Michele E. Paessler, DO
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
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DO - Philadelphia College of Osteopathic Medicine, Philadelphia, PA
Medicine - PCOM/Allegheny University Hospital, Philadelphia, PA
Pathology and Laboratory Medicine - University of Pennsylvania Medical Center, Philadelphia, PA
Molecular Pathology - University of Pennsylvania Medical Center, Philadelphia, PA
Hematopathology - University of Pennsylvania Medical Center, Philadelphia, PA
Molecular Genetic Pathology - University of Pennsylvania Medical Center, Philadelphia, PA
Clinical Pathology – American Board of PathologyHematopathology – American Board of PathologyMolecular Genetics – American Board of Pathology
Division Chief, Hematopathology
Medical Director, Clinical Immunology Laboratory
Interferon-γ mediates anemia but is dispensable for fulminant toll-like receptor 9-induced macrophage activation syndrome and hemophagocytosis in mice. Canna SW, Wrobel J, Chu N, Kreiger PA, Paessler M, Behrens EM. Arthritis Rheum. 2013 Jul;65(7):1764-75.
Rapamycin does not control hemophagocytic lymphohistiocytosis in LCMV-infected perforin-deficient mice. Rothman JA, Das R, Teachey DT, Paessler ME, Nichols KE. Pediatr Blood Cancer. 2011 Dec 15;57(7):1239-43. doi: 10.1002/pbc.23226.
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. Behrens EM, Canna SW, Slade K, Rao S, Kreiger PA, Paessler M, Kambayashi T, Koretzky GA. J Clin Invest. 2011 Jun;121(6):2264-77.
Not all hemophagocytes are created equally: appreciating the heterogeneity of the hemophagocytic syndromes. Behrens EM, Canna SW, Slade K, Rao S, Kreiger PA, Paessler M, Kambayashi T, Koretzky GA. J Clin Invest. 2011 Jun;121(6):2264-77.
Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis. Balamuth NJ, Nichols KE, Paessler M, Teachey DT. J Pediatr Hematol Oncol. 2007 Aug;29(8):569-73.
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