Craig A. Press, MD, PhD

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Craig A. Press, MD, PhD, is an attending physician in the Division of Neurology and Medical Director of the Neuroscience Unit at Children's Hospital of Philadelphia.

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Washington University School of Medicine in St. Louis, St. Louis, MO

Residency

Pediatric Neurology - University of Colorado, Boulder, CO

Fellowship

Pediatric Neurocritical Care - Lurie Children’s Hospital, Chicago, IL
Pediatric Epilepsy - University of Colorado, Aurora, CO

Board Certification

Child Neurology
Epilepsy
Neurology

Graduate Degree

PhD - Washington University School of Medicine in St. Louis, St. Louis, MO

Titles and Academic Titles

Attending Physician

Medical Director of the Neuroscience Unit

Departments and Services

Publications

Papers

2021

Murphy OC, Messacar K, Benson L, Bove R, Carpenter JL, Crawford T, Dean J, DeBiasi R, Desai J, Elrick MJ, Farias-Moeller R, Gombolay GY, Greenberg B, Harmelink M, Hong S, Hopkins SE, Oleszek J, Otten C, Sadowsky CL, Schreiner TL, Thakur KT, Van Haren K, Carballo CM, Chong PF, Fall A, Gowda VK, Helfferich J, Kira R, Lim M, Lopez EL, Wells EM, Yeh EA, Pardo CA, AFM working group. Acute flaccid myelitis: cause, diagnosis, and management. Lancet. 2021;397(10271):334-46. Epub 2020/12/29. doi: 10.1016/S0140-6736(20)32723-9. PubMed PMID: 33357469; PMCID: PMC7909727.

2020

Koh S, Wirrell E, Vezzani A, Nabbout R, Muscal E, Kaliakatos M, Wickström R, Riviello J J, Brunklaus A, Payne E, Valentin A, Wells E, Carpenter J, Lee K, Lai Y, Eschbach K, Press C A, Gorman, M, Stredny C M, Roche W, Mangum T. Proposal to Optimize Evaluation and Treatment of Febrile Infection - Related Epilepsy Syndrome (FIRES): A Report from FIRES Workshop. Epilepsia Open. Accepted Nov 2020.

O'Brien N, Reuter-Rice K, Wainwright M, Kaplan S, Appavu B, Erklauer J, Ghosh S, Kirschen M, Kozak B, Lidsky K, Lovett M, Mehollin-Ray A, Miles D, Press C, Simon D, Tasker R, LaRovere K. Practice Recommendations for Transcranial Doppler Ultrasonography in Critically Ill Children in the Pediatric Intensive Care Unit: A Multidisciplinary Expert Consensus Statement. J Pediatric Intensive Care. 2020. doi: 10.1055/s-0040-1715128.

2019

Press CA, Kirschen M, LaRovere K, Risen S, Guilliams KP, Chung M, et al. Variation in Treatment and Outcomes of Children With Acute Disseminated Encephalomyelitis. Hosp Pediatr. 2020;10(2):159-65. Epub 2020/01/31. doi: 10.1542/hpeds.2019-0129. PubMed PMID: 31996356.

Press CA, Chapman KE. Status epilepticus: Will we capture the moment or continue without evidence of efficacy or costs? Neurology. 2019. Epub 2019/05/10. doi: 10.1212/WNL.0000000000007494. PubMed PMID: 31068483.

2018

Messacar K, Spence-Davizon E, Osborne C, Press C, Schreiner TL, Martin J, et al. Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study. Lancet Infect Dis. 2020;20(2):230-9. Epub 2019/12/21. doi: 10.1016/S1473-3099(19)30632-2. PubMed PMID: 31859216.

Larson AA, Baker PR, 2nd, Milev MP, Press CA, Sokol RJ, Cox MO, Lekostaj JK, Stence AA, Bossler AD, Mueller JM, Prematilake K, Tadjo TF, Williams CA, Sacher M, Moore SA. TRAPPC11 and GOSR2 mutations associate with hypoglycosylation of alpha-dystroglycan and muscular dystrophy. Skelet Muscle. 2018;8(1):17. Epub 2018/06/02. doi: 10.1186/s13395-018-0163-0. PubMed PMID: 29855340; PMCID: PMC5984345.

2017

Smith G, Press CA. Ketogenic Diet in Super-Refractory Status Epilepticus. Pediatr Neurol Briefs. 2017;31(3):8. Epub 2017/12/01. doi: 10.15844/pedneurbriefs-31-3-2. PubMed PMID: 29184380; PMCID: PMC5681458.

Press CA, Morgan L, Mills M, Stack CV, Goldstein JL, Alonso EM, Wainwright MS. Spectral Electroencephalogram Analysis for the Evaluation of Encephalopathy Grade in Children With Acute Liver Failure. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2017;18(1):64-72. Epub 2016/11/05. doi: 10.1097/PCC.0000000000001016. PubMed PMID: 27811533.

Ducharme-Crevier L, Press CA, Kurz JE, Mills MG, Goldstein JL, Wainwright MS. Early Presence of Sleep Spindles on Electroencephalography Is Associated With Good Outcome After Pediatric Cardiac Arrest. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2017;18(5):452-60. Epub 2017/03/23. doi: 10.1097/PCC.0000000000001137. PubMed PMID: 28328788.

Press CA, Wainwright MS. Preventable Pediatric Stroke via Vaccination? Pediatr Neurol Briefs. 2015;29(10):76. Epub 2016/03/05. doi: 10.15844/pedneurbriefs-29-10-3. PubMed PMID: 26933534; PMCID: PMC4747138.

2015

Press CA, Wainwright MS. Preventable Pediatric Stroke via Vaccination? Pediatr Neurol Briefs. 2015;29(10):76. Epub 2016/03/05. doi: 10.15844/pedneurbriefs-29-10-3. PubMed PMID: 26933534; PMCID: PMC4747138.

Press CA, Lindsay A, Stence NV, Fenton LZ, Bernard TJ, Mirsky DM. Cavernous Sinus Thrombosis in Children: Imaging Characteristics and Clinical Outcomes. Stroke. 2015;46(9):2657-60. Epub 2015/08/08. doi: 10.1161/STROKEAHA.115.009437. PubMed PMID: 26251243.

Press CA, Knupp KG, Chapman KE. Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. Epilepsy Behav. 2015;45:49-52. Epub 2015/04/08. doi: 10.1016/j.yebeh.2015.02.043. PubMed PMID: 25845492.

Greninger AL, Messacar K, Dunnebacke T, Naccache SN, Federman S, Bouquet J, Mirsky D, Nomura Y, Yagi S, Glaser C, Vollmer M, Press CA, Kleinschmidt-DeMasters BK, Dominguez SR, Chiu CY. Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing. Genome Med. 2015;7:113. Epub 2015/12/02. doi: 10.1186/s13073-015-0235-2. PubMed PMID: 26620704; PMCID: PMC4665321.

Good RJ, Messacar K, Stence NV, Press CA, Carpenter TC. Abnormal Neuroimaging in a Case of Infant Botulism. Front Pediatr. 2015;3:108. Epub 2015/12/24. doi: 10.3389/fped.2015.00108. PubMed PMID: 26697417; PMCID: PMC4676149.

2014

Press C, Wallace A, Chapman KE. The Janus-faced nature of Rasmussen's encephalitis. Semin Pediatr Neurol. 2014;21(2):129-36. Epub 2014/08/26. doi: 10.1016/j.spen.2014.04.018. PubMed PMID: 25149947.

2013

Gaensbauer JT, Press CA, Hollister JR, Asturias EJ. Procalcitonin: a marker of infection not subverted by treatment with interleukin-6 receptor inhibition. Pediatr Infect Dis J. 2013;32(9):1040. Epub 2013/09/07. doi: 10.1097/INF.0b013e318295a3d0. PubMed PMID: 24008743.

2009

Press C, Milbrandt J. The purine nucleosides adenosine and guanosine delay axonal degeneration in vitro. J Neurochem. 2009;109(2):595-602. Epub 2009/02/28. doi: 10.1111/j.1471-4159.2009.06002.x. PubMed PMID: 19245660; PMCID: PMC2682787.

Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, DiAntonio A. A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nature neuroscience. 2009;12:387-9. doi: 10.1038/nn.2290. PubMed PMID: 19287387.

2008

Press C, Milbrandt J. Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. J Neurosci. 2008;28(19):4861-71. Epub 2008/05/09. doi: 10.1523/JNEUROSCI.0525-08.2008. PubMed PMID: 18463239; PMCID: PMC2678678.

2004

Jiang L, Rampalli S, George D, Press C, Bremer EG, O'Gorman MR, Bohn MC. Tight regulation from a single tet-off rAAV vector as demonstrated by flow cytometry and quantitative, real-time PCR. Gene Ther. 2004;11(13):1057-67. Epub 2004/05/21. doi: 10.1038/sj.gt.3302245. PubMed PMID: 15152187.

Posters and Presentations

2021

Francoeur C, Weiss M, MacDonald J, Press C, Berg R, Topjian A, Morrison W, Kirschen M. Variability in the Neurologic Determination of Death in Pediatric Institutions in the United States. 50th Critical Care Congress. Feb 2021. Virtual Meeting.

2020

Mazzio E, Rosenthal S, Eileen S, Jewell J, Martin J, Messer R, Press CA. Neuroimaging for Non-Index Seizures in Pediatric Emergency Rooms. The 16th International Child Neurology Congress and 49th Annual Child Neurology Society Meeting. October 21st, 2020. San Diego, CA.

Kilgallon K, Kim J, Press CA, Ruzas C. Cranial Ultrasound in Pediatric ECMO- Yield of Clinically Significant Findings. 31st Annual Extracorporeal Life Support Organization Virtual Conference Sept. 25, 2020.

2019

Messacar K, Spence-Davizon E, Osborne C, Press CA, Schreiner T, Martin J, Messer R, Maloney J, Burakoff A, Barnes M, Routh J, Gerber S, Oberste MS, Nix WA, Abzug MJ, Tyler K, Herlihy R, and Dominguez S. Clinical Features Distinguishing Enterovirus A71 and Enterovirus D68-Associated Acute Flaccid Myelitis in Colorado, 2013-2018. Oral presentation at ID Week 2019. Oct. 2019. Washington DC.

Stence N, Neuberger I, Mirsky D, Maloney J, Fenton L, Barry M, Press CA. ASL Perfusion Abnormalities on Acute MR Imaging Following Focal Onset Pediatric Seizures. Presented at the American Society of Neuroradiology, May 2019, Boston, MA.

Invited Lectures

2021

Dichiaro M, Press CA. Neurorecovery and Brain Injury Program at Children’s Hospital Colorado. Pediatric Neurocritical Care Research Group Mini-symposium. Feb. 2021

2020

Press CA, Moharir M, Udani, Vrajesh, Mackay M. Global Neurology Symposium: Global Challenges and Opportunities in Inpatient Child Neurology. The 16th International Child Neurology Congress and 49th Annual Child Neurology Society Meeting. October 21st, 2020. San Diego, CA.

2019

Press CA, Kurz J. Advances and controversies in the treatment of pediatric status epilepticus. Neurocritical Care Society Meeting. October 16, 2019. Vancouver, BC CA.

Press CA, Messer R. Debate: Medical Marijuana in neurology patients. Neurohospitalist Society Meeting. October 4, 2019. Aurora, CO.

Press CA. Autoimmune Encephalitis. Christopher Ward Neuroscience Nursing Conference. August 9, 2019. Aurora, CO.

Press, CA. Neuroimaging for Non-First Time Seizures in the Pediatric Emergency Department. University of Colorado Neurology Department Research Day. June 5, 2019. Aurora CO.

Press CA. Pediatric Stroke. Children’s Hospital Colorado Annual EMS Conference. 2018. Jan 25, 2018. Aurora, CO.

Awards and Honors

2014, Young Investigator Award – American Epilepsy Society
2008, Hope Center Award and Lecture from Washington University
2002, Northwestern University- Graduated Magna Cum Laude
1999, Undergraduate Summer Center for Molecular and Cellular Toxicology Scholarship
1999, Parkinson’s Disease Foundation Summer Fellow

Leadership and Memberships

Memberships in Professional Organizations

International

2016-present, International Pediatric Stroke Study Group

National

2018-present, Critical Care EEG Monitoring Research Consortium
2016-present, American Clinical Neurophysiology Society
2015-present, Pediatric Neurocritical Care Research Group
2013-present, American Epilepsy Society
2010-present, Child Neurology Society
2010-present, American Academy of Neurology