Jonathan J. Edwards, MD

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Jonathan J. Edwards, MD, is an attending physician with the Division of Cardiology at Children's Hospital of Philadelphia.

Areas of Expertise: Molecular mechanisms of right ventricular failure and remodeling, Familial cardiomyopathy
Locations: Main Hospital
Phone: 215-590-4040


Jonathan Edwards, MD is an attending physician in the Division of Cardiology, Section of Pediatric Heart Failure and Transplantation. He has special clinical and research interests in the genetic and molecular causes of right ventricular heart failure and cardiomyopathy. Dr. Edwards sees infants and children of all ages in the Cardiomyopathy Genetics clinic, including screening for familial forms of cardiomyopathy.

Dr. Edwards research focuses primarily on the deciphering the molecular mechanisms of right ventricular failure, which is critical given the prevalence of right ventricular failure in children and adolescents with congenital heart defects and the lack of proven medical therapies. This work integrates translational and basic science models, and has been supported through numerous funding sources, including from the National Heart, Lung, and Blood Institute and foundational and industry sponsored grants. Dr. Edwards has also investigated genetic causes of congenital heart disease, immunologic desensitization for patients listed for transplant, and outcomes of patients supported with ventricular assist devices.

Education and Training

Medical School

MD - Wake Forest School of Medicine of Wake Forest Baptist Medical Center, Winston-Salem, NC


Pediatrics (Physician Scientist Research Residency) - Icahn School of Medicine at Mount Sinai, New York, NY


Pediatric Cardiology - Children's Hospital of Philadelphia, Philadelphia, PA

Pediatric Heart Failure and Transplantation - Children's Hospital of Philadelphia, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Departments and Services

Selected Publications


Edelson JB*, Edwards JJ*,  Katcoff H, Mondal A, Reza N, Hanff T, Griffis H, Mazurek JA, Wald J, Owens A, Burstein D, Alturi P, O’Connor M, Goldberg L, Zamani P, Groenveld P, Rossano J, Lin KY, Birati EY. An Increasing Burden of Disease: Emergency Department Visits Among Patients with Ventricular Assist Devices from 2010-2017. J Am Heart Assoc. 2021 Feb 16;10(4):e018035. doi: 10.1161/JAHA.120.018035. PMID: 33543642; PMCIDPMC7955344. *Contributed equally to this work.


Edwards, JJ, Brandimarto JA, Dong-Qing H, Jeong S, et. al. Noncanonical WNT activation in human right ventricular heart failure. Frontiers in Cardiovasc Med. 2020; 7:582407 PMID: 33134326. PMCID: PMC7575695

Edwards JJ, Rouillard AD, Fernandez NF, Wang Z, Lachmann A, et al. Systems analysis implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC Basic Transl Sci. 2020 Apr, 5 (4) 376 – 386. PMID: 32368696. PMCID: PMC7188873

Murashige D, Jang C, Neinast M, Edwards JJ, et. al. Comprehensive quantification of fuel use by the failing and non-failing human heart. Science. 2020 Oct 16;370(6514):364-368. PMID: 33060364. PMCID: PMC7871704


Edwards JJ, Seliktar N, White R, Heron SD, Lin K, Rossano J, Monos D, Sesok-Pizzini D, O’Connor MJ. Impact and Predictors of Positive Response to Desensitization in Pediatric Heart Transplant Candidates. J Heart and Lung Trans. 2019 Nov;38(11):1206-1213. PMID: 31672220; PMCIDPMC6827717.


Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, et. al. RAF1 mutations in childhood-onset dilated cardiomyopathy. Nat Genet. 2014 Jun;46(6):635-639. PMID: 24777450; PMCID: PMC4049514.

Complete list of published work



Book chapters

Edwards J, Lin K, Rossano J. Diagnosis, Evaluation, and Management of Pediatric Heart Failure. Pediatric Cardiology: Fetal, Pediatric and Adult Congenital Cardiology (First Edition). Pahl E. and Abdulla R. (eds.) Elsevier [In Press]



1K08HL159311-01 NIH/NHLBI Edwards, Jonathan (PI)

Defining the Role of ROR2 in Right Ventricular Failure Pathogenesis

Role: Principal Investigator


5T32 HL007915 NIH/NHLBI Levy, R and Rossano, J (PI)

Training in Molecular Therapeutics for Pediatric Cardiology

Role: Research Trainee

CHD Coalition (PI) Edwards, J    

Investigating differential gene expression associated with right ventricular remodeling

Role: Principal Investigator

ENTELLIGENCE Young Investigator Award Program  (PI) Edwards, J

Investigating altered right ventricular myocardial gene expression and biomarkers patterns associated with adaptive and pathologic remodeling in diverse human models

Role: Principal Investigator

Matthew’s Heart of Hope (PI) Edwards, J    

WNT the Right Ventricle’s Had Enough

Role: Principal Investigator

Awards and Honors

2016, Kurt Hirschhorn Clinician-Scientist Award, Icahn School of Medicine at Mount Sinai

2016, House Office Research Award, Society for Pediatric Research

2011, Sarnoff Cardiovascular Research Foundation, Research Fellow

2009 Student Research Program, American Pediatrics Society/Society for Pediatrics Research

2008, Summa Cum Laude, East Carolina University

2008, Robert H Wright Alumni Leadership Award, East Carolina University

2007, Gerhard W Kalmus Scholarship, East Carolina University

2007, ACS Undergraduate Analytical Chemistry Award, East Carolina University

2007, Dr. Keith and Susan Holmes Scholastic Award, East Carolina University

Editorial and Academic Positions

2020-present, Clinical Genetics, Reviewer

2019-present, Archives of Disease in Childhood, Reviewer

Leadership and Memberships

2018–present, International Society for Heart and Lung Transplantation

2016–present, American College of Cardiology

2011–present, American Heart Association