Post-Doctoral Fellow - Harvard Medical School/Brigham and Women's Hospital, Boston, MA
PhD in Medical Sciences - Katholieke Universiteit Leuven, Leuven, Belgium
MS in Engineering of Cell and Gene Biotechnology - Katholieke Universiteit Leuve, Leuven, Belgium
Investigator
Assistant Professor of Pediatrics (Oncology), Perelman School of Medicine at the University of Pennsylvania
Jacquelyn Dougherty,Kyra Harvey,Angela Liou,Katherine Labella,Deborah Moran,Stephanie Brosius,Thomas De Raedt: Identification of therapeutic sensitivities in a spheroid drug combination screen of Neurofibromatosis Type I associated High Grade Gliomas. Plos One 2023.
Shannon Coy, Shu Wang, Sylwia A. Stopka, Jia-Ren Lin, Clarence Yapp, Cecily C. Ritch, Lisa Salhi, Gregory J. Baker, Rumana Rashid, Gerard Baquer, Michael Regan, Prasidda Khadka, Kristina A. Cole, Jaeho Hwang, Patrick Y. Wen, Pratiti Bandopadhayay, Mariarita Santi, Thomas De Raedt, Keith L. Ligon, Nathalie Y.R. Agar, Peter K. Sorger, Mehdi Touat, Sandro Santagata: Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma. Nature Communications 2022.
Ijaz H, Koptyra M, Gaonkar KS, Rokita JL, Baubet VP, Tauhid L, Zhu Y, Brown M, Lopez G, Zhang B, Diskin SJ, Vaksman Z; Children's Brain Tumor Tissue Consortium, Mason JL, Appert E, Lilly J, Lulla R, De Raedt T, Heath AP, Felmeister A, Raman P, Nazarian J, Santi MR, Storm PB, Resnick A, Waanders AJ, Cole KA.: Pediatric high-grade glioma resources from the Children's Brain Tumor Tissue Consortium. Neuro-oncology 22(1): 163-165, January 2020.
Kim A, Lu Y, Okuno SH, Reinke D, Maertens O, Perentesis J, Basu M, Wolters PL, De Raedt T, Chawla S, Chugh R, Van Tine BA, O'Sullivan G, Chen A, Cichowski K, Widemann BC.: Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023). Sarcoma Page: doi: 10.1155, January 30 2020 Notes: ecollection.
Guerra SL, Maertens O, Kuzmickas R, De Raedt T, Adeyemi RO, Guild CJ, Guillemette S, Redig AJ, Chambers ES, Xu M, Tiv H, Santagata S, Jänne PA, Elledge SJ, Cichowski K.: A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers. Cancer Cell 37(5): 705-719, May 2020.
Yang Zhang, Christelle Guillermier, Thomas De Raedt, Andrew G Cox, Ophelia Maertens, Dean Yimlamai, Mingyue Lun, Adam Whitney, Richard L Maas, Wolfram Goessling, Karen Cichowski, Matthew L Steinhauser: Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity. iScience 23(8): 101355, July 2020.
Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K.: MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas. Cancer Discovery 9(4): 526-545, April 2019.
Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, De Raedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS.: Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Cancer Cell 33(6): 985-1003, June 2018.
Olsen Sarah Naomi, Wronski Ania, Castaño Zafira, Dake Benjamin, Malone Clare, De Raedt Thomas, Enos Miriam, DeRose Yoko S, Zhou Wenhui, Guerra Stephanie, Loda Massimo, Welm Alana, Partridge Ann H, McAllister Sandra S, Kuperwasser Charlotte, Cichowski Karen: Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers. Cancer discovery 7(2): 202-217, Feb 2017.
Maertens Ophélia, McCurrach Mila E, Braun Benjamin S, De Raedt Thomas, Epstein Inbal, Huang Tannie Q, Lauchle Jennifer O, Lee Hyerim, Wu Jianqiang, Cripe Timothy P, Clapp D Wade, Ratner Nancy, Shannon Kevin, Cichowski Karen: A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Cancer research 77(21): 5706-5711, Nov 2017.
Zhang Haikuo, Qi Jun, Reyes Jaime M, Li Lewyn, Rao Prakash K, Li Fugen, Lin Charles Y, Perry Jennifer A, Lawlor Matthew A, Federation Alexander, De Raedt Thomas, Li Yvonne Y, Liu Yan, Duarte Melissa A, Zhang Yanxi, Herter-Sprie Grit S, Kikuchi Eiki, Carretero Julian, Perou Charles M, Reibel Jacob B, Paulk Joshiawa, Bronson Roderick T, Watanabe Hideo, Brainson Christine Fillmore, Kim Carla F, Hammerman Peter S, Brown Myles, Cichowski Karen, Long Henry, Bradner James E, Wong Kwok-Kin: Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer. Cancer discovery 6(9): 1006-21, Sep 2016.
Luscan Armelle, Shackleford Ghjuvan'ghjacumu, Masliah-Planchon Julien, Laurendeau Ingrid, Ortonne Nicolas, Varin Jennifer, Lallemand François, Leroy Karen, Dumaine Valérie, Hivelin Mikael, Borderie Didier, De Raedt Thomas, Valeyrie-Allanore Laurence, Larousserie Frédérique, Terris Benoît, Lantieri Laurent, Vidaud Michel, Vidaud Dominique, Wolkenstein Pierre, Parfait Béatrice, Bièche Ivan, Massaad Charbel, Pasmant Eric: The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis. Clinical cancer research : an official journal of the American Association for Cancer Research 20(2): 358-71, Jan 2014.
Malone CF, Fromm JA, Maertens O, De Raedt T, Ingraham R, Cichowski K.: Defining key signaling nodes and therapeutic biomarkers in NF1-mutant Cancers. Cancer Discovery 4(9): 1062-73, Sep 2014.
De Raedt Thomas, Beert Eline, Pasmant Eric, Luscan Armelle, Brems Hilde, Ortonne Nicolas, Helin Kristian, Hornick Jason L, Mautner Victor, Kehrer-Sawatzki Hildegard, Clapp Wade, Bradner James, Vidaud Michel, Upadhyaya Meena, Legius Eric, Cichowski Karen: PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature 514(7521): 247-51, Oct 2014.
McLaughlin Sara Koenig, Olsen Sarah Naomi, Dake Benjamin, De Raedt Thomas, Lim Elgene, Bronson Roderick Terry, Beroukhim Rameen, Polyak Kornelia, Brown Myles, Kuperwasser Charlotte, Cichowski Karen: The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer cell 24(3): 365-78, Sep 2013.
De Raedt Thomas, Walton Zandra, Yecies Jessica L, Li Danan, Chen Yimei, Malone Clare F, Maertens Ophélia, Jeong Seung Min, Bronson Roderick T, Lebleu Valerie, Kalluri Raghu, Normant Emmanuel, Haigis Marcia C, Manning Brendan D, Wong Kwok-Kin, Macleod Kay F, Cichowski Karen: Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer cell 20(3): 400-13, Sep 2011.
Beert Eline, Brems Hilde, Daniëls Bruno, De Wever Ivo, Van Calenbergh Frank, Schoenaers Joseph, Debiec-Rychter Maria, Gevaert Olivier, De Raedt Thomas, Van Den Bruel Annick, de Ravel Thomy, Cichowski Karen, Kluwe Lan, Mautner Victor, Sciot Raf, Legius Eric: Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors. Genes, chromosomes & cancer 50(12): 1021-32, Dec 2011.
Min Junxia, Zaslavsky Alexander, Fedele Giuseppe, McLaughlin Sara K, Reczek Elizabeth E, De Raedt Thomas, Guney Isil, Strochlic David E, Macconaill Laura E, Beroukhim Rameen, Bronson Roderick T, Ryeom Sandra, Hahn William C, Loda Massimo, Cichowski Karen: An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nature medicine 16(3): 286-94, Mar 2010.
McGillicuddy Lauren T, Fromm Jody A, Hollstein Pablo E, Kubek Sara, Beroukhim Rameen, De Raedt Thomas, Johnson Bryan W, Williams Sybil M G, Nghiemphu Phioanh, Liau Linda M, Cloughesy Tim F, Mischel Paul S, Parret Annabel, Seiler Jeanette, Moldenhauer Gerd, Scheffzek Klaus, Stemmer-Rachamimov Anat O, Sawyers Charles L, Brennan Cameron, Messiaen Ludwine, Mellinghoff Ingo K, Cichowski Karen: Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer cell 16(1): 44-54, Jul 2009.
Steinmann Katharina, Kluwe Lan, Cooper David N, Brems Hilde, De Raedt Thomas, Legius Eric, Mautner Viktor-Felix, Kehrer-Sawatzki Hildegard: Copy number variations in the NF1 gene region are infrequent and do not predispose to recurrent type-1 deletions. European journal of human genetics : EJHG 16(5): 572-80, May 2008.
Chantrain Christophe F, Jijon Priscilla, De Raedt Thomas, Vermylen Christiane, Poirel Hélène A, Legius Eric, Brichard Bénédicte: Therapy-related acute myeloid leukemia in a child with Noonan syndrome and clonal duplication of the germline PTPN11 mutation. Pediatric blood & cancer 48(1): 101-4, Jan 2007.
Maertens Ophélia, Prenen Hans, Debiec-Rychter Maria, Wozniak Agnieszka, Sciot Raf, Pauwels Patrick, De Wever Ivo, Vermeesch Joris R, de Raedt Thomas, De Paepe Anne, Speleman Frank, van Oosterom Allan, Messiaen Ludwine, Legius Eric: Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients. Human molecular genetics 15(6): 1015-23, Mar 2006.
Wimmer K, Yao S, Claes K, Kehrer-Sawatzki H, Tinschert S, De Raedt T, Legius E, Callens T, Beiglböck H, Maertens O, Messiaen L: Spectrum of single- and multiexon NF1 copy number changes in a cohort of 1,100 unselected NF1 patients. Genes, chromosomes & cancer 45(3): 265-76, Mar 2006.
De Raedt Thomas, Maertens Ophélia, Chmara Magdalena, Brems Hilde, Heyns Ine, Sciot Raf, Majounie Elisa, Upadhyaya Meena, De Schepper Sofie, Speleman Frank, Messiaen Ludwine, Vermeesch Joris Robert, Legius Eric: Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. Genes, chromosomes & cancer 45(10): 893-904, Oct 2006.
Maertens Ophélia, Brems Hilde, Vandesompele Jo, De Raedt Thomas, Heyns Ine, Rosenbaum Thorsten, De Schepper Sofie, De Paepe Anne, Mortier Geert, Janssens Sandra, Speleman Frank, Legius Eric, Messiaen Ludwine: Comprehensive NF1 screening on cultured Schwann cells from neurofibromas. Human mutation 27(10): 1030-40, Oct 2006.
De Raedt,T; Stephens, M; Heyns, I; Brems,H; Thijs,D; Messiaen, L; Stephens, K; Lazaro, C., Wimmer, K; Kehrer, Sawatzki, H; Vidaud, D; Kluwe, L; Marynen, P; Legius, E.: Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion. Nat. Genet. 38(12): 1419-23, Dec 2006.
de Raedt Thomas, Cools Jan, Debiec-Rychter Maria, Brems Hilde, Mentens Nicole, Sciot Raf, Himpens Jacques, de Wever Ivo, Schöffski Patrick, Marynen Peter, Legius Eric: Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA. Gastroenterology 131(6): 1907-12, Dec 2006.
De Raedt Thomas, Brems Hilde, Lopez-Correa Catalina, Vermeesch Joris Robert, Marynen Peter, Legius Eric: Genomic organization and evolution of the NF1 microdeletion region. Genomics 84(2): 346-60, Aug 2004.
Descheemaeker M J, Roelandts K, De Raedt T, Brems H, Fryns J P, Legius E: Intelligence in individuals with a neurofibromatosis type 1 microdeletion. American journal of medical genetics. Part A 131(3): 325-6, Dec 2004.
De Raedt T, Brems H, Wolkenstein P, Vidaud D, Pilotti S, Perrone F, Mautner V, Frahm S, Sciot R, Legius E: Elevated risk for MPNST in NF1 microdeletion patients. American journal of human genetics 72(5): 1288-92, May 2003.
Brems H, Vogels A, Ribai P, De Raedt T, Fryns J P, Legius E: Second polar body inclusion results in diploid/triploid mixoploidy. Genetic counseling (Geneva, Switzerland) 14(4): 425-9, 2003.
De Raedt T. Interneurons that BiTE, a Cellular therapy for NF1 High Grade Glioma, CTF conference, Scottsdale AZ. June 2023.
De Raedt T. cBioPortal User Case, CTF conference, Philadelphia, USA. June 2022.
2011, Excellence in Teaching Award, Harvard University
2010-2012, Young Investigator Award, Children's Tumor Foundation
2007-2008, Scholarship, Belgian American Educational Foundation
2004-2005, Scholarship, Flemish League against Cancer
2000-2005, IWT (Institute for Innovation by Science and Technology), doctoral student scholarship (administered by the Flemish Government)
2000, Magna Cum Laude, Katholieke Universiteit Leuve
2019-present, Reviewer, Scientific Reports
2019-present, Reviewer, JCO Precision Oncology
2019-present, Reviewer, Journal of Molecular Biology
2018-present, Neurofibromatosis (NF) Research Initiative
2016-present, Childrens Tumor Foundation
2019-present, Society of Neuro-Oncology
2018-present, Neurofibromatosis Clinical Trials Consortium
- 2020-present, Chair, Biology Committee
2018-present, American Association for Cancer Research