Shana E. McCormack, MD, MTR

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Shana E. McCormack, MD, MTR, is an attending physician and Scientific Director of the Neuroendocrine Center in the Division of Endocrinology and Diabetes at Children's Hospital of Philadelphia (CHOP). She also serves as a member of the clinical research team for Mitochondrial Medicine at CHOP.

Areas of Expertise: Neuroendocrinology, Endocrine disorders in individuals with hypothalamic/pituitary brain tumors, Pituitary disorders, Hypothalamic obesity, Endocrine disorders in individuals with mitochondrial diseases, Endocrine disorders in Friedreich's Ataxia, Diabetes mellitus, Hypoglycemia, Lipodystrophy, Pseudotumor cerebri syndrome/idiopathic intracranial hypertension
Locations: Main Campus; Specialty Care, Market Street

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Shana McCormack, MD, is an attending physician in the Division of Endocrinology and Diabetes and an assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. She cares for children with pediatric endocrine disease. She has a clinical interest in patients with endocrine dysfunction related to individually rare metabolic disorders such as primary mitochondrial disease, Freidreich ataxia, and lipodystrophy. She also has an interest in inherited and acquired forms of hypothalamic and pituitary dysfunction, in particular those associated with abnormal energy balance and obesity, like craniopharyngiomas. Finally, she cares for children with all types of obesity and its complications, such as type 2 diabetes mellitus and pseudotumor cerebri syndrome/idiopathic intracranial hypertension.

As a physician-scientist, she investigates the neuroendocrine systems that regulate energy balance in humans. Her translational research program has two main areas of focus. First, she studies individuals with metabolic disorders with characterized by risk for diabetes mellitus, including primary mitochondrial diseases, Friedreich's ataxia, and lipodystrophy. Second, she focuses on brain disorders associated with excess weight gain, including brain-tumor related hypothalamic obesity syndrome and pseudotumor cerebri syndrome/idiopathic intracranial hypertension. She performs detailed assessments of mitochondrial bioenergetics and metabolism in humans with these conditions using, for example, non-invasive imaging techniques, stable isotopes, and integrated metabolomics and proteomics. She complements these in vivo studies with in vitro experiments to more fully explore the tissue-specific causes and consequences of abnormal energy balance in model systems such as patient-derived cell lines.

Education and Training

Medical School

MD - Harvard Medical School and Massachusetts Institute of Technology, Boston, MA

Internship

Pediatrics - Massachusetts General Hospital, Boston, MA

Residency

Pediatrics - Massachusetts General Hospital, Boston, MA

Fellowship

Pediatric Endocrinology - Children's Hospital Boston, Boston, MA

Board Certification

Obesity Medicine
Pediatric Endocrinology
Pediatrics

Graduate Degree

Master of Science in Translational Research (MTR) - University of Pennsylvania Perelman School of Medicine, Philadelphia PA

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Dr. McCormack studies the neuroendocrine systems that regulate energy balance in humans. Her translational and clinical research program has two main areas of focus. First, her team studies individuals with metabolic disorders with characterized by risk for diabetes mellitus, including primary mitochondrial diseases, Friedreich's ataxia, and lipodystrophy. Second, her group focuses on brain disorders associated with excess weight gain, including brain-tumor related hypothalamic obesity syndrome and idiopathic intracranial hypertension.

Publications

Papers

2019

Gustafson MA, McCormick EM, Perera L, Longley MJ, Bai R, Kong J, Dulik M, Shen L, Goldstein AC, McCormack SE, Laskin BL, Leroy BP, Ortiz-Gonzalez XR, Ellington MG, Copeland WC, Falk MJ. Gustafson MA, McCormick EM, Perera L, Longley MJ, Bai R, Kong J, Dulik M, Shen L, Goldstein AC, McCormack SE, Laskin BL, Leroy BP, Ortiz-Gonzalez XR, Ellington MG, Copeland WC, Falk MJ. PLoS One. 2019 Sep 3;14(9):e0221829. doi: 10.1371/journal.pone.0221829. eCollection 2019. PMID: 31479473

2018

Zolkipli-Cunningham Z, Xiao R, Stoddart A, McCormick EM, Holberts A, Burrill N, McCormack S, Williams L, Wang X, Thompson JLP, Falk MJ. Mitochondrial disease patient motivations and barriers to participate in clinical trials. PLoS One. 2018 May 17;13(5):e0197513. doi: 10.1371/journal.pone.0197513.

2017

Parkih S, Goldstein A, Karaa A, Koenig MK, Anselm I, Brunel-Guitton C, Chinnery P, Cohen BH, Christodolou J, Dimmock D, Enns GM, Falk MJ, Feigenbaum A, Frye R, Ganesh J, Griessemer D, Haas R, Horvath R, Korson M, Kruer MC, Mancuso M, McCormack S, Rahman S, Reimschisel T, Salvarinova R, Saneto R, Scaglia F, Shoffner J, Stacpoole P, Sue CM, Tarnopolsky M, Karnebeek CV, Wolfe LA, Zolkipli Cunnigham Z: Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society. Genetics in Medicine Jul 2017.

McCormack SE, Cousminer DL, Chesi A, Mitchell JA, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Winer KK, Kelly A, Grant SFA, Zemel BS: Association between linear growth and bone accrual: a longitudinal assessment of a diverse cohort of children and adolescents. JAMA Pediatrics Jul 2017.

Karaa A, Rahman S, Lombes A, Yu-Wai-Man P, Sheikh MK, Alai-Hansen-S, Cohen BH, Dimmock D, Emrick L, Falk MJ, McCormack S, Mirsky D, Moore T, Parikh S, Shoffner J, Taivassalo T, Tarnopolsky M, Tein I, Odenkirchen JC, Goldstein A; Mito Working Group Participants. : Common data elements for clinical research in mitochondrial disease: a National Institute for Neurological Disorders and Stroke Project. J Inherit Metab Dis 40(3): 403-414, May 2017.

McCormack SE, Xiao R, Kilbaugh TJ, Karlsson M, Ganetzky RD, Zolkipli Cunningham Z, Goldstein M, Falk MJ, Damrauer SM: Hospitalizations for

mitochondrial disease across the lifespan in the U.S. Mol Genet Metab Page: doi: 10.1016/j.ymgme.2017.04.007. Apr 2017.

McCormack SE, Li D, Kim YJ, Lee JY, Kim SH, Rapaport R, Levine MA: Digenic inheritance of PROKR2 and WDR11 mutations in pituitary stalk interruption syndrome. J Clin Endocrinol Metab Page: doi: 10.1210/jc.2017-00332. Apr 2017.

Gandhi SS, Muraresku C, McCormick EM, Falk MJ, McCormack SE: Risk factors for poor bone health in primary mitochondrial disease. J Inherit Metab Dis Page: doi: 10.1007/s10545-017-0046-2. Apr 2017.

Chesi A, Mitchell JM, Kalkwarf HJ, Bradfield JP, Lappe JM, Cousminer DL, Roy SM, McCormack SE, Gilsanz V, Oberfield SE, Hakonarson H, Shepherd JA, Kelly A, Zemel BS, Grant SFA: A genome-wide association study identifies two sex-specific loci, at SPTB and IZUMO3, influencing pediatric bone mineral density at multiple skeletal sites. J Bone Miner Res Page: doi: 10.1002/jbmr.3097, Feb 2017.

McCormack SE, Chesi A, Mitchell JA, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Mahboubi S, Winer KK, Kelly A, Grant SFA, Zemel BS: Relative skeletal maturation and population ancestry in non-obese children and adolescents. J Bone Miner Res 32(1): 115-124, Jan 2017.

Kumar V, Chang H, Reiter D, Bradley B, Belury M, McCormack SE, Raman SV: Phosphorus-31 magnetic resonance spectroscopy: a tool for measuring in vivo mitochondrial oxidative phosphorylation capacity in human skeletal muscle. J Vis Exp 119: doi: 10.3791/54977, Jan 2017.

2016

Sengupta S, Yang G, O'Donnell JC, Hinson MD, McCormack SE, Falk MJ, La P, Robinson MB, Williams ML, Yohannes MT, Polyak E, Nakamaru-Ogiso E, Dennery PA. The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med. 2016 Apr;93:177-89. doi: 10.1016/j.freeradbiomed.2016.02.004. Epub 2016 Feb 5. PMID: 26855417 PMCID: PMC4905744.

Mitchell JA, Chesi A, McCormack SE, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SF. Rare EN1 Variants and Pediatric Bone Mass. J Bone Miner Res. 2016 Aug;31(8):1513-7. doi: 10.1002/jbmr.2833. Epub 2016 Mar 31. PMID: 26970088 PMCID: PMC4970877.

Isaacs CJ, Brigatti KW, Kucheruk O, Ratcliffe S, Sciascia T, McCormack SE, Willi SM, Lynch DR. Effects of Genetic Severity on Glucose Homeostasis in Friedreich Ataxia. Muscle Nerve. 2016 Apr 7. doi: 10.1002/mus.25136. [Epub ahead of print] PMID: 27061687.

Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SF, Zemel BS. Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density. J Bone Miner Res. 2016 Apr;31(4):789-95. doi: 10.1002/jbmr.2744. Epub 2015 Dec 14. PMID: 26572781 PMCID: PMC4826827.

Roy SM, Spivack JG, Faith MS, Chesi A, Mitchell JA, Kelly A, Grant SF, McCormack SE, Zemel BS. Infant BMI or Weight-for-Length and Obesity Risk in Early Childhood. Pediatrics. 2016 May;137(5). pii: e20153492. doi: 10.1542/peds.2015-3492. PMID: 27244803 PMCID: PMC4845873.

Kwon YJ, Allen JL, Liu GT, McCormack SE. Presumed Pseudotumor Cerebri Syndrome After Withdrawal of Inhaled Glucocorticoids. Pediatrics. 2016 Jun;137(6). pii: e20152091. doi: 10.1542/peds.2015-2091. Epub 2016 May 17. PMID: 27172274 PMCID: PMC4970901.

Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SF, Zemel BS. Physical Activity Benefits the Skeleton of Children Genetically Predisposed to Lower Bone Density in Adulthood. J Bone Miner Res. 2016 Aug;31(8):1504-12. doi: 10.1002/jbmr.2872. PMID: 27172274. PMCID: PMC4970901.

Felix JF, Bradfield JP, Monnereau C, van der Valk RJ, Stergiakouli E, Chesi A, Gaillard R, Feenstra B, Thiering E, Kreiner-Møller E, Mahajan A, Pitkänen N, Joro R, Cavadino A, Huikari V, Franks S, Groen-Blokhuis MM, Cousminer DL, Marsh JA, Lehtimäki T, Curtin JA, Vioque J, Ahluwalia TS, Myhre R, Price TS, Vilor-Tejedor N, Yengo L, Grarup N, Ntalla I, Ang W, Atalay M, Bisgaard H, Blakemore AI, Bonnefond A, Carstensen L, Eriksson J, Flexeder C, Franke L, Geller F, Geserick M, Hartikainen AL, Haworth CM, Hirschhorn JN, Hofman A, Holm JC, Horikoshi M, Hottenga JJ, Huang J, Kadarmideen HN, Kähönen M, Kiess W, Lakka HM, Lakka TA, Lewin AM, Liang L, Lyytikäinen LP, Ma B, Magnus P, McCormack SE, McMahon G, Mentch FD, Middeldorp CM, Murray CS, Pahkala K, Pers TH, Pfäffle R, Postma DS, Power C, Simpson A, Sengpiel V, Tiesler CM, Torrent M, Uitterlinden AG, van Meurs JB, Vinding R, Waage J, Wardle J, Zeggini E, Zemel BS, Dedoussis GV, Pedersen O, Froguel P, Sunyer J, Plomin R, Jacobsson B, Hansen T, Gonzalez JR, Custovic A, Raitakari OT, Pennell CE, Widén E, Boomsma DI, Koppelman GH, Sebert S, Järvelin MR, Hyppönen E, McCarthy MI, Lindi V, Harri N, Körner A, Bønnelykke K, Heinrich J, Melbye M, Rivadeneira F, Hakonarson H, Ring SM, Smith GD, Sørensen TI, Timpson NJ, Grant SF, Jaddoe VW. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet. 2016 Jan 15;25(2):389-403. doi: 10.1093/hmg/ddv472. Epub 2015 Nov 24. PMID: 26604143 PMCID: PMC4854022.

Sheldon CA, Paley GL, Xio R, Kesler A, Eyal O, Ko MW, Boisvert CJ, Avery RA, Salpietro V, Phillips PH, Heidary G, McCormack SE*, Liu GT* (*denotes equal contribution): Pediatric idiopathic intracranial hypertension: age, sex and anthropometrics at diagnosis in a large, retrospective, multi-site cohort. Ophthalmology 123(11): 2424-2431, Nov 2016.

DeBrosse C, Nanga RPR, Wilson N, D'Aquilla K, Elliott M, Hariharan H, Yan F, Wade K, Nguyen S, Worsley D, Parris-Skeete C, McCormick E, Xiao R, Zolkipli-Cunningham Z, Fishbein L, Nathanson KL, Lynch DR, Stallings VA, Yudkoff M, Falk MJ, Reddy R, McCormack SE: Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders. JCI Insight 1(18): e88207, Nov 2016.

Roizen JD, Danzig J, Groleau V, McCormack S, Casella A, Harrington J, Sochett E, Tershakovec A, Zemel BS, Stallings VA, Levine MA. Resting Energy Expenditure Is Decreased in Pseudohypoparathyroidism Type 1A. J Clin Endocrinol Metab. 2016 Mar;101(3):880-8. doi: 10.1210/jc.2015-3895. Epub 2015 Dec 28. PMID: 26709970 PMCID: PMC480316.

2015

Chesi A, Mitchell JA, Kalkwarf HJ, Bradfield JP, Lappe JM, McCormack SE, Gilsanz V, Oberfield SE, Hakonarson H, Shepherd JA, Kelly A, Zemel BS, Grant SFA.: A Trans-ethnic Genome-wide Association Study Identifies Gender Specific Loci Influencing Pediatric aBMD and BMC at the Distal Radius. Hum Mol Genet. 2015 Sep 1;24(17):5053-9. doi: 10.1093/hmg/ddv210. Epub 2015 Jun 3.

Roy SM, Chesi A, Mentch F, Xiao R, Chiavacci R, Mitchell JA, Kelly A, Hakonarson H, Grant SF, Zemel BS, McCormack SE.: Body mass index (BMI) trajectories in infancy differ by population ancestry and may presage disparities in early childhood obesity. The Journal of Clinical Endocrinology and Metabolism April 2015.

Mitchell JA, Chesi A, Elci O, McCormack SE, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SF: Genetics of Bone Mass in Childhood and Adolescence: Effects of Sex and Maturation Interactions. Journal of Bone and Mineral Research March 2015.

McCormack S, Polyak E, Ostrovsky J, Dingley SD, Rao M, Kwon YJ, Xiao R, Zhang Z, Nakamaru-Ogiso E, Falk MJ.: Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegant. Mitochondrion March 2015.

Paley GL, Sheldon CA, Burrows EK, Chilutti MR, Liu GT, McCormack SE: Overweight and obesity in pediatric secondary pseudotumor cerebri syndrome. American Journal of Ophthalmology 159(2), February 2015.

2014

Schrier Vergano Samantha, Rao Meera, McCormack Shana, Ostrovsky Julian, Clarke Colleen, Preston Judith, Bennett Michael J, Yudkoff Marc, Xiao Rui, Falk Marni J: In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans. Molecular genetics and metabolism 111(3): 331-41, March 2014.

2013

Zhang Zhe, Tsukikawa Mai, Peng Min, Polyak Erzsebet, Nakamaru-Ogiso Eiko, Ostrovsky Julian, McCormack Shana, Place Emily, Clarke Colleen, Reiner Gail, McCormick Elizabeth, Rappaport Eric, Haas Richard, Baur Joseph A, Falk Marni J: Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network. PloS one 8(7): e69282, July 2013.

McCormack S, McCarthy M, Harrington S, Farilla L, Hrovat M, Systrom D, Thomas B, Torriani M, McInnis K, Grinspoon S, Fleischman A.: Effects of exercise and lifestyle modification on fitness, insulin resistance, skeletal muscle oxidative phosphorylation, and intramyocellular lipid content in obese children and adolescents. Pediatric Obesity June 2013.

McCormack S, Shaham O, McCarthy M, Deik A, Wang TJ, Gerszten R, Clish C, Mootha V, Grinspoon S, Fleischman A.: Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatric Obesity 8(1): 52-61, February 2013.

Abstracts

2015

Basile KJ, Chesi A, Mitchell JA, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SFA: Multiple GWAS-implicated adult height loci operate in the context of pediatric bone mineral density and content determination. Endocrine Society Annual Meeting, San Diego CA, LB-OR01. Mar 2015.

Sheldon CA, Paley GL, Kesler A, Boisvert C, Avery RA, Heidary G, McCormack SE*, Liu GT* *denotes equal contribution: Pediatric primary pseudotumor cerebri syndrome (PTCS): a detailed, retrospective, multicenter analysis of anthropometrics. North American Neuro-Ophthalmology Society Annual Meeting, San Diego CA. Feb 2015.

Books

Chapters

2016

Roy SM, Kelley J, Hanley P, McCormack SE, Grant SFA: Genetics of pediatric obesity. Childhood obesity: causes, consequences, and intervention approaches. Goran M (eds.). CRC press, Oct 2016.

Sheldon CA, Lin GL, Szperka CL, McCormack SE, Liu GT.: Pediatric pseudotumor cerebri syndrome. Practical management of pediatric ocular disorders and strabismus Traboulsi EI, Utz V, Ariss M (eds.). Springer Science, Aug 2016.

2015

McCormack SE, Gai X, Place E, Falk MJ: Mitochondrial DNA depletion syndromes presenting in childhood. Mitochondrial case studies: underlying mechanisms and diagnosis. Saneto R, Parikh S, Cohen B (eds.). Elsevier, Dec 2015.

Posters and Presentations

2017

Mitchell JA, Chesi A, McCormack SE, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield S, Shepherd JA, Kelly A, Zemel BS, Grant SFA: Principal component-derived bone density phenotypes and genetic regulation of the pediatric skeleton. 8th International Conference on Children's Bone Health, Würzburg, Germany, Oral Presentation. Jun 2017

Mitchell JA, Cousminer DL, Chesi A, McCormack SE, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SFA: High and low impact physical activity substitution and pediatric bone density. American College of Sports Medicine Annual Meeting, Denver CO, Thematic Poster Session. May 2017.

Sheldon CA, Linton E, Paley G, McCormack SE, Liu GT.: Change in body mass index over time in non-overweight/obese children with Idiopathic Intracranial Hypertension. North American Neuro-Ophthalmological Society Annual Meeting, Washington DC, Poster Presentation. Apr 2017.

2016

McCormack SE, Xiao R, Kilbaugh T, Karsson M, Falk MJ, Damrauer SM: Hospitalizations related to mitochondrial disease in the U.S. United Mitochondrial Disease Foundation Annual Mitochondrial Medicine Symposium, Seattle WA, Platform Presentation. Jun 2016.

DeBrosse C, Nanga RPR, Wilson N, D'Aquilla K, Elliott M, Hariharan H, Yan F, Wade K, Nguyen S, Worsley D, Parris-Skeete C, McCormick E, Xiao R, Zolkipli-Cunningham Z, Fishbein L, Nathanson KL, Lynch DR, Stallings VA, Yudkoff M, Falk MJ, Reddy R, McCormack SE: Measurement of OXPHOS capacity in mitochondrial diseases with a novel imaging method: Creatine Chemical Exchange Saturation Transfer (CrCEST). NHLBI/NIDDK Mitochondrial Biology Symposium, Bethesda MD, Platform Presentation. May 2016.

Zolkipli-Cunningham Z, McCormack SE, McCormick E, Falk MJ: The diagnostic utility of aerobic exercise testing in mitochondrial myopathies. Society for Inherited Metabolic Diseases, Annual Meeting, Ponte Verde Beach FL, Platform Presentation. Apr 2016.

Roy SM, Ford EG, Drigo DC, Ma J, Medoff-Cooper B, Shults J, Gerber JS, Bushman FD, Elovitz MA, DeRusso PA, Berkowitz RI, Wu GD, McCormack SE, Zemel BS: Infant sucking intensity, weight gain, and adiposity in the first four months. Endocrine Society Annual Meeting, Boston MA, Poster Presentation, FRI 019. Apr 2016.

Mitchell JA, Chesi A, McCormack SE, Roy SM, Cousminer CL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SF: A rare variant near EN1 associates with pediatric bone mass in females but not males. Endocrine Society Annual Meeting, Boston MA, Poster Presentation, SUN 357. Apr 2016.

McCormack SE, Henrickson SE, Zhang Z, Wherry J, Wadden TA, Berkowitz R: Integrated proteomic and metabolomic profiles of successful weight loss in obese adolescents. Endocrine Society Annual Meeting, Boston MA, Oral Presentation, OR07-04. Apr 2016.

Foster YM, Yan F, Zhang Z, McCormack SE: Tissue-specific effects of oxytocin on mitochondrial bioenergetics. Endocrine Society Annual Meeting, Boston MA, Poster Presentation, FRI 478. Apr 2016.

Cousminer DL, Chesi A, Mitchell JA, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Voight BF, Oberfield SE, Shepherd JA, Kelly A, McCormack SE, Zemel BS, Grant SF: Individual variants and genetic risk score for age at menarche associate with pediatric bone mineral density. Endocrine Society Annual Meeting, Boston MA, Poster Presentation, SUN 354. Apr 2016.

2015

Chesi A, Roy SM, Mitchell JA, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Mahboubi S, Winer K, Kelly A, Grant SFA, Zemel BS, McCormack SE: Skeletal maturation and genetically determined population ancestry in non-obese, pre-pubertal children. American Society for Bone and Mineral Research Annual Meeting, Seattle WA, Oral Presentation 1094. Oct 2015.

Lu S, McCormack SE, Xia Q, Falk MJ, Grant SF: Insights from functional analysis of the TCF7L2 locus: PARP-1 inhibition rescues glucose-induced shortened lifespan in Caenorhabditis elegans. American Diabetes Association Annual 2015, Boston MA, Poster Presentation. Jun 2015.

DeBrosse C, Nanga RPR Wilson N, D'Aquilla K, Elliott M, Hariharan H, Yan F, Perez L, Nguyen S, Wade K, McCormick E, Falk MJ, McCormack SE, Reddy R: In vivo OXPHOS quantitation by magnetic resonance imaging in metabolic myopathy. International Society for Magnetic Resonance Medicine Annual Meeting, Toronto Ontario Canada, Platform Presentation. Jun 2015.

Roy SM, Spivack JG, Faith MS, Chesi A, Mitchell JA, Grant SFA, Zemel BS, McCormack SE: Concordance between weight-for-length and BMI under age 2 years in a large, longitudinal, multi-ethnic cohort. Endocrine Society Annual Meeting, San Diego CA, Presidential Poster Competition, FRI-554. Mar 2015.

Mitchell JA, Chesi A, Elci O, McCormack SE, Roy S, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SF: The skeletal benefits of physical activity in childhood are dependent on genetic variation at known bone density loci. Endocrine Society Annual Meeting, San Diego CA, Oral Presentation, OR08-06. Mar 2015.

Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Kalwarf HJ, Lappe JM, Gilsanz V, Oberfield S, Shepherd JA, Kelly A, Grant SFA, Zemel BS: The benefits of physical activity on bone density in childhood are dependent on genetic variation at known bone density loci. Cold Spring Harbor Meeting on Exercise Science and Health, Cold Spring Harbor NY, Platform Presentation. Mar 2015.

McCormack SE, Roy SM, Chesi A, Mitchell JA, Kalwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd J, Mahboubi S, Winer K, Kelly A, Grant SFA, Zemel BS: Skeletal maturation, population ancestry, and body composition in non-obese, pre-pubertal children. Endocrine Society Annual Meeting, San Diego CA, Poster Presentation, LBT-030. Mar 2015.

DeBrosse C, Nanga RPR Wilson N, D'Aquilla K, Elliott M, Hariharan H, Yan F, Perez L, Nguyen S, McCormick E, Falk MJ, Reddy R, McCormack SE: In vivo OXPHOS quantitation by magnetic resonance imaging in metabolic myopathy. Society for Inherited Metabolic Disorders Annual Meeting, Salt Lake City UT, Poster Presentation. Mar 2015.

Chesi A, Kwalkarf HJ, Mentch FD, Lappe JM, Gilsanz V, Oberfield S, Shepherd JA, Bradfield JP, Mahboubi S, Roy SM, Mitchell JA, Chiavacci R, Kelly A, Hakonarson H, Zemel BS, Grant SFA, McCormack SE: Loci influencing skeletal age in children and adolescents identified through a trans-ethnic appraisal of both common and rare genetic variants. Endocrine Society Annual Meeting, San Diego CA, Poster Presentation, SAT-145. Mar 2015.

Jensen AK, Sheldon CA, Paley GL, Liu GT, McCormack SE: Autism spectrum disorder in pediatric pseudotumor cerebri syndrome. North American Neuro-Ophthalmology Society Annual Meeting, San Diego CA, Poster Presentation. Feb 2015.

Beres SJ, Sheldon CA, Boisvert C, Szperka CL, Paley GL, Burrows EK, Chilutti MR, Liu GW, McCormack SE, Liu GT: Clinical and prognostic significance of CSF closing pressure in pediatric pseudotumor cerebri syndrome. North American Neuro-Ophthalmology Society Meeting, San Diego CA, Poster Presentation. Feb 2015.

Invited Lectures

2017

McCormack SE. “Non-invasive Measurement of Skeletal Muscle Bioenergetics,” Pediatric Endocrine Society Meeting, Clinical Scholar presentation, Washington DC. Sep, 2017.

McCormack SE. "Intranasal oxytocin to promote weight loss in children and adolescents with brain tumors and hypothalamic obesity syndrome," Children’s National Medical Center, Washington DC. Jul, 2017.

McCormack SE. "Intranasal oxytocin to promote weight loss in children and adolescents with brain tumors and hypothalamic obesity syndrome," Nemours Alfred I. duPont Hospital for Children, Division of Endocrinology Conference, Wilmington DE. Apr, 2017.

2016

McCormack SE. "Oxytocin and energy balance: applications in pediatric hypothalamic obesity", Harvard Interdisciplinary Initiative in Oxytocin Research, Boston MA. Nov, 2016.

McCormack SE. "Metabolic and Endocrine Biomarkers of Mitochondrial OXPHOS Capacity in FA: post-exercise CrCEST MRI, post-meal glucose and lactate homeostasis", Freidreich Ataxia Research Alliance Biomarkers Meeting, Tampa FL. Sep, 2016.

McCormack SE. "Hospitalizations related to mitochondrial disease in the U.S.", Platform Presentation, United Mitochondrial Disease Foundation Annual Mitochondrial Medicine Symposium, Seattle WA. Jun, 2016.

McCormack SE. "Ask the Mito Doc Panel - Child", United Mitochondrial Disease Foundation Mitochondrial Medicine Symposium, Seattle WA. Jun, 2016.

McCormack SE. "Alumni Panel: Practical Tips for Success", Howard Hughes Medical Institute Medical Fellows Session, American Society for Clinical Investigation Meeting, Chicago IL. Apr, 2016.

McCormack SE. "Integrated proteomic and metabolomic profiles of successful weight loss in obese adolescents", Oral Presentation OR07-04, Endocrine Society Annual Meeting, Boston MA. Apr, 2016.

2015

McCormack SE. "31P-MRS and Creatine CEST: in vivo application in Freidreich's Ataxia and other mitochondrial diseases to measure OXPHOS capacity", Freidrich Ataxia Research Alliance Biomarkers Meeting, Bethesda MD. Nov, 2015.

McCormack SE. "Weight Management in Pediatric Pseudotumor Syndrome: An Endocrine Perspective", North American Neuro-Ophthalmology Society Meeting, San Diego CA. Feb, 2015.

2014

McCormack SE. "Endocrine Considerations and Management in Mitochondrial Disease Patients", United Mitochondrial Disease Foundation Family Session, New Orleans LA. Dec, 2014.

McCormack SE. "In vivo OXPHOS Quantitation by Magnetic Resonance Imaging (MRI) in Mitochondrial Disease", North American Mitochondrial Disease Consortium (NAMDC) Fellowship, Web Conference. Sep, 2014.

McCormack SE. "Endocrine Considerations and Management in Mitochondrial Disease Patients", United Mitochondrial Disease Foundation Symposium, Pittsburgh PA. Jun, 2014.

Awards and Honors

2016, American Society for Clinical Investigation Young Investigators Award

2013, University of Pennsylvania School of Medicine Institute for Translational Medicine and Therapeutics (ITMAT) Fellowship

2012, Travel Award for Young Investigators Pediatric Academic Society, Boston MA

2011, Outstanding Abstract and Travel Award Endocrine Society, Boston MA

2010, Fellow Travel Award, Lawson Wilkins Pediatric Endocrine Society

2008, Resident Teaching Award, Harvard Medical School

2006, Family-Centered Care Award, Massachusetts General Hospital for Children

2002, Howard Hughes Medical Institute Medical Student Research Fellowship

1999, Phi Beta Kappa Society, Harvard College

1996, Howard Hughes Medical Institute Undergraduate Research Fellowship

Editorial and Academic Positions

Editorial Positions

Ad hoc reviewer

2016-present, Science Translational Medicine

2016-present, British Journal of Nutrition

2016-present, BMJ Open

2016-present, International Journal of Epidemiology

2015-present, Metabolism

2015-present, PLOS One

2014-present, Pediatric Obesity

2013-present, Journal of Clinical Endocrinology and Metabolism

Academic and Institutional Committees

2013-present, Division of Endocrinology and Diabetes, Scientific Review Committee

Leadership and Memberships

Memberships in Professional Organizations

International

2015-present, Society for Inherited Metabolic Disorders

National

2015-present, American Society for Bone and Mineral Research

2014-present, Society for Pediatric Research

2014-2017, National Institutes of Health, National Institute of Neurological Disorders and Stroke

 - 2014-2017, Chair, Mitochondrial Disease Common Data Element Working Group on Endocrinology, Diabetes, GI, Nutrition

2013-present, United Mitochondrial Disease Foundation

2013-present, Mitochondrial Medicine Society

 - 2016, Mitochondrial Preventative Care Work Group, Endocrinology Lead

2009-present, Pediatric Endocrine Society

2009-present, Endocrine Society

 - 2017-2020, Member, Research Affairs Core Committee

 - 2017-2020, Member, Diabetes Government and Public Affairs Advisory Board