Cassie Kline, MD, MAS

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Cassie Kline, MD, MAS, is an attending physician and director of clinical research in the department of Neuro-Oncology at Children's Hospital of Philadelphia. 

Areas of Expertise: Pediatric Neuro-Oncology, Clinical research, Early phase clinical trials in neuro-oncology, Developmental therapeutics
Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Residency

Resident - Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA.

Fellowship

Fellow - Pediatric Hematology-Oncology, University of California, San Francisco, CA.

Board Certification

American Board of Pediatrics

Undergraduate Degree

BA - University of Virginia, Charlottesville, VA.

Graduate Degree

MD - University of California, San Diego, San Diego, CA.

MAS - University of California, San Francisco, San Francisco, CA.

Titles and Academic Titles

Assistant Professor

Attending Physician

Director, Clinical Research

The Kortney Rose Foundation Clinical Researcher in Neuro-Oncology

Departments and Services

Research Interests

Pediatric neuro-oncology, pediatric brain tumors, clinical trials, developmental therapeutics, pediatric hematology-oncology

Selected Publications

Peer Reviewed Publications:

2020

Ferris SP, Velazquez VJ, Aboian M, Lee JC, Ziffle JV, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruis-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA. High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication – a comprehensive clinical, radiographic, pathologic, and genomic analysis. Brain Pathol, 2020;30(1):46-62.

Mueller S, Kline C, Buerki RA, Chen Y, Yasui Y, Howell R, Oeffinger K, Leisenring W, Robison LL, Armstrong GT, Fullerton HJ, Krull KR. Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study. Cancer, 2020;126(5):1051-1059.

2019

Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon D. Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma. Acta Neuropathol, 2019;137(5):851-854.

Miklja Z, Pasternak A, Stallard S, Nicolaides T, Kline-Nunnally C, Cole B, Beroukhim R, Bandopadhayay P, Chi S, Ramkissoon SH, Mullan B, Bruzek AK, Gautheir A, Garcia T, Atchison C, Marini B, Fouladi M, Parsons DW, Leary S, Mueller S, Ligon KL, Koschmann C. Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations. Neuro Oncol, 2019, epub ahead of print.

Mueller S, Jain P, Liang WS, Kilburn L, Kline C, Gupta N, Panditharatna E, Magge SN, Zhang B, Zhu Y, Crawford JR, Banerjee A, Nazemi K, Packer RJ, Petritsch CK, Truffaux N, Roos A, Nasser S, Phillips JJ, Solomon D, Molinaro A, Waanders A, Byron SA, Berens ME, Kuhn J, Nazarian J, Prados M, Resnick A. A pilot precision medicine trial for children with diffuse intrinsic pontine glioma – PNOC003: a report from the Pacific Pediatric Neuro- Oncology Consortium. Int J Cancer, 2019;145(7):1889-1901.

Byer L, Kline CN, Abadi CC, Whitaker E, Allen IA, Mueller S. A systematic review and metaanalysis of outcomes in pediatric, recurrent ependymoma. J Neurooncol, 2019;144(3):445- 452.

Chi AS, Tarapore RS, Hall MD, Shonka N, Gardner S, Umemura Y, Sumral A, Khatib Z, Mueller S, Kline C, Zaky W, Khatua S, Weathers SP, Odia Y, Niazi TN, Daghistani D, Cherrick I, Korones D, Karajannis MA, Kong XT, Minturn J, Waanders A, Arillaga-Romany I, Batchelor T, Wen PY, Merdinger K, Schalop L, Stogniew M, Allen JE, Oster W, Mehta MP. Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201. J Neurooncol, 2019;145(1):97-105.

Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA. Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas. Acta Neuropathol. 2019 Nov;138(5):877-881.

Aboian MS, Tong E, Solomon DA, Kline C, Gautam A, Vardapetyan A, Tamrazi B, Li Y, Jordan CD, Felton E, Weinberg B, Braunstein S, Mueller S, Cha S. Diffusion characteristics of pediatric diffuse midline gliomas with histone H3-K27M mutation using apparent diffusion coefficient histogram analysis. Am J Neuroradiol, 2019;40(11):1804-1810.

Lavergne V, Sabnis A, Tulpule A, Davidson PR, Kline C, Matthay K, Nicolaides T, Goldsby R, Braunstein S, Fogh SE, Sneed PK, Menzel P, Nakamura A, DuBois SD, Haas-Kogan DA, Nakamura JL. Germline MUTYH mutation in a pediatric cancer survivor developing a secondary malignancy. J Pediatr Hematol Oncol, 2019, epub ahead of print. 

2018

Kline CN, Felton E, Allen IE, Tahir P, Mueller S. Survival outcomes of pediatric high-grade glioma: results of a 20-year systematic review and meta-analysis. J Neurooncol, 2018;137:103-110. 11. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, et al. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol, 2018;29(1):85-96.

Kline CN, Lui J, Duriseti S, Banerjee A, Nicolaides T, Raber S, Gupta N, Haas-Kogan D, Braunstein S, Mueller S. Reirradiation with and without PD-1 inhibition for diffuse intrinsic pontine glioma: a single-institution experience. J Neurooncol, 2018;140(3):629-638.

Barkovich MJ, Tan CH, Nillo RM, Li Y, Xu D, Glastonbury CM, Glenn OA, Dillon WP, Hess CP, Mueller S, Kline C, Dale AM, Jernigan TL, Sugrue LP, Barkovich AJ, Desikan RS. Abnormal morphology of select cortical and subcortical regions in neurofibromatosis type 1. Radiology, 2018;289(2):499-508.

Lopez GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. The genetic landscape of gliomas arising after therapeutic radiation. Acta Neuropathol, 2018;137(1):139-150.

Panditharatna E, Kilburn LB, Aboian MS, Kambhampati M, Gordish-Dressman H, Magge SN, Gupta N, Myseros J, Hwang EI, Kline C, Crawford J, Warren KE, Cha Soonmee, Liang WS, Berens M, Packer RJ, Resnick AC, Prados M, Mueller S, Nazarian J. Clinically relevant and minimally invasive tumor surveillance of pediatric diffuse midline gliomas using patient derived liquid biome. Clin Cancer Res, 2018;24(23):5850:5859.

Aboian MS, Kline CN, Li Y, Solomon DA, Banerjee A, Braunstein SE, Mueller S, Dillon WP, Cha S. Early detection of recurrent medulloblastoma: the critical role of diffusion-weighted imaging. Neurooncol Pract, 2018;5(4):234-240. 

2017

Endicott AA, Morimoto LM, Kline CN, Weimels JL, Metayer C, Walsh KM. Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents. Pediatr Blood Cancer. 2017 Jun;64(6).

Kline CN, Joseph N, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh D, Braunstein S, Torkildson J, Samuel D, Bloomer M, de Alba Campomanes A, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen D, Phillips J, Korn M, Yeh I, Bastian B, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon D. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic mutations, and directs targeted therapy. Neuro Oncol 2017;19(5):699-709.

Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Rafael C, Bandopadhayay P, Solomon DA, Aboian M, Cha S, Mueller S. Case based review: medulloblastoma. Neurooncol Pract 2017;4(3):138-150.

Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA. Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than the cerebral cortex. Acta Neuropathol, 2017;134(4):671-673. 

2016

Ferris SP, Goode B, Joseph NM, Kline CN, Samuel D, Gupta N, Bollen A, Perry A, Mueller S, Solomon DA. IDH1 mutation can be present in diffuse astrocytoma and giant cell glioblastomas of young children under 10 years of age. Acta Neuropathol 2016;132(1):153- 5.

Byer L, Kline CN, Mueller S. Clinical trials in pediatric neuro-oncology: what is missing and how we can improve. CNS Oncol 2016;5(4):233-9.

Publications

Papers

Letters to the Editor

2016

Kline CN, Joseph N, Grenert JP, van Ziffle J, Yeh, I, Bastian B, Mueller S, Solomon D. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol 2016;18(5):752-3.

Books

2019

Kline C, Banerjee A, Gupta N. Supratentorial Lobar Gliomas, In: Oncology of CNS Tumors. J-C Tonn et al, eds. Springer-Verlag Berline Heidelberg, 443-457, 2019.

2018

Kline C, Mueller S. Chemotherapy of Pediatric Low-grade Gliomas, In: Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy. H Newton, ed. Elsevier/Academic Press, 574-556, 2018.

2017

Kline C, Forester C, Banerjee A. Ependymoma, In: Pediatric CNS Tumors. N Gupta, A Banerjee, D Haas-Kogan, eds. Springer, 69-92, 2017.

Posters and Presentations

2019

Mueller S, Kline C, Kilburn L, Liang WS, Jain P, Gupta N, Panditharatna E, Nazemi K, Magge SN, Crawford JR, Banerjee A, Packer RJ, Roos A, Zhang B, Zhu Y, Aboian M, Phillips JJ, Solomon D, Molinaro A, Kuhn J, Byron SA, Nazarian J, Resnick A, Berens ME, Prados M. PNOC003: Clinical impact of a precision medicine strategy for children with diffuse intrinsic pontine glioma. Podium presentation at: Biennial Conference on Pediatric Neuro-Oncology Basic and Translational Research; San Francisco, CA. May 3- 4, 2019.

Autry AW, Park I, Chen HY, Gordon JW, Kline CN, Vigneron DB, Lupo J, Li Y, Xu D, Mueller S. Feasibility of hyperpolarized 13C metabolic imaging in pediatric patients with DIPG and other CNS cancers. Poster presentation at: Biennial Conference on Pediatric Neuro-Oncology Basic and Translational Research; San Francisco, CA. May 3-4, 2019.

Calixto-Hope L, Lee J, Sloan E, Hofmann J, van Ziffle J, Onodera C, Grenert JP, Devine P, Kline CN, Banerjee A, Clarke J, Taylor JW, Oberheim-Bush NA, Buerki R, Butowski NA, Chang SM, McDermott MW, Aghi MK, Theodosopoulos PV, Hervey-Jumper SL, Berger MS, Raffel C, Gupta N, Keinschmidt-DeMasters B, Wood M, Grafe M, Guo H, Sun P, Torkildson J, Cooney T, Fata C, Sharnhorst D, Samuel D, Bannykh S, Khatib Z, Maher O, Chamyan G, Pelaez L, Brathwaite C, Jin LW, Lechpammer M, Born D, Vogel H, Lee H, Phillips JJ, Pekmezci M, Bollen A, Tihan T, Perry A, Solomon D. Rosetteforming glioneuronal tumor is defined by FGFR1 activating alterations with frequent accompanying PI3K and MAPK pathway mutations. Poster presentation at: Society for Neuro-Oncology Annual Meeting; Phoenix, AZ. Nov 20-24, 2019.

Kline CN, Schoenfeld JD, Catalano PJ, Li J, Paccaly AJ, Sims TN, Bredlau A-L, Prados M, Haas-Kogan D, Mueller S. A phase 1 study of cempiplimab in pediatric patients with relapses or refractory (R/R) solid and central nervous system (CNS) tumors. Poster presentation at: Society for Neuro-Oncology Annual Meeting; Phoenix, AZ. Nov 20-24, 2019.

Zhang C, Ostrom QT, Hansen HM, de Smith A, Kline CN, Kruchko C, Vaksman Z, Diskin S, Barnholtz-Sloan JS, Ramaswamy V, Taylor M, Bondy ML, Metayer C, Wiemels J, Walsh KM. European genetric ancestry associated with risk of childhood ependymoma. Poster presentation at: Society for Neuro-Oncology Annual Meeting; Phoenix, AZ. Nov 20-24, 2019.

2018

Kline CN, Felton E, Byer L, Stoller S, Torkildson J, Gauvain K, Samuel D, Tong E, Liu J, Fullerton, Dubal D, Mueller S. ApoE4 as a genetic predictor for neurocognitive outcomes in pediatric brain tumor survivors. Podium presentation at: International Symposium on Pediatric Neuro-Oncology Meeting; Denver, CA. June 29-July 3, 2018.

Steino A, Zhai B, Yang X, Kline C, Bacha J, Brown D, Daugaard M, Mueller S. Dianhydrogalactitol (VAL-083) has the potential to overcome major challenges in the treatment of diffuse intrinsic pontine glioma (DIPG). Poster presentation at: Society for Neuro-Oncology Annual Meeting; New Orleans, LA. November 15-19, 2018.

2017

Kline CN, Morimoto LM, Weimels JL, Metayer C, Walsh KM. Pre- and perinatal factors associated with development of pediatric ependymoma: results of case-control analysis. Poster presentation at: Society for Neuro-Oncology Pediatric Neuro-Oncology Basic and Translational Research Conference; New York, NY. June 15-16, 2017.

Kline CN, Felton E, Allen IE, Tahir P, Mueller S. Survival outcomes of pediatric highgrade glioma: results of a 20-year systematic review and meta-analysis. Podium presentation at: Society for Neuro-Oncology Pediatric Neuro-Oncology Basic and Translational Research Conference; New York, NY. June 15-16, 2017.

Kline CN, Felton E, Allen IE, Tahir P, Mueller S. Survival outcomes of pediatric highgrade glioma: results of a 20-year systematic review and meta-analysis. eTalk presentation at: Society for Neuro-Oncology Annual Meeting; San Francisco, CA. November 16-19, 2017.

Kline CN, Felton E, Edwards C, Fullerton H, Torkildson J, Gauvain K, Samuel D, Mueller S. Genetic markers and clinical characteristics related to neurocognitive outcomes of pediatric brain tumor patients. Podium presentation at: Society for Neuro- Oncology Annual Meeting; San Francisco, CA. November 16-19, 2017.

Aboian M, Solomon D, Kline C, Vadapetyan A, Tong E, Li Y, Felton E, Braunstein S, Mueller S, Cha S. Diffusion characteristics of pediatric diffuse midline gliomas with histone H3K27M mutation using apparent diffusion coefficient histogram analysis. Poster presentation at: Society for Neuro-Oncology Annual Meeting; San Francisco, CA. November 16-19, 2017.

2016

Kline CN, Joseph N, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh D, Braunstein S, Torkildson J, Samuel D, Bloomer M, de Alba Campomanes A, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen D, Phillips J, Korn M, Yeh I, Bastian B, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon D. Upfront, real-time tumor and germline sequencing of pediatric brain tumor patients: the UCSF experience. Poster presentation at: International Symposium on Pediatric Neuro-Oncology, 17th Annual International Symposium;Liverpool, England. June 12-15, 2016.

Kline CN, Joseph N, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh D, Braunstein S, Torkildson J, Samuel D, Bloomer M, de Alba Campomanes A, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen D, Phillips J, Korn M, Yeh I, Bastian B, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon D. Molecular profiling using targeted next-generation sequencing in pediatric neuro-oncology patients: the UCSF experience. Poster presentation at: CAC2 Pediatric Cancer Research Conference; Cold SpringHarbor Laboratory, NY. October 31-November 1, 2016.

Kline C, Duriseti S, Banerjee A, Nicolaides T, Raber S, Gupta N, Haas-Kogan D, Braunstein S, Mueller S. Reirradiation for diffuse intrinsic pontine glioma: a single institution experience. Poster presentation at: Society for Neuro-Oncology 21st Annual Meeting;Scottsdale, AZ. November 17-20, 2016.

Awards and Honors

Cannonball Kids’ Cancer - Young Investigator Award

UCSF Clinical and Translational Science Institute Career Development Award

Cannonball Kids’ Cancer Clinical Research Grant

Foundation Funding - Clinical Research Grant

Frank A. Campini Foundation Grant

UCSF School of Medicine John A. Watson Faculty Scholar