Thomas DeRaedt, PhD

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Thomas DeRaedt, PhD, is an investigator with the Center for Childhood Cancer Research at Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

PhD in Medical Sciences - Katholieke Universiteit Leuven, Leuven, Belgium

Fellowship

Post-Doctoral Fellow - Harvard Medical School/Brigham and Women's Hospital, Boston, MA

Graduate Degree

MS in Engineering of Cell and Gene Biotechnology - Katholieke Universiteit Leuve, Leuven, Belgium

Titles and Academic Titles

Investigator

Publications

Papers

2017

Olsen Sarah Naomi, Wronski Ania, Castaño Zafira, Dake Benjamin, Malone Clare, De Raedt Thomas, Enos Miriam, DeRose Yoko S, Zhou Wenhui, Guerra Stephanie, Loda Massimo, Welm Alana, Partridge Ann H, McAllister Sandra S, Kuperwasser Charlotte, Cichowski Karen: Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers. Cancer discovery 7(2): 202-217, Feb 2017.

2016

Zhang Haikuo, Qi Jun, Reyes Jaime M, Li Lewyn, Rao Prakash K, Li Fugen, Lin Charles Y, Perry Jennifer A, Lawlor Matthew A, Federation Alexander, De Raedt Thomas, Li Yvonne Y, Liu Yan, Duarte Melissa A, Zhang Yanxi, Herter-Sprie Grit S, Kikuchi Eiki, Carretero Julian, Perou Charles M, Reibel Jacob B, Paulk Joshiawa, Bronson Roderick T, Watanabe Hideo, Brainson Christine Fillmore, Kim Carla F, Hammerman Peter S, Brown Myles, Cichowski Karen, Long Henry, Bradner James E, Wong Kwok-Kin: Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer. Cancer discovery 6(9): 1006-21, Sep 2016.

2014

De Raedt Thomas, Beert Eline, Pasmant Eric, Luscan Armelle, Brems Hilde, Ortonne Nicolas, Helin Kristian, Hornick Jason L, Mautner Victor, Kehrer-Sawatzki Hildegard, Clapp Wade, Bradner James, Vidaud Michel, Upadhyaya Meena, Legius Eric, Cichowski Karen: PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature 514(7521): 247-51, Oct 2014.

Malone CF, Fromm JA, Maertens O, De Raedt T, Ingraham R, Cichowski K.: Defining key signaling nodes and therapeutic biomarkers in NF1-mutant Cancers. Cancer Discovery 4(9): 1062-73, Sep 2014.

Luscan Armelle, Shackleford Ghjuvan'ghjacumu, Masliah-Planchon Julien, Laurendeau Ingrid, Ortonne Nicolas, Varin Jennifer, Lallemand François, Leroy Karen, Dumaine Valérie, Hivelin Mikael, Borderie Didier, De Raedt Thomas, Valeyrie-Allanore Laurence, Larousserie Frédérique, Terris Benoît, Lantieri Laurent, Vidaud Michel, Vidaud Dominique, Wolkenstein Pierre, Parfait Béatrice, Bièche Ivan, Massaad Charbel, Pasmant Eric: The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis. Clinical cancer research : an official journal of the American Association for Cancer Research 20(2): 358-71, Jan 2014.

2013

McLaughlin Sara Koenig, Olsen Sarah Naomi, Dake Benjamin, De Raedt Thomas, Lim Elgene, Bronson Roderick Terry, Beroukhim Rameen, Polyak Kornelia, Brown Myles, Kuperwasser Charlotte, Cichowski Karen: The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer cell 24(3): 365-78, Sep 2013.

2011

Beert Eline, Brems Hilde, Daniëls Bruno, De Wever Ivo, Van Calenbergh Frank, Schoenaers Joseph, Debiec-Rychter Maria, Gevaert Olivier, De Raedt Thomas, Van Den Bruel Annick, de Ravel Thomy, Cichowski Karen, Kluwe Lan, Mautner Victor, Sciot Raf, Legius Eric: Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors. Genes, chromosomes & cancer 50(12): 1021-32, Dec 2011.

De Raedt Thomas, Walton Zandra, Yecies Jessica L, Li Danan, Chen Yimei, Malone Clare F, Maertens Ophélia, Jeong Seung Min, Bronson Roderick T, Lebleu Valerie, Kalluri Raghu, Normant Emmanuel, Haigis Marcia C, Manning Brendan D, Wong Kwok-Kin, Macleod Kay F, Cichowski Karen: Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer cell 20(3): 400-13, Sep 2011.

2010

Min Junxia, Zaslavsky Alexander, Fedele Giuseppe, McLaughlin Sara K, Reczek Elizabeth E, De Raedt Thomas, Guney Isil, Strochlic David E, Macconaill Laura E, Beroukhim Rameen, Bronson Roderick T, Ryeom Sandra, Hahn William C, Loda Massimo, Cichowski Karen: An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nature medicine 16(3): 286-94, Mar 2010.

2009

McGillicuddy Lauren T, Fromm Jody A, Hollstein Pablo E, Kubek Sara, Beroukhim Rameen, De Raedt Thomas, Johnson Bryan W, Williams Sybil M G, Nghiemphu Phioanh, Liau Linda M, Cloughesy Tim F, Mischel Paul S, Parret Annabel, Seiler Jeanette, Moldenhauer Gerd, Scheffzek Klaus, Stemmer-Rachamimov Anat O, Sawyers Charles L, Brennan Cameron, Messiaen Ludwine, Mellinghoff Ingo K, Cichowski Karen: Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer cell 16(1): 44-54, Jul 2009.

2008

Steinmann Katharina, Kluwe Lan, Cooper David N, Brems Hilde, De Raedt Thomas, Legius Eric, Mautner Viktor-Felix, Kehrer-Sawatzki Hildegard: Copy number variations in the NF1 gene region are infrequent and do not predispose to recurrent type-1 deletions. European journal of human genetics : EJHG 16(5): 572-80, May 2008.

2006

Maertens Ophélia, Brems Hilde, Vandesompele Jo, De Raedt Thomas, Heyns Ine, Rosenbaum Thorsten, De Schepper Sofie, De Paepe Anne, Mortier Geert, Janssens Sandra, Speleman Frank, Legius Eric, Messiaen Ludwine: Comprehensive NF1 screening on cultured Schwann cells from neurofibromas. Human mutation 27(10): 1030-40, Oct 2006.

De Raedt Thomas, Maertens Ophélia, Chmara Magdalena, Brems Hilde, Heyns Ine, Sciot Raf, Majounie Elisa, Upadhyaya Meena, De Schepper Sofie, Speleman Frank, Messiaen Ludwine, Vermeesch Joris Robert, Legius Eric: Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. Genes, chromosomes & cancer 45(10): 893-904, Oct 2006.

Maertens Ophélia, Prenen Hans, Debiec-Rychter Maria, Wozniak Agnieszka, Sciot Raf, Pauwels Patrick, De Wever Ivo, Vermeesch Joris R, de Raedt Thomas, De Paepe Anne, Speleman Frank, van Oosterom Allan, Messiaen Ludwine, Legius Eric: Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients. Human molecular genetics 15(6): 1015-23, Mar 2006.

2004

De Raedt Thomas, Brems Hilde, Lopez-Correa Catalina, Vermeesch Joris Robert, Marynen Peter, Legius Eric: Genomic organization and evolution of the NF1 microdeletion region. Genomics 84(2): 346-60, Aug 2004.

2003

Brems H, Vogels A, Ribai P, De Raedt T, Fryns J P, Legius E: Second polar body inclusion results in diploid/triploid mixoploidy. Genetic counseling (Geneva, Switzerland) 14(4): 425-9, 2003.

De Raedt T, Brems H, Wolkenstein P, Vidaud D, Pilotti S, Perrone F, Mautner V, Frahm S, Sciot R, Legius E: Elevated risk for MPNST in NF1 microdeletion patients. American journal of human genetics 72(5): 1288-92, May 2003.

Posters and Presentations

Invited Lectures

2017

De Raedt T. "Mechanisms and Therapies for Ras Driven Cancers", Cancer Center Seminar Series, University of California, San Francisco, San Francisco, CA. Jan, 2017.

2016

De Raedt T. "PRC2 loss amplifies Ras driven transcription and confers sensitivity to BRD4-based therapies", 5th Cancer Epigenetics Conference, Global Technology Community, San Francisco, CA. Nov, 2016.

De Raedt T. "The use of New Mouse Models for preclinical development", Children's Tumor Foundation Annual Meeting, Austin, TX. Jun, 2016.

Awards and Honors

2011, Excellence in Teaching award, Harvard University

2010-2012, Young Investigator Award, Children's Tumor Foundation

2007-2008, Scholarship from the BAEF (Belgian American Educational Foundation that awards scholarship to those who want to conduct research/education in the US)

2004-2005, Scholarship from the Flemish League against Cancer (Belgian non-profit that awards scholarships for cancer research)

2000-2005, IWT (Institute for Innovation by Science and Technology), doctoral student scholarship (administered by the Flemish Government)

2000, Magna Cum Laude, Katholieke Universiteit Leuve, Leuven, Belgium