Kristopher Bosse, MD

Kristopher Bosse, MD

Kristopher Bosse, MD, is an attending physician in the Division of Oncology at The Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Pennsylvania School of Medicine, Philadelphia, PA

Internship

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

American Academy of Pediatrics

Titles and Academic Titles

Attending Physician

Instructor, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Functional genomics
Immunotherapeutic approaches to treating pediatric cancer
Neuroblastoma
Circulating tumor DNA (ctDNA)

Publications

Papers

2017

Bosse KR, Raman P, Zhu Z, Lane M, Martinez D, Heitzeneder S, Rathi KS, Kendsersky NM, Randall M, Donovan L, Morrissy S, Sussman RT, Zhelev DV, Feng Y, Wang Y, Hwang J, Lopez G, Harenza JL, Wei JS, Pawel B, Bhatti T, Santi M, Ganguly A, Khan J, Marra MA, Taylor MD, Dimitrov S, Mackall CL, Maris JM. Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Cancer Cell. 2017;32(3):295–309. [Epub ahead of print]

2015

Martino J, Fisher BT, Bosse KR, Bagatell R. Suspected posaconazole toxicity in a pediatric oncology patient. Pediatric Blood Cancer. 2015; 62 (9): 1682.

Sterling ME, Long CJ, Bosse KR, Bagatell R, Shukla AR. A rapid progression of disease after surgical excision of a malignant rhabdoid tumor of the bladder. Urology. 2015; 85 (3): 664-6.

2016

Bosse KR and Maris JM. Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations. Cancer. 2016; 122 (1): 20-33.

Feng Y, Wang Y, Zhu Z, Li W, Sussman RT, Randall M, Bosse KR, Maris JM, Dimitrov, DS. Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes. MAbs. 2016; 8 (4): 799-810.

2015

Martino J, Fisher BT, Bosse KR, Bagatell R. Suspected posaconazole toxicity in a pediatric oncology patient. Pediatric Blood Cancer. 2015; 62 (9): 1682.

Sterling ME, Long CJ, Bosse KR, Bagatell R, Shukla AR. A rapid progression of disease after surgical excision of a malignant rhabdoid tumor of the bladder. Urology. 2015; 85 (3): 664-6.

Schnepp RW, Bosse KR, Maris JM. Improving patient outcomes with cancer genomics: Unique opportunities and challenges in pediatric oncology. JAMA. 2015; 314 (9): 881-3.

2014

Diskin SJ, Capasso M, Diamond M, Oldridge D, Bosse KR, Iolascon A, Hakonarson H, Devoto M, Maris JM. Rare variants in TP53 confer susceptibility to neuroblastoma. The Journal of the National Cancer Institute. 2014; 106 (4).

Bosse KR, Shukla A, Pawel B, Chikwava KR, Santi M, Took L, Castagna K, Biegel J, Bagatell R. Malignant rhabdoid tumor of the bladder and ganglioglioma in a 14 year-old male with a germline 22q11.2 deletion. Cancer Genetics. 2014; 207 (9): 415-9.

Abstracts

2016

Bosse KR, Raman P, Sussman R, Randall M, Martinez D, Zhu Z, Harenza JL, Pawel B, Bhatti  T, Khan J, Dimitrov D, Mackall C, and Maris JM. GPC2 is a putative oncogene and candidate immunotherapeutic target in high-risk neuroblastoma, Presented at the Advances in Neuroblastoma Research Congress, June 2016.

Sussman RT, Randall MR, Huang K, Bosse K, Feng Y, Wang Y, Zhu Z, Dimitrov DS, and Maris JM. A CD56 (NCAM1) targeting antibody-drug conjugate is potently effective in preclinical models of high-risk neuroblastoma, Presented at the Advances in Neuroblastoma Research Congress, June 2016.

Bosse KR, Raman P, Sussman R, Randall M, Martinez D, Zhu Z, Pawel B, Bhatti T, Khan J, Dimitrov D, Mackall C, and Maris JM. GPC2 is a candidate immunotherapeutic target and putative oncogene in high-risk neuroblastoma and other pediatric cancers, Presented at the Children's Hospital of Philadelphia Research Poster Day, February 2016.

2015

Bosse KR, Raman P, Sussman R, Randall M, Martinez D, Zhu Z, Pawel B, Bhatti T, Khan J, Dimitrov D, Mackall C, and Maris JM. GPC2 is a candidate immunotherapeutic target and putative oncogene in high-risk neuroblastoma and other pediatric cancers, Presented at the AACR Advances in Pediatric Cancer Research Conference, November 2015.

Bosse KR, Raman P, Sussman R, Martinez D, Pawel B, and Maris JM. The Identification of  SLC10A4 and GPC2 as Putative Immunotherapeutic Targets in High Risk Neuroblastoma Using an Unbiased and Integrated Transcriptome, Genomics, and Functional Approach, Presented at the Children's Hospital of Philadelphia Research Poster Day, February 2015.

2014

Maris J, Wood A, Schnepp R, Russell M, Cole K, Oldridge D, Bosse K, Winter C, Rahman N, Capasso M, Hakonarson H, Le H, Devoto M, Diskin SJ. A Genome-Wide Association Study (GWAS) Identifies Susceptibility Alleles within Neuroblastoma Oncogenes and Tumor Suppressors: An Explanation for the Paucity of Somatic Mutations?, Presented at the Advances in Neuroblastoma Research Congress, May 2014.

Posters and Presentations

2016 

Bosse KR, Raman P, Sussman R, Randall M, Martinez D, Zhu Z, Pawel B, Bhatti T, Khan J, Dimitrov D, Mackall C, and Maris JM. GPC2 is a candidate immunotherapeutic target and putative oncogene in high-risk neuroblastoma and other pediatric cancers, Presented at the Children's Hospital of Philadelphia Research Poster Day, February 2016.

2015

Bosse KR, Raman P, Sussman R, Randall M, Martinez D, Zhu Z, Pawel B, Bhatti T, Khan J, Dimitrov D, Mackall C, and Maris JM. GPC2 is a candidate immunotherapeutic target and putative oncogene in high-risk neuroblastoma and other pediatric cancers, Presented at the AACR Advances in Pediatric Cancer Research Conference, November 2015.

Bosse KR, Raman P, Sussman R, Martinez D, Pawel B, and Maris JM. The Identification of SLC10A4 and GPC2 as Putative Immunotherapeutic Targets in High Risk Neuroblastoma Using an Unbiased and Integrated Transcriptome, Genomics, and Functional Approach, Presented at the Children's Hospital of Philadelphia Research Poster Day, February 2015.

Invited Lectures

2016

Bosse KR, Raman P, Sussman R, Randall M, Martinez D, Zhu Z, Harenza JL, Pawel B, Bhatti  T, Khan J, Dimitrov D, Mackall C, and Maris JM. GPC2 is a putative oncogene and candidate immunotherapeutic target in high-risk neuroblastoma, Presented at the Advances in Neuroblastoma Research Congress, June 2016.

Sussman RT, Randall MR, Huang K, Bosse K, Feng Y, Wang Y, Zhu Z, Dimitrov DS, and Maris JM. A CD56 (NCAM1) targeting antibody-drug conjugate is potently effective in preclinical models of high-risk neuroblastoma, Presented at the Advances in Neuroblastoma Research Congress, June 2016.

2015

Bosse KR, Raman P, Sussman R, Randall M, Martinez D, Zhu Z, Pawel B, Bhatti T, Khan J, Dimitrov D, Mackall C, and Maris JM. GPC2 is a candidate immunotherapeutic target and putative oncogene in high-risk neuroblastoma and other pediatric cancers, Presented at the AACR Advances in Pediatric Cancer Research Conference, November 2015.

2014

Maris J, Wood A, Schnepp R, Russell M, Cole K, Oldridge D, Bosse K, Winter C, Rahman N, Capasso M, Hakonarson H, Le H, Devoto M, Diskin SJ. A Genome-Wide Association Study (GWAS) Identifies Susceptibility Alleles within Neuroblastoma Oncogenes and Tumor Suppressors: An Explanation for the Paucity of Somatic Mutations?, Presented at the Advances in Neuroblastoma Research Congress, May 2014.

Awards and Honors

2016, Damon Runyon Physician-Scientist Training Award
2016, Alex’s Lemonade Stand Young Investigator Award
2016, Abramson Cancer Center’s Paul Calabresi Career Development Award for Clinical Oncology (K12)
2015, AACR/Aflac Scholar-in-Training Award
2015, Children’s Hospital of Philadelphia Research Day Poster Prize
2009, Children’s Hospital of Philadelphia Research Day Poster Prize
2009, NIDDK Short-Term Research Training Fellowship
2008, HHMI Medical Student Research Training Fellowship
2006-2010, Dr. Clinton Noyes and Alice F. Peters Medical Scholarship
2002, Phi Beta Kappa
2002, Merck Index Award
2001, Philip W. Meserve Prize in Chemistry
2001, Rick Scala Coach’s Award, Bowdoin College Rugby
2001, Pfizer Summer Undergraduate Research Fellowship
2001, Surdna Foundation Undergraduate Research Fellowship
2000, James Stacy Coles Research Fellowship in Chemistry
1999-2001, Sarah and James Bowdoin Book Award

Editorial and Academic Positions

Editorial Positions

Ad Hoc Reviewer

2016, Cancer Letters
2015-2016, Cancer Cell
2015, Current Genomics

Leadership and Memberships

Memberships in Professional Organizations

2014-present, American Association for Cancer Research
2013-present, American Society of Pediatric Hematology/Oncology
2013-present, American Society of Clinical Oncology