Christopher P. Bonafide, MD, MSCE

male silhouette icon
Christopher P. Bonafide, MD, MSCE, is an Attending Physician at Children's Hospital of Philadelphia, caring for patients on the inpatient service.

Areas of Expertise: Optimizing clinical workflows, Patient safety
Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


Dr. Bonafide is an academic hospitalist in the Division of General Pediatrics, a core faculty member of the Center for Pediatric Clinical Effectiveness at CHOP, and an Assistant Professor of Pediatrics at the University of Pennsylvania. His research focuses on discovering the best methods to identify deteriorating patients in the hospital, and the best mechanisms for responding to those patients. Numerous barriers exist in the ability for physicians and  nurses to identify deteriorating patients, and one of these barriers is alarm fatigue from physiologic monitors.

Dr. Bonafide is focused on finding the best tools available for identifying deteriorating children in the hospital and establishing effective solutions to the problem of alarm fatigue in hospital units. Current projects include using video to gain insights into alarm fatigue from patient monitors, and using safety huddles to identify alarm “hot spots” and take immediate steps to reduce unnecessary alarms. Dr. Bonafide has made important contributions in the area of rapid response systems and physiologic monitor alarm fatigue, and has developed an international reputation as an expert in hospital patient safety research.

Education and Training

Medical School

MD - Pennsylvania State University College of Medicine, Hershey, PA


Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA (Chief Resident, 2007-2008)


Academic General Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Clinical Informatics – American Board of Pathology
Pediatrics – American Board of Pediatrics

Graduate Degree

MSCE in Clinical Epidemiology - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician, General Pediatric Inpatient Service

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Stollon NB, Weirich Paine C, Lucas MS, Brumley LD, Poole ES, Peyton T, Grant AW, Jan S, Trachtenberg S, Zander M, Bonafide CP, Schwartz LA. Transitioning adolescents and young adults with sickle cell disease from pediatric to adult healthcare: provider perspectives. Journal of Pediatric Hematology and Oncology in press 2015.

Bonafide CP, Lin R, Zander M, Sarkis Graham C, Paine CW, Rock W, Rich A, Roberts KE, Fortino M, Nadkarni VM, Localio AR, Keren R. Association between exposure to non-actionable physiologic monitor alarms and response time in a children's hospital. J Hosp Med. 2015 Jun;10(6):345-51.

Daymont C, Bonafide CP, Brady PW: Heart rates in hospitalized children by age and body temperature. Pediatrics. 2015 May;135(5):e1173-81.

Simpao AF, Ahumada LM, Desai BR, Bonafide CP, Gálvez JA, Rehman MA, Jawad AF, Palma KL, Shelov ED. Optimization of drug-drug interaction alert rules in a pediatric hospital's electronic health record system using a visual analytics dashboard. J Am Med Inform Assoc. 2015 Mar;22(2):361-9.


Paine CW, Stollon NB, Lucas MS, Brumley LD, Poole ES, Peyton T, Grant AW, Jan S, Trachtenberg S, Zander M, Mamula P, Bonafide CP, Schwartz LA. Barriers and facilitators to successful transition from pediatric to adult inflammatory bowel disease care from the perspectives of providers. Inflamm Bowel Dis. 2014 Nov;20(11):2083-91.

Bonafide CP, Localio AR, Song L, Roberts KE, Nadkarni VM, Priestley M, Paine CW, Zander M, Lutts M, Brady PW, Keren R. Cost-benefit analysis of a medical emergency team in a children's hospital. Pediatrics. 2014 Aug;134(2):235-41.

Bonafide CP, Zander M, Graham CS, Weirich Paine CM, Rock W, Rich A, Roberts KE, Fortino M, Nadkarni VM, Lin R, Keren R. Video methods for evaluating physiologic monitor alarms and alarm responses. Biomed Instrum Technol. 2014 May-Jun;48(3):220-30.

Gálvez JA, Ahumada L, Simpao AF, Lin EE, Bonafide CP, Choudhry D, England WR, Jawad AF, Friedman D, Sesok-Pizzini DA, Rehman MA. Visual analytical tool for evaluation of 10-year perioperative transfusion practice at a children's hospital. J Am Med Inform Assoc. 2014 May-Jun;21(3):529-34.

Roberts KE, Bonafide CP, Paine CW, Paciotti B, Tibbetts KM, Keren R, Barg FK, Holmes JH. Barriers to calling for urgent assistance despite a comprehensive pediatric rapid response system. Am J Crit Care. 2014 May;23(3):223-9.

Paciotti B, Roberts KE, Tibbetts KM, Paine CW, Keren R, Barg FK, Holmes JH, Bonafide CP. Physician attitudes toward family-activated medical emergency teams for hospitalized children. Jt Comm J Qual Patient Saf. 2014 Apr;40(4):187-92.

Bonafide CP, Localio AR, Roberts KE, Nadkarni VM, Weirich CM, Keren R: Impact of rapid response system implementation on critical deterioration events in children. JAMA Pediatr. 2014 Jan;168(1):25-33.


Huang EJ, Bonafide CP, Keren R, Nadkarni VM, Holmes JH. Medications associated with clinical deterioration in hospitalized children. J Hosp Med. 2013 May;8(5):254-60.

Bonafide CP, Roberts KE, Weirich CM, Paciotti B, Tibbetts KM, Keren R, Barg FK, Holmes JH. Beyond statistical prediction: qualitative evaluation of the mechanisms by which pediatric early warning scores impact patient safety. J Hosp Med. 2013 May;8(5):248-53.

Bonafide CP, Brady PW, Keren R, Conway PH, Marsolo K, Daymont C. Development of heart and respiratory rate percentile curves for hospitalized children. Pediatrics. 2013 Apr;131(4):e1150-7.

Bhalala US, Bonafide CP, Coletti CM, Rathmanner PE, Nadkarni VM, Berg RA, Witzke AK, Kasprzak MS, Zubrow MT. Correlations between first documented cardiac rhythms and preceding telemetry in patients with code blue events. J Hosp Med. 2013 Apr;8(4):225-8.

Editorial and Academic Positions

Editorial Positions

2015, Section Editor of Hospital Medicine for "Current Treatment Options in Pediatrics" Inaugural Issue, Jan. 2015

2014-present, Reviewer, Annals of the American Thoracic Society

2013-present, Reviewer, BMJ Quality and Safety

2013-present, Reviewer, Journal of the American Medical Informatics Association

2012-present, Reviewer, JAMA Pediatrics

2012-present, Reviewer, Hospital Pediatrics

2012-present, Reviewer, Paediatrics and Child Health

2011-present, Reviewer, Pediatrics

2011-present, Reviewer, Journal of Hospital Medicine

2010-present, Reviewer, Applied Clinical Informatics

2008-present, Reviewer, Pediatric Emergency Care

Academic and Institutional Committees

2015-present, Member, Scholarship Oversight Committee, Division of Cardiology, The Children's Hospital of Philadelphia (Fellow: S. Mohan)

2014-2015, Team Lead, Primary Care Provider Communication Quality Improvement Project, Division of General Pediatrics, The Children's Hospital of Philadelphia

2014-present, Member, Hospital Alarm Management Quality Improvement Program Committee

2014-present, Team Lead, Inpatient Maintenance IV Fluid Pathway Development Quality Improvement Team

2014-present, Member, Inpatient Sepsis Quality Improvement Committee

2013-present, Member, CHOP Pediatrics Residency Program Clinical Competency Committee

2010-present, Member, Center for Pediatric Clinical Effectiveness Scientific Review Committee

2007-present, Member, Resuscitation Committee

2007-present, Member, Clinical Decision Support Committee

2007-present, Member, Preventing Codes Outside the ICU Quality Improvement Committee