![Amit Bar-Or, MD, FRCP, FAAN, FANA](/sites/default/files/styles/crop_and_center_300x375/public/providers-new-bar-or-amit.jpg?itok=FXxMrPae)
Amit Bar-Or, MD, FRCP, FAAN, FANA
Areas of expertise: Multiple sclerosis, Neuroinflammatory disorders, Neuroimmunology, Immune regulation, Immune-neural interactions, Therapeutic mode-of-action and biological proof-of-principle studies, Biomarker development
About Amit Bar-Or
Dr. Bar-Or is the inaugural Melissa and Paul Anderson President’s Distinguished Professor of Neurology at the Perelman School of Medicine at the University of Pennsylvania, where he directs the Center for Neuroinflammation and Experimental Therapeutics and serves as Chief of the Division of Multiple Sclerosis and Related Disorders. Dr. Bar-Or’s clinical focus is multiple sclerosis (MS) and related disorders in both adults and children.
A research and clinical care collaborator with Children’s Hospital of Philadelphia (CHOP), he co-directs the CHOP-Penn Age-Span NeuroImmune Program with long-standing collaborator and friend Dr. Brenda Banwell. The program is designed to ensure a seamless transition of care from pediatric to adult care for individuals with MS and related disorders, and provide a focus on education and research.
Dr. Bar-Or’s research focuses on neuroimmune health and central nervous system (CNS) inflammatory diseases across the age span, with a particular interest on developing clinically meaningful biomarkers and advancing precision medicine in autoimmune and CNS inflammatory diseases. He runs a cellular and molecular neuroimmunology lab studying principles of immune regulation and immune-neural interaction in the context of injury and repair of the human CNS.
Dr. Bar-Or is passionate about education and mentoring, having trained over 80 students at all levels, with emphasis on clinician-scientist trainees. He has published over 250 peer-reviewed publications, led multiple national and international collaborative research initiatives, and is considered a highly sought-after speaker. He is past President of the Canadian Network of MS Clinics (CNMSC) and past member of the Board of Directors of the Federation of Clinical Immunology Societies (FOCIS). He currently serves on the FOCIS Education Committee, is a member of the Board of Directors of the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS), and on the Steering Committee of the NIH Immune Tolerance Network (ITN). Dr. Bar-Or is also a long-standing member of the Scientific Advisory Board of the International Society of Neuroimmunology (ISNI) and currently serves as ISNI President.
Titles
Attending Neurologist
Melissa and Paul Anderson President's Distinguished Professor of Neurology, Perelman School of Medicine at the University of Pennsylvania
Awards and Honors
2018, Lady Barbara Colyton Prize for Autoimmune Research
2017, Melissa and Paul Anderson President’s Distinguished Chair
2016, Finalist, Barancik Prize for Innovation in MS Research, NMSS
2010, Physician of Distinction Award, Accelerated Cure Project (ACP), Boston, MA
2009, Quebec Foundation of Stars Investigator Award for Pediatric Research
2007-2008, McGill-Japan Visiting Scholar Award
2007, Killam Chair Recipient, Montreal Neurological Institute, McGill University
2007, William Dawson Chair, McGill
2006, 2008, 2009, NMSS Travel Award, FOCIS
2005, Best presentation Award, ECTRIMS
2004, Don Paty Career Scientist Award, Multiple Sclerosis Society of Canada
2003, FRSQ Chercheur Boursier Clinicien and Subventions Award
2002, Best Scientific Presentation Award, ACTRIMS/ECTRIMS, Baltimore
2002, Canadian Foundation for Innovation (CFI) New Opportunities Award
2001, Career Scientist Award, Multiple Sclerosis Society of Canada
2000, Clinical Immunology Society (CIS) Young Investigator Award
1997-1999, Harvard/MIT Clinical Investigator Fellowship awarded, supported by Pfizer Inc.
1993, M.D, C.M awarded cum laude. Faculty Scholar. Dean’s list. Psychiatry Prize
1992, International Health Exchange Scholarship, epidemiological study in Brazil
1991, American Academy of Neurology Annual S. Korey award; Excellence in research
1988, B.Sc. awarded honoris causa. JLW Gill Prize: top of graduating class Psychology Society prize
Leadership and Memberships
Memberships in Professional Organizations
International
2012-present, International Society of Neuroimmunology
- 2018-present, President
- 2012-present, Advisory Board
2010-present, German National Neuroimmunology ‘Kompetenz Network’
- 2010-present, Chair, Scientific Advisory
2002-present, Canadian Medical Association (CMA)
2002-present, Federation of Clinical Immunology Societies
- 2015-present, Education Committee
2000-present, Federation des Médecins Specialists du Québec (FMSQ)
2000-present, Federation des Médecins du Québec (FMQ)
1994-present, Medical Council of Canada
National
2016-present, Immune Tolerance Network, Steering Committee
2012-present, American Committee for Treatment and Research in MS
- 2015-present, Board of Directors
- 2012-present, Advisory Board
1998-present, Federation of Am. Soc. For Exp. Biol. (FASEB)
1988, Clinical Immunology Society (CIS)
1998-present, American Board of Psychiatry and Neurology
1998-present, Royal College of Physicians of Canada (FRCPC)
1997-present, American Association of Immunologists (AAI)
1997-present, American Neurological Association (ANA)
1997-present, American Academy of Neurology (AAN)
- 2009-present, MS Monitoring Guideline Committee
Editorial and Academic Positions
Editorial Positions
Editorial Board
Neurology, including interim Associate Editor
Clinical and Experimental Neuroimmunology
Ad Hoc Reviewer
NEJM
Lancet
Lancet Neurology
PNAS
Brain
Annals of Neurology
Journal of Neuroscience
Neuroscience Letters
Neurology
Journal of Immunology
Blood
Nature Reviews Immunology
Archives of Neurology
Neurology
Epilepsia
Journal of Neuroimmunology
ACTA Biotheoretica
NeuroImage
Education & training
Graduate Degree
MSc in Medical Science and Translational Research - HMS and Massachusetts Institute of Technology, Cambridge, MA
Medical Degree
MD - McGill University, Montreal, Québec
Internship
Medicine - Massachusetts General Hospital (MGH), Harvard Medical School (HMS), Boston, MA
Fellowship
Neurology - Massachusetts General Hospital (MGH), Harvard Medical School (HMS), Boston, MA
Postdoctoral Research Fellow, Clinical Investigator Training Program - Harvard Medical School (HMS), Massachusetts Institute of Technology, Boston, MA
Neurology - Brigham and Women's Hospital, Boston, MA
Postdoctoral Research Fellow - Cellular and Molecular Immunology, Center for Neurologic Disease, Harvard Medical School, Boston, MA
Additional Training
Certificate Program in Clinical Effectiveness - Harvard School of Public Health, Cambridge, MA
Publications
Publications
2018
Lavery AM, Collins BN, Waldman AT, Hart CN, Bar-Or A, Marrie RA, Arnold D, O'Mahony J, Banwell B; Canadian Pediatric Demyelinating Disease Network. The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk. Mult Scler. 2018 Jan. 1:1352458518757089.
Havrdová E, Arnold DL, Bar-Or A, Comi G, Hartung HP, Kappos L, Lublin F,Selmaj K, Traboulsee A, Belachew S, Bennett I, Buffels R, Garren H, Han J, Julian L, Napieralski J, Hauser SL, Giovannoni G. No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a. Mult Scler J Exp Transl Clin. 2018 Mar12;4(1):2055217318760642.
Kappos L, Bar-Or A, Cree BAC, Fox RJ, Giovannoni G, Gold R, Vermersch P, Arnold DL, Arnould S, Scherz T, Wolf C, Wallström E, Dahlke F; EXPAND Clinical Investigators. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. Lancet. 2018 Mar pii: S0140-6736(18)30475-6.
Bar-Or A*, Grove RA, Austin DJ, Tolson JM, VanMeter SA, Lewis EW, Derosier FJ, Lopez MC, Kavanagh ST, Miller AE, Sorensen PS. Subcutaneous ofatumumab in patients with relapsing-remitting multiple sclerosis: The MIRROR study. Neurology. 2018 May 15;90(20):e1805-e1814.
Touil H, Kobert A, Lebeurrier N, Rieger A, Saikali P, Lambert C, Fawaz L, Moore CS, Prat A, Gommerman J, Antel JP, Itoyama Y, Nakashima I, Bar-Or A*; Canadian B Cell Team in MS. Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis. J Neuroinflammation. 2018 Apr 19;15(1):114.
Maranzano J, Till C, Assemlal HE, Fonov V, Brown R, Araujo D, O'Mahony J, Yeh EA, Bar-Or A, Marrie RA, Collins L, Banwell B, Arnold DL, Narayanan S; Canadian Pediatric Demyelinating Disease Network. Detection and clinical correlation of leukocortical lesions in pediatric-onset multiple sclerosis on multi contrast MRI. Mult Scler. 2018 May 1:1352458518779952.
Magalhaes S, Banwell B, Bar-Or A, Fortier I, Hanwell HE, Lim M, Matt GE, Neuteboom RF, O'Riordan DL, Schneider PK, Pugliatti M, Shatenstein B, Tansey CM, Wassmer E, Wolfson C. A framework for measurement and harmonization of pediatric multiple sclerosis etiologic research studies: The Pediatric MS Tool-Kit. Mult Scler. 2018 Jun 1:1352458518783345.
Darlington PJ, Stopnicki B, Touil T, Doucet JS, Fawaz L, Roberts ME, Boivin MN, Arbour N, Freedman MS, Atkins HL, Bar-Or A*. Natural Killer Cells Regulate Th17 Cells After Autologous Hematopoietic Stem Cell Transplantation for Relapsing Remitting Multiple Sclerosis. Front Immunol. 2018 May 7;9:834:11
Galicia G, Lee DSW, Ramaglia V, Ward LA, Yam JY, Leung LYT, Li R, Handy M, Zhang J, Drohomyrecky PC, Lancaster E, Bar-Or A, Martin A, Gommerman JL. Isotype-Switched Autoantibodies Are Necessary To Facilitate Central Nervous System Autoimmune Disease in Aicda-/- and Ung-/- Mice. J Immunol. 2018 Jul 6.
Fadda G, Brown RA, Longoni G, Castro DA, O'Mahony J, Verhey LH, Branson HM, Waters P, Bar-Or A, Marrie RA, Yeh EA, Narayanan S, Arnold DL, Banwell B; Canadian Pediatric Demyelinating Disease Network. MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study. Lancet Child Adolesc Health. 2018 Mar;2(3):191-204.
Cohen JA, Comi G, Arnold DL, Bar-Or A, Selmaj KW, Steinman L, Havrdová EK, Cree BA, Montalbán X, Hartung HP, Huang V, Frohna P, Skolnick BE, Kappos L; RADIANCE Trial Investigators. Efficacy and safety of ozanimod in multiple sclerosis: Dose-blinded extension of a randomized phase II study. Mult Scler. 2018 Jul 25:1352458518789884.
O'Mahony J, Marrie RA, Laporte A, Bar-Or A, Yeh EA, Brown A, Dilenge ME, Banwell B; Canadian Pediatric Demyelinating Disease Network. Pediatric-onset multiple sclerosis is associated with reduced parental health-related quality of life and family functioning. Mult Scler. 2018 Aug 30:1352458518796676.
Juźwik CA, Drake S, Lécuyer MA, Johnson RM, Morquette B, Zhang Y, Charabati M, Sagan SM, Bar-Or A, Prat A, Fournier AE. Neuronal microRNA regulation in Experimental Autoimmune Encephalomyelitis. Sci Rep. 2018 Sep 7;8(1):13437.
Chitnis T, Arnold DL, Banwell B, Brück W, Ghezzi A, Giovannoni G, Greenberg B, Krupp L, Rostásy K, Tardieu M, Waubant E, Wolinsky JS, Bar-Or A, Stites T, Chen Y, Putzki N, Merschhemke M, Gärtner J; PARADIG MS Study Group. Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis. N Engl J Med. 2018 Sep 13;379(11):1017-1027.
Longoni G, Brown RA, Aubert-Broche B, Grover SA, Branson HM, Fetco D, Bar-Or A, Marrie RA, Motl RW, Collins DL, Narayanan S, Arnold DL, Banwell B, Yeh EA. Physical activity and dentate gyrus volume in pediatric acquired demyelinating syndromes. Neurol Neuroimmunol Neuroinflamm. 2018 Sep 6;5(6):e499.
2017
Li R, Rezk A, Ghadiri M, Luessi F, Zipp F, Li H, Giacomini PS, Antel J, Bar-Or A*. Dimethyl Fumarate Treatment Mediates an Anti-Inflammatory Shift in B Cell Subsets of Patients with Multiple Sclerosis. J Immunol. 2017 Jan 15;198(2):691-698
Das S, Glatard T, Rogers C, Saigle J, Paiva S, MacIntyre L, Safi-Harab M, Rousseau ME, Stirling J, Khalili-Mahani N, MacFarlane D, Kostopoulos P, Rioux P, Madjar C, Lecours-Boucher X, Vanamala S, Adalat R, Mohaddes Z, Fonov VS, Milot S, Leppert I, Degroot C, Durcan TM, Campbell T, Moreau J, Dagher A, Collins DL, Karamchandani J, Bar-Or A, Fon EA, Hoge R, Baillet S, Rouleau G, Evans AC. Cyberinfrastructure for Open Science at the Montreal Neurological Institute. Front Neuroinform. 2017 Jan 6;10:53.
Montalbán X, Hauser SL, Kappos L, Arnold DL, Bar-Or A, Comi G, de Seze J, Giovannoni G, Hartung HP, Hemmer B, Lublin F, Rammohan KW, Selmaj K, Traboulsee A, Sauter A, Masterman D, Fontoura P, Belachew S, Garren H, Mairon N, Chin P, Wolinsky JS ;ORATORIO Clinical Investigators. Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis. N Engl J Med. 2017 Jan 19;376(3):209-220
Hauser SL, Bar-Or A, Comi G, Giovannoni G, Hartung HP, Hemmer B, Lublin F, Montalbán X, Rammohan KW, Selmaj K, Traboulsee A, Wolinsky JS, Arnold DL, Klingelschmitt G, Masterman D, Fontoura P, Belachew S, Chin P, Mairon N, Garren H, Kappos L; OPERA I and OPERA II Clinical Investigators. Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis. N Engl J Med. 2017 Jan 19;376(3):221-234
Longoni G, Brown RA, Momayyez Siahkal P, Elliott C, Narayanan S, Bar-Or A, Ann Marrie R, Ann Yeh E, Filippi M, Banwell B, Arnold DL. White matter changes in paediatric multiple sclerosis and monophasic demyelinating disorders. Canadian Pediatric Demyelinating Disease Network. Brain. Mar 2017
Li R, Rezk A, Li H, Gommerman JL, Prat A, Bar-Or A*; Antibody-Independent Function of Human B Cells Contributes to Antifungal T Cell Responses. Canadian B Cells in MS Team. J Immunol. 2017 Apr 15;198(8):3245-3254
Aubert-Broche B, Weier K, Longoni G, Fonov VS, Bar-Or A, Marrie RA, Yeh EA, Narayanan S, Arnold DL, Verhey LH, Banwell B, Collins DL; Canadian Pediatric, Demyelinating Disease Network. Monophasic demyelination reduces brain growth in children. Neurology. 2017 May 2;88(18):1744-1750
Cohen JA, Imrey PB, Planchon SM, Bermel RA, Fisher E, Fox RJ, Bar-Or A, Sharp SL, Skaramagas TT, Jagodnik P, Karafa M, Morrison S, Reese Koc J, Gerson SL, Lazarus HM. Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis. Mult Scler. Apr 2017
Ghadiri M, Rezk A, Li R, Evans A, Luessi F, Zipp F, Giacomini PS, Antel J, Bar-Or A*. Dimethyl fumarate-induced lymphopenia in MS due to differential T-cell subset apoptosis. Neurol Neuroimmunol Neuroinflamm. 2017 Mar 23;4(3):e340.
Kappos L, Arnold DL, Bar-Or A, Camm AJ, Derfuss T, Sprenger T, Davies M, Piotrowska A, Ni P, Harada T. Two-year results from a phase 2 extension study of oral amiselimod in relapsing multiple sclerosis. Mult Scler. 2017.
Ghadiri M, Fitz-Gerald L, Rezk A, Li R, Nyirenda M, Haegert D, Giacomini PS, Bar-Or A, Antel J. Reconstitution of the peripheral immune repertoire following withdrawal of fingolimod. Mult Scler. 2017 Aug;23(9):1225-1232.
Lisak RP*, Nedelkoska L, Benjamins JA, Schalk D, Bealmear B, Touil H, Li R, Muirhead G, Bar-Or A*. B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro. J Neuroimmunol. 2017 Aug 15;309:88-99.
Fleischer V, Friedrich M, Rezk A, Bühler U, Witsch E, Uphaus T, Bittner S, Groppa S, Tackenberg B, Bar-Or A, Zipp F, Luessi F. Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS. Mult Scler. 2017.
Healy LM, Jang JH, Won SY, Lin YH, Touil H, Aljarallah S, Bar-Or A, Antel JP. MerTK-mediated regulation of myelin phagocytosis by macrophages generated from patients with MS. Neurol Neuroimmunol Neuroinflamm. 2017 Oct 16;4(6):e402.
2016
Rao VT, Ludwin SK, Fuh SC, Sawaya R, Moore CS, Ho MK, Bedell BJ, Sarnat HB, Bar-Or A, Antel JP. MicroRNA Expression Patterns in Human Astrocytes in Relation to Anatomical Location and Age. J Neuropathol Exp Neurol. 2016 Feb;75(2):156-66.
Cohen JA, Arnold DL, Comi G, Bar-Or A, Gujrathi S, Hartung JP, Cravets M, Olson A, Frohna PA, Selmaj KW; RADIANCE Study Group. Safety and efficacy of the selective sphingosine 1-phosphate receptor modulator ozanimod in relapsing multiple sclerosis (RADIANCE): a randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2016 Apr;15(4):373-81
Healy LM, Perron G, Won SY, Michell-Robinson MA, Rezk A, Ludwin SK, Moore CS, Hall JA, Bar-Or A, Antel JP. MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells. J Immunol. 2016 Apr 15;196(8):3375-84
Gabrusiewicz K, Rodriguez B, Wei J, Hashimoto Y, Healy LM, Maiti SN, Thomas G, Zhou S, Wang Q, Elakkad A, Liebelt BD, Yaghi NK, Ezhilarasan R, Huang N, Weinberg JS, Prabhu SS, Rao G, Sawaya R, Langford LA, Bruner JM, Fuller GN, Bar-Or A, Li W, Colen RR, Curran MA, Bhat KP, Antel JP, Cooper LJ, Sulman EP, Heimberger AB. Glioblastoma-infiltration innate immune cells resemble M0 macrophage phenotype. JCI Insight. 2016;1(2)
Healy LM, Perron G, Won SY, Rao VT, Guiot MC, Moore C, Bar-Or A, Antel JP. Differential transcriptional response profiles in human myeloid cell populations. Clin Immunol. 2016 Apr 16. pii: S1521-6616(16)30065-1
Gold R, Arnold DL, Bar-Or A, Hutchinson M, Kappos L, Havrdova E, MacManus DG, Yousry TA, Pozzilli C, Selmaj K, Sweetser MT, Zhang R, Yang M, Potts J, Novas M, Miller DH, Kurukulasuriya NC, Fox RJ, Phillips TJ. Long-term effects of delayed release dimethyl fumarate in multiple sclerosis: Interim analysis of ENDORSE, a randomized extension study. Mult Scler. 2017 Feb;23(2):253-265
Atkins HL, Bowman M, Allan D, Anstee G, Arnold DL, Bar-Or A, Bence-Bruckler I, Birch P, Bredeson C, Chen J, Fergusson D, Halpenny M, Hamelin L, Huebsch L, Hutton B, Laneuville P, Lapierre Y, Lee H, Martin L, McDiarmid S, O'Connor P, Ramsay T, Sabloff M, Walker L, Freedman MS. Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. Lancet. 2016 Aug 6; 388(10044):576-85
Bühler U, Fleischer V, Luessi F, Rezk A, Belikan P, Graetz C, Gollan R, Wolf C, Lutz J, Bar-Or A, Siffrin V, Zipp F. Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment. Mult Scler. 2017 Apr;23(4):567-576
Rozenberg A, Rezk A, Boivin MN, Darlington PJ, Nyirenda M, Li R, Jalili F, Winer R, Artsy EA, Uccelli A, Reese JS, Planchon SM, Cohen JA, Bar-Or A*. Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses through a Prostaglandin E2 and myeloid-dependent mechanism. Stem Cells Transl Med. 2016 Nov;5(11):1506-1514
Kappos L, Arnold DL, Bar-Or A, Camm J, Derfuss T, Kieseier BC, Sprenger T, Greenough K, Ni P, Harada T. Safety and efficacy of amiselimod in relapsing multiple sclerosis (MOMENTUM): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2016 Oct;15(11):1148-59
Kaushik DK, Yong HYF, Hahn JN, Silva C, Jacque FH, Lisak R, Khan O, Ionette C, Larochelle C, Prat A, Bar-Or A, Yong VW. Evaluating EMMPRIN as a marker of disease activity in multiple sclerosis: studies of serum and cerebrospinal fluid. PLoS One, 2016 Oct 11;11(10):e0163802
2015
Villar LM, Costa-Frossard L, Masterman T, Fernandez O, Montalbán X, Casanova B, Izquierdo G, Coret F, Tumani H, Saiz A, Arroyo R, Fink K, Leyva L, Espejo C, Simó-Castelló M, García-Sánchez MI, Lauda F, Llufriú S, Álvarez-Lafuente R, Olascoaga J, Prada A, Oterino A, de Andrés C, Tintoré M, Ramió-Torrentà L, Rodríguez-Martín E, Picón C, Comabella M, Quintana E, Agüera E, Díaz S, Fernandez-Bolaños R, García-Merino JA, Landete L, Menéndez-González M, Navarro L, Pérez D, Sánchez-López F, Serrano-Castro PJ, Tuñón A, Espiño M, Muriel A, Bar-Or A, Álvarez-Cermeño JC. Lipid-specific IgM bands in CSF associated with a reduced risk of developing PML during treatment with natalizumab. Ann Neurol. 77(3):447-57; 2015
Moore CS, Cui QL, Warsi NM, Durafourt BA, Zorko N, Owen DR, Antel JP, and Bar-Or A*. Direct and Indirect Effects of Immune and Central Nervous System–Resident Cells on Human Oligodendrocyte Progenitor Cell Differentiation. J Immunol;194(2):761-72; 2015 Jan
Bar-Or A*, Wiendl H, Miller B, Benamor M, Truffinet P, Church M, Menguy-Vacheron F. Randomized study of teriflunomide effects on immune responses to neo-antigen and recall antigens. Neurol Neuroimmunol Neuroinflamm.;2(2):e70; 2015 Feb
Stork L, Brück W, Bar-Or A, Metz I. High CCR5 expression in natalizumab-associated progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome supports treatment with the CCR5 inhibitor maraviroc. Acta Neuropathol. 129(3):467-8; 2015 Jan.
Miller DH, Fox RJ, Phillips JT, Hutchinson M, Havrdova E, Kita M, Wheeler-Kingshott CA, Tozer DJ, MacManus DG, Yousry TA, Goodsell M, Yang M, Zhang R, Viglietta V, Dawson KT; CONFIRM study investigators. Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study. Neurology.;84(11):1145-52; 2015
Viglietta V, Miller D, Bar-Or A, Phillips JT, Arnold DL, Selmaj K, Kita M, Hutchinson M, Yang M, Zhang R, Dawson KT, Sheikh SI, Fox RJ, Gold R. Efficacy of delayed-release dimethyl fumarate in relapsing-remitting multiple sclerosis: integrated analysis of the phase 3 trials. Ann Clin Transl Neurol. 2(2):103-18; 2015 Feb
Bin Dhuban K, d'Hennezel E, Nashi E, Bar-Or A, Rieder S, Shevach EM, Nagata S, Piccirillo CA. Coexpression of TIGIT and FCRL3 Identifies Helios+ Human Memory Regulatory T Cells. J Immunol. 194(8):3687-96; 2015 Apr
Moore CS, Ase AR, Kinsara A, Rao VT, Michell-Robinson M, Leong SY, Butovsky O, Ludwin SK, Séguéla P, Bar-Or A, Antel JP. P2Y12 expression and function in alternatively activated human microglia. Neurol Neuroimmunol Neuroinflamm.;2(2):e80; 2015 Mar
Mery V, Kimoff RJ, Suarez I, Benedetti A, Kaminska M, Robinson A, Lapierre Y, Bar-Or A, Trojan DA. High false-positive rate of questionnaire-based restless legs syndrome diagnosis in multiple sclerosis. Sleep Med.;16(7):877-82; 2015 Jul
Nyirenda MH, Morandi E, Vinkemeier U, Constantin-Teodosiu D, Drinkwater S, Mee M, King L, Podda G, Zhang GX, Ghaemmaghami A, Constantinescu CS, Bar-Or A*, Gran B*. TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis. J Immunol. 94(12):5761-74; 2015 Jun
O'Mahony J, Marrie RA, Laporte A, Yeh EA, Bar-Or A, Phan C, Buckley D, Callen D, Connolly MB, Pohl D, Dilenge ME, Bernard G, Lortie A, Lowry N, MacDonald EA, Meek D, Sébire G, Venkateswaran S, Wood E, Yager J, Banwell B. Recovery From Central Nervous System Acute Demyelination in Children. Pediatrics. 136(1):e115-23; 2015 Jul
Makhani N, Banwell B, Tellier R, Yea C, McGovern S, O'Mahony J, Ahorro JM, Arnold D, Sadovnick AD, Marrie RA, Bar-Or A; Canadian Pediatric Demyelinating Disease Network. Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination. Mult Scler.2016 Mar;22(3):385-8
Li R, Rezk A, Miyazaki Y, Hilgenberg E, Touil H, Shen P, Moore C, Michel L, Althekair F, Rajasekharan S, Gommerman J, Prat A, Fillatreau S and Bar-Or A* on behalf of the 'Canadian B cells in MS Team'. Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy. Sci Transl Med. 2015 Oct 21;7(310):310ra166
Gold R, Phillips JT, Havrdova E, Bar-Or A, Kappos L, Kim N, Thullen T, Valencia P, Oliva L, Novas M, Li J, Sweetser MT, Kurukulasuriya N, Viglietta V, Fox RJ. Delayed-Release Dimethyl Fumarate and Pregnancy: Preclinical Studies and Pregnancy Outcomes from Clinical Trials and Postmarketing Experience. Neurol Ther. 2015 Dec;4(2):93-104
Pikor NB, Astarita JL, Summers-Deluca L, Galicia G, Qu J, Ward LA, Armstrong S, Dominguez CX, Malhotra D, Heiden B, Kay R, Castanov V, Touil H, Boon L, O'Connor P, Bar-Or A, Prat A, Ramaglia V, Ludwin S, Turley SJ, Gommerman JL. Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation. Immunity. 2015 Dec 15;43(6):1160-73
Shaked I, Hanna RN, Shaked H, Chodaczek G, Nowyhed HN, Tweet G, Tacke R, Basat AB, Mikulski Z, Togher S, Miller J, Blatchley A, Salek-Ardakani S, Darvas M, Kaikkonen MU, Thomas GD, Lai-Wing-Sun S, Rezk A, Bar-Or A, Glass CK, Bandukwala H, Hedrick CC. Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation. Nat Immunol. 2015 Dec;16(12):1228-34
Michell-Robinson MA, Moore CS, Healy LM, Osso LA, Zorko N, Grouza V, Touil H, Poliquin-Lasnier L, Trudelle AM, Giacomini PS, Bar-Or A, Antel JP. Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosis. Ann Clin Transl Neurol. 2015 Dec 2;3(1):27-41
2014
Kappos L, Gold R, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Sarda SP, Agarwal S, Zhang A, Sheikh SI, Seidman E, Dawson KT. Quality of life outcomes with BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: The DEFINE study. Mult Scler. ; 20(2):243-52; 2014.
Sato DK, Nakashima I, Bar-Or A, Misu T, Suzuki C, Nishiyama S, Kuroda H, Fujihara K, Aoki M. Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis. J Neuroimmunol. ; 268(1-2):95-8; 2014.
Zastepa E, Fitz-Gerald L, Hallett M, Antel J, Bar-Or A, Baranzini S, Lapierre Y, Haegert DG. Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS. Neurology; 82(8):681-90; 2014.
Giacomini PS, Rozenberg A, Metz I, Araujo D, Arbour N, Bar-Or A* and the Maraviroc in Multiple Sclerosis-Associated PML–IRIS (MIMSAPI) Group. Maraviroc and JC virus-associated immune reconstitution inflammatory syndrome. N Engl J Med. 370(5):486-8; 2014.
Shen P, T. Roch, V. Lampropoulou, R.A. O’Connor, U. Stervbo, E. Hilgenberg, S. Ries, V.D. Dang, Y. Jaimes, C. Daridon, R. Li, L. Jouneau, P. Boudinot, S. Wilantri, I. Sakwa, Y. Miyazaki, M.D. Leech, R.C. McPherson, S. Wirtz, M. Neurath, K. Hoehlig, E. Meinl, A. Grützkau, J.R. Grün, K. Horn, A.A. Kühl, T. Dörner, A. Bar-Or, S.H.E. Kaufmann, S.M. Anderton, and S. Fillatreau. IL-35-producing B cells: critical regulators of immunity during autoimmune and infectious diseases. Nature; 507(7492):366-70; 2014
Amrom D, Kinay D, Hart Y, Berkovic SF, Laxer K, Andermann F, Andermann E, Bar-Or A*. Rasmussen's encephalitis and co-morbid autoimmune diseases: a window into disease mechanism? Neurology; 16;83(12):1049-55; 2014.
Quintana FJ, Patel B, Yeste A, Nyirenda M, Kenison J, Rahbari R, Fetco D, Hussain M, O’Mahony J, Magalhaes S, McGowan M, Johnson T, Rajasekharan S, Narayanan S, Arnold DL, Weiner HL, Banwell B and Bar-Or A*, On behalf of the Canadian Pediatric Demyelinating Disease Network*. Epitope spreading as an early pathogenic event in pediatric multiple sclerosis, Neurology 83(24):2219-26; 2014
Villar LM; Casanova B, Ouamara N, Comabella M, Jalili F, Leppert D, de Andrés C, Izquierdo G, Arroyo R, Avlar T, Lapin SV, Johnson T, Montalbán X, Fernández O, Álvarez-Lafuente R, Masterman D, García-Sánchez MI, Coret F, Siva A, Evdoshenko E, Álvarez-Cermeño JC, Bar-Or A*. IgM oligoclonal bands: biomarker of targetable inflammation in PPMS. Ann Neurol; 76(2):231-40; 2014
Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, Solis M, Goiry LG, de Faria Junior O, Dang VD, Colman D, Dhaunchak AS, Antel J, Gommerman J, Prat A, Fillatreau S, Bar-Or A*; CIHR/MSSC New Emerging Team Grant in Clinical Autoimmunity and the MSSRF Canadian B cells in MS Team. A Novel MicroRNA-132-Surtuin-1 Axis Underlies Aberrant B-cell Cytokine Regulation in Patients with Relapsing-Remitting Multiple Sclerosis. PLoS One. 19;9(8):e105421; 2014
Arnold DL, Gold R, Kappos L, Bar-Or A, Giovannoni G, Selmaj K, Yang M, Zhang R, Stephan M, Sheikh SI, Dawson KT. Effects of delayed-release dimethyl fumarate on MRI measures in the Phase 3 DEFINE study. J Neurol. 261(9):1794-802; 2014
Ahn JJ, O'Mahony J, Moshkova M, Hanwell HE, Singh H, Zhang MA, Marrie RA, Bar-Or A, Sadovnick DA, Dunn SE, Banwell BL. Puberty in females enhances the risk of an outcome of multiple sclerosis in children and the development of central nervous system autoimmunity in mice. Mult Scler. 21(6):735-48; 2014
Posevitz-Fejfár A, Posevitz V, Gross CC, Bhatia U, Kurth F, Schütte V, Bar-Or A, Meuth SG, Wiendl H. Effects of blood transportation on human peripheral mononuclear cell yield, phenotype and function: implications for immune cell biobanking. PLoS One.;9(12):e115920; 2014
2013
Darlington PJ, Touil T, Doucet J-S, Gaucher D, Zeidan Z, Gauchat D, Corsini R, Kim HJ, Duddy M, Jalili F, Arbour N, Kebir H, Chen J, Arnold DL, Bowman M, Antel JP, Prat A, Freedman MS, Atkins H, Sekaly R, Cheynier R and Bar-Or A, for the Canadian MS/BMT Study Group. Diminished Th17 (not Th1) responses underlie MS disease abrogation after HSCT. Ann Neurol; 73(3):341-54. Mar 2013
Koeva V, Bar-Or A, Gendron D, Backman SB. Epidural blood patch in a patient with multiple sclerosis: is it safe? Can J Anaesth. 60(5):479-483. May 2013
Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis. Mult Scler. Apr 23 2013
Wu C, Leong SY, Moore CS, Cui QL, Gris P, Bernier LP, Johnson TA, Séguéla P, Kennedy TE, Bar-Or A, Antel JP. Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation. J Neuroinflammation. 10:41, Mar 19 2013
Bar-Or A, Gold R, Kappos L, Arnold DL, Giovannoni G, Selmaj K, O'Gorman J, Stephan M, Dawson KT. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the DEFINE study. J Neurol. June 2013
Moore CS, Rao V, Durafourt BA, Bedell BJ, Ludwin SK, Bar-Or A, Antel JP. Mir-155 as a multiple sclerosis-relevant regulator of myeloid cell polarization. Ann Neurol. 2013
Verhey LH, Signori A, Arnold DL, Bar-Or A, Sadovnick AD, Marrie RA, Banwell B, Sormani MP. Clinical and MRI activity as determinants of sample size for pediatric multiple sclerosis trials. Neurology. Aug 21 2013.
Bar-Or A, Freedman MS, Kremenchutzky M, Menguy-Vacheron F, Bauer D, Jodl S, Truffinet P, Benamor M, Chambers S, O'Connor PW. Teriflunomide effect on immune response to influenza vaccine in patients with multiple sclerosis. Neurology. 81(6):552-8. Aug 6 2013
Henault D, Galleguillos L, Moore C, Johnson T, Bar-Or A, Antel J. Basis for fluctuations in lymphocyte counts in fingolimod-treated patients with multiple sclerosis. Neurology. ; 81(20):1768-72. Nov 12, 2013
Evdoshenko E, Maslyanskiy A, Lapin S, Zaslavsky L, Dobson R, Totolian A, Skoromets A, Bar-Or* A. Dynamics of B-Cell Populations in CSF and Blood in Patients Treated with a Combination of Rituximab and Mitoxantrone. ISRN Neurol. 748127. Sep 10, 2013
Mayer MC, Breithaupt C, Reindl M, Schanda K, Rostásy K, Berger T, Dale RC, Brilot F, Olsson T, Jenne D, Pröbstel AK, Dornmair K, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A*, Meinl E*. Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases. J Immunol. 191(7):3594-604. Oct 2013
Yea C, Tellier R, Chong P, Westmacott G, Marrie RA, Bar-Or A*, Banwell B*; Canadian Pediatric Demyelinating Disease Network. Epstein-Barr virus in oral shedding of children with multiple sclerosis. Neurology. ;81(16):1392-9; 2013.
van Pelt ED, Mescheriakova JY, Makhani N, Ketelslegers IA, Neuteboom RF, Kundu S, Broer L, Janssens C, Catsman-Berrevoets CE, van Duijn CM, Banwell B, Bar-Or A*, Hintzen RQ*. Risk genes associated with pediatric-onset MS but not with monophasic acquired CNS demyelination. Neurology. ;81(23):1996-2001; 2013.
2012
Trojan DA, Kaminska M, Bar-Or A, Benedetti A, Lapierre Y, Da Costa D, Robinson A, Cardoso M, Schwartzman K, Kimoff RJ. Polysomnographic measures of disturbed sleep are associated with reduced quality of life in multiple sclerosis. J Neurol Sci. 316(1-2):158-63, 2012
Durafourt BA, Moore CS, Zammit DA, Johnson TA, Zaguia F, Guiot MC, Bar-Or A, Antel JP. Comparison of polarization properties of human adult microglia and blood-derived macrophages. Glia, 60(5):717-27, 2012
Waters PJ, McKeon A, Leite MI, Rajasekharan S, Lennon VA, Villalobos A, Palace J, Mandrekar JN, Vincent A, Bar-Or A, Pittock SJ. Serologic diagnosis of NMO: A multicenter comparison of aquaporin-4-IgG assays. Neurology, 78(9):665-71, 2012
Pool M, Rambaldi I, Darlington PJ, Wright MC, Fournier AE*, Bar-Or* A. Neurite outgrowth is differentially impacted by distinct immune cell subsets. Mol Cell Neurosci. 49(1):68-76, 2012
Vazquez-Tello A, Halwani R, Li R, Nadigel J, Bar-Or A, Mazer BD, Eidelman DH, Al-Muhsen S, Hamid Q. IL-17A and IL-17F Expression in B Lymphocytes. Int Arch Allergy Immunol, 157(4):406-416, 2012
Dhaunchak AS, Becker C, Schulman H, De Faria O Jr, Rajasekharan S, Banwell B, Colman DR, Bar-Or A*; on behalf of the Canadian Pediatric Demyelinating Disease Group. Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis. Ann Neurol. May;71(5):601-613; 2012
Confavreux C, Li DK, Freedman MS, Truffinet P, Benzerdjeb H, Wang D, Bar-Or A, Traboulsee AL, Reiman L, O'Connor P. Long-term follow-up of a phase 2 study of oral teriflunomide in relapsing multiple sclerosis: safety and efficacy results up to 8.5 years. Mult Scler, 2012
Kaminska M, Kimoff R, Benedetti A, Robinson A, Bar-Or A, Lapierre Y, Schwartzman K, Trojan D. Obstructive sleep apnea is associated with fatigue in multiple sclerosis. Mult Scler, 2012.
de Faria O Jr, Cui QL, Bin JM, Bull SJ, Kennedy TE, Bar-Or A, Antel JP, Colman DR, Dhaunchak AS. Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes. Front Genet.;3:46. Epub 2012 Mar 28, 2012
Waubant E, Pelletier D, Mass M, Cohen JA, Kita M, Cross A, Bar-Or A, Vollmer T, Racke M, Stüve O, Schwid S, Goodman A, Kachuck N, Preiningerova J, Weinstock-Guttman B, Calabresi PA, Miller A, Mokhtarani M, Iklé D, Murphy S, Kopetskie H, Ding L, Rosenberg E, Spencer C, Zamvil SS; On behalf of the ITN STAyCIS Study Group; Work on this study was conducted on the behalf of the ITN STAyCIS Study Group; ITN020AI Study Management Team. Randomized controlled trial of atorvastatin in clinically isolated syndrome: The STAyCIS study. Neurology. 2012 Apr 10;78(15):1171-1178. May 2012
Lisak RP, Benjamins JA, Nedelkoska L, Barger JL, Ragheb S, Fan B, Ouamara N, Johnson TA, Rajasekharan S, Bar-Or A*. Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro. J Neuroimmunol.;246(1-2):85-95. Mar 28 2012
Barr TA, Shen P, Brown S, Lampropoulou V, Roch T, Lawrie S, Fan B, O'Connor RA, Anderton SM, Bar-Or A, Fillatreau S, Gray D. B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells. J Exp Med. Apr 30, 2012
Belabani C, Rajasekharan S, Johnson T and Bar-Or A* on behalf of the CIHR/MSSC NET in Clinical Autoimmunity and the Canadian Pediatric Demyelinating Disease Network. A condensed performance-validation strategy for multiplex detection kits used in studies of human clinical samples. J Immunol Meth; 387 (1-2):1-10. Jan 31 2013
Côté I, Trojan DA, Kaminska M, Cardoso M, Benedetti A, Weiss D, Robinson A, Bar-Or A, Lapierre Y, Kimoff RJ. Impact of Sleep Disorder Treatment on Fatigue in Multiple Sclerosis. Mult Scler, 2012
O'Mahony J, Bar-Or A, Arnold DL, Sadovnick AD, Marrie RA, Banwell B; Canadian Pediatric Demyelinating Disease Network. Masquerades of Acquired Demyelination in Children: Experiences of a National Demyelinating Disease Program. J Child Neurol. 2012
Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Tornatore C, Sweetser MT, Yang M, Sheikh SI, Dawson KT; DEFINE Study Investigators. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med; 367(12):1098-107. Sep 20 2012
Fox RJ, Miller DH, Phillips JT, Hutchinson M, Havrdova E, Kita M, Yang M, Raghupathi K, Novas M, Sweetser MT, Viglietta V, Dawson KT; CONFIRM Study Investigators. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med;367(12):1087-97. Sep 2012
Sadaka Y, Verhey LH, Shroff MM, Branson HM, Arnold DL, Narayanan S, Sled JG, Bar-Or A, Sadovnick AD, McGowan M, Marrie RA, Banwell B; Canadian Pediatric Demyelinating Disease Network. 2010 McDonald criteria for diagnosing pediatric multiple sclerosis. Ann Neurol. Aug; 72(2):211-23. 2012
2011
Durafourt BA#, Lambert C#, Johnson TA, Blain M, Bar-Or A, Antel JP. Differential Responses of Human Microglia and Blood Derived Myeloid Cells to FTY720. J Neuroimmunol, 230(1-2):10-6, (#equal contribution), Jan 2011
Comi G, Cohen JA, Arnold DL, Wynn D, and the FORTE Study Group. Phase III dose-comparison study of glatiramer acetate for multiple sclerosis. Ann Neurol, 69(1):75-82, Jan 2011
De Vidi I, Boursier G, Delouche N, Portalès P, Cadars E, Bouthier M, Mettling C, Lin YL, Thouvenot E, Carlander B, Camu W, Antel JP, Bar-Or A, Zephir H, Vermersch P, De Seze J, Corbeau P, Eliaou JF, Vincent T. Strategy for anti-aquaporin-4 auto-antibody identification and quantification using a new cell-based assay. Clin Immunol, 138(3):239-46, Mar 2011
Venkateswaran S, Zheng K, Sacchetti M, Gagne D, Arnold DL, Sadovnick D, Scherer SW, Banwell B, Bar-Or A*, Simon DK*, on behalf of the Canadian Pediatric Demyelinating Disease Network. Mitochondrial DNA Haplogroups and Mutations in Pediatric Acquired Central Demyelination. Neurology, 1;76(9):774-80, 2011
Disanto G# Magalhaes M#, Handel A, Morrison KM, Sadovnick AD, Ebers GC, Banwell B, Bar-Or A*, on behalf of the Canadian Pediatric Demyelinating Disease Network. HLA-DRB1 Confers Increased Risk of Pediatric-Onset MS in Children with Acquired Demyelination. Neurology, 76(9):781-6, (# equal contribution), 2011
Haegert DG, Hackenbroch JD, Duszczyszyn D, Fitz-Gerald L, Zastepa E, Mason H, Lapierre Y, Antel J, Bar-Or A. Reduced thymic output and peripheral naïve CD4 T-cell alterations in primary progressive multiple sclerosis (PPMS). J Neuroimmunol, 233(1-2):233-9, 2011
Banwell B, Bar-Or A, Arnold DL, Sadovnick D, Narayanan S, McGowan M, O'Mahony J, Magalhaes S, Hanwell H, Vieth R, Tellier R, Vincent T, Disanto G, Ebers G, Wambera K, Connolly MB, Yager J, Mah JK, Booth F, Sebire G, Callen D, Meaney B, Dilenge ME, Lortie A, Pohl D, Doja A, Venketaswaran S, Levin S, Macdonald EA, Meek D, Wood E, Lowry N, Buckley D, Yim C, Awuku M, Cooper P, Grand'Maison F, Baird JB, Bhan V, Marrie RA. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study. Lancet Neuro, 10(5):436-45, May 2011
Johnson TA, Evans BL, Durafourt BA, Blain M, Lapierre Y, Bar-Or A, Antel JP. Reduction of the Peripheral Blood CD56bright NK Lymphocyte Subset in FTY720-Treated Multiple Sclerosis Patients. J Immunol, 1;187(1):570-9, July 2011
Nakashima I, Takahashi T, Cree BA, Kim HJ, Suzuki C, Genain CP, Vincent T, Fujihara K, Itoyama Y, Bar-Or A. Transient increases in anti-aquaporin-4 antibody titers following rituximab treatment in neuromyelitis optica, in association with elevated serum BAFF levels. J Clin Neurosci, 18(7):997-8, July 2011
Pool M, Rambaldi I, Durafourt BA, Wright MC, Antel JP, Bar-Or A*, Fournier AE*. Myeloid lineage cells inhibit neurite outgrowth through a myosin II-dependent mechanism. J Neuroimmunol, 15;237(1-2):101-5, 2011
Kimball S, Vieth R, Dosch HM, Bar-Or A, Cheung R, Gagne D, O'Connor P, D'Souza C, Ursell M, Burton JM. Cholecalciferol Plus Calcium Suppresses Abnormal PBMC Reactivity in Patients with Multiple Sclerosis. J Clin Endocrinol Metab,;96(9):2826-34, 2011
Nyirenda MH, Sanvito L, Darlington PJ, O'Brien K, Zhang GX, Constantinescu CS, Bar-Or A, Gran B. TLR2 Stimulation Drives Human Naive and Effector Regulatory T Cells into a Th17-Like Phenotype with Reduced Suppressive Function. J Immunol, 187(5):2278-90, 2011
Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forne I, Khademi M, Olsson T, Brilot F, Tantsis E, Dale RC, Wekerle H, Hohlfeld R, Banwell B*, Bar-Or A*, Meinl E*, Derfuss T*. Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology, 9;77(6):580-8, 2011
Darlington P, Touil T, Doucet J-S, Gaucher D, Zeidan J, Gauchat D, Corsini R, Kim HJ, Duddy M, Jalili F, Kebir H, Arbour N, Chen J, Arnold DL, Bowman M, Antel JP, Prat A, Freedman MS, Atkins H, Sekaly R, Cheynier R and Bar-Or A* for the Canadian MS/BMT Study Group. Diminished Th17 (not Th1) responses underlie MS disease abrogation after BMT. Accepted, Ann Neurol, 2011
Freedman MS, Bar-Or A, Oger J, Traboulsee A, Patry D, Young C, Olsson T, Li D, Hartung HP, Krantz M, Ferenczi L, Verco T; On behalf of the MAESTRO-01 Investigators. A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS. Neurology, 77(16):1551-60. 2011
Kappos L, Li D, Calabresi PA, O'Connor P, Bar-Or A, Barkhof F, Yin M, Leppert D, Glanzman R, Tinbergen J, Hauser SL. Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomized, placebo-controlled, multicentre trial. Lancet, 19;378(9805):1779-87, Nov 2011
Verhey LH, Branson HM, Shroff MM, Callen DJ, Sled JG, Narayanan S, Sadovnick AD, Bar-Or A, Arnold DL, Marrie RA, Banwell B; for the Canadian Pediatric Demyelinating Disease Network. MRI parameters for prediction of multiple sclerosis diagnosis in children with acute CNS demyelination: a prospective national cohort study. Lancet Neurol, 10(12):1065-1073, Dec 2011
2010
Comi G, O'Connor P, Montalbán X, Antel J, Radue EW, Karlsson G, Pohlmann H, Aradhye S, Kappos L; FTY720D2201 Study Group. Phase II study of oral Fingolimod (FTY720) in multiple sclerosis: 3-year results. Mult Scler, 16(2):197-207, 2010
Burton JM, Kimball S, Vieth R, Bar-Or A, Dosch HM, Cheung R, Gagne D, D'Souza C, Ursell M, O'Connor P. A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis. Neurology, 75(11), 2010
O'Connor KC, Lopez-Amaya C, Gagne D, Lovato L, Moore-Odom NH, Kennedy J, Krupp L, Tenembaum S, Ness J, Belman A, Boyko A, Bykova O, Mah JK, Stoian CA, Waubant E, Kremenchutzky M, Ruggieri M, Bardini MR, Rensel M, Hahn J, Weinstock-Guttman B, Yeh EA, Farrell K, Freedman MS, Iivanainen M, Bhan V, Dilenge M, Hancock MA, Gano D, Fattahie R, Kopel L, Fournier AE, Moscarello M, Banwell B and Bar-Or A. Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis. J Neuroimmunol, 223(1-2):92-9, 2010
Johnson TA, Shames I, Keezer M, Lapierre Y, Haegert DG, Bar-Or A, Antel J. Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients. Clin Immunol, 137(1):15-20, 2010
Bar-Or A*, Fawaz L, Fan B, Darlington PJ, Rieger A, Ghorayeb C, Calabresi PA, Waubant E, Hauser SL, Zhang J, Smith C. Abnormal B cell cytokine responses: A trigger of T-cell-mediated disease in MS? Ann Neurol, 67(4):452-61, 2010
Zhang Y, Jalili F, Ouamara N, Zameer A, Cosentino G, Mayne M, Hayardeny L, Antel JP, Bar-Or A*, John GR*. Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: Role of IGF-2. J Neuroimmunol, 227(1-2):71-9, 2010
Newell MK, Tobin RP, Cabrera JH, Sorensen MB, Huckstep A, Villalobos-Menuey EM, Burnett M, McCrea E, Harvey CP, Buddiga A, Bar-Or A, Freedman MS, Nalbantoglu J, Arbour N, Zamvil SS, Antel JP. TLR-mediated B cell activation results in ectopic CLIP expression that promotes B cell-dependent inflammation. J Leukoc Biol, 88(4):779-89, 2010
Dhaunchak AS, Huang J, De Faria Junior O, Roth A, Pedraza L, Antel JP, Bar-Or A, Colman D. A proteome map of axoglial specializations isolated and purified from human central nervous system. Glia, 58(16):1949-60, 2010
Johnson TA, Lapierre Y, Bar-Or A, Antel JP. Distinct properties of circulating CD8+ T cells in FTY720 treated multiple sclerosis patients. Arch Neurol, 67(12):1449-55, 2010
Darlington P, Boivin M-N, Renoux C, Francois M, Atkins HL, Freedman MS, Galipeau J, Cohen JA, Solchaga L, Bar-Or A*. Th1 and Th17 Regulation by Mesenchymal Stem Cells: Implication for MS. Ann Neurol, 68(4):540-5, 2010
2009
O'Connor P, Comi G, Montalbán X, Antel J, Radue EW, de Vera A, Pohlmann H, Kappos L. FTY720 D2201 Study Group. Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study. Neurology, 6;72(1):73-9, 6 Jan 2009
Banwell B*, Kennedy J, Sadovnick D, Arnold DL, Magalhaes S, Wambera K, Connolly MB, Yager J, Mah JK, Shah N, Sebire G, Meaney B, Dilenge ME, Lortie A, Whiting S, Doja A, Levin S, MacDonald EA, Meek D, Wood E, Lowry N, Buckley D, Yim C, Awuku M, Guimond C, Cooper P, Grand’Maison F, Baird JB, Bhan V, Bar-Or A*. Incidence of acquired demyelination of the CNS in Canadian children. Neurology, 72(3) :232-9, 20 Jan 2009
Cree BA, Reich DE, Khan O, De Jager PL, Nakashima I, Takahashi T, Bar-Or A, Tong C, Hauser SL, Oksenberg JR. Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. Arch Neurol, 66(2):226-33, Feb 2009
Goodman AD, Rossman H, Bar-Or A, Miller A, Miller DH, Schmierer K, Lublin F, Khan O, Bormann NM, Yang M, Panzara MA, Sandrock AW, GLANCE Investigators. GLANCE: results of a phase 2, randomized, double-blind, placebo-controlled study. Neurology, 72(9):806-12, 3 March 2009
Trojan DA, Arnold DL, Shapiro S, Bar-Or A, Robinson A, Le Cruguel JP, Narayanan S, Tartaglia MC, Caramanos Z, Da Costa D. Fatigue in post-poliomyelitis syndrome: association with disease-related, behavioral, and psychosocial factors. PMR, 1(5):442-9, May 2009
Pool M, Niino M, Rambaldi I, Robson K, Bar-Or A*, Fournier AE*. Myelin regulates immune cell adhesion and motility. Exp Neurol, 217(2):371-7, June 2009
Bar-Or A*, Oger J, Gibbs E, Niino M, Aziz T, Renoux C, Alatab S, Shi FD, Campagnolo D, Jalili F, Rhodes S, Yamashita T, Fan B, Freedman MS, Panitch H, Arnold DL, Vollmer T. Serial combination therapy: is immune modulation in multiple sclerosis enhanced by initial immune suppression? Mult Scler, 15(8):959-64, Aug 2009
McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol, 183(6):4067-76, 15. Sep 2009
2008
Banwell B, Tenembaum S, Lennon VA, Ursell E, Kennedy J, Bar-Or A, Weinshenker BG, Lucchinetti CF, Pittock SJ. Neuromyelitis optica-IgG in childhood inflammatory demyelinating CNS disorders. Neurology, 70(5):344-52, 2008
Pool M, Thiemann J, Bar-Or A, Fournier A. NeuriteTracer: A novel Image plugin for automated quantification of neurite outgrowth. J Neurosci Meth, 168(1):134-9, 2008
Banwell B, Bar-Or A*, Cheung R3, Kennedy J1, Becker DJ, Dosch HM*, on behalf of the Wadsworth Pediatric Multiple Sclerosis Study. Abnormal T cell reactivities to target-organ and environmental antigens in childhood multiple sclerosis and diabetes implicate both shared and distinct autoimmune disease mechanisms. Ann Neurol, 63(1):98-111, 2008
Hauser S, Waubant E, Arnold D, Vollmer T, Antel JP, Fox R, Bar-Or A, Sarkar N, Langer-Gould A, Panzara M, Smith C. B-cell depletion with Rituximab in relapsing-remitting multiple sclerosis. NEJM, 14; 358(7):676-88, 2008
Chen JT, Collins DL, Atkins HL, Freedman MS, Arnold DL; the Canadian MS/BMT Study Group. Magnetization transfer ratio evolution with demyelination and remyelination in multiple sclerosis lesions. Ann Neurol, 63(2):254-62, 2008
Ghassemi R, Antel SB, Narayanan S, Francis SJ, Bar-Or A, Sadovnick AD, Banwell B, Arnold DL; Canadian Pediatric Demyelinating Disease Study Group. Lesion distribution in children with clinically isolated syndromes. Ann Neurol, 63(3):401-5, March 2008
Schrijver HM, De Palma R, Sementa A, Chaudhuri A, Behan PO, Hauser SL, Waubant E, Bar-Or A; the HERMES Trial Group. Rituximab in Relapsing-Remitting Multiple Sclerosis. N Engl J Med, 12;358(24):2645-2647, 2008
Bar-Or A*, Calabresi P, Arnold D.L., Markowitz C, Shafer S, Kasper L, Waubant E, Gazda S, Fox R, Panzara M, Sarkar N, Agarwal S, Smith C. Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial. Ann Neurol, 63(3):395-400, 2008
Darlington PJ, Podjaski C, Horn KE, Costantino S, Blain M, Saikali P, Chen Z, Freedman M, Wiseman PW, Bar-Or A, Kennedy TE, Antel JP Innate immune-mediated Neuronal Injury Consequent to Loss of Astrocytes. JNEN, 67(6):590-9, 2008
Fordyce CB, Gagne D, Jalili F, Alatab S, Arnold DL, Da Costa D, Sawoszczuk S, Bodner C, Shapiro S, Collet J-P, Robinson A, Le Cruguel J-P, Lapierre Y, Bar-Or A*, Trojan DA*. Elevated Serum Inflammatory Markers in Post-Poliomyelitis Syndrome. J Neurol, 15;271(1-2):80-6, 2008
Vollmer T, Panitch H, Bar-Or A, Dunn J, Freedman MS, Gazda SK, Campagnolo D, Deutsch F, Arnold DL. Glatiramer acetate after induction therapy with mitoxantrone in relapsing multiple sclerosis. Mult Scler, 14(5):663-70, 2008
Vincent T, Saikali P, Cayrol R, Roth AD, Bar-Or A, Prat A, Antel JP. Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. J Immunol. 2008;181(8):5730-7
Mehling M, Brinkmann V, Antel J, Bar-Or A, Goebels N, Vedrine C, Kristofic C, Kuhle J, Lindberg RL, Kappos L. FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology, 71(16):1261-7, 2008
Arnold DL, Campagnolo D, Panitch H, Bar-Or A, Dunn J, Freedman MS, Gazda SK, Vollmer T. Glatiramer acetate after mitoxantrone induction improves MRI markers of lesion volume and permanent tissue injury in MS. J Neurol, 255(10):1473-8, 2008
Lambert C, Desbarats J, Arbour N, Hall JA, Olivier A, Bar-Or A, Antel JP. Dendritic cell differentiation signals induce anti-inflammatory properties in human adult microglia. J Immunol, 181(12):8288-97, 2008
2007
O’Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Tenembaum S, Wong SL, Rostasy K, Dale R, Freedman M, Steinman L, Hafler DA, Wucherpfennig KW. Self-Antigen Tetramers Discriminate between Myelin Autoantibodies to Native or Denatured Protein. Nat Med, 13(2):211-7, 2007
Nuttall RK, Silva K, Hader W, Bar-Or A, Patel K, Edwards DR, Yong VW. Metalloproteinases (MMPs and ADAMs) are enriched in microglia compared to leukocytes and they regulate cytokine levels in activated Microglia. Glia, 1; 55(5):516-26, 2007
Antel J, Bar-Or A, Gold R, Tabira T. 8th international congress of neuroimmunology. J Neuroimmunology, 185(1-2):6-8, 2007
Trojan D, Arnold D, Collet J-P, Shapiro S, Bar-Or A, Bernasconi A, Robinson A, Le Cruguel J-P, Ducruet T, Narayanan S, Arcelin K, Wong AM, Tartaglia MC, Lapierre Y, Caramanos Z, Da Costa D. Fatigue in Multiple sclerosis: Association with disease related, behavioral and psychosocial factors. Mult Scler, 13 (8):985-95, 2007
Duddy M, Niino M, Adatia F, Hebert S, Freedman M, Atkins H, Kim HJ, Bar-Or A*. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J Immunol, 15;178(10):6092-9, 2007
Banwell B*, Krupp L, Tellier R, Kennedy J, Tenembaum S, Ness J, Belman A, Boiko A, Bykova O, Waubant E, Mah J, Stoian C, Kremenchutzky M, Ruggieri M, Rensel M, Hahn J, Weinstock-Guttman B, Yeh A, Farrell K, Freedman M, Iivanainen M, Stephens D and Bar-Or A*. Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study. Lancet Neurol, 6(9):773-81, 2007
Bar-Or A*, Vollmer T*, Antel JP, Arnold D, Bodner C, Campagnolo D, Gianettoni J, Jalili F, Kachuck N, Lapierre Y, Niino M, Oger J, Price M, Rhodes S, Robinson WH, Shi FY, Utz PJ, Valone F, Weiner L, Steinman L and Garren H. Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase I/II trial. Arch Neurol, 64(10):1407-15, 2007
2006
Duszczyszyn DA, Beck JD, Antel JP, Bar-Or A, Lapierre Y, Gadag V, Haegert DG. Altered naive CD4 and CD8 T cell homeostasis in patients with relapsing-remitting multiple sclerosis: thymic versus peripheral (non-thymic) mechanisms. Clin Exp Immunol, 143 (2), 305-13, 2006
O’Connor P, Li D, Freedman MS, Bar-Or A, Rice GPA, Confavreux C, Paty DW, Stewart J, Scheyer R, on behalf of the Teriflunomide Multiple Sclerosis Trial Group and the University of BC MS/MRI Research group. A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology, 66; 894-900, 2006
Niino M, Bodner C, Simard ML, Alatab S, Gano D, Kim HJ, Trigueiro M, Racicot D, Guérette C, Antel JP, Fournier A, Grand’Maison F, Bar-Or A*. Natalizumab effects on Immune Responses in multiple sclerosis. Ann Neurol, 59(5):748-54, 2006
Stüve O, Marra CM, Bar-Or A, Niino M, Cravens PD, Cepok S, Frohman EM, Phillips JT, Arendt G, Jerome KR, Cook L, Grand'Maison F, Hemmer B, Monson NL, Racke MK. Altered CD4:CD8 T cells Ratios in Cerebrospinal spinal Fluid of Natalizumab-treated Patients with Multiple Sclerosis. Arch Neurol, 63(10):1383-7, Oct 2006
Kilpatrick LM, Harris RL, Owen KA, Bass R, Ghorayeb C, Bar-Or A*, Ellis V*. Initiation of plasminogen activation on the surface of monocytes expressing the type-II transmembrane serine protease matriptase. Blood, 15;108(8):2616-23, 2006
Bar-Or A* and Antel JP. Roles of immunoglobulins and B cells in multiple sclerosis: from pathogenesis to treatment. J Neuroimmunol, 180(1-2):3-8, Nov 2006
Shapiro AM, Jack CS, Lapierre Y, Arbour N, Bar-Or A, Antel JP. Potential for interferon Beta-induced serum antibodies in multiple sclerosis to inhibit endogenous interferon-regulated chemokine/cytokine responses within the central nervous system. Arch Neurol, 63(9):1296-9, Sept 2006
Chen JT, Collins DL, Atkins HL, Freedman MS, Galal A, Arnold DL. Canadian MS BMT Study Group. Brain atrophy after immunoablation and stem cell transplantation in multiple sclerosis. Neurology, 66(12):1935-7, 2006
Antony JM, Izad M, Bar-Or A, Warren K, Vodjgani M, Mallet F and Power C. Quantitative analysis of human endogenous retrovirus-W even in neuroinflammatory diseases. In process, AIDS Res Hum Retrovirus, 22(12):1253-9, 2006
2005
Guiliani F, Metz LM, Wilson T, Fan Y, Bar-Or A, Yong VW. Additive effect of the combination of glatiramer acetate and minocycline in a model of MS. J Neuroimmunol, 158(1-2):213-21, 2005
Magnus T, Schreiner B, Korn T, Jack C, Antel JP, Ifergan I, Chen L, Bar-Or A*, Wiendl H*. Microglial expression of the B7-family member B7homolog 1 confers strong immune inhibition: implications for immune response and autoimmunity in the CNS. J Neurosci, 25(10):2537-2546, 2005
Poppe A, Wardell L, Lowden D, Lapierre Y, Bar-Or A*. Hypothalamic involvement in Devic’s Neuromyelitis Optica. Multiple Sclerosis, 11(5); 617-621, 2005
Jack C, Ruffini F, Bar-Or A, Antel JP. Microglia and multiple sclerosis. J Neurosci, 81(3):363-73, 2005
Arbour A, Rastikerdar E, McCrea E, Lapierre Y, Dörr J, Bar-Or A, Antel JP. Upregulation of TRAIL expression on human T lymphocytes by Interferon and Glatiramer acetate. Multiple Sclerosis, 11(6):652-7, 2005
Chen JT, Collins DL, Freedman MS, Atkins H, Arnold DL, The Canadian MS/BMT Study Group. Local MTR signal inhomogeneity is related to subsequent change in MTR in lesions and normal-appearing white-matter of multiple sclerosis patients. Neuroimage, 25(4):1272-8, 2005
Wiendl H, Feger U, Mittelbronn M, Schreiner B, Stadelmann C, Antel JP, Brueck W, Meyermann R, Bar-Or A, Kieseier BC, Weller M. Expression of the non-classical major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity. Brain, 128(Pt 11):2689-704, 2005
2004
Duddy ME, Alter A, Bar-Or A*. Distinct profiles of human B cell effectors cytokines: A role in immune regulation? J Immunol, 172(6):3422-7, 2004
Kim HJ, Biernacki K, Prat A, Antel JP, Bar-Or A*. Effects of glatiramer acetate-reactive T cells from patients with multiple sclerosis on human Brain Endothelial Cells: Efficient migration without enhanced inflammation. Clin Immunol, 111:35-46, 2004
Kim HJ, Ifergan I, Antel JP, Seguin R, Duddy M, Lapierre Y, Jalili F, Bar-Or A*. Type-2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis. J Immunol, 172: 7144-7153, 2004
Prosser LA, Kuntz KM, Bar-Or A, Weinstein MC. Cost-Effectiveness of IFNβ 1a, IFNβ 1b, and Glatiramer Acetate in Non-Primary Progressive Multiple Sclerosis. Value in Health, 7(5):554-568, 2004
Hartung HP, Bar-Or A, Zoukos Y. What do we know about the mechanism of action of disease-modifying treatments in MS? J Neurol, 251 (Suppl 5), V12-29, 2004
2003
Oliveira EML*, Bar-Or A*, Waliszewska AI, Cai G, Anderson DE, Krieger JI, Hafler DA. CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. J Autoimmunity, 20:71-81, 2003
Seguin R, Biernacki K, Prat A,Wosik K, Kim H-J, Blain M, McCrea E, Bar-Or A, Antel JP. Differential effects of Th1/Th2 lymphocyte supernatants on human microglia. Glia, 42(1):36-45, 2003
O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. Myelin basic protein-reactive autoantibodies in the serum and CSF of multiple sclerosis patients are characterized by low-affinity interactions. J Neuroimmunol, 136(1-2):140-148, 2003
Alter A, Duddy M, Hebert S, Biernacki K, Prat A, Antel JP, Yong VW, Nuttall RK, Pennington CJ, Edwards DR, Bar-Or A*. Determinants of human B cell migration across brain endothelial cells. J Immunol, 170(9):4497-4505, 2003
Prosser LA, Kuntz KM, Bar-Or A, Weinstein MC. Patient and community preferences for treatments and health states in multiple sclerosis. Multiple Sclerosis, 9:311-319, 2003
Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid-beta protein in older humans and patients with Alzheimer disease. J Clin Invest, 112(3):415-422, 2003
Antel JP and Bar-Or A. Do myelin antibodies predict the diagnosis of multiple sclerosis? NEJM, 349(2):107-109, 2003
Bar-Or A*, Nuttall RK*, Duddy M, Alter A, Kim HJ, Ifergan I, Pennington CJ, Bourgoin P, Edwards DR,Yong VW. Analyses of all matrix metalloproteinase members in leukocytes: monocytes as major inflammatory mediators in Multiple Sclerosis. Brain, 126: 2738-2749, 2003
2002
Kim HJ, Antel JP, Duquette P, Alleva D, Conlon PJ, Bar-Or A*. Persistence of immune responses to altered and native myelin antigens in patients with Multiple Sclerosis treated with altered peptide ligand. J Immunol, 104(2):105, 2002
Prosser LA, Kuntz KM, Bar-Or A, Weinstein MC. The relationship between risk attitude and treatment choice in patients with relapsing-remitting MS. Med Dec Making, 22:506-513, 2002
2001
Bar-Or A*, Oliveira EML, Anderson DE, Krieger JI, Duddy M, O'Connor KC, Hafler DA. Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State. J Immunol, 167(10):5669-5677, 2001
2000
Anderson DE, Bieganowska K, Bar-Or A, Oliveira EML, Hafler DA. Paradoxical inhibition of T cell function in response to CTLA-4 blockade: heterogeneity within the human T cell repertoire. Nat Med, 6:211-214, 2000
Kipp B, Bar-Or A, Gausling G, Oliveira EM, Fruhan SA, Stuart DH, Hafler DA. A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis. Eur.J.Immunol, 30:2092-2100, 2000
1992
Williams K, Bar-Or A, Antel JP, Yong VW. Adult human microglia: biological characteristics compared with astrocytes & blood monocytes. J Neurop and Exp Neurol, 51(5):538-549, 1992
1991
Brown GM, Bar-Or A, Grossi D, Kashur S. Urinary 6-sulfatoxymelatonin, an index of pineal function in the rat. J Pineal Res, 10 (3):141-147, 1991
1989
Bar-Or A, Brown GM. Pineal involvement in diurnal rhythm of nociception in the rat. Life Sci, 44 (16):1067-1075, 1989
Lectures by Invitation
2018
Bar-Or A. Emerging Themes in the Neuroimmunology of Multiple Sclerosis. Neuroscience Symposium. Uniformed Services University Hospital. Bethesda MD, Jan 2018
Bar-Or A. B cells: Bedside to Bench and Back. Joint Neurology, Neurosurgery and Neuroscience Rounds. Temple University. Philadelphia, Jan 2018
Bar-Or A. Immune Monitoring Platforms: Functional Cell-based Assays. GJGFF and Immune Tolerance Network. Palos Verdes, CA, Feb 2018.
Bar-Or A. HSCT in MS: Reshaping the immune system and long term impact on disease activity. ACTRIMS 2018 Forum. San Diego, CA. February 2018.
Bar-Or A. Emerging Themes in Neuroimmunology of MS. Neurology Grand Rounds. Icahn School of Medicine at Mount Sinai. New York City, NY, Mar 2018.
Bar-Or A. Emerging Themes in Neuroimmunology of MS. Neuroscience Rounds. Beth Israel Hospital. New York City, NY, Mar 2018.
Bar-Or A. Translational Neuroimmunology in Multiple Sclerosis. Thomas Jefferson University Grand Rounds. Philadelphia, PA, May 2018.
Bar-Or A. Interim Analysis of the OBOE (Ocrelizumab Biomarker Outcome Evaluation) Study in Multiple Sclerosis (MS). AAN. Los Angeles, CA, April 2018.
Bar-Or A. VELOCE Vaccine Study – Results for Ocrelizumab in MS. AAN. Los Angeles, CA, April 2018
Bar-Or A. Evolving Themes in MS immune-pathophysiology and case discussion. Barzilay Medical Center, Ashkelon, Israel, May 2018
Bar-Or A. Neuroimmunology of MS. Hadassah University Medical Center Grand Rounds. Jerusalem, Israel. May 2018.
Bar-Or A. Emerging Roles of B cells in MS. Technion, Haifa, Israel, May 2018.
Bar-Or A. Treatment Considerations in MS. RAMBAM Hospital. Haifa, Israel. May 2018.
Bar-Or A. Emerging Themes in MS Neuroimmunology. Jefferson Grand Rounds, Philadelphia, May 2018
Bar-Or A. Precision Medicine in Neuroimmunology. Keynote Address, Inaugural CNS Precision Medicine Symposium, Wayne State University, Detroit, MI, May 2018.
Bar-Or A. Basic Neuroimmunology for Neurologists. Immunotherapy for Neurologic Disorders 2018 CME. Philadelphia, June 2018.
Bar-Or A. Immune Neural Interactions and CNS-compartmentalized Inflammation in MS. FOCIS 2018, San Francisco, June 2018.
Bar-Or A. What Children Can Teach Us About MS. ISNI 2018, Brisbane Australia, Aug 2018.
2017
Bar-Or A. Emerging concepts in MS pathogenesis. Weill Cornell Neurology Grand Rounds. New York, NY. Jan 2017
Bar-Or A. Multiple Sclerosis: Emerging Insights Across The Age-Span. Joint Grand Rounds, Department of Neurology, University of Pennsylvania, PA, Jan 2017
Bar-Or A. Emerging Themes in Multiple Sclerosis Neuroimmunology. Philadelphia Neurological Society. Philadelphia, PA. Feb 2017.
Bar-Or A. B Cell Cytokine Networks in Autoimmune Disease. Center for Childhood Cancer Seminar Series. CHOP; Philadelphia, PA. Feb 2017.
Bar-Or A. The compartmentalized immune response in MS. Annual Excemed conference in multiple sclerosis. Rome, Italy. Mar 2017
Bar-Or A. Neuroinflammation in Multiple Sclerosis. Biomarker challenges and opportunities. Biomarkers in Neuroinflammation Workshop. National Academy of Sciences, Washington DC, Mar 2017
Bar-Or A. Targeting Antibody-Independent B Cell Functions in Multiple Sclerosis. TrialNET annual meeting, Denver, CO, Mar 2017.
Bar-Or A. Emerging Themes in Neuroimmunology of MS. Neuroinflammatory Symposium. Children's Hospital of Pennsylvania, University of Pennsylvania, Philadelphia, PA, Apr 2017
Bar-Or A. Targeting B cell cytokine networks in T cell-mediated autoimmune disease. American Association of Immunology Major Symposium. AAI Annual Meeting. Washington, DC. May 2017
Bar-Or A. RRMS and SPMS Transition: Where are the limits? Annual Spanish Neurology Meeting. Madrid, Spain. Jun 2017
Bar-Or A. Progressive MS: Clinical and research perspectives. Annual Spanish Neurology Meeting. Madrid, Spain. Jun 2017
Bar-Or A. Charcot Lecture: Emerging Themes in Neuroimmunology of MS. Charcot Lecture, NIH. Bethesda, MD. Jun 2017
Bar-Or A. The few teaching us about the many: Lessons from special populations in MS. Neurology Grand Rounds, NIH. Bethesda, MD. Jun 2017
Bar-Or A. Is MS not a T-cell mediated disease? Keystone Symposium in Neuroinflammation. Keystone, CO. Jun 2017
Bar-Or A. MS neuroimmunology and B-eyond. Annual Argentinian Association of Neurology meeting. Buenos Aires, Argentina. Aug 2017
Bar-Or A. Emerging Themes in MS Pathogenesis. Annual Japanese Neuroimmunology Society Meeting. Sapporo and Tokyo, Japan. Oct. 2017
Bar-Or A. Mechanisms and Therapeutic Targets in Multiple Sclerosis. Autoimmunity Meeting. University of Toronto, ON. Oct 2017
Bar-Or A. Tanenbaum Keynote Speaker. Emerging Mechanisms in CNS Inflammatory Disease. University of Toronto, ON. Oct 2017
Bar-Or A. Interactions between B cells, T cells and Myeloid in MS, annual American Neurological Association (ANA) meeting, San Diego Oct 2017
Bar-Or A. B cell:T cell:Myeloid checkpoints. Annual ECTRIMS meeting, London, UK, Oct 2017
Bar-Or A. Emerging Themes in MS: B cells, T cells and Introduction to B Cell Therapies. Yale University, Nov 2017
Bar-Or A. B cell subsets and their roles in MS. At The Limits in Multiple Sclerosis. The Royal College of Physicians, London, UK, Nov 2017
Bar-Or A. The role of B cells in MS: From Hypothesis to Clinical Practice. The annual Israeli Neurological Association Meeting, Rosh Pina, Israel, Dec 2017
Bar-Or A. B cell Targeting in MS with ocrelizumab. Neurology Rounds, Sheba Medical Center, Tel Hashomer, Israel, Dec 2017.
Bar-Or A. Immune Mechanisms in Neuro Inflammatory Diseases. Fatigue Workshop: Challenges and Opportunities. UPenn, Dec 2017
2016
Bar-Or A. B Cells in MS: Roles Redefined, The Göttingen Lecture. Göttingen, Germany. February 2016
Bar-Or A. MS immune pathogenesis, ACTRIMS. New Orleans, LA. February 2016
Bar-Or A. Emerging immune modulators in MS, ACTRIMS. New Orleans, LA. February 2016
Bar-Or A. Current recommendations on vitamin D for people living with MS, MSSC Expert Panel Mtg. Toronto, ON. March 2016
Bar-Or A. Revisiting the roles of T cells and B cells in MS. EXCEMED Ann Conf. in MS. Berlin, Germany. Apr 2016
Bar-Or A. Targeting functionally distinct B Cell subsets in autoimmune disease. Canadian Society of Immunology Symposium. Ottawa, ON. Apr 2016
Bar-Or A. B cells in multiple sclerosis, CRNI. Bergamo, Italy. April 2016
Bar-Or A. B cell biology in multiple sclerosis, Int’l Congress on Autoimmunity. Leipzig, Germany. Apr 2016
Bar-Or A. Immune mechanisms in multiple sclerosis. Verily MS Innovation Workshop. Cambridge, MA. May 2016
Bar-Or A. Targeting B cells and T cells in MS; current and future treatment perspectives. CMSC Annual Mtg. National Harbour, MD. June 2016
Bar-Or A. GM-CSF expressing B cells in autoimmune disease. CSI-AAI Symposium. Seattle, WA. May 2016
Bar-Or A. Update on neuroimmunology of MS. Japan Tour – Sapporo/Tokyo/Sendai. July 2016
Bar-Or A. B cell contribution to peripheral inflammation. ISNI 14th Int’l Congress. Jerusalem, Israel. Sep 2016
Bar-Or A. B cells in pathogenesis of MS. ISNI 14th Int’l Congress. Jerusalem, Israel. Sep 2016
Bar-Or A. Evolving concepts in MS Biology and Therapeutics. T. Evans Wyckoff Lecture in Neuroscience at Virginia Mason Medical Center. Seattle, WA. Oct 2016
Bar-Or A. B cell roles Redefined. Benaroya Research Institute, Seattle, WA. Oct 2016
Bar-Or A. The role of B cells in CNS demyelinating disease. 9th PACTRIMS Congress. Bangkok, Thailand. Oct 2016
Bar-Or A. Immune suppression vs immune modulation: An immunologist’s perspective. 9th PACTRIMS Congress. Bangkok, Thailand. Oct 2016
Bar-Or A. From genes to cure. Inaugural MRCCT Symposium, Montreal, Nov 2016.
Bar-Or A. Interplay between inflammation and neurodegeneration in progressive MS. MSC endMS Conference. Toronto, ON. Dec 2016
Editorials, Reviews, Chapters
2011
Chitnis T, Bar-Or A. Pediatric MS: Biological presentation and research update. In: Demyelinating Disorders of the Central Nervous System in Childhood. Chabas D and Waubant EL, Eds. Cambridge Univ. Press, 2011
Waubant E and Bar-Or A. B cell based therapies for MS. In: Multiple Sclerosis Therapeutics. Cohen J and Rudick R, Eds. Cambridge University Press, 4 edition, 30 Nov 2011
Darlington P and Bar-Or A*. Immunology of MS. In: Multiple Sclerosis Therapeutics. Cohen J and Rudick R, Eds. Cambridge University Press; 4th Edition, Nov 30 2011
2008
Dubeau F, Andermann F, Wiendl H and Bar-Or A, Rasmussen’s encephalitis (chronic focal encephalitis). In: Epilepsy: A Comprehensive Textbook, Engel P and Pedley T, Eds. Lippincott Williams & Wilkins. 2nd edition. Vol 3: 2439-2454;2008
2006
Bar-Or A. Looking Ahead: The Future of Multiple Sclerosis. Advanced Studies in Medicine. Multiple Sclerosis update: John’s Hopkins Press, 2006
Bar-Or A. Human Immune studies in Multiple Sclerosis and Demyelinating Diseases. In: Advances in Neurology; Freedman M, Ed. Lippincott Williams & Wilkins, 98:91-109, 2006
2005
Bar-Or A. Immunology of Multiple Sclerosis. In: Multiple Sclerosis. Wolinsky J, Ed. Elsevier Press, Neurologic Clinics, 23(1):149-175, 2005
2004
Antel JP and Bar-Or A. Multiple Sclerosis: Therapy. In: Myelin Biology and Disorders. Lazzarini RA, Ed. Elsevier Press, pp. 791-806, 2004
2003
Antel JP and Bar-Or A. Multiple Sclerosis. In: Conn’s Current Therapy. 55th edition. Rakel RE and Bope ET, editors. W.B. Saunders Company. pp 997-1006, 2003
2002
Anderson DE, Bar-Or A, Hafler DA. Molecular pathology of multiple sclerosis. In: The Molecular Pathology of Autoimmune Diseases. 2nd Edition. Argyrios N. Theofilopoulos, Ed. Taylor and Francis Publishers, New York, NY. 2002
2001
Bar-Or A, O’Connor K and Hafler DA. Multiple Sclerosis. In: Samter’s Immunologic Diseases. 6th Ed. Austen, Frank, Atkinson and Cantor, Eds. Lippincott Williams and Wilkins. pp 711-737, 2001
Bar-Or A and Smith D. Epidemiology of Multiple Sclerosis. In: Textbook of Neuroepidemiology. Batchelor T, Cudcowicz M, editors. Butterworth Heinemann. 2001