Hyun-Duck Nah, DMD, MSD, PhD

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Hyun-Duck Nah-Cederquist, DMD, PhD, is Director of Craniofacial Orthodontics in the Division of Plastic and Reconstructive Surgery at Children's Hospital of Philadelphia.

Locations: Main Hospital

Phone: 215-590-3362

Education and Training

Medical School

DDS in Dental Medicine - Seoul National University, Seoul, South Korea (graduated summa cum laude)

DMD in Dental Medicine - University of Pennsylvania, Philadelphia, PA


Orthodontics - Case Western Reserve University, Cleveland, OH


Clinical Fellow in Orthodontics - University of Connecticut Health Center, Hartford, CT
Postdoctoral Fellow in Biochemistry - School of Dental Medicine, University of Pennsylvania, Philadelphia, PA

Graduate Degree

MSD in Orthodontics - Case Western Reserve University, Cleveland, OH

PhD in Molecular Biology - University of Connecticut Health Center, Farmington, CT 

Additional Training

Postdoctoral Fellow with Department of Biochemistry - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Craniofacial Orthodontist

Director, Craniofacial Orthodontics

Research Associate Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania

Clinical Associate Professor, University of Pennsylvania School of Dental Medicine, Philadelphia PA

Departments and Services




Ahn NJ, Stratigis JD, Coons BE, Flake AW, Nah-Cederquist HD, Peranteau WH. Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model. J Vis Exp. 2018 Oct 9;(140). doi: 10.3791/58047. PubMed PMID: 30371676; PubMed Central PMCID: PMC6235462.

Kurio N, Saunders C, Bechtold TE, Salhab I, Nah HD, Sinha S, Billings PC, Pacifici M, Koyama E. Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilage. Matrix Biol. 2018 Apr;67:15-31. doi: 10.1016/j.matbio.2018.02.011. Epub 2018 Feb 12. PubMed PMID: 29447948; PubMed Central PMCID: PMC5910228.


Bechtold, T., Saunders, C., Decker, RS., Billings, PC., Um, HB., Naiga Cottingham, N., Kurio, N., Salhab, I; Pacifici, M., Nah, HD., Koyama, E. 2016. Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling. Matrix Biol, in press.

Chen I, Salhab I, Setzer FC, Kim S, Nah HD. A New Calcium Silicate-based Bioceramic Material Promotes Human Osteo- and Odontogenic Stem Cell Proliferation and Survival via the Extracellular Signal-regulated Kinase Signaling Pathway. J Endod. 2016 Mar;42(3):480-6. doi: 10.1016/j.joen.2015.11.013. Epub 2016 Jan 6. PubMed PMID: 26778265.


Chen I, Karabucak B, Wang C, Wang HG, Koyama E, Kohli MR, Nah HD, Kim S. Healing after root-end microsurgery by using mineral trioxide aggregate and a new calcium silicate-based bioceramic material as root-end filling materials in dogs. J Endod. 2015 Mar;41(3):389-99. doi: 10.1016/j.joen.2014.11.005. Epub 2015 Jan 14. PubMed PMID: 25596728; PubMed Central PMCID: PMC4415855.


Gerety PA, Wink JD, Sherif RD, Clarke N, Nah HD, Taylor JA. Treatment of large calvarial defects with bone transport osteogenesis: a preclinical sheep model. J Craniofac Surg. 2014 Sep;25(5):1917-22. doi: 10.1097/SCS.0000000000000987. PubMed PMID: 25119411.

Wink JD, Gerety PA, Sherif RD, Lim Y, Clarke NA, Rajapakse CS, Nah HD, Taylor JA. Sustained delivery of rhBMP-2 by means of poly(lactic-co-glycolic acid) microspheres: cranial bone regeneration without heterotopic ossification or craniosynostosis. Plast Reconstr Surg. 2014 Jul;134(1):51-9. doi: 10.1097/PRS.0000000000000287. PubMed PMID: 24622573; PubMed Central PMCID: PMC4105220.


Caselli A, Olson TS, Otsuru S, Chen X, Hofmann TJ, Nah HD, Grisendi G, Paolucci P, Dominici M, Horwitz EM. IGF-1-mediated osteoblastic niche expansion enhances long-term hematopoietic stem cell engraftment after murine bone marrow transplantation. Stem Cells. 2013 Oct;31(10):2193-204. doi: 10.1002/stem.1463. PubMed PMID: 23818291.


Siclari VA, Zhu J, Akiyama K, Liu F, Zhang X, Chandra A, Nah HD, Shi S, Qin L. Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow. Bone. 2013 Apr;53(2):575-86. doi: 10.1016/j.bone.2012.12.013. Epub 2012 Dec 27. PubMed PMID: 23274348; PubMed Central PMCID: PMC3674849.

Wu C, Endo M, Yang BH, Radecki MA, Davis PF, Zoltick PW, Spivak RM, Flake AW, Kirschner RE, Nah HD. Intra-amniotic transient transduction of the periderm with a viral vector encoding TGFβ3 prevents cleft palate in Tgfβ3(-/-) mouse embryos. Mol Ther. 2013 Jan;21(1):8-17. doi: 10.1038/mt.2012.135. Epub 2012 Oct 23. PubMed PMID: 23089732; PubMed Central PMCID: PMC3538297.

Nah HD, Koyama E, Agochukwu NB, Bartlett SP, Muenke M. Phenotype profile of a genetic mouse model for Muenke syndrome. Childs Nerv Syst. 2012 Sep;28(9):1483-93. doi: 10.1007/s00381-012-1778-9. Epub 2012 Aug 8. PubMed PMID: 22872265; PubMed Central PMCID: PMC4131982.

McGrath J, Gerety PA, Derderian CA, Steinbacher DM, Vossough A, Bartlett SP, Nah HD, Taylor JA. Differential closure of the spheno-occipital synchondrosis in syndromic craniosynostosis. Plast Reconstr Surg. 2012 Nov;130(5):681e-689e. doi: 10.1097/PRS.0b013e318267d4c0. PubMed PMID: 22777037.


Kim SG, Kim SG, Viechnicki B, Kim S, Nah HD. Engineering of a periodontal ligament construct: cell and fibre alignment induced by shear stress. J Clin Periodontol. 2011 Dec;38(12):1130-6. doi: 10.1111/j.1600-051X.2011.01790.x. Epub 2011 Sep 27. PubMed PMID: 22092876.

Laurita J, Koyama E, Chin B, Taylor JA, Lakin GE, Hankenson KD, Bartlett SP, Nah HD. The Muenke syndrome mutation (FgfR3P244R) causes cranial base shortening associated with growth plate dysfunction and premature perichondrial ossification in murine basicranial synchondroses. Dev Dyn. 2011 Nov;240(11):2584-96. doi: 10.1002/dvdy.22752. PubMed PMID: 22016144.


Marshall SD, Currier GF, Hatch NE, Huang GJ, Nah HD, Owens SE, Shroff B, Southard TE, Suri L, Turpin DL. Ask us. Self-ligating bracket claims. Am J Orthod Dentofacial Orthop. 2010 Aug;138(2):128-31. PubMed PMID: 20715337.

McDonald-McGinn DM, Feret H, Nah HD, Bartlett SP, Whitaker LA, Zackai EH. Metopic craniosynostosis due to mutations in GLI3: A novel association. Am J Med Genet A. 2010 Jul;152A(7):1654-60. doi: 10.1002/ajmg.a.33495. PubMed PMID: 20583172.

Ang BU, Spivak RM, Nah HD, Kirschner RE. Dura in the pathogenesis of syndromic craniosynostosis: fibroblast growth factor receptor 2 mutations in dural cells promote osteogenic proliferation and differentiation of osteoblasts. J Craniofac Surg. 2010 Mar;21(2):462-7. doi: 10.1097/SCS.0b013e3181cfe9a0. PubMed PMID: 20489451.

Zajac A, Baek SH, Salhab I, Radecki MA, Kim S, Hakonarson H, Nah HD. Novel ANKH mutation in a patient with sporadic craniometaphyseal dysplasia. Am J Med Genet A. 2010 Mar;152A(3):770-6. doi: 10.1002/ajmg.a.33317. PubMed PMID: 20186813; PubMed Central PMCID: PMC2944898.


Grant SF, Wang K, Zhang H, Glaberson W, Annaiah K, Kim CE, Bradfield JP, Glessner JT, Thomas KA, Garris M, Frackelton EC, Otieno FG, Chiavacci RM, Nah HD, Kirschner RE, Hakonarson H. A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24. J Pediatr. 2009 Dec;155(6):909-13. doi: 10.1016/j.jpeds.2009.06.020. Epub 2009 Aug 4. PubMed PMID: 19656524.

Suri L, Huang G, English JD Jr, Owen S, Nah HD, Riolo ML, Shroff B, Southard TE, Turpin DL. Ask us. Topical fluoride treatment. Am J Orthod Dentofacial Orthop. 2009 May;135(5):561-3. Review. PubMed PMID: 19412990.


Marshall SD, English JD Jr, Huang GJ, Messersmith ML, Nah HD, Riolo ML, Shroff B, Southard TE, Suri L, Turpin DL. Ask us. Long-term stability of maxillary expansion. Am J Orthod Dentofacial Orthop. 2008 Jun;133(6):780-1. doi: 10.1016/j.ajodo.2008.02.001. PubMed PMID: 18538225.

Lin IC, Smartt JM Jr, Nah HD, Ischiropoulos H, Kirschner RE. Nitric oxide stimulates proliferation and differentiation of fetal calvarial osteoblasts and dural cells. Plast Reconstr Surg. 2008 May;121(5):1554-66; discussion 1567-9. doi: 10.1097/PRS.0b013e31816c3bd7. PubMed PMID: 18453977.


Lin IC, Slemp AE, Hwang C, Sena-Esteves M, Nah HD, Kirschner RE. Dihydrotestosterone stimulates proliferation and differentiation of fetal calvarial osteoblasts and dural cells and induces cranial suture fusion. Plast Reconstr Surg. 2007 Oct;120(5):1137-47. PubMed PMID: 17898587.

Loomes KM, Stevens SA, O'Brien ML, Gonzalez DM, Ryan MJ, Segalov M, Dormans NJ, Mimoto MS, Gibson JD, Sewell W, Schaffer AA, Nah HD, Rappaport EF, Pratt SC, Dunwoodie SL, Kusumi K. Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects. Dev Dyn. 2007 Oct;236(10):2943-51. Erratum in: Dev Dyn. 2008 Jun;237(6):1754. PubMed PMID: 17849441.

Cabiling DS, Kim E, Yan D, Jacob S, Nah HD, Kirschner RE. Differential effects of TGF-beta isoforms on murine fetal dural cells and calvarial osteoblasts. Plast Reconstr Surg. 2007 Sep;120(3):614-24. PubMed PMID: 17700112.


Mao JJ, Nah HD. More research needed to understand how orthodontists communicate with cells. Am J Orthod Dentofacial Orthop. 2005 Apr;127(4):400. PubMed PMID: 15821679.

Fakhry A, Ratisoontorn C, Vedhachalam C, Salhab I, Koyama E, Leboy P, Pacifici M, Kirschner RE, Nah HD. Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential. Bone. 2005 Feb;36(2):254-66. PubMed PMID: 15780951.

Choi KY, Kim HJ, Lee MH, Kwon TG, Nah HD, Furuichi T, Komori T, Nam SH, Kim YJ, Kim HJ, Ryoo HM. Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development. Dev Dyn. 2005 May;233(1):115-21. PubMed PMID: 15765505.


Mao JJ, Nah HD. Growth and development: hereditary and mechanical modulations. Am J Orthod Dentofacial Orthop. 2004 Jun;125(6):676-89. Review. PubMed PMID: 15179392.


Ratisoontorn C, Fan GF, McEntee K, Nah HD. Activating (P253R, C278F) and dominant negative mutations of FGFR2: differential effects on calvarial bone cell proliferation, differentiation, and mineralization. Connect Tissue Res. 2003;44 Suppl 1:292-7. PubMed PMID: 12952211.


Nicozisis JL, Nah-Cederquist HD, Tuncay OC. Relaxin affects the dentofacial sutural tissues. Clin Orthod Res. 2000 Nov;3(4):192-201. PubMed PMID: 11553074.



Bechtold, TE., Saunders, C., Kuri0, N., Billings, PC., Pacifici, M., Nah, HD., and Koyama, E. TMJ degenerative changes in Prg4-null mice are associated with ectopic hedgehog signaling. International Association of Dental Research. Seoul, Korea June 20-23, 2016


Kirschner RE, Nah HD. Craniofacial growth: genetic and morphological processes in craniosynostosis. In: Duyuron B, editor.  Plastic surgery. 2008

Posters and Presentations

Invited Lectures


Craniofacial Orthodontics: One patient at a time. Beijing University

Cleft lip and Palate: Disease mechanisms, Genetic animal models and In utero gene-mediated rescue approach, Beijing University

Awards and Honors

2010-2011, Chair, Council of Scientific Affairs, AAO

2010-2011, President, Craniofacial Biology Group, IADR/AADR

2009-2010, President-elect, Craniofacial Biology Group, IADR/AADR

2008-2009, Vice -President, Craniofacial Biology Group, International Association for Dental Research (IADR) and AADR

2004, Honorary Committee Member, The Arthritis Foundation Symposium, Eastern Pennsylvania Chapter

2000, Stewart J. McCracken Award, Arthritis Foundation, Eastern Penna. Chapter

1996, Young Investigator's Award, American Society for Bone and Mineral Research

1996, Caulk/Dentsply Award, American Association for Dental Research

1994, Young Investigator Award, East Coast Connective Tissue Society

1984-1987, University Fellowship, Univ. of Connecticut School of Dental Medicine

1981, Alumni Association Award, Seoul National Univ. School of Dental Medicine

1980, Korean delegate to the Convention of the Asian Pacific Dental Student Association, Singapore

1978, Delegate of the Korean Dental Student Association to the Congress of the International Association of Dental Students, Cleveland, OH, USA

1975- 1980, Scholarship for Academic Distinction, Seoul National University

Editorial and Academic Positions

Editorial Positions

2010-present, Frontiers in Craniofacial Biology, Editorial Board,
2005-present, Orthodontics and Craniofacial Research, Editorial Board
1998-present, American Journal of Orthodontics and Dentofacial Orthopedics, referee


American Journal of Orthodontics and Dentofacial Orthopedics
Annals of Biomedical Engineering
Cell Transplantation
Clinical Orthodontics and Research
Connective Tissue Research
Frontiers in Bioscience
Frontiers in Physiology
Journal of Biological Chemistry
Journal of Cellular Biochemistry
Journal of Cellular Biology
Journal of Dental Research
Journal of Orthopaedic Research
Tissue Engineering

Academic and Institutional Committees

2011-2015, Institutional Animal Care and Use Committee, The Children’s Hospital of Philadelphia, Philadelphia, PA

Leadership and Memberships

Memberships in Professional Organizations


1984-present, International Association for Dental Research

1979, Asian Pacific Dental Student Association


2005-present, American Cleft Palate Association

2001-present, American Dental Association

1996-present, American Society for Bone and Mineral Research

1989-present, American Association for the Advancement of Science

1981-present, American Association of Orthodontists