Kimberly Y. Lin, MD

Papers

2020

Ritter A, Bedoukian E, Berger JH, Copenheaver D, Gray C, Krantz I, Izumi K, Juusola J, Leonard J, Lin K, Medne L, Santani A, Skraban C, Yang S, Ahrens-Nicklas RC: Clinical Utility of Exome Sequencing in Infantile Heart Failure. Genetics in Medicine 22(2): 423-426, February 2020.

Nandi D, Chin C, Schumacher KR, Fenton M, Singh RK, Lin KY, Conway J, Cantor RS, Koehl DA, Lamour JM, Kirklin JK, Pahl E: Surveillance for cardiac allograft vasculopathy: Practice variations among 50 pediatric heart transplant centers. Journal of Heart and Lung Transplantation 39(11): 1260-69, November 2020.

Burstein DS, Gaynor JW, Griffis H, Ritter A, OʼConnor MJ, Rossano JW, Lin KY, Ahrens-Nicklas RC  : Genetic variant burden and adverse outcomes in pediatric cardiomyopathy  Pediatric Research 2020 Notes: Epub ahead of print, August 3, 2020.

2019

Burstein DS, Li Y, Getz KD, Huang YV, Rossano JW, O'Connor MJ, Lin KY, Aplenc R: Mortality, Resource Utilization And Inpatient Costs Vary Among Pediatric Heart Transplant Indications: A Merged Data Set Analysis From The United Network For Organ Sharing And The Pediatric Health Information Systems (UNOS-PHIS) Databases. Journal of Cardiac Failure 25(1): 28-35, January 2019.

Schumacher KR, SunkyungYu, Butts R, Castleberry C, Chen S, Edens E, Godown J, Johnson J, Kemna M, Lin K, Lowery R, Simpson K, West S, Wilmot I, Gossett JG: Fontan-associated protein-losing enteropathy and postâ€'heart transplant outcomes: A multicenter study. Journal of Heart and Lung Transplantation 31(1): 17-25, January 2019.

Burstein DS, Shamszad P, Dai D, Almond CS, Price JF, Lin KY, O'Connor MJ, Shaddy RE, Mascio CE, Rossano JW: Significant mortality, morbidity and resource utilization associated with advanced heart failure in congenital heart disease in children and young adults. American Heart Journal 209: 9-19, March 2019.

White BR, Katcoff H, Faerber JA, Lin KY, Rossano JW, Mercer-Rosa L, O'Connor MJ: Echocardiographic Assessment of Right Ventricular Function in Clinically Well Pediatric Heart Transplantation Patients and Comparison With Normal Control Subjects. Journal of the American Society of Echocardiography 32(4): 537-544, April 2019.

Lipshultz SE, Law YM, Asante-Korang A, Austin ED, Dipchand AI, Everitt MD, Hsu DT, Lin KY, Price JF, Wilkinson JD, Colan SD; American Heart Association Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; and Council on Genomic and Precision Medicine.: Cardiomyopathy in Children: Classification and Diagnosis: A Scientific Statement From the American Heart Association. Circulation 140(1): e9-e68, July 2019.

Ahrens-Nicklas RC, Pappas CT, Farman GP, Mayfield RM, Larrinaga TM, Medne L, Ritter A, Krantz ID, Murali C, Lin KY, Berger JH, Yum SW, Carreon CK, and Gregorio CC: Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: a novel mechanism of neonatal dilated cardiomyopathy    Science Advances 5(9): eaax2066, September 2019.

Edwards JJ, Seliktar N, White R, Heron SD, Lin K, Rossano J, Monos D,  Sesok-Pizzini D, O'Connor MJ: Impact and Predictors of Positive Response to Desensitization in Pediatric Heart Transplant Candidates. Journal of Heart Lung Transplantation 38(11): 1206-1213, November 2019.

Lebo CA, Lin KY, Rossano JW: Real-world continuous physiologic monitoring in paediatric cardiomyopathy patients: a safety and feasibility study. Cardiology in the Young 29(11): 1400-1401, November 2019.

Axelsson Raja A, Shi L, Day SM, Russell M, Zahka K, Lever H, Colan SD,  Margossian R, Hall EK, Becker J, Jefferies JL, Patel A, Choudhury L, Murphy AM, Canter C, Bach R, Taylor M, Mestroni L, Wheeler MT, Benson L, Owens AT, Rossano J, Lin KY, Pahl E, Pereira AC, Bundgaard H, Lewis GD, Vargas J, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E, Ho CY: Baseline characteristics of the Valsartan for Attenuating Disease Evolution in Early Sarcomeric Hypertrophic Cardiomyopathy cohort. Circulation: Heart Failure 12(12): e006231, December 2019.

2018

Mejia EJ, O'Connor MJ, Lin KY, Song L, Griffis H, Mascio CE, Shamszad P, Donoghue A, Ravishankar C, Shaddy RE, Rossano JW: Characteristics and Outcomes of Pediatric Heart Failure Related Emergency Department Visits in the United States: A Population-Based Study. Journal of Pediatrics  193: 114-118, Feb 2018.

O'Connor MJ, Miller KD, Shaddy RE, Lin KY, Hanna BD, Ravishankar C, Rossano JW: Disopyramide Use in Infants and Children with Hypertrophic Cardiomyopathy. Cardiology in the Young 28(4): 530-535, April 2018.

Rossano JW, Cantor RS, Dai D, Shamszad P, Huang YS, Hall M, Lin KY, Edens RE, Parrino PE, Kirklin JK: Resource Utilization in Pediatric Patients Supported With Ventricular Assist Devices in the United States: A Multicenter Study From the Pediatric Interagency Registry for Mechanically Assisted Circulatory Support and the Pediatric Health Information System. Journal of the American Heart Association 7(11): e008380, June 2018.

Mahle WT, Hu C, Trachtenberg F, Menteer J, Kindel SJ, Dipchand AI, Richmond ME, Daly KP, Henderson HT, Lin KY, McCulloch M, Lal AK, Schumacher KR, Jacobs JP, Atz AM, Villa CR, Burns KM, Newburger JW; Pediatric Heart Network Investigators.: Heart failure after the Norwood procedure: An analysis of the Single Ventricle Reconstruction Trial. J Heart Lung Transplant 37(7): 879-885, July 2018.

Welch GD, Lin KY, Fisher MJ, Hill-Kayser CE: Cardiac Toxicity after Craniospinal Irradiation: A Late Effect that May be Eliminated with Proton Therapy. Journal of Pediatric Hematology and Oncology 40(5): e330-e333, July 2018.

Burstein DS, Maude S, Grupp S, Griffis H, Rossano J, Lin K: Cardiac Profile of Chimeric Antigen Receptor T Cell Therapy in Children: A Single-Institution Experience. Biology of Blood and Marrow Transplant 24(8): 1590-1595, August 2018.

Butto A, Rossano JW, Nandi D, Ravishankar C, Lin KY, O'Connor MJ, Shaddy RE, Shamszad P.: Elevated Troponin in the First 72 Hours of Hospitalization for Pediatric Viral Myocarditis is Associated with ECMO: an Analysis of the PHIS+ Database Pediatric Cardiology. Pediatric Cardiology 39(6): 1139-1143, August 2018.

O'Connor MJ, Glatz AC, Rossano JW, Shaddy RE, Ryan R, Ravishankar C, Fuller S, Mascio CE, Gaynor JW, Lin KY: Cumulative Effect of Preoperative Risk Factors on Mortality after Pediatric Heart Transplantation. Annals of Thoracic Surgery 106(2): 561-566, August 2018.

Edelson JB, Rossano JW, Griffis H, Dai D, Faerber J, Ravishankar C, Mascio CE, Mercer-Rosa LM, Glatz AC, Lin KY: Emergency Department Visits by Children With Congenital Heart Disease Journal of the American College of Cardiology 72(15): 1817-1825, October 2018.

2017

McCormick A, Shinnick J, Schadt K, Rodriguez R, Addonizio L, Hirano M, Perlman S, Lin KY, Lynch DR: Cardiac transplantation in Friedreich Ataxia: Extended follow up. Journal of the Neurological Sciences 375: 471-473, April 2017.

Wittlieb-Weber CA, Rossano JW, Weber DR, Lin KY, Ravishankar C, Mascio CE, Shaddy RE, O'Connor MJ: Emergency department utilization in pediatric heart transplant recipients. Pediatric Transplantation 21(4): doi: 10.1111, June 2017.

Keeshan BC, O'Connor MJ, Lin KY, Monos D, Lind C, Mascio CE, Rame JE, Spray TL, Shaddy RE, Rossano JW: Value of a flow cytometry crossmatch in the setting of a negative complement-dependent cytotoxicity crossmatch in heart transplant recipients. Clinical Transplantation 31(10): doi: 10.1111, October 2017.

2016

Nandi D, Lin KY, O'Connor MJ, Elci OU, Kim JJ, Decker JA, Price JF, Zafar F, Morales DL, Denfield SW, Dreyer WJ, Jefferies JL, Rossano JW: Hospital Charges for Pediatric Heart Failure-Related Hospitalizations from 2000 to 2009. Pediatric Cardiology 37(3): 512-8, March 2016.

2015

Wittlieb-Weber CA, Lin KY, Zaoutis TE, O'Connor MJ, Gerald K, Paridon SM, Shaddy RE, Rossano JW: Pediatric versus adult cardiomyopathy and heart failure-related hospitalizations: a value-based analysis. Journal of Cardiac Failure 21(1): 76-82, Jan 2015.

Mansfield RT, Lin KY, Zaoutis T, Mott AR, Mohamad Z, Luan X, Kaufman BD, Ravishankar C, Gaynor JW, Shaddy RE, Rossano JW: The Use of Pediatric Ventricular Assist Devices in Children's Hospitals From 2000 to 2010: Morbidity, Mortality, and Hospital Charges. Pediatric Critical Care Medicine 16(6): 522-8, Jul 2015.

O'Connor MJ, Keeshan BC, Lin KY, Monos D, Lind C, Paridon SM, Mascio CE, Shaddy RE, Rossano JW: Changes in the methodology of pre-heart transplant human leukocyte antibody assessment: an analysis of the United Network for Organ Sharing database. Clinical Transplantation 29(9): 842-50, Sep 2015.

Savla J*, Lin KY*, Pradhan M, Ruebner RL, Rogers RS, Haskins SS, Owens AT, Abt P, Gaynor JW, Shaddy RE, Rossano JW. *co-first authors: Heart retransplant recipients have better survival with concurrent kidney transplant than with heart retransplant alone. J Am Heart Assoc 4(12): e002435, December 2015.

2014

Keeshan BC, Goldfarb SB, Lin KY, Kreindler JL, Kaufman BD, Gaynor JW, Shaddy RE, Rossano JW.: Impact of congenital heart disease on outcomes of pediatric heart-lung transplantation. Pediatric Transplantation 18(2): 204-10, Mar 2014.

Rhee E, Hurst R, Pukenas B, Ichord R, Cahill AM, Rossano J, Fuller S, Lin K.: Mechanical embolectomy for ischemic stroke in a pediatric ventricular assist device patient. Pediatric Transplantation 18(3): E88-92, May 2014.

Savla J, Lin KY, Lefkowitz DS, Paridon SM, William Gaynor J, Hammond R, Shaddy RE, Rossano JW: Adolescent age and heart transplantation outcomes in myocarditis or congenital heart disease. Journal of Heart and Lung Transplantation 33(9): 943-9, Sep 2014.

Lin KY, Kerur B, Witmer CM, Beslow LA, Licht DJ, Ichord RN, Kaufman BD: Thrombotic events in critically ill children with myocarditis. Cardiology in the Young 24(5): 840-847, Oct 2014.

Lin KY, Furth SL, Schwartz GJ, Shaddy RE, Ruebner RL: Renal function assessment in child and adolescent heart transplant recipients during routine cardiac catheterization. Pediatric Transplantation 18(7): 757-63, Nov 2014.

2013

Lin KY, D'Alessandro LCA, Goldmuntz E: Genetic testing in congenital heart disease: Ethical considerations. World Journal for Pediatric and Congenital Heart Surgery  4(1): 53-57, Jan 2013.

Friedman LS, Schadt KA, Regner SR, Mark GE, Lin KY, Sciascia T, St John Sutton M, Willi S, and Lynch DR: Elevation of serum cardiac troponin I in asymptomatic subjects with Friedreich ataxia. International Journal of Cardiology 167(4): 1622-4, Aug 2013.

Rossano JW, Lin KY, Paridon SM, Zhang X, Gaynor JW, Kaufman BD, Shaddy RE: Pediatric heart transplantation from donors with depressed ventricular function: An analysis of the United Network of Organ Sharing database. Circulation: Heart Failure 6(6): 1223-9, Nov 2013.

2012

Schadt KA, Friedman LS, Regner SR, Mark GE, Lynch DR, Lin KY: Cross-Sectional Analysis of Electrocardiograms in a Large Heterogeneous Cohort of Friedreich Ataxia Subjects. J Child Neurology  27(9): 1187-1192, Sep 2012.

Kaczorowski DJ, Sathanandam S, Ravishankar C, Gillespie MJ, Montenegro LM, Gruber PJ, Spray TL, Gaynor JW, and Lin KY: Coronary ostioplasty for congenital atresia of the left main coronary artery ostium. Annals of Thoracic Surgery 94(4): 1307-1310, Oct 2012.

2011

Lin KY, Sullivan P, Salam A, Kaufman B, Paridon S, Hanna B, Spray T, Weber J, and Shaddy R: Troponin I levels from donors accepted for pediatric heart transplantation do not predict graft survival. Journal of Heart and Lung Transplantation  30(8): 920-927, Aug 2011.

2008

Cotts T, Goldberg C, Palma Davis L, DuRussel-Weston J, Lin K, Eagle K: A school-based health education program can improve cholesterol values for middle school students. Pediatric Cardiology 29(5): 940-945, Sep 2008.

2003

Yee KC, Mukherjee D, Smith DE, Kline-Rogers EM, Fang J, Mehta RH, Almanaseer Y, Akhras E, Cooper JV, and Eagle KE: Prognostic significance of an elevated creatine kinase in the absence of an elevated troponin I during an acute coronary syndrome. American Journal of Cardiology 92(12): 1442-1444, Dec 2003.

Abstracts

2020

Matesanz SE, Edelson JB, Iacobellis KA, Mejia E, Brandsema JF, Griffis H, Okunowo O, Lin KY: Characteristics of Health-care Users in Pediatric Patients with Muscular Dystrophy in the United States. Abstract accepted for the Muscular Dystrophy Association Annual Meeting March 2020.

Mejia E, Edelson JB, Iacobellis KA, Matesanz SE, Brandsema J, Griffis H, Okunowo O, Lin KY: Healthcare Utilization of Cardiac Specialty Care in Pediatric Patients with Muscular Dystrophy in the United States. Abstract accepted for the Muscular Dystrophy Association Annual Meeting March 2020.

Edelson JB, Edwards JJ, Katcoff H, Mondal A, Reza N, Mazurek JA, Wald J, Griffis H, Burstein DS, Rossano JW, Lin KY, Birati EY: Epidemiology of Patients with Ventricular Assist Devices Presenting to the Emergency Room from 2006-2014. Abstract accepted for the International Society for Heart and Lung Transplantation Annual Meeting, published in JHLT 39(4): S334, April 2020.

Edelson JB, Edwards JJ, Katcoff H, Mondal A, Reza N, Mazurek JA, Wald J, Griffis H, O'Connor MJ, Rossano JW, Lin KY, Birati EY: Comparing Resource Use and Outcomes between Patients with Ventricular Assist Devices and Orthotopic Heart Transplant in the United States from 2006-2014: A Nationally Representative Sample of Emergency Department Visits. Abstract accepted for the International Society for Heart and Lung Transplantation Annual Meeting, published in JHLT 39(4): S151, April 2020.

Edwards JJ, Edelson JB, Katcoff H, Mondal A, Reza N, Griffis H, Mazurek JA, Wald J, Lin KY, Birati EY: Impact of Hemocompatibility on Emergency Resource Utilization in Ventricular Assist Device Patients. Abstract accepted for the International Society for Heart and Lung Transplantation Annual Meeting, published in JHLT 39(4): S49, April 2020.

Edwards JJ, Edelson JB, Katcoff H, Mondal A, Reza N, Griffis H, Ravishankar C, Rossano J, Lin KY, Birati EY: Age-Dependent Emergency Department Resource Utilization in Patients with a Ventricular Assist Device. Abstract accepted for the International Society for Heart and Lung Transplantation Annual Meeting, published in JHLT 39(4): S465, April 2020.

Kemna MS, Shaw D, Ameduri R, Azeka E, Bradford T, Jorgensen N, Lin KY, Menteer J, Moller T, Reardon L, Schumacher K, Shih R, Stendahl G, West S, Wisotzkey B, Zangwill S: Posterior Reversible Encephalopathy Syndrome (PRES) after Pediatric Heart Transplantation: A Multicenter Study. Abstract accepted for the International Society for Heart and Lung Transplantation Annual Meeting, published in JHLT 39(4): S66-67, April 2020.

O'Connor MJ, Restaino K, Burstein DS, Rossano JW, Mascio CE, Lin KY: Temporal Trends in Financing of Pediatric Heart Transplantation in the United States. Abstract accepted for the International Society for Heart and Lung Transplantation Annual Meeting, published in JHLT 39(4): S453, April  2020.

Books

Chapters

2016

Lin KY and Rossano JW: Dilated Cardiomyopathy. Moss and Adams' Heart Disease in Infants, Children, and Adolescents (Ninth Edition). Allen HD, Shaddy RE, Penny DJ, Feltes TF, Cetta F (eds.). Wolters Kluwer, Page: 1283-1296, 2016.

2014

Rossano JW and Lin KY: Cardiomyopathies. Congenital Heart Disease. Moodie, D (eds.). Cardiotext Publishing, Minneapolis, 2014.

2013

Beslow L, Lin KY, Licht D : Neurologic Complications of Cardiac Surgery, Heart Failure, and Congenital Heart Disease. Pediatric Neurocritical Care. Abend N and Helfaer M (eds.). Demos Medical, New York, Page: 419-430, 2013.

2012

Lin KY, Bernadzikowski T, Walker S, Hanna B, and Kaufman B: Heart Failure, Cardiomyopathy, and Pulmonary Hypertension. Pediatric Practice Cardiology. Gleason MM, Rychik J, and Shaddy RE (eds.). McGraw-Hill Companies, New York, Page: 249-264, 2012.

2011

Lin KY and Shaddy RE: Diagnosis and management of the child with chronic heart failure and congenital heart disease. Heart Failure in Congenital Heart Disease. Shaddy RE (eds.). Springer-Verlag Publishers, London, 2011.

2000

Yee KC  : Bertha Van Hoosen  Know Thy Place: A Victor Vaughn Society Publication. Schimpf, M (eds.). Victor Vaughn Society, Ann Arbor, MI, Page: 121-122, 2000.

Posters and Presentations

2019

Burstein D, Shah M, Delgrasso J, Rossano J, O'Connor M, Lin K, McBride M, Paridon S: Low Utility of Nuclear Perfusion Exercise Stress Testing for Detecting Graft Vasculopathy in Children after Heart Transplantation. Poster presentation at the International Society for Heart Lung Transplantation Annual Meeting, Orlando, Florida April 2019.

Burstein DS, Dori Y, Smith C, Pinto E, Lin KY, Rossano JW, O'Connor MJ: Successful Percutaneous Lymphatic Intervention for Chylothorax after Pediatric Heart Transplantation. Poster presentation at the International Society for Heart Lung Transplantation Annual Meeting, Orlando, Florida April 2019.

Edelson JB, Huang YV, Griffis H, Mascio CE, Chen JM, Burstein DS, Lin KY,  O'Connor MJ, Rossano JW: Post-Transplant Outcomes in Pediatric Patients Receiving Mechanical Circulatory Support: A Multicenter Study from the International Society for Heart and Lung Transplantation (ISHLT) Registry. Poster presentation at the International Society for Heart Lung Transplantation Annual Meeting, Orlando, Florida April 2019.

Edwards J, Seliktar N, Heron S, Lin K, Monos D, Sesok-Pizzini D, Rossano J, White R, O'Connor M: Dose-Dependent Response to Desensitization in Pediatric Heart Transplant Candidates Assessed by Single Antigen Bead Technology. Poster presentation at the International Society for Heart Lung Transplantation Annual Meeting, Orlando, Florida April 2019.

Vazquez Alvarez MC, Cantor R, Koehl D, Nandi D, Kemna MS, Urschel S, West SC, Lin KY, Lim HM, Allain-Rooney T, Dipchand AI. : Retransplantation: An underutilized resource or only for a select few?  Oral abstract presentation at the International Society for Heart Lung Transplantation Annual Meeting, Orlando, Florida April  2019.

Burstein D, Mondal A, Min J, Faerber J, Rossano JW, Ho C, Margossian RE, Colan SD, O'Connor MJ, Soslow JH, Markham LW, Disalvo T, Lever HM, Zahka KG, Wilmot I, Sublett J, Russell MW, Day S, Patel A, Murphy AM, Canter CE, Bach RG, Mestroni L, Taylor M, Ashley EA, Wheeler MT, Benson L, Owens AT, Pahl E, Thrush P, Da Costa Pereira A, Bundgaard H, Axelsson A, Lin KY: Quality of Life and Exercise Performance in Low Risk Hypertrophic Cardiomyopathy: VANISH Ancillary Study. Abstract poster presented at the Scientific Sessions of the American Heart Association, Philadelphia PA November 2019.

Burstein DS, Gaynor JW, Griffis H, Ritter A, O'Connor MJ, Rossano JW, Lin KY, Ahrens-Nicklas RC: Genetic Variant Burden and Outcomes in Pediatric Cardiomyopathy. Oral abstract presented for the Young Hearts Early Career Investigator Award Finalist Scientific Session at the American Heart Association Annual Meetings, Philadelphia PA November 2019.

Edelson JB, Rossano J, Griffis H, Quarshie W, Ravishankar C, O'Connor M, Mascio C, Mercer-Rosa L, Glatz A, Lin KY: Resource Use and Outcomes of Children with Congenital Heart Disease Admitted to the Hospital from 2003 to 2016. Abstract poster presented at the Scientific Sessions of the American Heart Association, Philadelphia PA November 2019.

Invited Lectures

2020

Lin K. "Cardiac Manifestations of Friedreich Ataxia," Friedreich Ataxia Research Alliance Patient Virtual Symposium (Online). Oct 2020.

2019

Lin K. "When to Refer, When to Transplant: Late Stage Fontan and Other Complex CHD," American Heart Association Scientific Sessions, Philadelphia PA. Nov 2019.

Lin K. "Current and Future Therapy for Myocarditis," American College of Cardiology Annual Meeting, New Orleans LA. Mar 2019.

Lin K. "Failure (at Any Stage) and the Role of Mechanical Circulatory Support" 22nd Annual Update on Pediatric and Congenital Cardiovascular Disease Plenary Session, Huntington Beach CA. Feb 2019.

Lin K. "Destination Therapy for Mechanical Circulatory Support in Pediatrics: Is It a Reality?" 22nd Annual Update on Pediatric and Congenital Cardiovascular Disease Preconference, Huntington Beach CA. Feb 2019.

Lin K. "How Does the Heart Fail II: Freidrich's Ataxia and Duchenne Muscular Dystrophy," 22nd Annual Update on Pediatric and Congenital Cardiovascular Disease Preconference, Huntington Beach CA. Feb 2019.