Michael L. O’Byrne, MD, MSCE, is an interventional cardiologist in the Cardiac Center at Children’s Hospital Philadelphia (CHOP). He is a magna cum laude graduate of Harvard University who earned his MD from Columbia University’s College of Physicians and Surgeons. In 2014, he completed his Master of Science in Clinical Epidemiology at the University of Pennsylvania.
Dr. O’Byrne’s primary clinical focus is on performing cardiac catheterization procedures for children with congenital heart disease, a treatment option that’s less invasive than open heart surgery. He combines his clinical practice with work as a clinical epidemiologist, doing research aimed at understanding how to improve quality of care for children with cardiac disease and their families.
“I think this is a natural combination,” he explained. “My research is grounded by my clinical work, which helps identify and articulate questions that are important to our patients and their families. At the same time, my research informs my clinical care, helping me identify an approach based on the best possible evidence.”
As a researcher, Dr. O’ Byrne receives funding from the NIH/NHLBI. He has authored and peer-reviewed dozens of research papers and abstracts. He was honored in 2017 with the Christopher J White, MD, Early Career Reviewer Award, and was a 2018 AHA Council for Cardiovascular Disease in the Young, Young Investigator Award Finalist.
The collaborative nature of the team at CHOP’s Cardiac Center is a source of inspiration for Dr. O’Byrne. “As interventional cardiologists, we are constantly moving forward together to develop new techniques and ways to help children and their families,” he says. “That means using cutting-edge technology and adapting existing techniques to new applications, both on our own in the cath lab and in cooperation with our surgical colleagues and other cardiologists.”
Education and Training
MD - Columbia University College of Physicians and Surgeons, New York, NY
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Advanced Fellow in Interventional Cardiology - Children’s Hospital of Philadelphia, Philadelphia, PA
Advanced Fellow in Cardiovascular Research and Interventional Cardiology - Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatric Cardiology - Children’s Hospital of Philadelphia, Philadelphia, PA
Master of Science in Clinical Epidemiology (MSCE) - University of Pennsylvania, Philadelphia, PA
Titles and Academic Titles
Attending Interventional Cardiologist
Assistant Professor of Pediatrics (CE track), Perelman School of Medicine at the University of Pennsylvania
Departments and Services
O’Byrne ML, et al 2017. Effect of Obesity and Underweight Status on Perioperative Outcomes of Congenital Heart Operations in Children, Adolescents, and Young Adults: An Analysis of Data from the Society of Thoracic Surgeons Database. Circulation. 2017 Jun 16.
Giaccone A, Zuppa AF, Sood B, Cohen MS, O’Byrne ML, et al. 2017. Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn. American Journal of Perinatology, 34(8):749-758. doi: 10.1055/s-0036-1597996
Goldberg DJ, Surrey LF, Glatz AC, Dodds K, O’Byrne ML, et al. 2017. Hepatic Fibrosis is Universal Following Fontan Operation and Severity is Associated with Time from Surgery: A Liver Biopsy and Hemodynamic Study. J Am Heart Assoc. 2017 Apr 26;6(5).
O’Byrne ML, et al. 2017. Relationship between habitual exercise and performance on cardio-pulmonary exercise testing differs between children with single and bi-ventricular circulation. Pediatr Cardiol. 38(3):472-483.
Harasheh A, O’Byrne ML, et al. 2017. Pediatric Chest Pain: Low Probability Referral: A Multi-Institutional Analysis From Standardized Clinical Assessment and Management Plans (SCAMPs®), the Pediatric Health Information Systems Database, and the National Ambulatory Medical Care Survey. Epublished ahead of print. doi: 10.1177/0009922816684605.
Jayaram N, Spertus JA, O’Byrne ML, et al. 2017. Relationship Between Hospital Procedure Volume and Complications Following Cardiac Catheterization: A Report from the IMPACT® Registry. 183:118-128.
Surrey LF, Russo P, Rychik J, Goldberg DJ, Dodds K, O’Byrne ML, et al. 2016. Prevalence and characterization of fibrosis in surveillance liver biopsies of patients with Fontan circulation. Human Pathology. 57:106-115.
O’Byrne ML, et al. 2016. Outcomes of patients with pulmonary atresia and major aortopulmonary collaterals without intervention in infancy. Pediatric Cardiology, 37(7): 1380-1391.
O’Byrne ML, et al. 2016. The Influence of Deficient Retro-Aortic Rim on Tehcnical Success and Early Adverse Events Following Device Closure of Secundum Atrial Septal Defects: An Analysis of the IMPACT Registry ®. Catheterization Cardiovascular Intervention,37(7):1380-91.
Patel JK, O’Byrne M, et al. 2016. Diagnostic Electrophysiology Study Has Limited Value in Risk Stratification of Children and Young Adults With and Without Congenital Heart Disease. Journal of Innovations in Cardiac Rhythm Management. 7(2016):2257-2264.
O’Byrne ML, et al. 2016. Cost comparison of Transcatheter and Operative Pulmonary Valve Replacement (from the Pediatric Health Information Systems Database). American Journal of Cardiology, 117(1):121-126.
O’Byrne ML, et al. 2015. Intra-procedural Bronchoscopy to Prevent Bronchial Compression During Pulmonary Artery Stent Angioplasty. Pediatric Cardiology, 37(3):433-441.
O’Byrne ML, et al. 2015. Predictors of catastrophic adverse outcomes in children with pulmonary hypertension undergoing cardiac catheterization. Journal of the American College of Cardiology, 66(11):1261-1269.
O’Byrne ML, et al. 2015. Effect of center catheterization volume on risk of catastrophic adverse event after cardiac catheterization in children. American Heart Journal, 169(6):823-832.
O’Byrne ML, et al. 2015. Cost-comparison of trans-catheter and operative closure of ostium secundum atrial septal defects. American Heart Journal, 169(5):727-735.
O’Byrne ML, et al. 2015. Middle-term results of trans-catheter creation of atrial communication in patients receiving mechanical circulatory support. Catheterization Cardiovascular Intervention, 85(7):1189-95.
O’Byrne ML, et al. 2015. Trends in Pulmonary Valve Replacement In Children and Adults with Tetralogy of Fallot. American Journal of Cardiology, 115(1):118-124.
O’Byrne ML, et al. 2015. Accuracy of transthoracic echocardiography in assessing retro-aortic rim prior to device closure of atrial septal defects. Congenital Heart Disease,10(4):E146-154.
Glatz AC, O’Byrne ML, et al. 2016. Variability in Practice Patterns and Consistency With Published Guidelines for Aortic and Pulmonary Balloon Valvuloplasty: An Analysis of Data From the IMPACT Registry. American Heart Association Scientific Sessions, 2016. New Orleans, LA. November 2016.
O’Byrne ML et al. 2016. Variations in practice patterns in device closure of atrial septal defects and patent ductus arteriosus: An analysis of data from the IMPACT® Registry. American Heart Association Scientific Sessions, 2016. New Orleans, LA. November 2016.
O’Byrne ML and Rome JJ. 2015. Iatrogenic Aorto-pulmonary Window. C3 Summit 2015. Society for Cardiac Angiography and Intervention Scientific Sessions. San Diego, CA. May 2015.
Goldberg DJ, Surrey LF, Lin HC, Glatz AC, O’Byrne ML, et al. 2015. Risk Factors for Hepatic Fibrosis in Children and Adolescents After Fontan Operation. Circulation 132 (Supp 3), A17110-A17110. American Heart Association Scientific Sessions November 8-10 Orlando, FL.
O’Byrne ML, et al. 2015. Cost Comparison of Trans-Catheter and Operative Pulmonary Valve Replacement. American College of Cardiology Scientific Sessions 2015. San Diego, CA. March 2015. Moderated Poster Session.
O’Byrne ML, et al. 2014. Prevalence of deficient retro-aortic rim and its effects on outcomes in device closure of atrial septal defects. American College of Cardiology Scientific Sessions 2014. Poster. Washington D.C. March 2014.
O’Byrne ML, et al. 22q11.2 Deletion Syndrome Is Associated with Increased Perioperative Events and More Complicated Postoperative Course in Infants Undergoing Infant Operative Correction of Truncus Arteriosus Communis or Interrupted Aortic Arch. Cardiology 2014. Poster. Orlando FL. February 2014.
O’Byrne ML, Gillespie MJ. Melody Valve and Transcatheter Pulmonary Valve Replacement. In: Ailawadi G and Kron IL, editors. Catheter Based Valvular and Aortic Surgery. New York: Springer; 2016. p. 266-282.
O’Byrne ML, Shaddy RE. 2012. Pediatric heart failure and adult congenital heart disease. Advances in Heart Failure Management. 116-127
O’Byrne ML, Collins RT. Hypertension. In: Florin TA, Ludwig SL, editors. Netter Pediatrics. Philadelphia: Saunders; 2011. Chapter 47, p. 289-293.
O’Byrne ML, John A. Cyanotic Heart Disease. In: Florin TA, Ludwig SL, editors. Netter Pediatrics. Philadelphia: Saunders; 2011. Chapter 44, p. 269-277.
Posters and Presentations
O’Byrne ML. Transcatheter Versus Surgical Pulmonary Valve Replacement: Long-Term Outcomes and Benefits. Adult Congenital Heart Disease in the 21st Century. Washington DC, September 2016.
O’Byrne ML. Improving quality of care surrounding cardiac catheterization. Invited lecture at Children’s National Medical Center Washington D.C. February 2015.
O’Byrne ML, et al. 2015. The Influence Deficient Retro-Aortic Rim on Technical Success and Early Adverse Events Following Device Closure of Secundum Atrial Septal Defects: An Analysis of the Impact® Registry. American College of Cardiology Scientific Sessions 2015. San Diego, CA. March 2015. Oral presentation in Highlighted Original Research: Congenital Heart Disease and the Year in Review.
Awards and Honors
2017, The Christopher J White, MD, Early Career Reviewer Award
2010, Senior Resident Clinician Award (The Children’s Hospital of Philadelphia graduation award for excellence in clinical care)
2007, Marie Nercessian Award for Compassionate Care of Patients (Columbia University College of Physicians and Surgeons)|
2007, Rebecca Schwartz Prize in Pediatric Cardiology (Columbia University College of Physicians and Surgeons)
2007, Arnold P. Gold Humanism Honor Society
2006, AOA Debbie Glaser Medical Student Essay Contest: Honorable Mention
Editorial and Academic Positions
2015-Present, Circulation: CV Intervention
2015-Present, Circulation: CV Quality and Outcomes
2015-Present, JAMA: Pediatrics
2014-Present, Catheterization and Cardiovascular Intervention
2014-Present, American Heart Journal
2013-Present, Annals of Thoracic Surgery
2010-Present, Pediatric Emergency Care
Leadership and Memberships
Memberships in Professional Organizations
2005-present, American Heart Association
2010-present, American College of Cardiology
2013-present, Society for Cardiac Angiography and Intervention
Patient Experience Ratings
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