Caroline Diorio, MD, MSTR, FRCPC, FAAP
Locations: Main Building
About Caroline Diorio, MD, MSTR, FRCPC, FAAP
Titles
Attending Physician
Assistant Professor, Perelman School of Medicine at the University of Pennsylvania
Certifications
Fellow – Royal College of Surgeons of Canada
Pediatrics – American Board of Pediatrics
Pediatric Hematology-Oncology – American Board of Pediatrics
Awards and Honors
2022, Stat Wunderkind, Awarded for innovative early-career research
2020, Gail Slap Department of Pediatrics Fellowship Award
2019, ITMAT Scholarship, University of Pennsylvania
2014, Dr. Carl Witus (3T6) Memorial Prize in Pediatrics , University of Toronto
2013, Class of Medicine 1924 War Service Scholarship, University of Toronto
2012-2013, Dr. Frederick James Colling OBE Memorial Scholarship, University of Toronto
2012, Thomas R. Turrall Memorial Scholarship, University of Toronto
2011-2012, CREMS Scholar, University of Toronto
2008-2010, Millennium Excellence Award Laureate, Wilfrid Laurier University
2006-2010, Dean’s Honour Roll, Wilfrid Laurier University
2009, F. W. Minkler Scholarship, Wilfrid Laurier University
2006, Lieutenant-Governor’s Community Volunteer Award
Leadership and Memberships
2020-present, American Society of Hematology (ASH)
2019-present, American Society of Pediatric Hematology Oncology (ASPHO)
2018-present, Children’s Oncology Group (COG)
2017-present, International Society of Pediatric Oncology (SIOP)
2010-present, Ontario Medical Association
2010-present, Canadian Medical Association
Education & training
Undergraduate Degree
Honors BSc in Biology and Psychology - Wilfrid Laurier University, Waterloo, Ontario
Graduate Degree
MS in Translational Research - University of Pennsylvania, Philadelphia, PA
Medical Degree
MD - University of Toronto, Toronto, Ontario
Residency
Pediatrics - McMaster University, Hamilton, Ontario
Fellowship
Hematology/Oncology - Children’s Hospital of Philadelphia, Philadelphia, PA
Clinical Practice Guideline - Pediatric Oncology Group of Ontario and Sick Kids Hospital, Toronto, Ontario
Publications
Publications
2025
McGuire JL, Pinto SN, Erdogan E, Li Y, Bhatia A, Vossough A, Wright J, Oztek MA, Ishak G, Shah R, Carapia NT, Shams N, Westermann C, Taraseviciute A, Naik S, Yates B, Gardner R, Annesley C, Hsieh E, Diorio C, Myers M, Epperly R, Talleur A, Shalabi H, Shah N, Gust J. Neuroimaging findings in pediatric CAR T cell therapy. Accepted to Neurology June 2025.
Newman H, Lee SHR, Pölönen P, Shraim R, Li Y, Liu H, Aplenc R, Bandyopadhyay S, Chen C, Devidas M, Diorio C, Dunsmore K, Elghawy O, Elhachimi A, Fuller T, Gupta S, Hall J, Hughes AD, Hunger SP, Loh ML, Martinez Z, McCoy MF, Mullen CG, Pounds SB, Raetz E, Seffernick AE, Shi G, Sussman J, Tan K, Uppuluri L, Vincent TL, Wang'ondu R, Winestone LE, Winter SS, Wood BL, Wu G, Xu J, Yang W, Mullighan CG, Yang JJ, Bona K, Teachey DT. Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia. Blood Cancer Discov. 2025 May 28. Epub ahead of print. PMID: 40434808.
Shraim R, Diorio C, Canna SW, Macdonald-Dunlop E, Bassiri H, Martinez Z, Mälarstig A, Abbaspour A, Teachey DT, Lindell RB, Behrens EM. A Method for Comparing Proteins Measured in Serum and Plasma by Olink® Proximity Extension Assay. Mol Cell Proteomics. 2025 May 27:101000. Epub ahead of print. PMID: 40441439.
Frank-Kamenetskii AM, Klinghoffer H, Varghese JA, Dang V, Morrissette J, Fraietta JA, Diorio C, Burkhardt JK, Canna S. Modeling the HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death. Blood. 2025 May 13:blood.2024027179. Epub ahead of print. PMID: 40359482.
Myers RM*, DiNofia AM*, Li Y, Diorio C, Liu H, Wertheim G, Fraietta JA, Gonzalez VE, Plesa G, Siegel DL, Iannone E, Shinehous L, Brodon JL, Taylor C, Jadlowsky JK, Hexner EO, Engels B, Baniewicz D, Callahan C, Ruella M, Aplenc R, Leahy AB, McClory SE, Rheingold SR, Wray L, June C, Maude SL, Frey NV, Grupp SA. CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy. J Immunother Cancer. 2025 Apr 17;13(4):e011549PMID: 40246579.
Xu J, Sussman JH, Yang A, Yoshimura S, Hu J, Chen C, Vincent TL, Bandyopadhyay S, Li EY, Lim TL, Elghawy O, Barsouk A, Karanfilovski D, Wald SL, Chen GM, Wu DW, Newman H, Li A, Chen CH, Bernt KM, Wood BL, Winter SS, Dunsmore KP, Raetz EA, Devidas M, Pounds SB, Loh ML, Hunger SP, Chiang M, Diorio C, Giacomo DD, Pölönen P, Mullighan CG, Yang JJ, Tan K, Sun Y, Teachey DT. STAT1-driven interferon signatures are associated with JAK inhibitor sensitivity in T-ALL. Blood. Epub ahead of print. PMID: 40101143.
Chen C, Xu J, Sussman J, Vincent T, Tumulty J, Yoshimura S, Alikarami F, Yu W, Ding Y, Chen C, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng JJ, Pölönen P, Newman H, Wood B, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang J, Bernt KM, Teachey DT, TanK (2025). Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood. Epub ahead of print. PMID: 40089994.
2024
Xu J, Chen C, Sussman JH, Yoshimura S, Vincent T, Pölönen P, Hu J, Bandyopadhyay S, Elghawy O, Yu W, Tumulty J, Chen CH, Li EY, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen GM, Wu DW, Ding YY, Xu JA, Karanfilovski D, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh ML, Raetz EA, Chen Z, Wood BL, Devidas M, Dunsmore KP, Winter SS, Chang TC, Wu G, Pounds SB, Zhang NR, Carroll W, Hunger SP, Bernt K, Yang JJ, Mullighan CG, Tan K, Teachey DT. A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia. Nat Cancer. 2024 Nov 25. doi: 10.1038/s43018-024-00863-5. Epub ahead of print. PMID: 39587259.
Diorio C, Teachey DT, Grupp SA. Allogeneic chimeric antigen receptor cell therapies for cancer: progress made and remaining roadblocks. Nat Rev Clin Oncol. 2024 Nov 15. doi: 10.1038/s41571-024-00959-y. Epub ahead of print. PMID: 39548270.
Diorio C*, Hernandez-Miyares L*, Espinoza DA, Banwell BL, Bar-Or A, DiNofia AM, Barz Leahy A, Martinez Z, Myers RM, Hopkins SE, Rheingold SR, Teachey DT, Viaene AN, Wray LM, Maude SL, Grupp SA, McGuire JL. Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents. Blood. 2024 Sep 26;144(13):1387-1398. PMID: 38905637.
Bai Z, Feng B, McClory SE, de Oliveira BC, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara PG, Chen S, Tang L, June CH, Melenhorst JJ, Grupp SA, Fan R. Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission. Nature. 2024 Sep 25. PMID: 39322664.
Gallo PM, Kim J, McNerney KO, Diorio C, Foley C, Kagami L, Wagner K, Petrosa WL, Conlon H, Gollomp KL, Canna SW, Seif AE, Conrad MA, Kelsen JR, Romberg N, Bassiri H, Sullivan KE, Teachey DT, Paessler ME, Behrens EM, Lambert MP. Serum Cytokine Panels in Pediatric Clinical Practice. J Allergy Clin Immunol. 2024 Sep 18:S0091-6749(24)00977-1. PMID: 39303891.
Carol HA, Mayer AS, Zhang MS, Dang V, Varghese J, Martinez Z, Schneider C, Baker JE, Tsoukas P, Behrens EM, Cron RQ, Diorio C, Henderson LA, Schulert G, Lee P, Kernan KF, Canna SW. Hyperferritinemia Screening to Aid Identification and Differentiation of Patients with Hyperinflammatory Disorders. J Clin Immunol. 2024 Sep 12;45(1):4. PMID: 39264477.
Perna F, Parekh S, Diorio C, Smith M, Subklewe M, Mehta R, Locke FL, Shah NN. CAR T-cell toxicities: from bedside to bench, how novel toxicities inform laboratory investigations. Blood Adv. 2024 Aug 27;8(16):4348-4358. PMID: 38861351;
Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, Kimura S, Benini F, Montefiori LE, Wood BL, Xu J, Chen C, Cheng Z, Newman H, Myers J, Iacobucci I, Li E, Sussman J, Hedges D, Hui Y, Diorio C, Uppuluri L, Frank D, Fan Y, Chang Y, Meshinchi S, Ries R, Shraim R, Li A, Bernt KM, Devidas M, Winter SS, Dunsmore KP, Inaba H, Carroll WL, Ramirez NC, Phillips AH, Kriwacki RW, Yang JJ, Vincent TL, Zhao Y, Ghate PS, Wang J, Reilly C, Zhou X, Sanders MA, Takita J, Kato M, Takasugi N, Chang BH, Press RD, Loh M, Rampersaud E, Raetz E, Hunger SP, Tan K, Chang TC, Wu G, Pounds SB, Mullighan CG, Teachey DT. The genomic basis of childhood T-lineage acute lymphoblastic leukaemia. Nature. 2024 Aug;632(8027):1082-1091. Epub 2024 Aug 14. PMID: 39143224.
Hughes AD, Teachey DT, Diorio C. Riding the storm: managing cytokine-related toxicities in CAR-T cell therapy. Semin Immunopathol. 2024 Jul 16;46(3-4):5. PMID: 39012374;
Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Martinez Z, Diorio C, Chen C, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K. Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging. Cell. 2024 May 2:S0092-8674(24)00408-2. PMID: 38714197.
Dain AS, Diorio C, Fisher BT, Hankins JS, Witmer CM, Boustany M, Burton M, Ferrolino J, Sadaf S, Ross HS, Maron G, for the Pediatric COVID-19 US Registry. Description of a National, Multi-Center Cohort of Patients with Sickle Cell Disease and SARS-CoV-2 Infection: Data from the Pediatric COVID-19 Registry. Pediatr Blood Cancer. 2024 Jun;71(6):e30909. PMID: 38469996
Patel P, Robinson PD, Fisher BT, Phillips R, Morgan JE, Lehrnbecher T, Kuczynski S, Koenig C, Haeusler G, Esbenshade A, Elgarten C, Duong N, Diorio C, Castagnola E, Beauchemin M, Ammann RA, Dupuis LL, Sung L. Guideline for the Management of Clostridioides difficile Infection in Pediatric Patients with Cancer and Hematopoietic Cell Transplantation Recipients: 2024 Update. EClinicalMedicine. 2024 Apr 20;72:102604. PMID: 38680517.
Biery DN, Turicek DP, Diorio C, Schroeder BA, Shah NN. Cytokine Profiling in CAR T-Cell Therapy: Another Biomarker in Need of Standardization, Scoping Review (Part 2). Mol Ther. 2024 Mar 26:S1525-0016(24)00171-0. PMID: 38532629.
Ligon JA, Ramakrishna S, Ceppi F, Calkoen FGJ, Diorio C, Davis KL, Jacoby E, Gottschalk S, Schultz L, Capitini CM. INSPIRED Symposium Part 4B: CAR T cell correlative studies – established findings and future priorities. Transplant Cell Ther. 2024 Feb;30(2):155-170. PMID: 37863355.
2023
Schechter T, Tardif-Theriault C, Culos-Reed N, Lewis V, Orsey A, Diorio C, Tomlinson GA, Sung L. Yoga versus iPad active control for fatigue in paediatric cancer therapy: a randomized controlled trial. BMJ Support Palliat Care. 2023 Dec 30:spcare-2023-004609. PMID: 38160047.
Schuelke M, Bassiri H, Behrens EM, Canna S, Croy C, Dinofia A, Gollomp K, Grup SA, Lambert MP, Lambrix A, Maude SL, Myers RM, Newman H, Petrosa W, Seif AE, Sullivan KE, Teachey DT, Diorio C. Emapalumab for the treatment of Cytokine Release Syndrome in Pediatric Patients. Blood Adv. 2023 Sep 26;7(18):5603-5607. PMID: 37721859
Glisovic-Aplenc T, Diorio C*, Chukinas JA*, Veliz K, Shestova O, Vincent T, Shen F, Nunez-Cruz S, Miao F, Milone MC, June CH, Teachey DT, Tasian SK, Aplenc R, Gill S. CD38 as a pan-hematologic target for chimeric antigen receptor T cells. Blood Adv. 2023 May 12. PMID: 37171449.
Niswander LM, Chung P, Diorio C, Tasian SK. Clinical responses in pediatric patients with relapsed/refractory leukemia treated with azacitidine and venetoclax. Haematologica. 2023 Apr 6. PMID: 37021525.
Diorio C, Teachey DT, Canna SW. Cytokine Storm Syndromes in Pediatric Patients. J Allergy Clin Immunol Pract. 2023 Mar 27:S2213-2198(23)00320-3. PMID: 36990432.
Chu Y, Gardenswartz A, Diorio C, Marks LJ, Lowe E, Teahey DT, Cairo M. Cellular and Humoral Immunotherapy in Children, Adolescents and Young Adults with Non-Hodgkin Lymphoma. Best Practice & Research Clinical Haematology. 2023 Feb 7; 36(1). PMID: 36907635.
Newman H, Li Y, Liu H, Myers RM, Tam V, DiNofia A, Wray L, Rheingold SR, Callahan C, White C, Baniewicz D, Winestone LE, Kadauke S, Diorio C, June CH, Getz K, Aplenc R, Teachey DT, Maude SL, Grupp SA, Bona K, Barz Leahy A. Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy. Blood. 2023 Feb 9;141(6):609-619. PMID: 36351239.
2022
Diorio C*, Shraim R*, Myers R, Burudpakdee C, Leahy AB, Aplenc R, Lambert MP, Bassiri H, Canna S, Behrens EM, Gonzalez V, Chen F, Levine BL, Maude SL, Dinofia A, Seif A, Melenhorst J, Lacey SF, June CH, Barrett DM, Grupp S, Teachey DT. Comprehensive Secretome Profiling Elucidates Novel Disease Biology and Identifies Pre-Infusion Candidate Biomarkers to Predict the Development of Severe Cytokine Release Syndrome in Pediatric Patients Receiving CART19. Clin Cancer Res. 2022 Sep 1;28(17):3804-3813. PMID: 35705524.
Diorio C*, Murray R,* Edwards A, Barrera L, Camblin A, Chukinas J, Coholan L, Fuller T, Gonzales C, Grupp SA, Ladd A, Le M, Messana A, , Musenge F, Naniong M, Newman H, Poh YC, Poulin H, Ryan T, Shraim R, Tasian SK, Vincent T, Young L, Zhang Y, Giaramella G, Gehrke J*, Teachey DT*. Cystosine Base Editing Enables Quadruple-Edited Allogeneic CAR-T Cells for T-ALL. Blood 2022 Aug 11;140(6):619-629. PMID: 35560156.
Diorio C*, Vatsayan A*, Talleur AC, Annesley C, Jaroscak J, Shalabi H, Ombrello AK, Hudspeth M, Maude SL, Gardner RA, Shah NN. Anakinra utilization in pediatric CAR T-cell therapy. Blood Adv. 2022 Jun 14;6(11):3398-3403. PMID: 35395068.
Devine KJ*, Diorio C*, Richman SA, Henderson A, Oranges K, Armideo E, Kolb M, Freedman JL, Aplenc R, Fisher MJ, Minturn JE, Olson T, Bagatell R, Barakat L, Croy C, Mauro J, Vitlip L, Pasquariello C, Reilly A. Guideline for Children with Cancer Receiving General Anesthesia for Procedures and Imaging. J Pediatr Hematol Oncol. 2022 May 1;44(4):e859-e865. PMID: 35235547.
Diorio C, Vardaro J, Wei Y, Mauro J, Croy C, Oranges K, Flanagan L, Reilly A, Bailey LC, Jubelirer T, Elgarten C, Freedman J. Improving Guideline Congruent Care for Chemotherapy Induced Nausea and Vomiting Prophylaxis in Pediatric Oncology Patients. JCO Oncol Pract. 2022 Mar;18(3):e412-e419. PMID: 34705478.
2021
Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrell A, Lambert MP, Sullivan KE, Wherry EJ, Teachey DT, Bassiri H, Behrens EM. Proteomic Profiling of MIS-C Patients Reveals Heterogeneity Relating to Interferon Gamma Dysregulation and Vascular Endothelial Dysfunction. Nat Commun. 2021 Dec 10;12(1):7222. PMID: 34893640.
Whitworth H, Sartain SE, Kumaar R, Armstrong K, Ballester L, Betsneky M, Cohen C, Diaz R, Diorio C, Jafrey J, Goldenberg NA, Keegan J, Malone K, Randolph A, Rifken-Zeneberg S, Leung WS, Sochet A, Srivaths L, Zia A, Raffini L. Thrombosis in children hospitalized with SARS-COV-2 and MIS-C. Blood. 2021 Jul 15;138(2):190-198. PMID: 33895804.
36.
Chang JC, Matsubara DM, Morgan R, Diorio C, Nadaraj S, Teachey DT, Behrens EM, Banerjee A. Skewed cytokine responses rather than the magnitude of the cytokine storm may be responsible for cardiac dysfunction in multi-system inflammatory syndrome in children. J Am Heart Assoc. 2021 Aug 17;10(16):e021428. PMID: 34365798.
Vella L,* Giles JR,* Baxter AE,* Oldridge DA,* Diorio C, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen C, Giannini HM, Andrea K, Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MMR, Wherry EJ. Deep Immune Profiling of MIS-C Demonstrates Marked but Transient Immune Activation Compared to Adult and Pediatric COVID-19. Sci Immunol. 2021 Mar 2;6(57):eabf7570. PMID: 33653907.
Jacobs S, Plenert E, Stein E, Mowbray C, Stewart R, Schechter T, Diorio C, Sung L. Challenges of Implementing Multi-center Studies of Yoga for Pediatric Cancer and Hematopoietic Stem Cell Transplantation Recipients. Int J Yoga Therap. 2021 Jan 1;31(1):Article_17.PMID: 33444458.
2020
Diorio C,* McNerney KO,* Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth F, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT. Evidence of Thrombotic Microangiopathy in Children with SARS-CoV-2 across the Spectrum of Clinical Presentations. Blood Adv. 2020 Dec 8;4(23):6051-6063. PMID: 33290544.
Corwin DJ, Sartori LF, Chiotos K, John ARO, Cohn K, Bassiri H, Behrens EM, Teachey DT, Henrickson SE, Diorio C, Zorc JJ, Balamuth F. Distinguishing multisystem inflammatory syndrome in children (MIS-C) from Kawasaki Disease and benign inflammatory illnesses in the SARS-CoV-2 pandemic. Pediatr Emerg Care. 2020 Nov;36(11):554-558. PMID: 32970023.
Anderson EA,* Diorio C,* Goodwin EC, McNerney KO, Weirick ME, Gouma S, Bolton MJ, Arevalo CP, Chase JC, Hicks P, Manzoni TB, Baxter AE, Andrew KP, Budurpakdee C, Lee JH, Vella LA, Henrickson SE, Harris RB, Wherry EJ, Bates P, Bassiri H, Behrens EM, Teachey DT, Hensley SE. SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19. J Pediatric Infect Dis Soc. 2020 Dec 2:piaa161. PMID: 33263756.
Diorio C, Maude S. CAR-T Cells vs. Allogeneic HSCT for Poor Risk ALL. Am Soc Hematol Educ Program. 2020 Dec 4;2020(1):501-507. PMID: 33275706.
Diorio C,* Anderson EA,* McNerney KO, Goodwin EC, Chase JC, Bolton MJ, Arevalo CP, Weirick ME, Gouma S, Vella L, Henrickson SE, Chiotos K, Fitzgerald JC, Killbaugh TJ, John ARO, Blatz AM, Lambert MP, Sullivan KE, Tartaglione MR, Zambrano D, Martin M, Lee JF, Young P, Friedman D, Sesok-Pizzini DA, Hensley SE, Behrens EM,* Bassiri H,* Teachey DT.* Convalescent plasma for pediatric patients with COVID-19 associated acute respiratory distress syndrome [published online ahead of print, 2020 Sep 4]. Pediatr Blood Cancer. 2020;e28693. PMID: 32885904.
Dulek DD, Fuhlbrigge RC, Tribble AC, Connelly JA, Loi MM, El Chebib H, Chandrakasan S, Otto WR, Diorio C, Keim G, Walkovich K, Jaggi P, Girotto JE, Yarbrough A, Behrens EM, Cron RQ, Bassiri H. Multi-disciplinary guidance regarding the use of immunomodulatory therapies for acute COVID-19 in pediatric patients. J Pediatric Infect Dis Soc. 2020 Dec 31;9(6):716-737. PMID: 32808988.
Diorio C,* Shaw PA,* Pequignot E, Orlenko A, Chen F, Aplenc R, Barrett DM, Bassiri H, Behrens EB, Dinofia AM, Gonzalez V, Koterba N, Levine BL, Maude SL, Meyer NJ, Moore JH, Paessler MP, Porter DL, Bush JL, Siegel DL, Davis MM, Zhang D, June CH, Grupp SA, Melnhorst JJ, Lacey SF,** Weiss SL,** Teachey DT.** Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children. Blood Adv. 2020 Oct 27;4(20):5174-5183. PMID: 33095872.
Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase JM, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell B, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, Odom John AR, Lambert MP, Liebling EJ, Paessler M, Petrosa W, Phillips CA, Reilly AF, Romberg N, Seif AE, Sesok-Pizzini D, Sullivan K, Vardaro J, Behrens EM, Teachey DT, Bassiri H. Multisystem inflammatory syndrome in
children and COVID-19 are distinct presentations of SARS-CoV-2. J Clin Invest. 2020 Jul 30:140970. PMID: 32730233.
Ding Y, Ramakrishna S, Long A, Phillips C, Montiel-Esparza R, Diorio C, Bailey C, Maude S, Aplenc R, Batra V, Reilly A, Rheingold S, Lacayo N, Sakamoto K, Hunger S. Delayed cancer diagnoses and high mortality in children during the COVID-19 pandemic. Pediatr Blood Cancer 2020: 67: e28427. PMID: 32588960.
Chiotos K, Bassiri H, Behrens EM, Blatz AM, Chang J, Diorio C, Fitzgerald JC, Topjian A, John ARO. Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series. J Pediatric Infect Dis Soc. 2020;9(3):393-398. PMID: 32463092
Diorio C, Kelly KM, Afungchwi GM, Ladas EJ, Marjerrison S. Nutritional traditional and complementary medicine strategies in pediatric cancer: A narrative review. Pediatr Blood Cancer. 2020 Jun;67 Suppl 3:e28324. PMID: 32614139.
Diorio C, Teachey DT. Harnessing immunotherapy for pediatric T-cell malignancies. Expert Rev Clin Immunol. 2020 Apr;16(4):361-371. PMID: 32103690.
2019
Diorio C, Nowaczyk M. Half As Sad: A Plea for Narrative Medicine in Pediatric Residency Training. Pediatrics. 2019 Jan;143(1):e20183109. PMID: 30523202.
2018
Diorio C, Robinson PD, Ammann RA, Castagnola E, Erickson K, Esbenshade A, Fisher BT, Haeusler GM, Kuczynski S, Lehrnbecher T, Phillips R, Cabral S, Dupuis LL, Sung L. Guideline for the Management of Clostridium Difficile Infection in Children and Adolescents With Cancer and Pediatric Hematopoietic Stem-Cell Transplantation Recipients. J Clin Oncol. 2018 Nov 1;36(31):3162-3171. PMID: 30216124.
Diorio C, Afanasiev M, Salena K, Marjerrison S. ‘A world of competing sorrows’: a mixed methods analysis of media reports of children with cancer abandoning conventional treatment. PLoS One. 2018;13(12):e0209738. PMID: 30576389.
Diorio C, Lin M, Ginn E, Ladas EJ. Psychosocial determinants of physical activity and dietary behaviors in adolescents and young adults with cancer and survivors. Pediatr Blood Cancer. 2018 Sep;65(9):e27243. PMID: 29797639.
Radossi AL, Taromina K, Marjerrison S, Diorio C, Similio R, Njuguna F, Afungchwi GM, Ladas EJ. A systematic review of integrative clinical trials for supportive care in pediatric oncology: a report from the International Society of Pediatric Oncology, T&CM collaborative. Support Care Cancer. 2018 Feb;26(2):375-391. PMID: 29026997.
2017
Diorio C, Salena K, Ladas EJ, Lam CG, Afungcwhi GM, Njuguna F, Marjerrison S. Traditional and complementary medicine used with curative intent in childhood cancer: A systematic review. Pediatr Blood Cancer. 2017 Sep;64(9). PMID: 28244653.
Diorio C, Lam CG, Ladas EJ, Njuguna F, Afungchwi GM, Taromina K, Marjerrison S. Global Use of Traditional and Complementary Medicine in Childhood Cancer: A Systematic Review. J Glob Oncol. 2017 Dec;3(6):791-800. PMID: 29244989.
2016
Diorio C, Celis Ekstrand A, Hesser T, O'Sullivan C, Lee M, Schechter T, Sung L. Development of an Individualized Yoga Intervention to Address Fatigue in Hospitalized Children Undergoing Intensive Chemotherapy. Integr Cancer Ther. 2016 Sep;15(3):279-84.
2015
Diorio C, Schechter T, Lee M, O'Sullivan C, Hesser T, Tomlinson D, Piscione J, Armstrong C, Tomlinson G, Sung L. A pilot study to evaluate the feasibility of individualized yoga for inpatient children receiving intensive chemotherapy. BMC Complement Altern Med. 2015 Jan 24;15:2.
2014
Tomlinson D,* Diorio C,* Beyene J, Sung L. Effect of exercise on cancer-related fatigue: a meta-analysis. Am J Phys Med Rehabil. 2014 Aug;93(8):675-86.
2012
Diorio C, Tomlinson D, Boydell KM, Regier DA, Ethier MC, Alli A, Alexander S, Gassas A, Taylor J, Kellow C, Mills D, Sung L. Attitudes toward infection prophylaxis in pediatric oncology: a qualitative approach. PLoS One 2012; 7(10):e47815.
Regier DA, Diorio C, Ethier MC, Alli A, Alexander S, Boydell KM, Gassas A, Taylor J, Kellow C, Mills D, Sung L. Discrete choice experiment to evaluate factors that influence preferences for antibiotic prophylaxis in pediatric oncology. PLoS One 2012; 7(10):e47470.
Gavidia R, Fuentes SL, Vasquez R, Bonilla M, Ethier MC, Diorio C, Caniza M, Howard SC, Sung L. Low socioeconomic status is associated with prolonged times to assessment and treatment, sepsis and infectious death in pediatric fever in el Salvador. PLoS One 2012; 7(8):e43639.
Teuffel O, Cheng S, Ethier MC, Diorio C, Martino J, Mayo C, Wing R, Sung L, Alibhai SM. Health-related quality of life anticipated with different management strategies for febrile neutropenia in adult cancer patients. Supp Care in Cancer 2012; 20(11):2755-64.
2011
Diorio C, Martino J, Boydell K, Ethier MC, Mayo C, Wing R, Teuffel O, Sung L, Tomlinson D. Parental perspectives on inpatient versus outpatient management of pediatric febrile neutropenia. J Pediatr Oncol Nurs 2011; 28(6):355-62.
Cheng S, Teuffel O, Ethier MC, Diorio C, Martino J, Mayo C, Regier D, Wing R, Alibhai SM, Sung L. Health-related quality of life anticipated with different management strategies for paediatric febrile neutropaenia. Br J Cancer. 2011 Aug 23;105(5):606-11.
Bender JL, Radhakrishnan A, Diorio C, Englesakis M, Jadad AR. Can pain be managed through the Internet? A systematic review of randomized controlled trials. Pain. 2011 Aug;152(8):1740-50.
2010
Wang B, Mao YK, Diorio C, Pasyk M, Wu RY, Bienenstock J, Kunze WA. Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility within minutes. FASEB J. 2010 Oct;24(10):4078-88.
Wang B, Mao YK, Diorio C, Wang L, Huizinga JD, Bienenstock J, Kunze W. Lactobacillus reuteri ingestion and IK(Ca) channel blockade have similar effects on rat colon motility and myenteric neurones. Neurogastroenterol Motil. 2010 Jan;22(1):98-107, e33.
Abstracts (includes Posters and Scientific Presentations)
2025
Diorio C & Tikhonov A. The Role of Measuring Cytokines in Cancer Immunotherapy (Invited). Presented at the Association of Diagnostic and Laboratory Medicine, Chicago, Illinois, July 28, 2025.
Diorio C. Cytokine-Mediated Toxicities following CAR T-Cell Therapy (Invited). Presented at the Association of Diagnostic and Laboratory Medicine, Chicago, Illinois, July 28, 2025.
Diorio C. CRS Following CART19 & CART22: What can we learn about immune toxicities from pediatric B-ALL? (Invited). Presented at Cellicon Valley, Philadelphia, Pennsylvania May 1, 2025.
Diorio C. CART for Paediatric T-ALL (Invited). Presented at Pediatric Oncology Conference Columbia University, New York City, New York, March 10, 2025.
Diorio C. Hemophagocytic Lymphohistiocytosis (Invited). Presented at the Pediatric Oncology Educational Meeting, Philadelphia, Pennsylvania, February 13, 2025.
Diorio C. Understanding and Mitigating Immune Related Adverse Events due to Cellular Immunotherapies (Invited). Center for Childhood Cancer Research Seminar, Philadelphia, PA, January 14, 2025.