V. Ramesh Iyer, MD, MRCP

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V. Ramesh Iyer, MD, MRCP, is an attending electrophysiologist in the Cardiac Center at Children's Hospital of Philadelphia with special interest in pacemakers and device therapy.

Areas of Expertise: Pacemakers and device therapy
Locations: Main Hospital; Pediatric Cardiologists in Exton, PA

Phone: 215-590-4040

Education and Training

Medical School

Safdarjang Hospital University of Delhi, India


Pediatrics - LNJP Hospitals University of Delhi, India
Pediatrics - University of Connecticut, Farmington, CT


Neonatology Fellowship - University of Connecticut Health Center, Farmington, CT
Pediatric Cardiology - The Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatric Cardiac Electrophysiology - The Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification

Neonatal-Perinatal Medicine – American Board of Pediatrics
Pediatric Cardiology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Graduate Degree

Master in Law - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Electrophysiologist

Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




S. Khanna, VR Iyer, VL Vetter: Reply  "Can Pediatric Practitioners Correctly interpret electrocardiogram" Journal of Pediatrics, 2020, Feb; 217: 218-219. doi:10.1016/jpeds.2019.10.040(217), 218-219, February 2020.

Daniel J. Blackwell, Michela Faggioni, Matt Wleklinski, Kyungsoo Kim1, Nieves Gomez-Hurtado1, Ramesh Iyer, Franz Baudenbacher, Glenn Fishman, Karl Pfeifer, Bjorn C. Knollmann: Subendocardial ventricular myocytes are the cellular trigger of CPVT. Journal Clinical Investigation 2020 Notes: submitted, under revision- June 2020.


Christopher M Janson, Reina Bianca Tan, V Ramesh Iyer, R Lee Vogel, Victoria L Vetter, Maully J Shah : Ivabradine for treatment of tachyarrhythmias in children and young adults. Heart Rhythm Journal Elsivier, 5 (6)(6): 333-337, March 2019 Notes: DOI: 10.1016/j.hrcr.2019.03.007.

Sahil Khanna, Ramesh Iyer, Victoria Vetter. : Can Pediatric Practitioners Correctly Interpret Electrocardiograms? Journal of Pediatrics 206: 113-118, March 2019.


Nosta Glaser 1 Venkat Ramesh Iyer 1 Clara Franzini-Armstrong : Functionally Driven Modulation of Sarcomeric Structure and Membrane Systems in the Fast Muscles of a Copepod (Gaussia princeps).  Anatomical Record. Wiley Periodicals, 301: 2164-2176, October 2018.


Manuela Lavorato, V. Ramesh Iyer, Williams Dewight, Ryan R. Cupo, Valentina Debattisti, Ludovic Gomez, Sergio De la Fuente, Yan-Ting Zhao, Héctor H. Valdivia, György Hajnóczky, and Clara Franzini-Armstrong : Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges. Proceeding of National Academy of SciencesPNAS 2017 114 (5) E849-E858; published ahead of print January 17, 2017,  doi:10.1073/pnas.1617788113  114(5): E849-858, January  2017.


JYOTI K. PATEL, MD, MICHAEL O'BYRNE, MD, WILLIAM BONNEY, MD, MAULLY J. SHAH, MD, FHRS, JUSTINE SHULTZ, PhD, TAMMY WIEAND, MS, VICTORIA VETTER, MD, MPH, FHRS, V RAMESH IYER, MD, FRCP, FHRS : Diagnostic Electrophysiology Study Has Limited Value in Risk Stratification of Children and Young Adults with and without Congenital Heart Disease. Journal of Innovation in Cardiac Rhythm ManagementDOI: 10.19102/icrm.2016.070202,Vol 2, 10-18: February 2016 February 2016.

Vetter VL, Haley DM, Dugan NP, Iyer VR, Shults J.: Innovative cardiopulmonary resuscitation and automated external defibrillator programs in schools: Results from the Student Program for Olympic Resuscitation Training in Schools (SPORTS) study.   Resuscitation 104: 46-52, May 2016.


Vetter Victoria L, Covington Theresa M, Dugan Noreen P, Haley Danielle Main, Dykstra Heather, Overpeck Mary, Iyer V Ramesh, Shults Justine: Cardiovascular deaths in children: General overview from the National Center for the Review and Prevention of Child Deaths. American Heart journal 169(3): 426-437.e23, Mar 2015.

Lavorato Manuela, Huang Tai-Qin, Iyer Venkat Ramesh, Perni Stefano, Meissner Gerhard, Franzini-Armstrong Clara: Dyad content is reduced in cardiac myocytes of mice with impaired calmodulin regulation of RyR2. Journal of Muscle Research and Cell Motility. 2015 Apr;36(2):205-14. doi: 10.1007/s10974-015-9405-5. Epub 2015 Feb 19 April 2015.

Maalika M. Banerjee, V. Ramesh Iyer,Deipanjan Nandi, Victoria L. Vetter &Anirban Banerjee: Reliability of Left Ventricular Hypertrophyby ECG Criteria in Children with Syncope:Do the Criteria Need to be Revised? Pediatr CardiolDOI 10.1007/s00246-015-1336-9. Springer, Page: 1336-39, December 2015.


Elias Matthew D, Iyer V Ramesh, Cohen Meryl S: Prevalence of electrocardiogram use in infants with apparent life-threatening events: a multicenter database study. Pediatric Emergency Care 30(4): 236-9, Apr 2014.

Guo Ang, Zhang Xiaoying, Iyer Venkat Ramesh, Chen Biyi, Zhang Caimei, Kutschke William J, Weiss Robert M, Franzini-Armstrong Clara, Song Long-Sheng: Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress. Proceedings of the National Academy of Sciences of the United States of America. August 2014 EPUB PMID: 25092313 Aug 2014.

Vetter Victoria L, Dugan Noreen P, Haley Danielle Main, Covington Theresa M, Dykstra Heather, Overpeck Mary, Iyer V Ramesh, Shults Justine: Development of a data set of national cardiovascular deaths in the young. American Heart journal 168(4): 568-576.e3, Oct 2014.


Iyer V Ramesh, Chin Alvin J: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). American Journal of Medical Genetics. Part C, Seminars in Medical Genetics 163C(3): 185-97, Aug 2013.

Singh Vivek P, Rubinstein Jack, Arvanitis Demetrios A, Ren Xiaoping, Gao Xiaoqian, Haghighi Kobra, Gilbert Mark, Iyer Venkat R, Kim Do Han, Cho Chunghee, Jones Keith, Lorenz John N, Armstrong Clara F, Wang Hong-Sheng, Gyorke Sandor, Kranias Evangelia G: Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein. Journal of the American Heart Association 2(5): e000460, Oct 2013.


Patel Jyoti Kandlikar, Iyer V Ramesh: Managing arrhythmias before and after aortic valve surgery in children. American Journal of Cardiovascular Drugs  12(1): 23-34, Feb 2012.

Perni Stefano, Iyer V Ramesh, Franzini-Armstrong Clara: Ultrastructure of cardiac muscle in reptiles and birds: optimizing and/or reducing the probability of transmission between calcium release units. Journal of Muscle Research and Cell Motility 33(2): 145-52, Jun 2012.


Vetter Victoria L, Dugan Noreen, Guo Rong, Mercer-Rosa Laura, Gleason Marie, Cohen Meryl, Vogel R Lee, Iyer Ramesh: A pilot study of the feasibility of heart screening for sudden cardiac arrest in healthy children. American Heart Journal 161(5): 1000-1006.e3, May 2011.

Aziz Peter F, Wieand Tammy S, Ganley Jamie, Henderson Jacqueline, Patel Akash R, Iyer V Ramesh, Vogel R Lee, McBride Michael, Vetter Victoria L, Shah Maully J: Genotype- and mutation site-specific QT adaptation during exercise, recovery, and postural changes in children with long-QT syndrome. Circulation. Arrhythmia and electrophysiology 4(6): 867-73, Dec 2011.


Ramesh Iyer V: Ventricular dysfunction: tachycardia induced cardiomyopathy. Indian pacing and electrophysiology journal 8(Suppl. 1): S122-9, 2008.

Ramesh Iyer V: Drug therapy considerations in arrhythmias in children. Indian pacing and electrophysiology journal 8(3): 202-10, 2008.


Moltedo Jose M, Iyer Ramesh V, Forman Howard, Fahey John, Rosenthal Geoffrey, Snyder Christopher S: Is exercise stress testing a cost-saving strategy for risk assessment of pediatric wolff-Parkinson-white syndrome patients? The Ochsner journal 6(2): 64-7, 2006.


Cohen M I, Vetter V L, Wernovsky G, Bush D M, Gaynor J W, Iyer V R, Spray T L, Tanel R E, Rhodes L A: Epicardial pacemaker implantation and follow-up in patients with a single ventricle after the Fontan operation. The Journal of thoracic and cardiovascular surgery 121(4): 804-11, Apr 2001.

L. Zhang, C. Franzini-Armstrong, V. Ramesh Iyer, and L. R. Jones.: Structural alterations in Cardiac Calcium Release Units resulting from overexpression of junctin   Journal of Molecular and Cellular Cardiology 33: 233-247, 2001.


VK Sharma, V. Ramesh, C. Franzini-Armstrong, S S Sheu: Transport of Ca from sarcoplasmic reticulum to mitochondria in rat ventricular myocytes. Bioenergetics Biomembrane 32: 97-104, 2000.


C. Franzini-Armstrong, V. Ramesh and F. Protasi: Shape, Size and distribution of Calcium Release units and couplons in Skeletal and Cardiac muscle  Biophys Journal 77: 1528-39, 1999.

M. I.  Cohen, J. William Gaynor, V. Ramesh Iyer, T. R. Karl, J. M. Steven, J. Posner, B. J. Clark, L. A. Rhodes: Extracorporeal Membrane Oxygenation for patients with refractory ventricular arrhythmias  The Journal of Thoracic and Cardiovascular Surgery 118: 961-63, 1999.

V. Ramesh, J. William Gaynor, M. J. Shah, T. S. Wieand, T. L. Spray, V. L. Vetter & L. A. Rhodes: Comparison of Left and Right atrial Epicardial pacing in patients with congenital heart disease"   Annals of Thoracic Surgery 68: 2314-19, 1999.


C. Franzini-Armstrong, F. Protasi & V. Ramesh: Comparative ultra structure of calcium release units in skeletal and cardiac muscle  Annals of NY Academy of Sciences "Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility 853: 341-345, 1998.

L. R. Jones, Y. J. Suzuki, W. Wang, Y. M. Kobayashi, V. Ramesh, C. F. Armstrong, L. Cleeman, M. Morad: Regulation of Ca 2+ signalling in transgenic mouse cardiac myocytes overexpressing calsequestrin    Journal of Clinical Investigation 101 (7): 1385-93, 1998.

V. Ramesh, V.K.Sharma, S-S Sheu & C. Franzini-Armstrong: Structural proximity of mitochondria to calcium release units in rat ventricular myocardium may suggest role in calcium sequestration    Annals of NY Academy of Sciences "Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility" Suppl 853: 20-31, 1998.


V. Ramesh, M.J. Kresch, A.M. Katz and D.H. Kim.: Characterization of calcium release channel receptors in fetal and adult rat myocardium.    Vol 269: H778-782 1995. American Journal of Physiology (Heart and Circulatory physiology) 269: H778-782, 1995.




Christopher M. Janson, Maully J. Shah, Kevin F. Kennedy, , V. Ramesh Iyer, Shashank Behere, Tammy L. Sweeten and Michael L. O'Byrne: Association of Weight with Ablation Outcomes in Pediatric Wolff-Parkinson-White Syndrome:_Analysis of the NCDR® IMPACT Registry American Heart Association Meeting November 2020.




Peter Aziz, J. William Gaynor, V. Ramesh Iyer: Surgical considerations for Pacemaker and ICD implantation. Book Chapter, Textbook of Pediatric Cardiac Surgery. Larry Kaiser MD, Irving Kron MD, Thomas L. Spray MD (eds.). Wolters Kluver, Lippincott Williams and Wilkins, 2013.


Camilla Londono-Obregon, Paul Farrel, Lisa Montenegro, V. Ramesh Iyer: Pediatric issues in CHD. Book Chapter, Textbook:  Pediatric Practice Cardiology. Marie Gleason MD, Jack Rychik MD,  Robert Shaddy MD (eds.). McGraw-Hill Companies, 2012.


Maully Shah, V. Ramesh Iyer: The Use of Ablation to Treat Arrhythmias in Children and Patients with Congenital Heart Disease. Book Chapter, Textbook of Electrophysiology disorders of Heart. Sanjiv Saksena MD and John Camm MD (eds.). Elsiever Health Sciences, 2011.


Christopher Snyder, M.D., V. Ramesh Iyer, M.D., Joshua Copel M.D.: Fetal Arrhythmias. Textbook of Obstetrics and Gynecology. Joshua Copel MD (eds.). Elsiever, 2004.


V. Ramesh Iyer MD: Supraventricular Tachycardia  Five minute Pediatric Consults. Mitchell Cohen MD, Victoria L Vetter MD (eds.). Williams & Wilkins, 1998.

Posters and Presentations


Clara Franzini-Armstrong and V. Ramesh Iyer: To Face or not to Face: Relationship of IP3 Receptors and Mitochondria in Purkinje Cells of Cerebellum. Biophysical Journal February 2020 Notes: Abstract presented at the Biophysical Society Meeting February 2020.


¹Manuela Lavorato, ²V. Ramesh Iyer, ¹Clara Franzini-Armstrong: Mitochondrial nanotunnels are specific to cardiac myocytes and are inducib. Abstract presented at the Gordon Conference- EC Coupling, Tuscanny, Italy 2019 May 2019.

Christopher M. Janson, MD, CEPS-P1, Maully J. Shah, MBBS, FHRS, CCDS, CEPS-P1, V. Ramesh Iyer, MD, MRCP1, Kevin F. Kennedy, MS2, Tammy L. Sweeten, MS1, Andrew C. Glatz, MD, MSCE1 and Michael L. O'Byrne, MD, MSCE1: Comparison Of Outcomes Of Pediatric Catheter Ablation Under General Anesthesia Versus Sedation: An Analysis Of Data From The IMPACT Registry. Abstract presented at Heart Rhythm Society May 2019.

Invited Lectures


V. Ramesh. Advance in management of SVT in children Pediatric Grand Rounds, Bumengrad Hospital, Bangkok, Thailand. June 2019.

Awards and Honors

2013, 2016-2017, Main Line Today Top Doctors
2013, Heart Rhythm Society, Fellowship award
2013, Royal College of Physicians, Edinburgh, Fellowship award
2005, McNeill Teaching Award for Resident Teaching, Connecticut Children's Hospital, University of Connecticut School of Medicine
1987, ST Achar Award for Best Research paper, University of Delhi

Editorial and Academic Positions

Editorial Positions

2015-present, Journal of Invasive Cardiology, Future of Medicine, Advisory Board
2014-present, Reviewer, Pacing and Clinical Electrophysiology
2013-present, Reviewer, Pediatrics, Journal of Invasive Cardiology
2012-present, Reviewer, Journal of Pediatrics
2010-present, Reviewer Heart Rhythm Journal, Journal of Interventional Electrophysiology

Academic and Institutional Committees

2015-present, CHOP Electrophysiology Quality Improvement (QI)committee
2015-present, Penn Global India Committee
2013-present, Examiner Committee, Royal College of Physicians, Edin,UK
2013-present, Cardiac Cath Lab Sedation Committee
2013-present, Faculty Senate Committee, Perelman School of Medicine
2011-present, Pediatric Cardiology Fellowship Selection Review Committee
2009-present, Pediatric Cardiology and Electrophysiology Fellowship Interview Committee
2009-present, Pediatric Cardiology Scholarship Oversight Committee

Leadership and Memberships

Memberships in Professional Organizations


2013-present, American Heart Association International Mentorship Programme
 - 2013-present, International Mentor Committee
1998-present, Royal College of Physicians
 - 2013-present, International Advisor, CME development
 - 2013-present, Examiner Committee


2014-present, Biophysical Society
2005-present, Heart Rhythm Society
 - 2012-present, Clinical Advisory Committee
 - 2001-present, Pediatric and Adult Congenital Electrophysiology Society