Shana E. McCormack, MD, MTR, is an attending physician and Scientific Director of the Neuroendocrine Center in the Division of Endocrinology and Diabetes at Children's Hospital of Philadelphia (CHOP). She also serves as a member of the clinical research team for Mitochondrial Medicine at CHOP.
Areas of Expertise:
Neuroendocrinology, Endocrine disorders in individuals with hypothalamic/pituitary brain tumors, Pituitary disorders, Hypothalamic obesity, Endocrine disorders in individuals with mitochondrial diseases, Endocrine disorders in Friedreich's Ataxia, Diabetes mellitus, Hypoglycemia, Lipodystrophy, Pseudotumor cerebri syndrome/idiopathic intracranial hypertension Locations:Specialty Care, Market Street; Main Hospital
Shana McCormack, MD, is an attending physician in the Division of Endocrinology and Diabetes and an assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. She cares for children with pediatric endocrine disease. She has a clinical interest in patients with endocrine dysfunction related to individually rare metabolic disorders such as primary mitochondrial disease, Freidreich ataxia, and lipodystrophy. She also has an interest in inherited and acquired forms of hypothalamic and pituitary dysfunction, in particular those associated with abnormal energy balance and obesity, like craniopharyngiomas. Finally, she cares for children with all types of obesity and its complications, such as type 2 diabetes mellitus and pseudotumor cerebri syndrome/idiopathic intracranial hypertension.
As a physician-scientist, she investigates the neuroendocrine systems that regulate energy balance in humans. Her translational research program has two main areas of focus. First, she studies individuals with metabolic disorders with characterized by risk for diabetes mellitus, including primary mitochondrial diseases, Friedreich's ataxia, and lipodystrophy. Second, she focuses on brain disorders associated with excess weight gain, including brain-tumor related hypothalamic obesity syndrome and pseudotumor cerebri syndrome/idiopathic intracranial hypertension. She performs detailed assessments of mitochondrial bioenergetics and metabolism in humans with these conditions using, for example, non-invasive imaging techniques, stable isotopes, and integrated metabolomics and proteomics. She complements these in vivo studies with in vitro experiments to more fully explore the tissue-specific causes and consequences of abnormal energy balance in model systems such as patient-derived cell lines.
Dr. McCormack studies the neuroendocrine systems that regulate energy balance in humans. Her translational and clinical research program has two main areas of focus. First, her team studies individuals with metabolic disorders with characterized by risk for diabetes mellitus, including primary mitochondrial diseases, Friedreich's ataxia, and lipodystrophy. Second, her group focuses on brain disorders associated with excess weight gain, including brain-tumor related hypothalamic obesity syndrome and idiopathic intracranial hypertension.
2016, American Society for Clinical Investigation Young Investigators Award
2013, University of Pennsylvania School of Medicine Institute for Translational Medicine and Therapeutics (ITMAT) Fellowship
2012, Travel Award for Young Investigators Pediatric Academic Society, Boston MA
2011, Outstanding Abstract and Travel Award Endocrine Society, Boston MA
2010, Fellow Travel Award, Lawson Wilkins Pediatric Endocrine Society
2008, Resident Teaching Award, Harvard Medical School
2006, Family-Centered Care Award, Massachusetts General Hospital for Children
2002, Howard Hughes Medical Institute Medical Student Research Fellowship
1999, Phi Beta Kappa Society, Harvard College
1996, Howard Hughes Medical Institute Undergraduate Research Fellowship
Editorial and Academic Positions
Ad hoc reviewer
2016-present, Science Translational Medicine
2016-present, British Journal of Nutrition
2016-present, BMJ Open
2016-present, International Journal of Epidemiology
2015-present, PLOS One
2014-present, Pediatric Obesity
2013-present, Journal of Clinical Endocrinology and Metabolism
Academic and Institutional Committees
2013-present, Division of Endocrinology and Diabetes, Scientific Review Committee
Leadership and Memberships
Memberships in Professional Organizations
2015-present, Society for Inherited Metabolic Disorders
2015-present, American Society for Bone and Mineral Research
2014-present, Society for Pediatric Research
2014-2017, National Institutes of Health, National Institute of Neurological Disorders and Stroke
- 2014-2017, Chair, Mitochondrial Disease Common Data Element Working Group on Endocrinology, Diabetes, GI, Nutrition
2013-present, United Mitochondrial Disease Foundation
2013-present, Mitochondrial Medicine Society
- 2016, Mitochondrial Preventative Care Work Group, Endocrinology Lead
2009-present, Pediatric Endocrine Society
2009-present, Endocrine Society
- 2017-2020, Member, Research Affairs Core Committee
- 2017-2020, Member, Diabetes Government and Public Affairs Advisory Board
Patient Experience Ratings
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