Audrey R. Odom John, MD, PhD

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Audrey R. Odom John, MD, PhD, is the Chief of the Division of Pediatric Infectious Diseases at Children's Hospital of Philadelphia. She holds the Stanley Plotkin Endowed Chair in Pediatric Infectious Diseases.

Areas of Expertise: Infectious diseases
Locations: Main Hospital
Appointments: 267-425-3377
Fax: 267-876-2203


A physician-scientist, Dr. John’s NIH-funded research focuses on the Plasmodium falciparum malaria parasite, with a particular interest in understanding its basic molecular and cellular biology and functions of its specific metabolic pathways — what the parasite needs to make and why it needs to make it — to identify new antimalarial drug targets and develop new diagnostics.  Dr. John is an investigator in the Pathogenesis of Infectious Diseases of the Burroughs Welcome Fund. She has received numerous accolades, including awards from the American Chemical Society, March of Dimes, and, most recently the IDea Incubator Grand Prize from the Infectious Diseases Society of America.

More about Dr. John's research >

Education and Training

Medical School

MD - Duke University School of Medicine, Durham, NC


Pediatric, Special Alternative Pathway - University of Washington, Seattle, WA


Pediatric Infectious Diseases - University of Washington, Seattle, WA

Board Certification

Pediatric Infectious Diseases – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Graduate Degree

PhD in Biochemistry - Duke University School of Medicine, Durham, NC

Titles and Academic Titles

Chief, Division of Pediatric Infectious Diseases

Stanley Plotkin Endowed Chair in Pediatric Infectious Diseases

Professor, Perelman School of Medicine, University of Pennsylvania

Departments and Services




Suazo, K.F., Schey, G., Schaber, C., Odom John, A.R. and Distefano, M.D., 2019. Proteomic Analysis of Protein–Lipid Modifications: Significance and Application. Mass Spectrometry‐Based Chemical Proteomics, pp.317-347.

Hotez, P.J., John, A.R.O. and LaBeaud, A.D., 2019. Pediatric tropical medicine: The neglected diseases of children. PLoS neglected tropical diseases, 13(5), p.e0007008.

Frasse, P.M. and Odom John, A.R., 2019. Haloacid Dehalogenase Proteins: Novel Mediators of Metabolic Plasticity in Plasmodium falciparum. Microbiology insights, 12, p.1178636119848435.

Budge, P.J. and John, A.R.O., 2019. The Longest Mile: Moving Malaria from Clinical Care to Elimination of Transmission. Clinical chemistry, 65(8), pp.946-948.

Berna, A, Schaber CL, Bollinger L, Mwale M, Mlotha-Mitole R, Trehan I, Odom John AR. Comparison of breath sampling methods: a post hoc analysis from observational cohort studies. Analyst. 2019;144(6):2026-33.

Berna AZ, DeBosch B, Stoll J, Odom John AR. Breath Collection from Children for Disease Biomarker Discovery. JoVE (Journal of Visualized Experiments). 2019 Feb 14(144):e59217.

Heitmeier MR, Hresko RC, Edwards RL, Prinsen MJ, Ilagan MX, Odom John AR, Hruz PW. Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering. PloS One. 2019 May 9;14(5):e0216457.


Wang X, Edwards RL, Ball H, Johnson C, Haymond A, Girma M, Manikkam M, Brothers RC, McKay KT, Arnett SD, Osbourn DM, Alvarez S, Boshoff HI, Meyers MJ, Couch RD, Odom John AR, Dowd CS. MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria. J Med Chem. 2018 Oct 11;61(19):8847-8858. doi: 10.1021/acs.jmedchem.8b01026. Epub 2018 Sep 24. PubMed PMID: 30192536; PubMed Central PMCID: PMC6300130.

Guggisberg AM, Frasse PM, Jezewski AJ, Kafai NM, Gandhi AY, Erlinger SJ, Odom John AR. Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites. mBio. 2018 Nov 13;9(6). pii: e01193-18. doi: 10.1128/mBio.01193-18. PubMed PMID: 30425143; PubMed Central PMCID: PMC6234871.

Guggisberg AM, Sayler KA, Wisely SM, Odom John AR. Natural History of Plasmodium odocoilei Malaria Infection in Farmed White-Tailed Deer. mSphere. 2018 Apr 18;3(2). pii: e00067-18. doi: 10.1128/mSphere.00067-18. Print 2018 Apr 25. PubMed PMID: 29669881; PubMed Central PMCID: PMC5907657.

Amdani SM, Kim HS, Orvedahl A, Odom John AR, Said A, Simpson K. Successful treatment of fulminant neonatal enteroviral myocarditis in monochorionic diamniotic twins with cardiopulmonary support, intravenous immunoglobulin and pocapavir. BMJ Case Rep. 2018 May 18;2018. pii: bcr-2017-224133. doi: 10.1136/bcr-2017-224133. PubMed PMID: 29776940.

Schaber CL, Katta N, Bollinger LB, Mwale M, Mlotha-Mitole R, Trehan I, Raman B, Odom John AR. Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants. J Infect Dis. 2018 Apr 23;217(10):1553-1560. doi: 10.1093/infdis/jiy072. PubMed PMID: 29415208. Invited commentary: Fidock DA, Journal of Infectious Diseases, 2018.


Edwards RL, Brothers RC, Wang X, Maron MI, Ziniel PD, Tsang PS, Kraft TE, Hruz PW, Williamson KC, Dowd CS, Odom John AR. MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis. Scientific Reports, 2017 Aug 21;7(1):8400. doi: 10.1038/s41598-017- 07159-y. PubMed PMID: 28827774; PubMed Central PMCID: PMC5567135.

Hatch AJ, Odom AR, York JD. Inositol phosphate multikinase dependent transcriptional control. Adv Biol Regul. 2017 May;64:9-19. doi: 10.1016/j.jbior.2017.03.001. Epub 2017 Mar 21. PubMed [citation] PMID: 28342784

Vila PM, Ghogomu NT, Odom John AR, Hullar TE, Hirose K. Infectious complications of pediatric cochlear implants are highly influenced by otitis media. Int J Pediatr Otorhinolaryngol. 2017 Jun;97:76-82. doi: 10.1016/j.ijporl.2017.02.026. Epub 2017 Mar 12. PubMed PMID: 28483256.


Suazo KF, Schaber C, Palsuledesai CC, Odom John AR*, Distefano MD*. Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue. Scientific Reports. 2016 Dec 7;6:38615. doi: 10.1038/srep38615. PubMed [citation] PMID: 27924931, PMCID: PMC5141570

Price KE, Armstrong CM, Imlay LS, Hodge DM, Pidathala C, Roberts NJ, Park J, Mikati M, Sharma R, Lawrenson AS, Tolia NH, Berry NG, O'Neill PM, Odom John AR. Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD. Scientific Reports. 2016 Nov 18;6:36777. doi: 10.1038/srep36777. PubMed [citation] PMID: 27857147, PMCID: PMC5114681

Kraft TE, Heitmeier MR, Putanko M, Edwards RL, Ilagan MX, Payne MA, Autry JM, Thomas DD, Odom AR, Hruz PW. A Novel Fluorescence Resonance Energy Transfer-Based Screen in High- Throughput Format to Identify Inhibitors of Malarial and Human Glucose Transporters. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7407-7414. Print 2016 Dec. PubMed [citation] PMID: 27736766, PMCID: PMC5119023

San Jose G, Jackson ER, Haymond A, Johny C, Edwards RL, Wang X, Brothers RC, Edelstein EK, Odom AR, Boshoff HI, Couch RD, Dowd CS. Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis. ACS Infect Dis. 2016 Dec 9;2(12):923-935. Epub 2016 Oct 12. PubMed [citation] PMID: 27676224, PMCID: PMC5266543

Guggisberg AM, Sundararaman SA, Lanaspa M, Moraleda C, González R, Mayor A, Cisteró P, Hutchinson D, Kremsner PG, Hahn BH, Bassat Q, Odom AR. Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure with Fosmidomycin-Clindamycin. J Infect Dis. 2016 Oct 1;214(7):1085-91. doi: 10.1093/infdis/jiw304. Epub 2016 Jul 20. PubMed [citation] PMID: 27443612, PMCID: PMC5021231


Imlay LS, Armstrong CM, Masters MC, Li T, Price KE, Edwards RL, Mann KM, Li LX, Stallings CL, Berry NG, O'Neill PM, Odom AR. Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target. ACS Infect Dis. 2015 Apr 10;1(4):157-167. Epub 2015 Mar 2. PubMed [citation] PMID: 26783558, PMCID: PMC4714788

Iannotti LL, Delnatus JR, Odom AR, Eaton JC, Griggs JJ, Brown S, Wolff PB. Determinants of Anemia and Hemoglobin Concentration in Haitian School-Aged Children. Am J Trop Med Hyg. 2015 Nov;93(5):1092-8. doi: 10.4269/ajtmh.15-0073. Epub 2015 Sep 8. PubMed [citation] PMID: 26350448, PMCID: PMC4703262

Park J, Guggisberg AM, Odom AR*, Tolia NH*. Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1. Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1824-34. doi: 10.1107/S1399004715012067. Epub 2015 Aug 25. PubMed [citation] PMID: 26327372, PMCID: PMC4556313

Kraft TE, Armstrong C, Heitmeier MR, Odom AR, Hruz PW. The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV Protease Inhibitor Lopinavir. Antimicrob Agents Chemother. 2015 Oct;59(10):6203-9. doi: 10.1128/AAC.00899-15. Epub 2015 Jul 27. PubMed [citation] PMID: 26248369, PMCID: PMC4576095

Armstrong CM, Meyers DJ, Imlay LS, Freel Meyers C, Odom AR. Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr). Antimicrob Agents Chemother. 2015 Sep;59(9):5511-9. doi: 10.1128/AAC.00602-15. Epub 2015 Jun 29. PubMed [citation] PMID: 26124156, PMCID: PMC4538460

Kelly M, Su CY, Schaber C, Crowley JR, Hsu FF, Carlson JR, Odom AR. Malaria parasites produce volatile mosquito attractants. mBio. 2015 Mar 24;6(2). pii: e00235-15. doi: 10.1128/mBio.00235-15. PubMed [citation] PMID: 25805727, PMCID: PMC4453533


Guggisberg AM, Park J, Edwards RL, Kelly ML, Hodge DM, Tolia NH*, Odom AR*. A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites. Nat Commun. 2014 Jul 24;5:4467. doi: 10.1038/ncomms5467. PubMed [citation] PMID: 25058848, PMCID: PMC4112465


Howe R, Kelly M, Jimah J, Hodge D, Odom AR. Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum. Eukaryot Cell. 2013 Feb;12(2):215-23. doi: 10.1128/EC.00073-12. Epub 2012 Dec 7. PubMed [citation] PMID: 23223036, PMCID: PMC3571303


Endo-Streeter S, Tsui MK, Odom AR, Block J, York JD. Structural studies and protein engineering of inositol phosphate multikinase. J Biol Chem. 2012 Oct 12;287(42):35360-9. doi: 10.1074/jbc.M112.365031. Epub 2012 Aug 15. PubMed [citation] PMID: 22896696, PMCID: PMC3471723


Zhang B, Watts KM, Hodge D, Kemp LM, Hunstad DA, Hicks LM, Odom AR. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. Biochemistry. 2011 May 3;50(17):3570-7. doi: 10.1021/bi200113y. Epub 2011 Apr 11. PubMed [citation] PMID: 21438569, PMCID: PMC3082593


Odom AR, Van Voorhis WC. Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. Mol Biochem Parasitol. 2010 Apr;170(2):108-11. doi: 10.1016/j.molbiopara.2009.12.001. Epub 2009 Dec 16. PubMed [citation] PMID: 20018214, PMCID: PMC2814890


Stevenson-Paulik J, Odom AR, York JD. Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. J Biol Chem. 2002 Nov 8;277(45):42711-8. Epub 2002 Sep 10. PubMed [citation] PMID: 12226109


Davidson RC, Moore TD, Odom AR, Heitman J. Characterization of the MFalpha pheromone of the human fungal pathogen Cryptococcus neoformans. Mol Microbiol. 2000 Dec;38(5):1017-26. PubMed [citation] PMID: 11123675

Odom AR, Stahlberg A, Wente SR, York JD. A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Science. 2000 Mar 17;287(5460):2026-9. PubMed [citation] PMID: 10720331


York JD, Odom AR, Murphy R, Ives EB, Wente SR. A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science. 1999 Jul 2;285(5424):96-100. PubMed [citation] PMID: 10390371


Odom AR, Misra UK, Pizzo SV. Nickel inhibits binding of alpha2-macroglobulin-methylamine to the low-density lipoprotein receptor-related protein/alpha2-macroglobulin receptor but not the alpha2-macroglobulin signaling receptor. Biochemistry. 1997 Oct 14;36(41):12395-9. PubMed [citation] PMID: 9376342

Odom A, Muir S, Lim E, Toffaletti DL, Perfect J, Heitman J. Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 1997 May 15;16(10):2576-89. PubMed [citation] PMID: 9184205, PMCID: PMC1169869

Odom A, Del Poeta M, Perfect J, Heitman J. The immunosuppressant FK506 and its non immunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob Agents Chemother. 1997 Jan;41(1):156-61. PubMed [citation] PMID: 8980772, PMCID: PMC163677


Martenson CH, Odom A, Sheetz MP, Graham DG. The effect of acrylamide and other sulfhydryl alkylators on the ability of dynein and kinesin to translocate microtubules in vitro. Toxicol Appl Pharmacol. 1995 Jul;133(1):73-81. PubMed [citation] PMID: 7597712




Suazo KF, Schey G, Schaber, C, Odom John, AR, Distefano MD. (2018) Proteomic analysis of protein-lipid modifications: significance and application, in Mass Spectrometry-based Chemical Proteomics (Tao, W. A., Ed.), Wiley, New York.


Hunstad DA, Jhaveri R, Odom AR, and St. Geme JW III. “Chapter 1: MOLECULAR DETERMINANTS OF MICROBIAL PATHOGENESIS” Feigin and Cherry’s Textbook of Pediatric Infectious Disease, 8th edition., 2015.


Odom AR. "Tropical Medicine." Oxford American Handbook of Pediatrics. Ed. Stapleton, B Oxford University Press, 2009.

Posters and Presentations

Invited Lectures


Odom A. Invited speaker, University of Buffalo, Department of Microbiology, Buffalo, NY. 2019.

Odom A.Frontier lecture, St. Jude/PIDS Pediatric Infectious Diseases Research Conference, Memphis, TN. 2019.

Odom A.Invited speaker, Department of Microbiology, University of Pennsylvania, Philadelphia, PA. 2019.


Odom A.Keynote address, American Physician-Scientist Association Midwest meeting, St. Louis, MO. 2018.

Odom A.Invited speaker, Johns Hopkins Malaria Research Institute, Baltimore, MD. 2018.

Odom A.Invited speaker, Johns Hopkins Malaria Research Institute, Baltimore, MD. 2018.

Odom A.Keynote address, Danish Society of Parasitology Annual Conference, Copenhagen, Denmark. 2018.

Odom A.Invited speaker, Harvard T.H. Chan School of Public Health, Boston, MA. 2018.

Odom A.Invited speaker, Drexel University School of Medicine, Philadelphia, PA. 2018.

Odom A.Student-invited speaker, Eukaryotic Pathogens Innovation Center (EPIC), Clemson University, Clemson, SC. 2018.

Odom A.Symposium speaker, CC Wang Award Symposium, Experimental Biology 2013 (ASBMB), San Diego, CA. 2018.


Odom A.Infectious Diseases Grand Rounds, Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center (joint conference), New York, NY. 2017.

Odom A.Invited speaker, Spotlight on Women in Medicine and Science (SWIMS), Washington University. 2017.

Odom A.Invited speaker and panelist, Infectious Diseases Society of America and NIH/NIAID Infectious Diseases Research Careers meeting, Bethesda, MD. 2017.

Odom A.Invited speaker, FASEB Protein Lipidation, Saxtons River, VT. 2017.

Odom A.Invited speaker, University of Florida, Emerging Pathogens Institute, Gainesville FL. 2017.

Odom A.Keynote address, Postdoctoral Research Day, Institute of Molecular Medicine, Lisbon, Portugal. 2017.

Awards and Honors

2018, Infectious Diseases Society of America (IDSA), IDea Incubator Grand Prize winner

2016, Burroughs Wellcome Fund, Investigator in the Pathogenesis of Infectious Diseases

2016, Young Investigator Award, American Chemical Society – Infectious Diseases

2016, Emerging Leader Award, Duke University School of Medicine Alumni Association

2015, Grand challenge winner and invited speaker, TEDxKC

2014, Election, Society for Pediatric Research

2013, Basil O’Connor Starter Scholar Award, March of Dimes

2013, Outstanding Commitment to Teaching Award, Department of Pediatrics

2012, Innovator Award, St. Louis Academy of Science

2010, Mentor of the Year, Washington University

2010, Doris Duke Charitable Foundation, Clinical Scientist Development Award

2008, Scholar, Washington University Child Health Research Center of Excellence

2007, Pediatric Infectious Diseases Society, Fellowship Award

2001, Harold M. Weintraub Graduate Student Award, national award for outstanding achievement in graduate studies in the biological sciences

1999, American Cancer Society, Graduate Research Award

1998, Alpha Omega Alpha, medical honor society

1996, Phi Beta Kappa

1996, summa cum laude, Duke University

1995, Howard Hughes Medical Institute, Forum Fellows Grant

Editorial and Academic Positions

Editorial Positions

2019-present, Infectious Diseases of Children, Editorial Advisory Board Member
2018-present, Frontiers in Cellular and Infection Microbiology, Editorial Board Member
2018-present, Scientific Reports, Editorial Advisory Board Member
2017-present, ACS Infectious Diseases Journal, Editorial Advisory Board Member
2017-present, Pearls Editor, PLoS Pathogens, Editorial Advisory Board Member
2015-present, PeerJ, Editorial Board Member

Ad Hoc Reviewer

Antimicrobial Agents and Chemotherapy
Biotechnology Reports
Cell Host and Microbe
Cellular Microbiology
Clinical Infectious Diseases
Current Molecular Medicine
International Journal of Inf. Diseases
International J. of Parasitology: DDR
Journal of Clinical Microbiology
Journal of Infectious Diseases
Journal of Medicinal Chemistry
Journal of the Pediatric Inf. Dis. Soc.
Molecular Microbiology
Molecular Pharmacology
Natural Product Reviews
Nature Microbiology
Nature Reviews Microbiology
Pediatric Infectious Diseases Journal
PLoS One
PLoS Biology
PLoS Pathogens
PLoS Medicine
Scientific Reports
Science Translational Medicine
Trends in Parasitology
Zoonoses and Public Health

Leadership and Memberships

Memberships in Professional Organizations

National Institutes of Health
 - 2019-present, NIAID Drugs and Drug Resistance (DDR) study section
 - 2018-present, Scientific Advisory Group (SAG) for Sub-Saharan and East Africa International Centers for Malaria Excellence (ICEMR)
 - 2017-present, Special Emphasis Panel (Topics in Drug Discovery, Antimicrobial Resistance and Field Studies)
 - 2015-present, Drugs and Drug Resistance 1 (DDR)
 - 2015-present, Drugs and Drug Resistance 2 (DDR)
Infectious Diseases Society of America
 - 2019-present, Diagnostics Committee
Pediatric Infectious Diseases Society
 - 2018-present, Nominations and Awards Committee