Peter Kurre, MD

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Peter Kurre, MD, is Director of the Pediatric Comprehensive Bone Marrow Failure Center at Children's Hospital of Philadelphia.

Areas of Expertise: Bone marrow failure, Fanconi anemia, Stem cell gene therapy, Pediatric stem cell transplantation, Refractory cytopenias (myelodysplasia), Telomere disorders
Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


With extended training in pediatric hematology, oncology and stem cell transplantation, Dr. Kurre’s clinical work is focused on children with hematopoiesis failure (i.e., bone marrow failure) across a wide spectrum of inherited and acquired conditions that lead to loss of blood formation. As a physician-scientist, his clinical and scientific goals are directed at improving our understanding and broadening our treatment options for patients with bone marrow failure.

Dr. Kurre's clinical interests focus on diagnosis and treatment of bone marrow failure, specifically on improving diagnostic and therapeutic capabilities. Along with colleagues at other institutions, he is spearheading efforts to leverage molecular technologies toward the development of tests that improve diagnostic certainty and timeliness of genetic hematopoiesis failure conditions. Dr. Kurre’s laboratory has longstanding expertise in Fanconi anemia (FA), a rare inherited genetic condition with prominent hematologic complications. The long-term goal is to improve our understanding of the progressive hematopoietic failure that occurs in patients with FA. His other lab projects are focused on stem cell regulation by trafficking of extracellular vesicles in the bone marrow microenvironment.

Visit the Comprehensive Bone Marrow Failure Center research page for more information.

Education and Training

Medical School

MD - RWTH Aachen University, Aachen, Germany


Heinrich-Heine University, Düsseldorf, Germany


Heinrich-Heine University, Düsseldorf, Germany
University of Chicago, Chicago, IL


University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA

Board Certification

Pediatric Hematology-Oncology – American Board of Pediatrics

Titles and Academic Titles

Director, Pediatric Comprehensive Bone Marrow Failure Center

Buck Family Endowed Chair in Hematology

Conditions Treated

Departments and Services

Research Interests

  • Hematopoiesis failure in Fanconi anemia
  • Developmental hematopoiesis in bone marrow failure conditions
  • Hematopoietic stem cell biology
  • Stem cell gene therapy
  • Extracellular vesicle biology




Abdelhamed S, Butler JT, Doron B, Halse A, Nemecek E, Wilmarth PA, Marks DL, Chang BH, Horton T, Kurre P. Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche. EMBO Rep. 2019 Jun 17. pii: e47546. doi: 10.15252/embr.201847546. [Epub ahead of print]

Rogers ZR, Nakano TA, Olson TS, Bertuch AA4, Wang W, Gillio A, Coates TD, Chawla A, Castillo P, Kurre P Immunosuppressive Therapy for Pediatric Aplastic Anemia: A North American Pediatric Aplastic Anemia Consortium Study. Haematologica. 2019 Apr 4. pii: haematol.2018.206540. doi: 10.3324/haematol.2018.206540.

Doron B, Abdelhamed S, Butler JT, Hashmi SK, Horton TM, Kurre P. Transmissible ER stress shapes the leukemic microenvironment. Leukemia. 2019 Apr;33(4):918-930.


Doron Ben, Abdelhamed S, Butler JT, Hashmi SK, Horton TM, Kurre P. Transmissible ER stress reconfigures the AML bone marrow compartment. Leukemia. 2018 Sep 11. doi: 10.1038/s41375-018-0254-2. [Epub ahead of print]

Butler JT, Abdelhamed S, Kurre P. Extracellular vesicles in the hematopoietic microenvironment. Haematologica. 2018 Mar;103(3):382-394. doi: 10.3324/haematol.2017.183335. Epub 2018 Feb 8.


Goloviznina Natalya A, Verghese Santhosh Chakkaramakkil, Yoon Young Me, Taratula Oleh, Marks Daniel L, Kurre Peter: Mesenchymal stromal cell-derived extracellular vesicles promote myeloid-biased multipotent hematopoietic progenitor expansion via Toll-like receptor engagement. The Journal of biological chemistry 292(8): 3541, Feb 2017.


Yoon Young Me, Storm Kelsie J, Kamimae-Lanning Ashley N, Goloviznina Natalya A, Kurre Peter: Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(-/-) Hematopoietic Stem and Progenitor Cells. Stem cell reports 7(5): 840-853, Nov 2016. PMCID: PMC5106485

Goloviznina Natalya A, Verghese Santhosh Chakkaramakkil, Yoon Young Me, Taratula Oleh, Marks Daniel L, Kurre Peter: Mesenchymal Stromal Cell-derived Extracellular Vesicles Promote Myeloid-biased Multipotent Hematopoietic Progenitor Expansion via Toll-Like Receptor Engagement. The Journal of biological chemistry 291(47): 24607-24617, Nov 2016. PMCID: PMC5114412

Chakkaramakkil Verghese Santhosh, Goloviznina Natalya A, Kurre Peter: Phenotypic correction of Fanconi anemia cells in the murine bone marrow after carrier cell mediated delivery of lentiviral vector. Stem cell research & therapy 7(1): 170, Nov 2016. PMCID: PMC5116221

Hornick Noah I, Doron Ben, Abdelhamed Sherif, Huan Jianya, Harrington Christina A, Shen Rongkun, Cambronne Xiaolu A, Chakkaramakkil Verghese Santhosh, Kurre Peter: AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB. Science signaling 9(444): ra88, Sep 2016.

Viola Shelton, Traer Elie, Huan Jianya, Hornick Noah I, Tyner Jeffrey W, Agarwal Anupriya, Loriaux Marc, Johnstone Brian, Kurre Peter: Alterations in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance. British journal of haematology 172(6): 983-6, Mar 2016. PMCID: PMC4755922


Hornick Noah I, Huan Jianya, Doron Ben, Goloviznina Natalya A, Lapidus Jodi, Chang Bill H, Kurre Peter: Serum Exosome MicroRNA as a Minimally-Invasive Early Biomarker of AML. Scientific reports 5: 11295, Jun 2015. PMCID: PMC4650871

Geng Huimin, Hurtz Christian, Lenz Kyle B, Chen Zhengshan, Baumjohann Dirk, Thompson Sarah, Goloviznina Natalya A, Chen Wei-Yi, Huan Jianya, LaTocha Dorian, Ballabio Erica, Xiao Gang, Lee Jae-Woong, Deucher Anne, Qi Zhongxia, Park Eugene, Huang Chuanxin, Nahar Rahul, Kweon Soo-Mi, Shojaee Seyedmehdi, Chan Lai N, Yu Jingwei, Kornblau Steven M, Bijl Janetta J, Ye B Hilda, Ansel K Mark, Paietta Elisabeth, Melnick Ari, Hunger Stephen P, Kurre Peter, Tyner Jeffrey W, Loh Mignon L, Roeder Robert G, Druker Brian J, Burger Jan A, Milne Thomas A, Chang Bill H, Müschen Markus: Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer cell 27(3): 409-25, Mar 2015. PMCID: PMC4618684

Kamimae-Lanning Ashley N, Krasnow Stephanie M, Goloviznina Natalya A, Zhu Xinxia, Roth-Carter Quinn R, Levasseur Peter R, Jeng Sophia, McWeeney Shannon K, Kurre Peter, Marks Daniel L: Maternal high-fat diet and obesity compromise fetal hematopoiesis. Molecular metabolism 4(1): 25-38, Jan 2015. PMCID: PMC4314531


Gagne Katelyn E, Ghazvinian Roxanne, Yuan Daniel, Zon Rebecca L, Storm Kelsie, Mazur-Popinska Magdalena, Andolina Laura, Bubala Halina, Golebiowska Sydonia, Higman Meghan A, Kalwak Krzysztof, Kurre Peter, Matysiak Michal, Niewiadomska Edyta, Pels Salley, Petruzzi Mary Jane, Pobudejska-Pieniazek Aneta, Szczepanski Tomasz, Fleming Mark D, Gazda Hanna T, Agarwal Suneet: Pearson marrow pancreas syndrome in patients suspected to have Diamond-Blackfan anemia. Blood 124(3): 437-40, Jul 2014. PMCID: PMC4102714

Verghese Santhosh Chakkaramakkil, Goloviznina Natalya A, Skinner Amy M, Lipps Hans J, Kurre Peter: S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection. Nucleic acids research 42(7): e53, Apr 2014. PMCID: PMC3985655


Skinner Amy M, Chakkaramakkil Verghese Santhosh, Kurre Peter: Cell-cell transmission of VSV-G pseudotyped lentivector particles. PloS one 8(9): e74925, 2013. PMCID: PMC3769293

Sutton Kathryn S, Shereck Evan B, Nemecek Eneida R, Kurre Peter: Immune markers of disease severity and treatment response in pediatric acquired aplastic anemia. Pediatric blood & cancer 60(3): 455-60, Mar 2013.

Kamimae-Lanning Ashley N, Goloviznina Natalya A, Kurre Peter: Fetal origins of hematopoietic failure in a murine model of Fanconi anemia. Blood 121(11): 2008-12, Mar 2013. PMCID: PMC3645055

Huan Jianya, Hornick Noah I, Shurtleff Matthew J, Skinner Amy M, Goloviznina Natalya A, Roberts Charles T, Kurre Peter: RNA trafficking by acute myelogenous leukemia exosomes. Cancer research 73(2): 918-29, Jan 2013.


Skinner Amy M, Grompe Markus, Kurre Peter: Intra-hematopoietic cell fusion as a source of somatic variation in the hematopoietic system. Journal of cell science 125(Pt 12): 2837-43, Jun 2012. PMCID: PMC3434805

Russell Thomas B, Skinner Amy M, Kurre Peter: Programmed vesicle transfer of green fluorescent protein from a stably transduced cell line to primary hematopoietic cells. Blood 119(22): 5330-2, May 2012.


Russell Thomas B, Kurre Peter: Double-negative T cells are non-ALPS-specific markers of immune dysregulation found in patients with aplastic anemia. Blood 116(23): 5072-3, Dec 2010.

O'Neill Lee S, Skinner Amy M, Woodward Josha A, Kurre Peter: Entry kinetics and cell-cell transmission of surface-bound retroviral vector particles. The journal of gene medicine 12(5): 463-76, May 2010. PMCID: PMC2864923


De Mola Rebecca Loret, Kurre Peter: MRI findings in aplastic anemia. American journal of hematology 84(11): 754, Nov 2009.

Zhang Zili, Zhong Wenwei, Hall Mark J, Kurre Peter, Spencer Doran, Skinner Amy, O'Neill Stacy, Xia Zhenwei, Rosenbaum James T: CXCR4 but not CXCR7 is mainly implicated in ocular leukocyte trafficking during ovalbumin-induced acute uveitis. Experimental eye research 89(4): 522-31, Oct 2009. PMCID: PMC2745349

Skinner Amy M, O'Neill S Lee, Kurre Peter: Cellular microvesicle pathways can be targeted to transfer genetic information between non-immune cells. PloS one 4(7): e6219, Jul 2009. PMCID: PMC2704871

Pan Yung-Wei, Kurre Peter: Avoiding lentiviral transduction culture induced MSC senescence. Journal of cellular and molecular medicine 13(6): 1186-7, Jun 2009. PMCID: PMC4496114

O'Neill Lee, Skinner Amy M, Kurre Peter: Is hematopoietic stem cell homing deficient in Fanconi anemia? Blood 113(21): 5361; author reply 5362, May 2009. PMCID: PMC2686198

Anur Praveen, Nemecek Eneida R, Kurre Peter: The evolving spectrum of 'non-classical' Diamond-Blackfan anaemia -- a case of eADA positive pancytopenia in a young adult. British journal of haematology 145(3): 428-30, May 2009.


Chatham-Stephens Kevin, Devere Theresa, Guzman-Cottrill Judith, Kurre Peter: Metachronous manifestations of Sweet's syndrome in a neutropenic patient with Fanconi anemia. Pediatric blood & cancer 51(1): 128-30, Jul 2008.

Skinner Amy M, O'Neill S Lee, Grompe Markus, Kurre Peter: CXCR4 induction in hematopoietic progenitor cells from Fanca(-/-), -c(-/-), and -d2(-/-) mice. Experimental hematology 36(3): 273-82, Mar 2008. PMCID: PMC2335150


Harkey Michael A, Kaul Rajinder, Jacobs Michael A, Kurre Peter, Bovee Don, Levy Ruth, Blau C Anthony: Multiarm high-throughput integration site detection: limitations of LAM-PCR technology and optimization for clonal analysis. Stem cells and development 16(3): 381-92, Jun 2007.

Pan Yung-Wei, Scarlett Jarrad M, Luoh Tammy T, Kurre Peter: Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo. Journal of virology 81(2): 639-49, Jan 2007. PMCID: PMC1797443


Platzbecker Uwe, Kurre Peter, Guardiola Philippe, Ward Jessica L, Radich Jerald P, Kiem Hans-Peter, Deeg H Joachim: Fanconi anemia type C-deficient hematopoietic cells are resistant to TRAIL (TNF-related apoptosis-inducing ligand)-induced cleavage of pro-caspase-8. Experimental hematology 32(9): 815-21, Sep 2004.

Kurre Peter, Anandakumar Ponni, Harkey Michael A, Thomasson Bobbie, Kiem Hans-Peter: Efficient marking of murine long-term repopulating stem cells targeting unseparated marrow cells at low lentiviral vector particle concentration. Molecular therapy : the journal of the American Society of Gene Therapy 9(6): 914-22, Jun 2004.


Kurre Peter, Morris Julia, Thomasson Bobbie, Kohn Donald B, Kiem Hans-Peter: Scaffold attachment region-containing retrovirus vectors improve long-term proviral expression after transplantation of GFP-modified CD34+ baboon repopulating cells. Blood 102(9): 3117-9, Nov 2003.

Guardiola Philippe, Kurre Peter, Vlad Amalia, Cayuela Jean-Michel, Espérou Hélène, Devergie Agnès, Ribaud Patricia, Socié Gérard, Richard Patrice, Traineau Richard, Storb Rainer, Gluckman Eliane: Effective graft-versus-leukaemia effect after allogeneic stem cell transplantation using reduced-intensity preparative regimens in Fanconi anaemia patients with myelodysplastic syndrome or acute myeloid leukaemia. British journal of haematology 122(5): 806-9, Sep 2003.

Kurre Peter, Pulsipher Michael, Woolfrey Ann, Maris Michael, Sandmaier Brenda, Kiem Hans-Peter, Storb Rainier: Reduced toxicity and prompt engraftment after minimal conditioning of a patient with Fanconi anemia undergoing hematopoietic stem cell transplantation from an HLA-matched unrelated donor. Journal of pediatric hematology/oncology 25(7): 581-3, Jul 2003.


Kurre Peter, Anandakumar Ponni, Grompe Markus, Kiem Hans Peter: In vivo administration of interferon gamma does not cause marrow aplasia in mice with a targeted disruption of FANCC. Experimental hematology 30(11): 1257-62, Nov 2002.

Kurre Peter, Morris Julia, Andrews Robert G, Kohn Donald B, Kiem Hans-Peter: Kinetics of fluorescence expression in nonhuman primates transplanted with GFP retrovirus-modified CD34 cells. Molecular therapy : the journal of the American Society of Gene Therapy 6(1): 83-90, Jul 2002.

Kiem Hans-Peter, Rasko John E J, Morris Julia, Peterson Laura, Kurre Peter, Andrews Robert G: Ex vivo selection for oncoretrovirally transduced green fluorescent protein-expressing CD34-enriched cells increases short-term engraftment of transduced cells in baboons. Human gene therapy 13(8): 891-9, May 2002.



Sherif Abdelhamed, Noah Hornick, Young me Yoon Jeff Tyner, Bill Chang, Kurre Peter: Extracellular vesicles contribute to the erosion of hematopoietic function in the AML niche. Second Scientific Workshop on The Tumour Environment in Haematological Malignancies April 2017.


Young Me Yoon, Natalya A Goloviznina, John Butler, Santhosh Chakkaramakkil Verghese, Kurre Peter: TLR Activation By MSC Derived Extracellular Vesicles Drives Myeloid Commitment. 2016 Annual meeting of the American Society of Hematology December 2016.

Sherif Abdelhamed, Noah I Hornick, Kurre Peter: Residual HSPC in the Leukemia Microenvironment Are Reprogrammed Via Extracellular Vesicle Trafficking.  2016 Annual meeting of the American Society of Hematology December 2016.

Santhosh Chakkaramakkil Verghese, John Butler, Natalya A. Goloviznina, Helmut Hanenberg, Kurre Peter: Phenotypic reversion in Fanconi Anemia by a mitotically stable, anchored non-integrating lentiviral vector. Annual Scientific Symposium, Fanconi Anmeia Research Foundation September 2016.

Katherine Michaelis, Pete Levasseur, Xinxia Zhu, Kevin G. Burfeind, Santhosh Chakkaramakkil Verghese, Kurre Peter: Tumor-Derived Extracellular Vesicles as Centrally Acting Endocrine Mediators of Pancreatic Cancer Cachexia.  Gordon Research Conference August 2016.

Young me Yoon, N. Goloviznina, Santhosh Chakkaramakkil Verghese, Kurre Peter: TLR-4 engagement by MSC derived extracellular vesicles drives canonical inflammatory signaling and expansion of HSPC. EMBO EMBO | EMBL Symposium:  June 2016.

Sherif Abdelhamed, Noah Hornick, Ben Doron, Young me Yoon, Kurre Peter : Epigenetic Dysregulation of Hematopoietic Stem Cell Function by Extracellular Vesicle (EV) Trafficking in the Leukemia Microenvironment. Annual Meeting of the International Society for Extracellular Vesicles May 2016.

Ben Doron, Noah I. Hornick, Sherif Abdelhamed, Kurre Peter: A comprehensive approach to resolve the cellular targets of miRNA trafficking in the leukemic niche.  EMBO EMBO | EMBL Symposium: Tumour Microenvironment and Signalling April 2016.

Sherif Abdelhamed, Noah Hornick, Ben Doron, Young me Yoo, Kurre Peter: Extracellular Vesicle (EV) Trafficking in the Leukemia Microenvironment Differentially Modulates the Fate of Residual Hematopoietic Stem and Progenitor Cells. Keystone Meeting on hematopoiesis February 2016.

Ben Doron, Noah I. Hornick, Jianya Huan, Kurre Peter: Systemic trafficking of leukemia-derived extracellular vesicles impairs hematopoiesis through miRNA action on c-Myb. Keystone Conference on Tumor Microenvironment. February 2016.

Awards and Honors

2018, Hyundai Scholar, Hyundai 'Hope on Wheels' Foundation
2014-2017, Hyundai Scholar, Hyundai 'Hope on Wheels' Foundation
2012, Hyundai Scholar, Hyundai 'Hope on Wheels' Foundation
2009, Judge, American Biomedical Research Conference for Minority Students Phoenix, Travel Award
2005, Moderator, Simultaneous Session, American Society of Hematology,  47th Annual Meeting, 2005, Atlanta, GA
2000, Travel Award, American Society of Hematology, 42nd Annual Meeting
1999, Travel Award, American Society of Hematology, 41st Annual Meeting
1998, Travel Award, American Society of Hematology, 40th Annual Meeting
1995, Association of Medical School Pediatric Department Chairs, Inc. (AMSPDC) Frontiers in Science Program, Annual Meeting, invited housestaff (1/69)
1993, Doctoral Thesis: Urea Kinetic Modeling in End Stage Renal Disease

Editorial and Academic Positions

Editorial Positions

2017, Editorial Board, Current Stem Cell Reports
2017-present, Editorial Board, Scientific Reports (Nature Publishing)

Leadership and Memberships

Memberships in Professional Organizations 


2013-present, North American Pediatric Aplastic Anemia Consortium
 - 2017-present, Executive Committee
 - 2013-present, Steering Committee
2011-present, International Society for Extracellular Vesicles


2003-present, American Society of Pediatric Hematology Oncology
2001-present, American Society of Hematology