Tricia Bhatti, MD

Tricia Bhatti, MD

Tricia Bhatti, MD, is an attending pathologist who works with the Congenital Hyperinsulinism Center and the Division of Anatomic Pathology at Children's Hospital of Philadelphia.

Areas of Expertise: Transplant immunopathology
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Medical College of Georgia, Augusta, GA

Residency

Pediatrics - The George Washington University Hospital, Washington, DC

Fellowship

Pediatric Pathology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Anatomic and Clinical Pathology
Pediatric Pathology

Titles and Academic Titles

Attending Pathologist

Assistant Professor of Clinical Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Congenital hyperinsulinism

Publications

Papers

2017

MacFarland SP, Mostoufi-Moab S, Zelley K, Mattei PA, States LJ, Bhatti TR, Duffy KA, Brodeur GM, Kalish JM: Management of adrenal masses in patients with Beckwith-Wiedemann syndrome. Pediatric Blood Cancer 2017.

2016

Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, Albeida SM, Hancock WW: Ubiquitin-specific protease-7 inhibition impairs Tip60-dependent Foxp3+ T-regulatory cell function and promotes anti-tumor immunity. EBioMedicine 13: 99-112, 2016.

Levine MH, Wang Z, Xiao H, Jiao J, Wang L, Bhatti TR, Hancock WW, Beier UH: Targeting Sirtuin-1 prolongs murine renal allograft survival and function. Kidney Int 89(5): 1016-26, May 2016 Notes: Epub 2016 Mar 16.

Bhatti TR, Ganapathy K, Huppmann AR, Conlin L, Boodhansingh KE, MacMullen C, Becker S, Ernst LM, Adzick NS, Ruchelli ED, Ganguly A, Stanley CA: Histologic and Molecular Profile of Pediatric Insulinomas: Evidence of a Paternal Parent-of-Origin Effect. J Clin Endocrinol Metab. Epub 2016 Jan 12, 101(3): 914-22, Mar 2016.

Gmuca S, Boos MD, Treece A, Narula S, Billinghurst L, Bhatti T, Laje P, Perman MJ, Vossough A, Harding B, Burnham J, Banwell B.: Degos disease mimicking primary vasculitis of the CNS. Neurol Neuroimmunol Neuroinflamm 3(2): e206, Feb 2016.

2015

Kakajiwala A, Bhatti T, Kaplan BS, Ruebner RL, Copelovitch L.: Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab? Clin Kidney J 9(1): 90-6, Feb 2016 Notes: Epub 2015 Nov 26.

Kalish JM, Boodhansingh KE, Bhatti TR, Ganguly A, Conlin LK, Becker SA, Givler S, Mighion L, Palladino AA, Adzick NS, De León DD, Stanley CA, Deardorff MA: Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith-Wiedemann syndrome. J Med Genet 53(1): 53-61, Jan 2016 Notes: Epub 2015 Nov 6.

Kakajiwala A, Meyers KE, Bhatti TR, Kaplan BS: Rapid progression to end-stage renal disease in a child with sporadic ACTN4 mutation. Clinical Kidney Journal Page: 1-7, 2015.

Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T, Greene MI, Hiebert SW, Hancock WW: FOXP3⁺ regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest 125(8): 1111-23, Aug 2015 Notes: Epub 2015 Aug 3.

Wang H, Guan Y, Kamamercan MA, Ye L, Bhatti T, Becker LB, Baur JA, Sims CA: Resveratrol rescues kidney mitochondrial function following hemorrhagic shock. Shock 44(2): 173-80, Aug 2015.

Mardekian SK, Fortuna D, Nix A, Bhatti T, Wiley CA, Flanders A, Urtecho J, Sloane J, Ahmad J, Curtis MT: Severe human parechovirus type 3 myocarditis and encephalitis in an adolescent with hypogammaglobulinemia. Int J Infect Dis 36: 6-8, Jul 2015 Notes: Epub 2015 May 11.

Liu YH, O'leary CE, Wang LS, Bhatti TR, Dai N, Kapoor V, Liu P, Mei, J, Guo L, Oliver PM, Albelda SM, Worthen GS: CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis. OncoImmunology 5(1): e1061175, July 2015.

Dekio F, Bhatti TR, Zhang S, Sullivan KO: Positive Impact of Fungal Histopathology on Immunocompromised Pediatric Patients With Histology-Proven Invasive Fungal Infection. Am J Clin Pathol 144(1): 61-7, Jul 2015.

Beier UH, Angelin A, Akomova T, Wang LQ, Liu Y, Xio H, Koike MA Hancock SA, Bhatti TR, Han R, Jiao J, Veasey, Sims CA, Baur JA, Wallace DC, Hancock WW: Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and induction of allograft tolerance. FASEB J 29(6): 2315-26, Jun 2015 Notes: Epub 2015 Feb 13.

Levine MH, Wang Z, Bhatti TR, Wang Y, Aufhauser DD, McNeal S, Liu Y, Cheraghlou S, Han R, Wang L, Hancock WW: Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation. Am J Transplant 15(4): 965-73, Apr 2015.

Levine M H, Wang Z, Bhatti T R, Wang Y, Aufhauser D D, McNeal S, Liu Y, Cheraghlou S, Han R, Wang L, Hancock W W: Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15(4): 965-73, Apr 2015.

Sgariglia F, Pedrini E, Bradfield JP, Bhatti TR, D'Adamo P, Dormans JP, Gunawardena AT, Hakonarson H, Hecht JT, Sangiorgi L, Pacifici M, Enomoto-Iwamoto M, Grant SF.: The Type 2 Diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented in Hereditary Multiple Exostoses: Insights into pathogenesis.  Bone 72: 123-127, Mar 2015.

Arva NC, Russo PA, Erlichman J, Hancock WW, Haber BA, Bhatti TR.: The inflammatory phenotype of the fibrous plate is distinct from the liver and correlates with clinical outcome in biliary atresia. Pathol Res Pract 211(3): 252-60, Mar 2015.

Abstracts

2016

Kristopher R. Bosse, MD; Pichai Raman; Robyn T. Sussman, PhD; Michael Randall; Dan Martinez; Zhongyu Zhu; Jo Lynne Harenza, PhD, Bruce Pawel, MD; Tricia Bhatti, MD; Javed Khan, MD; Dimiter S. Dimitrov, PhD ScD; Crystal Mackall, MD; and John M. Maris, MD: GPC2 is a putative oncogene and candidate immunotherapeutic target in high-risk neuroblastoma. Advances in Neuroblastoma Research Conference 2016.

Aufhauser DD Jr, Wang Z, Murken DR, Bhatti TR, Wang Y, Ge G, Redfield RR 3rd, Abt PL, Wang L, Svoronos N, Thomasson A, Reese PP, Hancock WW, Levine MH: Improved renal ischemia tolerance in females influences kidney transplantation outcomes. J Clin Invest April 2016.

Books

Suchi M, Bhatti TR, Ruchelli ED: Pancreatic histopathology of hyperinsulinism. Frontiers in Diabetes: Monogenic Hyperinsulinemic Hypoglycemia Disorders. Stanley CA, De Leon DD  (eds.). Basel, Karger, 21: 57-70,  2012.

Posters and Presentations

Lectures by Invitation

2016

Bhatti TR. Pathology of Genetic Syndromes of Childhood. Presented at: Thomas Jefferson University; 2016 Mar; Philadelphia, PA.

Bhatti TR. Pathology of Genetic Syndromes of Childhood. Presented at: Pennsylvania Hospital; 2016 Feb; Philadelphia, PA.

2015

Bhatti TR. Pathology of Genetic Syndromes of Childhood. Presented at: Hospital of the University of Pennsylvania; 2015 Dec; Philadelphia, PA.

Bhatti TR. Pediatric solid tumor pathology: Differential diagnosis of the small round cell tumors. Presented at: Thomas Jefferson University Hospital Department of Pathology; 2015 Sep; Philadelphia, PA.

Awards and Honors

2008, Society for Pediatric Pathology, Gordon L. Vawter Pathologist-In-Training Award
2002, Southern  Society  for  Pediatric  Research,  Clinical  Science  Young  Investigator Award Finalist
2002, Southern Society for Pediatric Research, Travel Award

Editorial and Academic Positions

Editorial Positions

Ad-hoc Reviewer

2015-present, Journal of Cutaneous Pathology
2012-present, Modern Pathology
2010-present, Pediatric Hematology and Oncology

Academic and Institutional Committees

2015-present, Member, Graduate Medical Education Committee, The Children's Hospital of Philadelphia
2015-present, Pediatric Pathology Fellowship, Co-Director, The Children's Hospital of Philadelphia
2015-present, Member, Department of Pathology and Laboratory Medicine faculty search committee  
2015-present, Member, Death Packet/Autopsy and EPIC, The Children's Hospital of Philadelphia

Leadership and Memberships

2006-present, Society for Pediatric Pathology (Member)
2003-present, United States and Canadian Academy of Pathology (Member)