Maurizio Pacifici, PhD, is Director of Orthopaedic Research at CHOP and has a special interest in creating new treatments for rare diseases, including hereditary multiple exostoses (HME), fibrodysplasia ossificans progressiva (FOP), and heterotopic ossification (HO).
Post-doctoral Fellow — Institute of Histology and Embryology, University of Rome, Rome, Italy
European Molecular Biology Organization (EMBO) Fellow — Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, PA
Orthopaedic Surgery – American Board of Orthopaedic Surgery
BA — Liceo Scientifico
PhD — Institute of Histology & Embryology, University of Rome School of Medicine, Rome, Italy
Research Associate — Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, PA
Titles and Academic Titles
Director of Research, Department of Orthopaedic Surgery
Dr. Bong S. Lee Endowed Chair in Pediatric Orthopaedics
Mechanisms that control skeletal development and growth
Synovial joint formation in fetal and postnatal life
Creating new treatments for rare diseases, including hereditary multiple exostoses (HME), fibrodysplasia ossificans progressiva (FOP), and heterotopic ossification (HO)
Koyama E, Yasuda T, Minugh-Purvs N, Kinumatsu T, Yallowitz AR, Wellik DM, et al. Hox 11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements. Development . 2010; 137: 3795-3800.
Williams JA, Kane M, Okabe T, Enomoto-Iwamoto M, Napoli JL, Pacifici M, et al. Endogenous retinoids in mammalian growth plate cartilage: analysis and roles in matrix homeostasis and turnover. J. Biol. Chem. 2010; 285: 36674-36681.
Kondo N, Yuasa T, Shimono K, Tung W, Okabe T, Yasuhara R, et al. Imbalance of Wnt/b-catenin signaling causes deformity of intervertebral disc organization. Spine. 2011 Epub Jan. 25; doi 10:1097/BRS.0b013e3181f52cb.
Koyama, E., Yasuda, T., Wellik, D.M., and Pacifici, M. (2010). Hox11 paralogous genes are required for formation of wrist and ankle joints and articular surface organization. Annu. N.Y. Acad. Sci. 1192, 307-316.
Editorial and Academic Positions
2007-present, Editorial Advisory Board, Journal of Cell Communication and Signaling
2007-present, Editorial Advisory Board, Journal of Arthroplasty
2006-present, Editorial Advisory Board, Matrix Biology
2008-2010, Member, Research Advisory Committee, Thomas Jefferson University
2003-2010, Member, Kimmel Cancer Center, Thomas Jefferson University
2003-2007, Member, Research Committee, Thomas Jefferson University
2002-present, External examiner, Honors Program, Swarthmore College
1999-present, External examiner, PhD thesis, Medical School, University of Rome
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