Jonathan Edwards, MD is an attending physician in the Division of Cardiology, Section of Pediatric Heart Failure and Transplantation. He has special clinical and research interests in the genetic and molecular causes of right ventricular heart failure and cardiomyopathy. Dr. Edwards sees infants and children of all ages in the Cardiomyopathy Genetics clinic, including screening for familial forms of cardiomyopathy.
Dr. Edwards research focuses primarily on the deciphering the molecular mechanisms of right ventricular failure, which is critical given the prevalence of right ventricular failure in children and adolescents with congenital heart defects and the lack of proven medical therapies. This work integrates translational and basic science models, and has been supported through numerous funding sources, including from the National Heart, Lung, and Blood Institute and foundational and industry sponsored grants. Dr. Edwards has also investigated genetic causes of congenital heart disease, immunologic desensitization for patients listed for transplant, and outcomes of patients supported with ventricular assist devices.
MD - Wake Forest School of Medicine of Wake Forest Baptist Medical Center, Winston-Salem, NC
Pediatrics (Physician Scientist Research Residency) - Icahn School of Medicine at Mount Sinai, New York, NY
Pediatric Cardiology - Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Heart Failure and Transplantation - Children's Hospital of Philadelphia, Philadelphia, PA
Attending Physician
Edelson JB*, Edwards JJ*, Katcoff H, Mondal A, Reza N, Hanff T, Griffis H, Mazurek JA, Wald J, Owens A, Burstein D, Alturi P, O’Connor M, Goldberg L, Zamani P, Groenveld P, Rossano J, Lin KY, Birati EY. An Increasing Burden of Disease: Emergency Department Visits Among Patients with Ventricular Assist Devices from 2010-2017. J Am Heart Assoc. 2021 Feb 16;10(4):e018035. doi: 10.1161/JAHA.120.018035. PMID: 33543642; PMCID: PMC7955344. *Contributed equally to this work.
Edwards, JJ, Brandimarto JA, Dong-Qing H, Jeong S, et. al. Noncanonical WNT activation in human right ventricular heart failure. Frontiers in Cardiovasc Med. 2020; 7:582407 PMID: 33134326. PMCID: PMC7575695
Edwards JJ, Rouillard AD, Fernandez NF, Wang Z, Lachmann A, et al. Systems analysis implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC Basic Transl Sci. 2020 Apr, 5 (4) 376 – 386. PMID: 32368696. PMCID: PMC7188873.
Murashige D, Jang C, Neinast M, Edwards JJ, et. al. Comprehensive quantification of fuel use by the failing and non-failing human heart. Science. 2020 Oct 16;370(6514):364-368. PMID: 33060364. PMCID: PMC7871704
Edwards JJ, Seliktar N, White R, Heron SD, Lin K, Rossano J, Monos D, Sesok-Pizzini D, O’Connor MJ. Impact and Predictors of Positive Response to Desensitization in Pediatric Heart Transplant Candidates. J Heart and Lung Trans. 2019 Nov;38(11):1206-1213. PMID: 31672220; PMCID: PMC6827717.
Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, et. al. RAF1 mutations in childhood-onset dilated cardiomyopathy. Nat Genet. 2014 Jun;46(6):635-639. PMID: 24777450; PMCID: PMC4049514.
Edwards J, Lin K, Rossano J. Diagnosis, Evaluation, and Management of Pediatric Heart Failure. Pediatric Cardiology: Fetal, Pediatric and Adult Congenital Cardiology (First Edition). Pahl E. and Abdulla R. (eds.) Elsevier [In Press]
Active
1K08HL159311-01 NIH/NHLBI Edwards, Jonathan (PI)
Defining the Role of ROR2 in Right Ventricular Failure Pathogenesis
Role: Principal Investigator
Completed
5T32 HL007915 NIH/NHLBI Levy, R and Rossano, J (PI)
Training in Molecular Therapeutics for Pediatric Cardiology
Role: Research Trainee
CHD Coalition (PI) Edwards, J
Investigating differential gene expression associated with right ventricular remodeling
Role: Principal Investigator
ENTELLIGENCE Young Investigator Award Program (PI) Edwards, J
Investigating altered right ventricular myocardial gene expression and biomarkers patterns associated with adaptive and pathologic remodeling in diverse human models
Role: Principal Investigator
Matthew’s Heart of Hope (PI) Edwards, J
WNT the Right Ventricle’s Had Enough
Role: Principal Investigator
2016, Kurt Hirschhorn Clinician-Scientist Award, Icahn School of Medicine at Mount Sinai
2016, House Office Research Award, Society for Pediatric Research
2011, Sarnoff Cardiovascular Research Foundation, Research Fellow
2009 Student Research Program, American Pediatrics Society/Society for Pediatrics Research
2008, Summa Cum Laude, East Carolina University
2008, Robert H Wright Alumni Leadership Award, East Carolina University
2007, Gerhard W Kalmus Scholarship, East Carolina University
2007, ACS Undergraduate Analytical Chemistry Award, East Carolina University
2007, Dr. Keith and Susan Holmes Scholastic Award, East Carolina University
2020-present, Clinical Genetics, Reviewer
2019-present, Archives of Disease in Childhood, Reviewer
2018–present, International Society for Heart and Lung Transplantation
2016–present, American College of Cardiology
2011–present, American Heart Association