Background

Dustin D. Flannery, DO, MSCE, is an attending physician at Children’s Hospital of Philadelphia (CHOP) and CHOP Newborn Care at Pennsylvania Hospital, an Assistant Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania, and a core faculty member in the CHOP Center for Pediatric Clinical Effectiveness (CPCE). He is a graduate of the Pediatric Hospital Epidemiology and Outcomes Research Training (PHEOT) program managed by the CPCE, and the Master of Science in Clinical Epidemiology (MSCE) program at the University of Pennsylvania.

Dr. Flannery received a Doctor of Osteopathic Medicine (DO) degree from the Philadelphia College of Osteopathic Medicine and a Bachelor of Science (BS) with Honors from Virginia Tech. After completing a residency and chief residency in Pediatrics at Alfred I. DuPont Hospital for Children/Thomas Jefferson University Hospital, he completed a fellowship in Neonatal-Perinatal Medicine at CHOP. His research interests are neonatal infectious diseases and antimicrobial stewardship. His current research projects involve 1) analyzing antimicrobial resistance patterns in neonatal intensive care units across the country; 2) analyzing contemporary maternal and neonatal Group B Streptococcus seroepidemiology; and 3) identifying meaningful metrics of neonatal antibiotic use for more accurate inter-hospital comparison. He has received research funding from CHOP, National Institute of Child Health and Human Development (T32), Agency for Healthcare Research and Quality (K08), and Centers for Disease Control and Prevention.

Education and Training

Medical School

DO - Philadelphia College of Osteopathic Medicine, Philadelphia, PA

Internship

Pediatrics - Nemours Alfred I DuPont Hospital/Jefferson Medical College, Philadelphia, PA

Residency

Pediatrics - Nemours Alfred I DuPont Hospital/Jefferson Medical College, Philadelphia, PA (Chief Resident)

Fellowship

Neonatal-Perinatal Medicine - Children's Hospital of Philadelphia, PA (Chief Fellow)

Board Certification

Neonatal-Perinatal Medicine
Pediatrics

Graduate Degree

MS in Clinical Epidemiology (MSCE) - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Neonatologist

Assistant Professor of Pediatrics, University of Pennsylvania Perelman School of Medicine

Departments and Services

Publications

Papers

2021

Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Triebwasser JE, Gerber JS, Morris JS, Weirick ME, McAllister CM, Bolton MJ, Arevalo CP, Anderson EM, Goodwin EC, Hensley SE, Puopolo KM. Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios. JAMA Pediatr. Published online January 29, 2021.

Flannery DD, Puopolo KM. Perinatal COVID-19: Guideline Development, Implementation, and Challenges. Current Opinion in Pediatrics, accepted January 13, 2021 (in press)

2020

Flannery DD, Akinboyo IC, Mukhopadhyay S, Tribble AC, Song L, Chen F, Li Y, Gerber JS, Puopolo, KM. Antibiotic Susceptibility of Escherichia coli Among Infants Admitted to Neonatal Intensive Care Units Across the US from 2009 to 2017. JAMA Pediatr. Published online November 09, 2020.

Flannery DD, Horbar JD. Metrics of Neonatal Antibiotic Use. Semin Perinatol. 2020 Dec;44(8):151329.

Flannery DD, Jensen EA, Tomlinson LA, Yu Y, Ying GS, Binenbaum G. Poor postnatal weight growth is a late finding after sepsis in very preterm infants. Archives of Disease in Childhood - Fetal and Neonatal Edition Published online November 4, 2020.

Dhudasia MD, Flannery DD, Pfeifer MR, Puopolo KM. Updated Guidance: Prevention and Management of Perinatal Group B Streptococcus Infection. Neoreviews, American Academy of Pediatrics. Accepted October 12, 2020 (in press)

Garber SJ, Dhudasia MB, Flannery DD, Passarella MR, Puopolo KM, Mukhopadhyay S. Delivery-based criteria for empiric antibiotic administration among preterm infants. J Perinatol. 2020 Aug; Online ahead of print. PubMed PMID: 32792629

Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Gerber JS, Arevalo CP, Bolton MJ, Weirick ME, Goodwin EC, Anderson EM, Greenplate AR, Kim J, Han N, Pattekar A, Dougherty J, Kuthuru O, Mathew D, Baxter AE, Vella LA, Weaver J, Verma A, Leite R, Morris JS, Rader DJ, Elovitz MA, Wherry EJ, Puopolo KM, Hensley SE. SARS-CoV-2 seroprevalence among parturient women in Philadelphia. Sci Immunol. 2020 Jul 29;5(49): eabd5709. PubMed PMID: 32727884.

Bamat NA, Ekhaguere OA, Zhang L, Flannery DD, Handley SC, Herrick HM, Ellenberg SS. Protocol adherence rates in superiority and noninferiority randomized clinical trials published in high impact medical journals. Clin Trials. 2020 Jul, online ahead of print. PMID: 32666826.

Flannery DD, Mukhopadhyay S, Jensen EA, Gerber JS, Passarella MR, Dysart K, Aghai ZH, Greenspan J, Puopolo KM. Influence of Patient Characteristics on Antibiotic Use Rates Among Preterm Infants. J Pediatric Infect Dis Soc. 2020 Mar 14. pii: piaa022. doi: 10.1093/jpids/piaa022. PMID: 32170951

Gordon SM, Srinivasan L, Taylor DM, Master SR, Tremoglie MA, Hankeova A, Flannery DD, Abbasi S, Fitzgerald JC, Harris MC. Derivation of a metabolic signature associated with bacterial meningitis in infants. Pediatr Res. 2020 Aug;88(2):184-191. PubMed PMID: 32120377.

2019

Sloane A, Flannery DD, Lafferty M, Jensen E, Dysart K, Cook A, Greenspan J, Aghai Z. Hypertensive Disorders During Pregnancy Are Associated with Reduced Severe Intraventricular Hemorrhage in Very Low Birth Weight Infants. J Perinatol, Epub ahead of print, July 1, 2019

Dhudasia MB, Flannery DD, Mukhopadhyay S. Early limited formula for breastfeeding infants: too much or just enough? J Perinatol, Epub ahead of print, June 9, 2019

2018

Flannery DD, Dysart K, Cook A, Greenspan J, Aghai ZH, Jensen EA. Association Between Early Antibiotic Exposure and Bronchopulmonary Dysplasia or Death. J Perinatol, Epub ahead of print, June 13, 2018. doi:10.1038/s41372-018-0146-3

Flannery DD, Ross RK, Mukhopadhyay S, Tribble AC, Puopolo KM, Gerber JS. Temporal Trends and Center Variation in Early Antibiotic Use Among Premature Infants. JAMA Network Open. 2018;1(1):e180164. doi:10.1001/jamanetworkopen.2018.0164

Flannery DD, Puopolo KM. Neonatal Antibiotic Use: How Much is Too Much? Pediatrics. 2018; 142(3):e20181942.

Flannery DD, Puopolo KM. Neonatal Antibiotic Use: What Are We Doing and Where Shall We Go? Neoreviews, American Academy of Pediatrics. 2018;19(9):e516-525.

2017

Flannery DD, Brandsma E, Saslow J, Mackley AB, Paul DA, Aghai ZA. Do infants in the neonatal intensive care unit diagnosed with urinary tract infection need a routine voiding cystourethrogram? J Matern Fetal Neonatal Med. 2017 Dec 10:1-121 [Epub ahead of print]. doi: 10.1080/14767058.2017.1416352

Flannery DD, Foglia EE. Critical appraisal of: [Patel RM, Knezevic A, Shenvi N, Hinkes M, Keene S, Roback JD, et al. Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis in Very Low-Birth-Weight Infants. JAMA. 2016;315(9):889-897] J Perinatol 2017, 37: 626-628.

Hay S, Zupancic JA, Flannery DD, Kirpalani H, Dukhovny D. Should We Believe in Transfusion-Associated Necrotizing Enterocolitis? Applying a GRADE to the Literature. Semin Perinatol 2017, 41(1): 80-91

Flannery DD, Foglia EE. The contributions of red blood cell transfusion and severe anemia in necrotizing enterocolitis: causes or confounders? J Perinatol. 2017 Mar 23. [Epub ahead of print]

2016

Flannery DD, Stephens CL, Thompson AD. The Impact of High-Profile Sexual Abuse Cases in the Media on a Pediatric Emergency Department. J Child Sex Abus 2016, 25(6): 627-635

Flannery DD, O’Donnell E, Kornhauser M, Dysart K, Greenspan J, Aghai ZH. Continuous Positive Airway Pressure versus Mechanical Ventilation on the First Day of Life in Very Low Birth Weight Infants. Am J Perinatol 2016, 33(10): 939-944

2014

Flannery DD, Chan S, Swami SK, Eppes SC. Prescriber Perceptions of a Pediatric Antimicrobial Stewardship Program. Clin Pediatr 2014, 53(8): 743-746

2013

Flannery DD, Akinboyo I, Ty JM, Averill LW, Freedman A. Septic Arthritis and Concern for Osteomyelitis in a Child with Rat Bite Fever. J Clin Microbiol 2013, 51(6): 1987-1989

Awards and Honors

2020, Neonatal Abstinence Syndrome Quality Care Subaward: Pennsylvania Hospital Newborn Medicine, Pennsylvania Perinatal Quality Collaborative

2019, Alumni Professional Development Grant Award, Philadelphia College of Osteopathic Medicine Alumni Association

2019, Trainee Travel Grant Award, Pediatric Academic Societies Meeting

2019, Young Investigator Coaching Program (Coach: Dr. Thomas Newman), Society for Pediatric Research

2018, Thomas Boggs Perinatal-Neonatal Fellow Research Award Finalist, Philadelphia Perinatal Society

2017, Excellence in Clinical Research Award, Children’s Hospital of Philadelphia Research Institute

2017, Trainee Travel Grant Award, Eastern Society for Pediatric Research Meeting

2016, Quality and Patient Safety Honorable Mention: Supporting Premature Infant Nutrition (SPIN), Penn Medicine Clinical Effectiveness and Quality Improvement Initiative

2016, Antimicrobial Stewardship Fellowship Award, Pediatric Infectious Diseases Society

2015, Section on Infectious Diseases Travel Grant Award, American Academy of Pediatrics

2014, Rosenblum Award for Excellence (Outstanding Senior Resident), Alfred I. duPont Hospital for Children

2014, Bambi Taylor, M.D. Pediatric Emergency Medicine Award, Alfred I. duPont Hospital for Children

Editorial and Academic Positions

Editorial Positions

Ad Hoc Reviewer

2020-present, Archives of Disease in Childhood
2020-present, Lancet Infectious Diseases
2020-present, Scientific Reports
2020-present, BMJ Paediatrics Open
2019-present, Journal of Perinatology
2017-present, The Pediatric Infectious Disease Journal
2017-present, Journal of the Pediatric Infectious Diseases Society
2016-present, Virulence
2016-present, American Journal of Perinatology
2015-present, Pediatrics

Invited Reviewer

2019, Reviewer, Pediatric Infectious Diseases Society Antimicrobial Stewardship Fellowship Award
2019, Judge, Philadelphia College of Osteopathic Medicine Research Poster Day
2019, Abstract Reviewer, American Academy of Pediatrics National Conference and Exhibition
2016-present, Abstract Reviewer, Pediatric Academic Societies Annual Meeting Scientific

Academic and Institutional Committees

2017-present, Neonatology Fellowship Selection Committee
2018-present, UTI Management Pathway Development Team, Children’s Hosp. of Philadelphia
2019-present, Neonatology Scientific Review Committee, Children’s Hosp. of Philadelphia
2019-present, Pediatric Sepsis Program, Children’s Hosp. of Philadelphia

Leadership and Memberships

Memberships in Professional Organizations

International

2018-present, International Society of Evidence-Based Neonatology (EBNEO)

National

2018-present, Society for Healthcare Epidemiology of America

2018-present, PIDS Pediatric Committee on Antimicrobial Stewardship

2018-present, CDC/VON Antimicrobial Stewardship Special Interest Group

2016-2018, Liaison, AAP Section on Breastfeeding/Section on Pediatric Trainees

2015-present, Society for Pediatric Research (SPR)

2013-present, Pediatric Infectious Diseases Society (PIDS)

2013-present, Academic Pediatric Association (APA)

2011-present, American Academy of Pediatrics (AAP)