necrosis factor-α therapy in Crohn’s disease.  J Clin Endocrinol Metab, 99(6):E991-8, Jun 2014, doi: 10.1210/jc.2013-3846. Epub March 11 2014. PMID: 24617709.      

Zahm AM, Hand NJ, Tsoucas DM, Le Guen Cl,  Baldassano RN, Friedman JR.  Rectal microRNAs are perturbed in pediatric inflammatory bowel disease of the colon.  J Crohns Colitis, March 6, 2014, pii: S1873-9946(14)00061-0, doi: 10.1016/j.crohns.2014.02.012. [Epub ahead of print].  PMID: 24613022.

Fish S, Baldassano RN.  Can we change the natural history of Crohn’s disease? “Are we under- or mistreating patients at the time of presentation?” Dig Dis, 32(4):364-9, 2014, doi 10.1159/000358139. Epub Jun 23 2014.  PMID: 24969281.

Walters TD, Kim MO, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano RN…Hyams JS; PRO-KIIDS Research Group.  Increased effectiveness of early therapy with anti-tumor necrosis factor-α vs an immunomodulator in children with Crohn’s disease.  Gastroenterology, 146(2):383-91, Feb 2014.  doi: 10.1053/J.gastro.2013.10.027. Epub 2013 Oct 23. PMID: 24162032.

Crandall WV, Baldassano RN, Bousvaros A, Denson LA, Gupta N, Mackner LM.  NASPGHAN single-topic symposium: Discovering the future of pediatric IBD care.  J Pediatric Gastroenterol Nutr, 58(1):130-8, Jan 2014.  PMID: 24378522.

2013

Prosnitz Aaron R, Leonard Mary B, Shults Justine, Zemel Babette S, Hollis Bruce W, Denson Lee A, Baldassano Robert N, Cohen Aaron B, Thayu Meena: Changes in vitamin D and parathyroid hormone metabolism in incident pediatric Crohn's disease. Inflamm Bowel Dis Jan 2013.

Tsampalieros Anne, Lam Carol K L, Spencer Jenna C, Thayu Meena, Shults Justine, Zemel Babette S, Herskovitz Rita M, Baldassano Robert N, Leonard Mary B: Long Term Inflammation and Glucocorticoid Therapy Impair Skeletal Modeling during Growth in Childhood Crohn Disease. The Journal of Clinical Endocrinology and Metabolism May 2013 Notes: Epub ahead of print.

Wei Zhi, Wang Wei, Bradfield Jonathan, Li Jin, Cardinale Christopher, Frackelton Edward, Kim Cecilia, Mentch Frank, Van Steen Kristel, Visscher Peter M, Baldassano Robert N, Hakonarson Hakon: Large Sample Size, Wide Variant Spectrum, and Advanced Machine-Learning Technique Boost Risk Prediction for Inflammatory Bowel Disease. American Journal of Human Genetics May 2013 Notes: Epub ahead of print.

Gupta Kernika, Noble Angela, Kachelries Kelly E, Albenberg Lindsey, Kelsen Judith R, Grossman Andrew B, Baldassano Robert N: A novel enteral nutrition protocol for the treatment of pediatric Crohn's disease. Inflammatory Bowel Dis 19(7): 1374-8, Jun 2013.

Cardinale CJ, Kelsen J, Baldassano RN, Hakonarson H.  Impact of exome sequencing in inflammatory bowel disease.  World J Gastroenterol, 19(40):6721-9, Oct 28, 2013. doi:10.3748/wjg.v19.i40.6721. PMID: 24187447; PMCID: PMC3812471.

Cardinale CJ, Wei Z, Panossian S, Wang F, Kim CE, Mentch FD, Chiavacci RM, Kachelries KE, Pandey R, Grant SFA, Baldassano RN, Hakonarson H.  Targeted resequencing identifies defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease.  Genes Immun, 14(7):447-52, Oct 2013. doi:10.1038/gene.2013.43. Epub 2013 Aug 22.  PMID: 23965943.

Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A…International IBD Genetics Consortium [Baldassano RN]. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genet, 9(9):e1003723, Sept 12, 2013. doi: 10.1371/journal.pgen.1003723. Epub2013 Sept 12. PMID: 24068945.

Tsampalieros A, Lam CK, Spencer JC, Thayu M, Shults J, Zemel BS, Herskovitz RM, Baldassano RN, Leonard MB.  Long-term inflammation and glucocorticoid therapy impair skeletal modeling during growth in childhood Crohn disease.  J Clin Endocrinol Metab, 98(8):3438-45, Aug 2013. doi: 10.1210/jc.2013-1631. Epub 2013 May 20.  PMID: 23690309.

Wei Z, Wang W, Bradfield J, Li J, Cardinale C, Frackelton E, Kim C, Mentch F, Van Steen K, Visscher PM, Baldassano RN, Hakonarson H; The International IBD Genetics Consortium,  Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease.  Am J Hum Genet, 92(6):1008-12, Jun 6, 2013. doi: 10.1016/j.ajhg.2013.05.002 Epub 2013 May 23.  PMID: 23731541.  PMCID: 

2012

Crandall Wallace V, Margolis Peter A, Kappelman Michael D, King Eileen C, Pratt Jesse M, Boyle Brendan M, Duffy Lynn F, Grunow John E, Kim Sandra C, Leibowitz Ian, Schoen Bess T, Colletti Richard B: Improved outcomes in a quality improvement collaborative for pediatric inflammatory bowel disease. Pediatrics 129(4): e1030-41, Apr 2012.

Gray Wendy N, Denson Lee A, Baldassano Robert N, Hommel Kevin A: Treatment adherence in adolescents with inflammatory bowel disease: the collective impact of barriers to adherence and anxiety/depressive symptoms. Journal of Pediatric Psychology 37(3): 282-91, Apr 2012.

Hyams Jeffrey, Damaraju Lakshmi, Blank Marion, Johanns Jewel, Guzzo Cynthia, Winter Harland S, Kugathasan Subra, Cohen Stanley, Markowitz James, Escher Johanna C, Veereman-Wauters Gigi, Crandall Wallace, Baldassano Robert, Griffiths Anne: Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis. Clinical Gastroenterology and Hepatology: The official clinical practice journal of the American Gastroenterological Association 10(4): 391-9.e1, Apr 2012.

Yatsunenko Tanya, Rey Federico E, Manary Mark J, Trehan Indi, Dominguez-Bello Maria Gloria, Contreras Monica, Magris Magda, Hidalgo Glida, Baldassano Robert N, Anokhin Andrey P, Heath Andrew C, Warner Barbara, Reeder Jens, Kuczynski Justin, Caporaso J Gregory, Lozupone Catherine A, Lauber Christian, Clemente Jose Carlos, Knights Dan, Knight Rob, Gordon Jeffrey I: Human gut microbiome viewed across age and geography. Nature 486(7402): 222-7, Jun 2012.

Hyams Jeffrey S, Griffiths Anne, Markowitz James, Baldassano Robert N, Faubion William A, Colletti Richard B, Dubinsky Marla, Kierkus Jaroslaw, Rosh Joel, Wang Yaqin, Huang Bidan, Bittle Barry, Marshall Michael, Lazar Andreas: Safety and Efficacy of Adalimumab for Moderate to Severe Crohn's Disease in Children. Gastroenterology Aug 2012.

Horton DB, Sherry DD, Baldassano RN, Weiss PF. : Enthesitis is an extraintestinal manifestation of inflammatory bowel disease. Ann Paediatr Rheum 1(4): 214-221, 2012.

Abstracts

2016

Plantz Kristen, Maxwell Elizabeth, Mamula Petar, Baldassano Robert, Stein Ronen: O-022 Intravenous Iron Sucrose for Treatment of Iron Deficiency Anemia in Pediatric Inflammatory Bowel Disease. Inflammatory bowel diseases 22 Suppl 1: S8, Mar 2016.

Kelsen Judith, Dawany Noor, Conrad Maire, Martinez Alejuandro, Mamula Petar, Piccoli David, Artis David, Sonnenberg Gregory, Baldassano Robert, Sullivan Kathleen, Devoto Marcella: O-003 Understanding the Relevance of Whole Exome Sequencing Identified Variants in Patients with Very Early-Onset-IBD. Inflammatory bowel diseases 22 Suppl 1: S1-2, Mar 2016.

2014

Kelsen J, Moran C, Noor D, Pauly-Hubbard H, Rapport E, Mamula P, Piccoli DA, Winter H, Daly M, Sonnenberg G, Artis D, Baldassano RN, Marcella D.: Digenic inheritance of primary immunodeficiency gene variants identified by whole exome sequence in very early onset IBD patients.   2014 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation's Clinical & Research Conference, Orlando FL, Dec 4-6,2014; Inflamm Bowel Dis. 20(()): S9-S10, Dec 2014.

Cardinale C, Li J, Wei Z, Chang X, Baldassano RN, Hakonarson H.: Pathway-based genome-wide association study reveals an association between ErbB signaling and inflammatory bowel disease. Poster presentation. 2014 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation's Clinical & Research Conference, Orlando FL, Dec 4-6, 2014; Inflamm Bowel Dis.  29(()): S103-S104, Dec 2014.

2013

Baldassano RN, Colletti R, Cucchiara S, Dubinsky M, Escher J, Faubion W, Fell J, Gold B, Griffiths A, Hyams J, Koletzko S, Kugathasan S, Markowitz J, Ruemmele F, Veereman G, Callegari P, Molenda M, Tang KL, Wright R, Geldhof A, Winter H.: Serious infections and associated risk factors in patients receiving infliximab and immunotherapies for children with inflammatory bowel disease: DEVELOP Registry Data.   8th Congress of the European Crohn's and Colitis Organisation (ECCO), Vienna, Austria.  Feb 14-16 2013.

Colletti R, Cucchiara S, Dubinsky M, Escher J, Faubion W, Fell J, Gold B, Griffiths A, Hyams J, Koletzko S, Kugathasan S, Winter H, Baldassano RN, Markowitz J, Ruemmele F, Callegari P, Goldhof A, Molenda M, Tang KL, Wright R, Veereman G. : Malignancies in children receiving infliximab and other inflammatory bowel disease therapies: An inflammatory bowel disease multicenter, prospective, long-term registry of pediatric patients (DEVELOP) registry data. Poster Presentation. 8th Congress of the European Crohn's and Colitis Organisation (ECCO), Vienna, Austria. Feb 14-16 2013.

Albenberg L, Judge CP, Esipova TV, Sinha R, Bailey AG, Bittinger K, Grunberg S, Chen J, Bhopale VM, Baldassano RN, Lewis JD, Li H, Thom SR, Bushman FD, Vinogradov S, Wu GD.  : Biological oximetry using phosphorescence quenching reveals a dynamic oxygen equilibrium maintained between the gut microbiota and the host.  American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology 144(5; S1): S-156-157, May 2013.

Baldassano RN, Colletti RB, Cucchiara S, Dubinsky M, Escher JC, Faubion WA, Fell J, Gold BD, Griffiths AM, Hyams JS, Koletzko S, Kugathasan S, Markowitz J, Ruemmele F, Veereman G, Callegari P, Geldhof A, Molenda MR, Wright R, Tang KL, Winter HS.: Serious infections and associated risk factors in patients receiving infliximab and immunotherapies for children with inflammatory bowel disease: DEVELOP Registry Data. American Gastroenterological Association:  American Gastroenterological Association; Digestive Disease Week 2013, Orlando, FL, May 19-21; Gastroenterology 144(5; S1): S-11, May 19-21 2013.

Colletti RB, Cucchiara S, Dubinsky M, Escher JC, Faubion WA, Fell J, Gold BD, Griffths AM, Hyams JS, Koletzko S, Kugathasan S, Winter HS, Baldassano RN, Markowitz J, Ruemmele F, Callegari P, Geldhof A, Molenda MR, Tang KL, Wright R, Veereman G. : Malignancies in children receiving infliximab and other inflammatory bowel disease therapies: An inflammatory bowel disease multicenter, prospective, long-term registry of pediatric patients (DEVELOP) registry data.  American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology 144(5; S1): S-147, May  2013.

Haberman Y, Jurickova I, Dexheimer PJ, Karns R, Tang D, Bonkowski EL, Fey B, Noe JD, Markowitz J, Heyman MB, Crandall W, Snapper SB, Kellermayer R, Kappelman M, Rosh JR, Otley AR, Pfefferkorn MD, Cohen SA, Patel AS, Kirschner BS, Baldassano RN, Dubinsky M, Walters TD, Aronow BJ, Denson L.  : Ileal RNA-Seq analyses reveal decreased mucosal myeloid cell immune responses in pediatric Crohn disease patients with phagocyte dysfunction due to neutralizing granulocyte macrophage colony stimulating factor (GM-CSF) auto-antibodies. Poster Presentation. American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013.  Gastroenterology 144(5; S1): S-708-709, May 2013.

Hyams JS, Kim M, Denson L, Griffiths AM, Dubinsky M, Markowitz J, Baldassano RN, Crandall W, Rosh JR, Pfefferkorn MD, Otley AR, Heyman MB, Leleiko NS, Baker SS, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens MC, Mack DR, Oliva-Hemker M, Essers JB, Patel AS, Kirschner BS, Moulton E, Cohen SA, Liu C, Kugathasan S, Walters TD.: Early anti-TNFa therapy is superior to early immunomodulator therapy in newly diagnosed children with Crohn's disease. American Gastroenterological Association; Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology  144(5; S1): S-146, May 2013.

Kelsen JR, Posivak L, Pauly-Hubbard H, Baily AG, Bittinger K, Grunberg S, Baldassano RN, Lewis JD, Bushman FD, Wu GD. : Longitudinal characterization of the subgingival microbiota in pediatric Crohn's disease. Poster Presentation. American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology  144(5; S1): S-309-310, May 2013.

Kugathasan S, Dubinsky M, Guthery SL, Okou DT, Bose P, Zwick ME, Cutler DJ, Waters JP, Hymans JS, Baldassano RN, Stephens MC, Heyman MB, Griffths AM, Crandall W, Markowitz J, Essers JB, Snapper SC, Walters TD, Aronow BJ, Denson L.: Early onset Crohn's disease exhibit distinct allele architecture differences and reveal new IBD loci.   American Gastroenterological Association; Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology  144(5; S1): S-178, May 2013.

Baldassano RN, Ruemmele F, Rosh J. Faubion WA, Kierkus J, Hyams JS, Lazar A, Wang Y, Eichner S, Thakkar RB. : Long-term safety of adalimumab in paediatric patients with Crohn's disease.  United European Gastroenterology (UEG) Week Berlin 2013, Berlin, Germany Oct 12-16 2013.Griffiths A, Baldassano RN, Walters T, Bronksy J, Hyams JS, Lazar A, Wang Y, Eichner S. Thakkar RB. : Improvement in markers of bone metabolism with adalimumab in children with moderately to severely active Crohn's disease: Results from Imagine 1.   United European Gastroenterology (UEG) Week Berlin 2013, Berlin, Germany Oct 12-16 2013.

Kierkus J, Crandall W, Hyams JS, Rosh J, Markowitz J, Baldassano RN, Lazar A, Wang Y, Eichner S, Thakkar RB.: Early response to treatment with adalimumab in children with moderately to severely active Crohn's disease: Results from Imagine 1.   United European Gastroenterology (UEG) Week Berlin 2013, Berlin, Germany Oct 12-16 2013.

2012

Hyams J, Griffiths A, Markowitz J, Baldassano RN, Lazar A.: Induction and maintenance adalimumab therapy for the treatment of moderate to severe Crohn's disease in children. 2012 Canadian Digestive Diseases Week (CDDW), Montreal, Quebec, Canada. Feb 24-27 2012.

Flint RA, Jarvis HW, Overton MH, Baldassano RN, Kim SC.: Characterization of mucosally-adherent Escherichia coli in pediatric inflammatory bowel disease patients. Poster Presentation. American Gastroenterological Association; Digestive Disease Week 2012. Gastroenterology 142(5; S1): S-373, May 2012.

Hyams JS, Kim M, Denson L, Stephens MC, Markowitz J, Griffiths AM, Crandall W, Essers JB, Baldassano RN, Dubinsky M, Rosh JR, Pfefferson MD, Kim SC, Otley AR, Kellermayer R, Heyman MB, Leleiko NS, Baker SS, Guthery SL, Evans J, Ziring D, Kugathasan S, Walters TD.: Effect of deep ulceration at diagnostic colonoscopy on initial therapy and one year outcome in children with Crohn's disease. American Gastroenterological Association; Digestive Disease Week 2012. Gastroenterology 142(5; S1): S-36, May 2012.

Overton M, Jarvis W, Flint R, Baldassano RN, Kim SC.: Quantification and characterization of Klebsiella pneumoniae in pediatric patients with inflammatory bowel disease. Poster Presentation. American Gastroenterological Association; Digestive Disease Week 2012. Gastroenterology 142(5; S1): S373-374, May 2012.

Walters TD, Dubinsky M, Griffiths AM, Baldassano RN, Hyams JS, Stephens MC, Markowitz J, Crandall W, Heyman MB, Kellermayer R, Mack DR, Oliva-Hemker M, Patel AS, Kirschner BS, Moulton DE, Cohen SA, Aronow B, Denson L, Kugathasan S. : Anti-microbial serology patterns in 824 children with newly diagnosed Crohn's disease: Association with GM-CSF auto-antibodies and specific clinical phenotypes. American Gastroenterological Association; Digestive Disease Week 2012. Gastroenterology 142(5; S1): S36-37, May 2012.

Albenberg L, Spengler C, Klink A, Mattei P, Baldassano RN, Mamula P, Kelsen JR.: Diverting ileostomy for the treatment of severe refractory indeterminate colitis. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 203, Oct 2012.

Gold BD, Kirschner BS, Cohen SA, O'Conner S, Heyman MH, Ferry GD, Baldassano RN, Garnett EA, Thompson AD, Tierney M, Yakrus MA, Winter HS. : Molecular analysis of Mycobacterium Avium Subspecies Paratuberculosis(MAP) in mucosal biopsies from treatment naïve children with IBD and controls Poster presentation. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 205, Oct 2012.

Judge CP, Albenberg LG, Esipova T, Grunberg S, Chen J, Li H, Baldassano RN, Lewis JD, Bushman FD, Vinogradov SA, Wu GD.: An oxygen equilibrium at the host-microbial interface determined by phosphorescent nanoprobe technology. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 237, Oct 2012.

Judge CP, Lee DY, Long J, Zemel BS, Baldassano RN, Leonard MB.: Children with Crohn disease continue to exhibit inflammatory cachexia despite advances in therapies. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55 (S1): 197, Oct 2012.

Kaplan J, Bhasin M, Gold BD, Kirschner BS, Ward NL, Cohen SA, Heyman MB, Ferry GD, Baldassano RN, Moran CJ, Steven B, Garnett EA, Tierney MP, Drake L, Dowd SE, Cox SB, Mir SA, Kellermayer R, Libermann TA, Winter HS. : Ileal mucosa-associated microbiota changes in children with newly diagnosed, treatment-naïve Crohn's Disease. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 205, Oct 2012.

Kelsen JR, Posivak L, Grunberg S, Bailey A, Baldassano RN, Lewis J, Bushman F, Wu G.: The oral microbiome in pediatric Crohn Disease. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 235, Oct 2012.

Lee D, Kachelries KE, Gupta K, Lorusso M, Whitehead KM, Herskovitz RM, Leonard MB, Baldassano RN.: The impact of supplemental nasogastric tube nutrition on height and weight in pediatric Crohn's Disease. Poster of Distinction Award. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 295, Oct 2012.

Lee D, Kachelries KE, Gupta K, Lorusso M, Whithead KM, Herskovitz RM, Leonard MB, Baldassano RN. : The impact of supplemental nasogastric tube nutrition on height and weight in pediatric Crohn's disease. Poster Presentation. Food and Nutrition Conference and Expo (FNCE), Academy of Nutrition and Dietetics Annual Conference, Philadelphia, PA Oct 6-9 2012.

Lee D, Lorusso M, Klink A, Gupta K, Martin A, Gilroy E, Nessel L, Otley A, Griffiths A, Lionetti P, Bushman F, Wu G, Baldassano RN, Lewis J.: Response to enteral nutritional therapy versus anti-TNFS in pediatric Crohn's Disease. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 202, Oct 2012.

Lorusso M, Lee D, Klink A, Gupta K, Martin A, Gilroy E, Nessel L, Otley A, Griffiths A, Lionetti P, Bushman F, Wu G, Lewis J, Baldassano RN. : Children with Crohn's Disease on 100% vs. 80% enteral nutritional therapy: Interim analysis of a prospective cohort study. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 234, Oct 2012.

Procopi T, Zimmerman A, Grossman A, Baldassano RN.: Infusion and post-infusion reactions to infliximab in pediatric inflammatory bowel disease patients. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 227, Oct 2012.

Zahm AM, Baldassano RN, Friedman J. : Rectal micro RNA levels are altered in pediatric ulcerative colitis. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 217, Oct 2012.

Cardinale CJ, Panossian S, Wang F, Frackelton EC, Kim CE, Mentch FD, Chiavacci RM, Kachelries KE, Pandey R, Grant SFA, Baldassano RN, Hakonarson H.: Targeted resequencing identifies secretion-defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease. 62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA. Poster Presentation. Nov 6-10 2012.

Kao C, Wei Z, Li J, Wang W, Glessner J, Cardinale C, Bradfield J, Frackelton E, Kim C, Mentch F, Qui H, Grant S, Baldassano RN, Hakonarson H and The International IBD Genetics Consortium: Pathway-based meta analysis of ulcerative colitis genome-wide association studies. 62nd Annual Meeting of the American Society of Human Genetics, San Francisco CA. Poster Presentation. Nov 6-10 2012.

Pandey R, Cardinale CJ, Panossian S, Wang F, Frackelton E, Kim C, Mentch F, Chiavacci R, Kachelries K, Grant S, Baldassano RN, Hakonarson H.: Functional characterization of DcR3 and NF-kB in EBV transformed cell lines from IBD patients of different allelic background and role in disease pathogenesis 62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA. Poster Presentation. Nov 6-10 2012.

Wei Z, Wang W, Bradfield J, Frackelton E, Kim C, Mentch F, Baldassano RN, Hakonarson H and The International IBD Genetics Consortium : Large-sample size, comprehensive catalog of variants and advanced machine learning technique boost risk prediction for inflammatory bowel disease. 62nd Annual Meeting of the American Society of Human Genetics, San Franciso, CA Nov 6-10 2012.

Albenberg L, Judge C, Esipova T, Grunberg S, Chen J, Baldassano RN, Lewis J, Bushman F, Vinogradov S, Wu G. : An oxygen equilibrium at the host-microbial interface determined by phosphorescent nanoprobe technology. Poster Presentation. 2012 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation's National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012. Inflamm Bowel Dis. 18(S)(12): S112,P-257, Dec 2012.

Kelsen J, Posivak L, Bailey A, Grunberg S, Baldassano RN, Lewis J, Bushman F, Wu G.: The subgingival oral microbiome in pediatric patients with Crohn's Disease. 2012 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation's National Clinical & Research Conference, Hollywood, FL, Dec 13-15,2012. Poster presentation. Inflamm Bowel Dis. 18(S)(12): S61,P-117, Dec 2012.

Zahm A, Tsoucas D, Baldassano RN, Friedman J.: MicroRNA-regulated pathways in pediatric IBD. 2012 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation's National and Clinical Research Conference, Hollywood, FL, Dec 13-15, 2012. Oral and Poster presentations. Inflamm Bowel Dis. 18(S)(12): S7,O-15 and S103,P-226, Dec 2012 Notes: Crohn's & Colitis Foundation's National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012.

Books

Mamula P, Markowitz J, Baldassano RN (eds): Pediatric Inflammatory Bowel Disease. Pediatric Inflammatory Bowel Disease 2nd Edition. Mamula P, Markowitz J, Baldassano RN (eds.). Springer Science+Business Media, New York, NY, 2012.

Mamula P, Markowitz J, Baldassano RN (eds): Pediatric Inflammatory Bowel Disease. Pediatric Inflammatory Bowel Disease. Mamula P, Markowitz J, Baldassano RN (eds.). Springer Science+Business Media, New York, NY, 2008.

Chapters

2015

Grossman AB, Baldassano RN: Inflammatory Bowel Disease     Nelson Textbook of Pediatrics, 2-Volume Set, 20th Edition. Kliegman RM, Stanton B, St. Geme J, Schor NF  (eds.). Elsevier, Inc: Philadelphia, PA, 2(Part XVIII, Sec 4, Chapter 336), May 2015 Notes: ISBN-13: 978-1455775668; ISBN-10: 1455775665.

Grossman AB, Baldassano RN: Eosinophilic Gastroenteritis. Nelson Textbook of Pediatrics, 2-Volume Set, 20th Edition. Kliegman RM, Stanton B, St. Geme J, Schor NF (Eds) (eds.). Elsevier, Inc, Philadelphia, PA, 2(Part XVIII, Sec 4, Chapter 337), May 2015 Notes: ISBN-13: 978-1455775668; ISBN-10: 1455775665.

2014

Albenberg L, Baldassano RN, Kelsen J: Pediatric Issues in Treating Ulcerative Colitis. Medical Therapy of Ulcerative Colitis. Lichtenstein GR (eds.). Springer, NY, Page: 281-290, Oct 2014 Notes: Chapter 25.

2013

Albenberg L, Baldassano RN: What is the Current Understanding of the Etiology of Inflammatory Bowel Disease? Curbside Consultation in Pediatric GI: 49 Clinical Questions. Rosh J, Bousvaros A (eds.). Slack, Inc., Thorofare, NJ, 2013 Notes: in press.

Albenberg L, Kelsen J, Baldassano RN: Pediatric Issues in Treating Ulcerative Colitis. Medical Therapy of Ulcerative Colitis. Lichtenstein GR (eds.). Springer, NY, 2013 Notes: In press.

Grossman AB, Baldassano RN: Inflammatory Bowel Disease. Nelson Textbook of Pediatrics, 20th Edition. Kliegman R, Stanton B, St. Geme J, Schor N. (eds.). Elsevier, Inc., Philadelphia, PA, Chapter 328, 2013 Notes: submitted.

Grossman AB, Baldassano RN.: Eosinophilic Gastroenteritis. Nelson Textbook of Pediatrics, 20th Edition. Kliegman R, Stanton B, St. Geme J, Schor N. (eds.). 2013 Notes: submitted.

Kelsen J, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with Crohn's Disease. The Complete Guide to Medical Management, 2nd Edition. Lichtenstein GR (eds.). 2013 Notes: in press.

2011

Ghanem LR, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with Inflammatory Bowel Disease. Crohn's Disease: The Complete Guide to Medical Management. Lichtenstein GR (eds.). Slack, Inc., Thorofare, NJ, Apr 2011 Notes: Chapter 5.

Ghanem LR, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with Inflammatory Bowel Disease. Ulcerative Colitis: The Complete Guide to Medical Management. Lichtenstein GR (eds.). Slack, Inc., Thorofare, NJ, Apr 2011 Notes: Chapter 5.

Kelsen J, Hunter A, Baldassano RN: Pediatric Therapies in Inflammatory Bowel Disease. Advanced Therapy in Inflammatory Bowel Disease, 3rd Edition Vol 2: IBD and Crohn's Disease, Crohn's Disease Therapy. Bayless TM, Hanauer SB (eds.). People's Medical Publishing House-USA August 2011.

Grossman AB and Baldassano RN: Eosinophilic Gastroenteritis. Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 329), 1304, 2011.

Grossman AB and Baldassano RN: Inflammatory Bowel Disease. Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 328), 1294-1295, 2011.

Grossman AB and Baldassano RN: Chronic Ulcerative Colitis. Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 328.1), 1295-1300, 2011.

Grossman AB and Baldassano RN: Crohn Disease (Regional Enteritis, Regional Ileitis, Granulomatous Colitis). Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 328.2), 1300-1304, 2011.

2008

Grant SF, Baldassano RN, Hakonarson H: Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene. Expert Rev Mol Diagn 8(2): 199-207, Mar 2008.

Jacobstein D, Baldassano RN: Crohn Disease. The 5-Minute Pediatric Consult, 5th Edition. Schwartz MW (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, Page: 228-229, 2008.

Jacobstein D, Baldassano RN: Inflammatory Bowel Disease. Pediatric Gastroenterology: The Requisites in Pediatrics. Liacouras CA, Piccoli DA (eds.). Mosby Elsevier, Philadelphia, PA, Page: 131-136, 2008.

2007

Kelsen J, Baldassano RN: Inflammatory Bowel Disease: The Difference between Children and Adults, Inflammatory Bowel Disease: Epidemiology, Pathogenesis, Diagnosis and Management 2007 Notes: Fiorcchi C, Katz J, Prantera C, Thomson A

2006 

Jacobstein D, Baldassano RN. Pediatric considerations in medical therapy in patients with ulcerative colitis and Crohn’s disease. In: Lichtenstein GR, editor. Inflammatory bowel disease: The complete guide to medical management. Philadelphia: Slack Inc.; 2006.

2004

Mamula P, Markowitz J, Baldassano RN. Clinical features and natural history of pediatric inflammatory bowel disease (Chapter 21). In: Sartor RB, Sandborn WJ, editors. Kirsner’s inflammatory bowel diseases. 6th ed. Philadelphia: Saunders Company; 2004. p. 301-315.

Russo P, Brown K, Baldassano RN. Colitis in childhood (Chapter 5). In: Russo P, Rucchelli ED, Piccoli DA, editors. Pathology of pediatric gastrointestinal and liver disease. New York: Springer-Verlag Inc.; 2004. p. 100-127.

2003

Batres AL, Baldassano RN. Evaluation of the patient suspected of having inflammatory bowel disease (Chapter 16). In: Lichtenstein GR, editor. The clinical guide to inflammatory bowel disease. Thorofare: Slack Inc.; 2003. p. 315-324.

Batres AL, Baldassano RN. Special considerations for the pediatric and adolescent patients with inflammatory bowel disease (Chapter 17). In: Lichtenstein GR, editor. The clinical guide to inflammatory bowel disease. Thorofare: Slack Inc.; 2003. p. 325-342.

Mamula P, Markowitz J, Baldassano RN. Clinical features and natural history of pediatric inflammatory bowel disease In: Sandborn WJ, Sartor RB, editors. Kirsner’s inflammatory bowel disease. 6th ed. Philadelphia: Saunders Company; 2003.

1999

Baldassano RN. Crohn’s disease. In: Schwartz MW, editor. The 5-minute pediatric consult. 2nd ed. Baltimore: Williams & Wilkins; 1999. p. 290-291.

Baldassano RN. Ulcerative colitis. In: Schwartz MW, editor. The 5-minute pediatric consult. 2nd ed. Baltimore: Williams & Wilkins; 1999. p. 846-847

1997

Baldassano RN. Inflammatory bowel disease. In: Schwartz MW, Curry TA, Sargent AJ, Blum NJ, Fein J, editors. Pediatric primary care: a problem-oriented approach. 3rd ed.  Philadelphia: Mosby-Year Book, Inc.; 1997. p. 543-547. 

Kelsen J, Baldassano RN: Pediatric Considerations In Medical Therapy in Patients with Ulcerative Colitis. The Complete Guide to Medical Management, 2nd Edition. Lichtenstein GR (eds.). 2013 Notes: in press.

Posters and Presentations

2016

Walters TD, Faubion WA, Griffths AM, Baldassano RN, Escher J, Ruemmele FM, Hyams JS, Lazar A, Eichner S, Li Y, Thakkar RB, Robinson AM. : Adalimumab treatment improves linear growth in children with moderately to severely active Crohn's Disease: results from the Imagine 1 Trial. Poster presentation.  2016 World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada. Oct 5-8 2016.

Sauer, CG, Venkateswaran S, Tangpricha V, Ziegler T, Mack D, Boyle, B, Griffiths A, LeLeiko N, Keljo D, Markowitz J, Baker S, Rosh J, Baldassano RN, Davis S, Marquis A, Spada K, Kugathasan S, Walters T, Hyams J, Denson L.: Vitamin D status in newly diagnosed pediatric ulcerative colitis and racial differences determined by genetic polymorphisms: results from the Protect Study. Oral presentation. 2016 World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada.  Oct 5-8 2016.

Mack DR, Walters T, Boyle B, Griffiths A, LeLeiko N, Sauer C, Keljo D, Markowitz J, Baker S, Rosh J, Baldassano RN, Patel A, Pfefferkorn M, Otley A, Heyman M, Kugathasan S, Marquis A, Davis S, Denson L, Hyams J. : Fecal calprotectin is inferior to standard laboratory tests in predicting severity of disease:  The predicting response to standardized pediatric colitis therapy (Protect) study.  Poster presentation. 2016 World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada. Oct 5-8 2016.

Conrad M, Dawany N, Bittinger K, Baldassano RN, Piccoli DA, Bushman F, Devoto M, Kelsen J.: Characterization of the intestinal microbiome of very early onset inflammatory bowel disease. Poster presentation. 2016 World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada. Oct 5-8 2016.

Boyle B, Hyams J, Collins M, Wang Z, Mack D, Griffiths A, LeLeiko N, Sauer C, Keljo D, Markowitz J, Baker S, Rosh J, Baldassano RN, Patel A, Pfefferkorn M, Otley A, Heyman M, Kugathansan S, Walters T, Denson T. : Characterization of histologic changes in children newly diagnosed with ulcerative colitis:  The Protect Study. Poster presentation.  2016 World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada. Oct 5-8 2016.

2014

Cardinale C, Li J, Wei Z, Chang X, Baldassano RN, Hakonarson H.  Pathway-based genome-wide association study reveals an association between ErbB signaling and inflammatory bowel disease.  2014 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando FL, Dec 4-6, 2014; Inflamm Bowel Dis 29():S103-S104, Dec 2014.  Poster presentation.

Kelsen J, Moran C, Noor D, Pauly-Hubbard H, Rapport E, Mamula P, Piccoli DA, Winter H, Daly M, Sonnenberg G, Artis D, Baldassano RN, Marcella D.  Digenic inheritance of primary immunodeficiency gene variants identified by whole exome sequence in very early onset IBD patients.  2014 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando FL, Dec 4-6, 2014; Inflamm Bowel Dis 20():S9-S10, Dec 2014. Oral presentation.

Stein RE, Lee DY, Leonard MB, Thayu M, Herskovitz RM, Kerbowski T, Chuang E, Baldassano RN. The association between drug levels, anti-drug antibodies, and therapeutic response during infliximab therapy in pediatric Crohn disease. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting and Postgraduate Course, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S165. Poster presentation.

Kelsen J, Moran C, Sasson A, Pauly-Hubbard H, Rappaport E, Mamula P, Piccoli D, Artis D, Sonnenberg G, Winter H, Baldassano RN, Devoto M.  Analysis of candidate genes by whole exome sequencing in very early-onset IBD. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S147. Poster presentation.  NASPGHAN Young Investigator Award.

Lee D, Baldassano RN, Compher C, Albenberg L, Otley A, Griffiths A, Bushman F, Wu GD, Lewis JD.  Effectiveness of nutritional and anti-TNF therapy in North American children with active Crohn’s disease.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S37. Poster presentation.

Sahn B, De Matos, V, Ruchelli E, Masur S, Klink A, Baldassano RN, Piccoli, DA, Russo P, Mamula P.  A histological scoring system for ileitis in children with inflammatory bowel disease.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S34. Poster presentation.

Walters T, Faubion W, Griffiths A, Baldassano RN, Escher J, Ruemmele F, Hyams J, Lazar A, Eichner S, Li Y, Papparlardo B, Thakkar R.  Growth improvement in adalimumab-treated pediatric patients with Crohn’s disease: Data from Imagine I.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S22. Poster presentation.

Lee DY, Baldassano RN, Compher CW, Albenberg LG, Otley AR, Griffths AM, Bushman FD, Wu GD, Lewis JD.  Effectiveness of nutritional and anti-TNF therapy in North American children with active Crohn’s disease.  3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands, Sept 10-13, 2014. Oral presentation – accepted for Best Abstract.

Otley R, Lee DY, Baldassano RN, Griffths AM, Compher CW, Albenberg LG, Bushman FD, Wu GD, Lewis JD. Comparison of quality of life among children treated with nutritional and anti-TNF therapies for active Crohn’s disease in North America. 3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands, Sept 10-13, 2014. Poster presentation.

Stein RE, Lee DY, Leonard MB, Thayu M, Herskovitz RM, Kerbowski T, Baldassano RN. The association between drug levels, anti-drug antibodies, and therapeutic response during infliximab therapy in pediatric Crohn disease. 3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands, Sept 10-13, 2014. Poster presentation.

Walters T, Faubion WA, Griffths A, Baldassano RN, Escher J, Ruemmele F, Hyams JS, Lazar A, Eichner S, Li Y, Pappalardo B, Thakkar RB.  Growth improvement in adalimumab-treated paediatric patients with Crohn’s disease: Data from Imagine 1.  3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands, Sept 10-13, 2014. Poster presentation.

2013

Cardinale CJ, Wei Z, Li J, Zhu J, Baldassano RN, Hakonarson H.  Transcriptome profiling of human ulcerative colitis mucosa shows altered expression of pathways overlapping genome-wide association susceptibility loci.  American Society of Human Genetics 63rd Annual Meeting, Boston, Oct 22-26, 2013.  Poster presentation. 

Baldassano RN, Ruemmele F, Rosh J. Faubion WA, Kierkus J, Hyams JS, Lazar A, Wang Y, Eichner S, Thakkar RB.  Long-term safety of adalimumab in paediatric patients with Crohn’s disease. United European Gastroenterology (UEG) Week 2013, Berlin, Germany, Oct 12-16, 2013.  Poster presentation.

Griffiths A, Baldassano RN, Walters T, Bronksy J, Hyams JS, Lazar A, Wang Y, Eichner S. Thakkar RB.  Improvement in markers of bone metabolism with adalimumab in children with moderately to severely active Crohn’s disease: Results from Imagine 1.  United European Gastroenterology (UEG) Week 2013, Berlin, Germany, Oct 12-16, 2013.  Poster presentation.

Kierkus J, Crandall W, Hyams JS, Rosh J, Markowitz J, Baldassano RN, Lazar A, Wang Y, Eichner S, Thakkar RB.  Early response to treatment with adalimumab in children with moderately to severely active Crohn’s disease: Results from Imagine 1.  United European Gastroenterology (UEG) Week 2013, Berlin, Germany, Oct 12-16, 2013.  Poster presentation.

Rosh J, Kierkus J, Crandall W, Hyams J, Markowitz J, Baldassano RN, Lazar A, Wang Y, Eichner S, Thakkar RB.  Early response to treatment with adalimumab in children with moderately to severely active Crohn’s disease: Results from IMAGINE 1.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013;JPGN:57(S1),E148, Oct 2013.  Oral and Poster presentation.

Rosh J, Baldassano RN, Ruemmele F, Faubion WA, Kierkus J, Hyams J, Lazar A, Wang Y, Eichner S, Thakkar RB.  Long-term safety of adalimumab in pediatric patients with Crohn’s disease.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013;JPGN:57(S1),E110, Oct 2013. Poster presentation.

Fish S, Wei Z, Bradfield J, Gupta K, Spengler C, Martin A, Judge C, Ghanem L, Hakonarson H, Baldassano RN, Kelsen J.  SLC11A1 polymorphism increases the risk of early surgery in pediatric patients with inflammatory bowel disease. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013;JPGN:57(S1),E97, Oct 2013.  Oral and Poster presentation.

Moran CJ, Kelsen J, Kaplan JL, Baril-Dore M, Schindelar L, Vais B, Kirschner B, Baldassano RN, Xavier R, Winter H, Daly MJ.  Whole exome sequencing in very early onset inflammatory bowel disease. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013;JPGN:57(S1),E69, Oct 2013. Poster presentation.

Lee D, Lewis JD, Baldassano RN, Leonard M.  Decomposing PCDAI into constituent components in the analysis of body composition in pediatric Crohn’s disease. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013; JPGN:57(S1),E67, Oct 2013. Poster presentation.

Augustine M, Leonard M, Thayu M, Baldassano RN, Shults J, Denburg M.  Changes in Vitamin D-related mineral metabolism following infliximab induction in Crohn’s disease.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013; JPGN:57(S1),E13, Oct 2013.  Poster presentation.

Haberman Y, Jurickova I, Dexheimer PJ, Karns R…Baldassano RN…Denson L.  Ileal RNA-Seq analyses reveal decreased mucosal myeloid cell immune responses in pediatric Crohn disease patients with phagocyte dysfunction due to neutralizing granulocyte macrophage colony stimulating factor (GM-CSF) auto-antibodies. American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013.  Poster presentation. Gastroenterology 144(5);S1, pS-708-709, May 2013.

Kelsen JR, Posivak L, Pauly-Hubbard H, Baily AG…Baldassano RN…Wu GD.  Longitudinal characterization of the subgingival microbiota in pediatric Crohn’s disease.  American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013.  Poster presentation. Gastroenterology 144(5);S1, pS-309-310, May 2013.

Colletti R, Cucchiara S, Dubinsky M, Escher J…Baldassano RN, et al.  Malignancies in children receiving infliximab and other inflammatory bowel disease therapies: an inflammatory bowel disease multicenter, prospective, long-term registry of pediatric patients (DEVELOP) registry data.  8th Congress of the European Crohn’s and Colitis Organisation (ECCO), Vienna, Austria, Feb 14-16, 2013; Poster presentation.

2012

Albenberg L, Judge C, Esipova T, Grunberg S, Chen J, Baldassano RN, Lewis J, Bushman F, Vinogradov S, Wu G.  An oxygen equilibrium at the host-microbial interface determined by phosphorescent nanoprobe technology. 2012 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012.  Inflamm Bowel Dis 18(S);12: S112,P-257, Dec 2012.  Poster presentation.

Kelsen J, Posivak L, Bailey A, Grunberg S, Baldassano RN, Lewis J, Bushman F, Wu G.  The subgingival oral microbiome in pediatric patients with Crohn’s Disease.  2012 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012.  Inflamm Bowel Dis 18(S);12: S61,P-117, Dec 2012.  Poster presentation.

Zahm A, Tsoucas D, Baldassano RN, Friedman J.  MicroRNA-regulated  pathways in pediatric IBD.  2012 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012.  Inflamm Bowel Dis 18(S);12: S7,O-15 and S103,P-226, Dec 2012. Oral and Poster presentations.

Lee D, Kachelries KE, Gupta K, Lorusso M, Whitehead KM, Herskovitz RM, Leonard MB, Baldassano RN.  The impact of supplemental nasogastric tube nutrition on height and weight in pediatric Crohn’s Disease. NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster of Distinction Award; JPGN  55(S1):295, Oct 2012.

Lee D, Kachelries KE, Gupta K, Lorusso M, Whitehead KM, Herskovitz RM, Leonard MB, Baldassano RN.  The impact of supplemental nasogastric tube nutrition on height and weight in pediatric Crohn’s Disease. Food and Nutrition Conference and Expo (FNCE), Academy of Nutrition and Dietetics Annual Conference, Philadelphia, PA, Oct 6-9, 2012, Poster Presentation. 

Kelsen JR, Posivak L, Grunberg S, Bailey A, Baldassano RN, Lewis J, Bushman F, Wu G.  The oral microbiome in pediatric Crohn Disease. NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012,  Poster presentation; JPGN 55(S1):235, Oct 2012. 

Lorusso M, Lee D, Klink A, Gupta K, Martin A, Gilroy E, Nessel L, Otley A, Griffiths A, Lionetti P, Bushman F, Wu G, Lewis J, Baldassano RN.  Children with Crohn’s disease on 100% vs. 80% enteral nutritional therapy: Interim analysis of a prospective cohort study. NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):234, Oct 2012.

Procopi T, Zimmerman A, Grossman A, Baldassano RN.  Infusion and post-infusion reactions to infliximab in pediatric inflammatory bowel disease patients.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):227, Oct 2012. 

Zahm AM, Baldassano RN, Friedman J.  Rectal micro RNA levels are altered in pediatric ulcerative colitis.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):217, Oct 2012.

Albenberg L, Spengler C, Klink A, Mattei P, Baldassano RN, Mamula P, Kelsen JR.  Diverting ileostomy for the treatment of severe refractory indeterminate colitis.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):203, Oct 2012.

Lee D, Lorusso M, Klink A, Gupta K, Martin A, Gilroy E, Nessel L, Otley A, Griffiths A, Lionetti P, Bushman F, Wu G, Baldassano RN, Lewis J. Response to enteral nutritional therapy versus anti-TNFS in pediatric Crohn’s Disease.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):202, Oct 2012. 

Judge CP, Albenberg LG, Esipova T, Grunberg S, Chen J, Li H, Baldassano RN, Lewis JD, Bushman FD, Vinogradov SA, Wu GD.   An oxygen equilibrium at the host-microbial interface determined by phosphorescent nanoprobe technology. NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):237, Oct 2012.

Kaplan J, Bhasin M, Gold BD, Kirschner BS, Ward NL, Cohen SA, Heyman MB, Ferry GD, Baldassano RN, Moran CJ, Steven B, Garnett EA, Tierney MP, Drake L, Dowd SE, Cox SB, Mir SA, Kellermayer R, Libermann TA, Winter HS.  Ileal mucosa-associated microbiota changes in children with newly diagnosed, treatment-naïve Crohn’s Disease.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):220, Oct 2012.

Gold BD, Kirschner BS, Cohen SA, O’Conner S, Heyman MH, Ferry GD, Baldassano RN, Garnett EA, Thompson AD, Tierney M, Yakrus MA, Winter HS.  Molecular analysis of Mycobacterium Avium Subspecies Paratuberculosis (MAP) in mucosal biopsies from treatment naïve children with IBD and controls.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012,  Poster presentation; JPGN 55(S1):205, Oct 2012.

Judge CP, Lee DY, Long J, Zemel BS, Baldassano RN, Leonard MB.  Children with Crohn disease continue to exhibit inflammatory cachexia despite advances in therapies.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55 (S1):197, Oct 2012.

Kao C, Wei Z, Li J, Wang W, Glessner J, Cardinale C, Bradfield J, Frackelton E, Kim C, Mentch F, Qui H, Grant S, Baldassano RN, Hakonarson H and The International IBD Genetics Consortium.  Pathway-based meta analysis of ulcerative colitis genome-wide association studies.  62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA, Nov 6-10, 2012.  Poster presentation. 

Pandey R, Cardinale CJ, Panossian S, Wang F, Frackelton E, Kim C, Mentch F, Chiavacci R, Kachelries K, Grant S, Baldassano RN, Hakonarson H.  Functional characterization of DcR3 and NF-қB in EBV transformed cell lines from IBD patients of different allelic background and role in disease pathogenesis.  62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA, Nov 6-10, 2012.  Poster presentation. 

Cardinale CJ, Panossian S, Wang F, Frackelton EC, Kim CE, Mentch FD, Chiavacci RM, Kachelries KE, Pandey R, Grant SFA, Baldassano RN, Hakonarson H.  Targeted resequencing identifies secretion-defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease.  62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA, Nov 6-10, 2012.  Poster presentation. 

Overton M, Jarvis W, Flint R, Baldassano RN, Kim SC.  Quantification and characterization of Klebsiella pneumoniae in pediatric patients with inflammatory bowel disease. American Gastroenterological Association; Digestive Disease Week, May 20-22, 2012. Poster Presentation. Gastroenterology 142(5):S1, p S-373-374, May 2012.

Flint RA, Jarvis HW, Overton MH, Baldassano RN, Kim SC.  Characterization of mucosally-adherent Escherichia coli  in pediatric inflammatory bowel disease patients. American Gastroenterological Association; Digestive Disease Week, May 20-22, 2012. Poster Presentation. Gastroenterology 142(5):S1,p S-373, May 2012.

Invited Lectures

2016

"Step-up or top-down: Is it time for change?" 2016 World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada, October 2016.

2015

"Are There Ways to Use Immunomodulators and Biologics More Effectively?", 2015 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation of America's Clinical & Research Conference, Orlando, FL, December 2015.

Debate: 'Step up' versus 'top down' therapy in patients with Crohn's disease and growth failure.  Pro: "Patients with Crohn's Disease and Growth Failure Should be Managed with 'Step Up' Therapy: Nutrition, Steroids, and Immunomodulators--Before Biologics".  2015 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation of America's Clinical & Research Conference, Orlando, FL, December 2015.

"Stump the Panel: Challenging Crohn's Disease Cases", 2015 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation of America's Clinical & Research Conference, Orlando, FL, December 2015.

Panel Discussion: "Challenges in Pediatric IBD 1", 2015 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation's Clinical & Research Conference, Orlando, FL, December 2015.

"Stump the Panel: Challenging Ulcerative Colitis Cases", 2015 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation of America's Clinical & Research Conference, Orlando, FL, December 2015.

"Gut Microbiome", Second Annual Microbiome Symposium, PennCHOP Microbiome Program and PennVet, Hospital of the University of Pennsylvania, Philadelphia, PA, October 2015.

2014

December 6, 2014:  “Stump the Panel: Challenging Inpatient IBD Cases”, 2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

December 6, 2014: Meet the Experts, “What  Approaches will Help Us Treat Refractory Pediatric Ulcerative Colitis?, 2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

December 5, 2014: “Stump the Panel: Challenging Outpatient IBD Cases”, 2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

December 5, 2014: Debate: Thiopurines in Pediatric IBD: Love Them or Leave Them, “Con: Thiopurines Have No Role in the Management of Pediatric IBD”, 2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

December 5, 2014: “Can Nutritional Therapy Be Used on a Practical Basis for Maintenance?”,  2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

October 23, 2014: “Diet and the Microbiome”, NASPGHAN 2014 Postgraduate Course, Atlanta, GA.

October 23, 2014: “Fad or Fiction: Case-Based Discussion of Alternative Diets”, NASPGHAN 2014 Postgraduate Course, Atlanta, GA.

September 12, 2014: “Enteral Nutrition for IBD – Is It In The Nutrition Or In The Environment”, 3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands.

2013

December 14, 2013:  “Stump the Panel: Challenging Inpatient IBD Cases”, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Hollywood, FL.

December 13, 2013:  “Stump the Panel: Challenging Outpatient IBD Cases”, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Hollywood, FL.

December 13, 2013: Debate: What Should Be Our End-Points of Therapy?, “Con: The Only End-Points of Therapy That Matter Are Mucosal Healing, Normal Blood Work, and Negative Radiologic Studies”, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Hollywood, FL.

December 13, 2013: “What Do We Do When the Patient Loses Their Response to an Anti-TNF: Minor Tweaks or Major Treatment Changes?”, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Hollywood , FL.

October 12, 2013:  “Nutrition in Inflammatory Bowel Disease”, NASPGHAN Nutrition Symposium for Dieticians, 2013 Annual Meeting and Postgraduate Course, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL.

October 10, 2013: “Enteral Nutrition in Crohn Disease: Where Should This Be in Our Treatment Algorithm?” 2013 Annual Meeting and Postgraduate Course, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL.

October 10, 2013: “Crohn Disease: Challenging Cases”, 2013 Annual Meeting and Postgraduate Course, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL.

October 2, 2013: “Are We Under-Treating or Mistreating Patients at the Time of Presentation?”, Challenges in the Care of IBD in Patients of All Ages, Falk Symposium 190, London, Great Britain.

March 8, 2013: “Nutritional Therapy for Children and Adults”, Therapeutic Options – What’s New; The 8th Penn Inflammatory Bowel Disease Symposium, Philadelphia, PA.

Awards and Honors

2014, America’s Top Doctors, 14th Edition
2013 & 2014, Top Doctors for Kids, Philadelphia Magazine
2013, Fellows Faculty Honor Roll
2012, Blockley-Osler Award
2003, Pediatric Resident Teaching Honor Roll
2003-2008, Best Doctors in America
2003-2012, America's Top Doctors
2002, Best Pediatricians in America, Best Doctors List
2002, Physician of the Year Award
2001, Doctors Who Make a Difference, Child Magazine
2001, David Cornfeld Bedside Teaching Award
2001-2013, Top Doctors for Kids, Philadelphia Magazine,
1993, Education Award for Excellence in Inflammatory Bowel Disease Teaching, Research and Clinical Care
1992, Golden Apple Award for Excellence in Pediatric Resident Teaching
1990-1993, Crohn's and Colitis Foundation of American Research Fellowship Award
1988, Pediatric Housestaff Humanitarian Award
1988, NIH Research Fellowship Award
1984-1985, Honor Scholarship, SUNY Health Science Center
1983-1987, Alpha Omega Alpha, SUNY Health Science Center
1975-1977, Mathematical Association of American, Mathematics Honor Society
1975-1977, Summa Cum Laude-State University of New York
1975-1977, Phi Beta Kappa-State University of New York
1975-1977, Sigma Phi Sigma, Physics Honor Society-State University of New York

Editorial and Academic Positions

Editorial positions

2006-present, Gastroenterology and Hepatology, editorial advisory board
2003-present, Clinical Gastroenterology and Hepatology, reviewer
2001-present, emedicine: PEDIATRICS, Medical Textbook for Health Professionals and Consumers, medical editor
1996-present, Journal of Pediatric Gastroenterology and Nutrition, reviewer

Academic and Institutional Committees

2015-present, Pediatric Advisory Board, AbbVie
2015-present, Scholarship Oversight Committee (SOC), advisor
2014-present, GI Fellowship Candidates, interviewer
2014-present, Mentorship Steering Committee, GI
2014-present, Pediatric Advisory Board, Vedolizumab
2012-present, Resident Search Committee, Children's Hospital of Philadelphia
2012-present, Scholarship Oversight Committee (SOC), advisor
1997-present, IBD Support Group and Annual Education Seminar

Leadership and Memberships

Memberships in professional organizations

International

2004-present, World Congress of Pediatric Gastroenterology, Hepatology and Nutrition

National

1996-present, Crohn's and Colitis Foundation of America

  • 2012-present, Principal Investigator, ProKiids
  • 2011-present, Oversight Committee, Pediatric Risk Stratification Group
  • 2010-present, Principal Investigator, Pediatric Risk Stratification Group
  • 2005-present, Quality Improvement/Adverse Event Tracking Focus Group

1991-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

  • 2013, Publications Committee, Committee Member
  • 2013, Clinical Trials Committee, Committee Member
  • 2013, Quality Measures for Pediatric IBD, C0mmittee Member
  • 2013, Scientific Advisory Board, Clinician Research Registry (CRR), Committee Member

1988-present, American Gastroenterological Association